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  1. Article ; Online: No patient left behind: A multilayered approach to mitigate COVID-19 in transplant recipients.

    Yetmar, Zachary A / Razonable, Raymund R

    Transplant infectious disease : an official journal of the Transplantation Society

    2023  Volume 25, Issue 1, Page(s) e13956

    MeSH term(s) Humans ; COVID-19 ; Transplant Recipients ; SARS-CoV-2 ; Organ Transplantation
    Language English
    Publishing date 2023-01-23
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.13956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Author's reply.

    Yetmar, Zachary A / Saleh, Omar M Abu

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2023  Volume 42, Issue 6, Page(s) 797–798

    Language English
    Publishing date 2023-04-18
    Publishing country Germany
    Document type Letter
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-023-04604-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Chronic Granulomatous Disease Presenting With Recurrent Skin Infections.

    Khodadadi, Ryan B / Yetmar, Zachary A / Montagnon, Carmen M

    Mayo Clinic proceedings

    2023  Volume 99, Issue 3, Page(s) 357–358

    MeSH term(s) Humans ; Granulomatous Disease, Chronic/complications ; Granulomatous Disease, Chronic/diagnosis
    Language English
    Publishing date 2023-12-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2023.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: SARS-CoV-2 spike codon mutations and risk of hospitalization after antispike monoclonal antibody therapy in solid organ transplant recipients.

    Yetmar, Zachary A / Yao, Joseph D / Razonable, Raymund R

    Journal of medical virology

    2023  Volume 95, Issue 6, Page(s) e28885

    Abstract: Neutralizing antispike monoclonal antibody (mAb) therapies were highly efficacious in preventing coronavirus disease 2019 (COVID-19) hospitalization. While severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants may harbor spike protein ... ...

    Abstract Neutralizing antispike monoclonal antibody (mAb) therapies were highly efficacious in preventing coronavirus disease 2019 (COVID-19) hospitalization. While severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants may harbor spike protein mutations conferring reduced in vitro susceptibility to these antibodies, the effect of these mutations on clinical outcomes is not well characterized. We conducted a case-control study of solid organ transplant recipients who received an antispike mAb for treatment of mild-to-moderate COVID-19 and had an available sample from initial COVID-19 diagnosis for genotypic sequencing. Patients whose SARS-CoV-2 isolate had at least one spike codon mutation conferring at least fivefold decreased in vitro susceptibility were classified as resistant. Overall, 9 of 41 patients (22%) had at least one spike codon mutation that confers reduced susceptibility to the antispike mAb used for treatment. Specifically, 9 of 12 patients who received sotrovimab had S371L mutation that was predicted to confer a 9.7-fold reduced susceptibility. However, among 22 patients who required hospitalization, 5 had virus with resistance mutation. In contrast, among 19 control patients who did not require hospitalization, 4 also had virus-containing resistance mutations (p > 0.99). In conclusion, spike codon mutations were common, though mutations that conferred a 9.7-fold reduced susceptibility did not predict subsequent hospitalization after treatment with antispike mAb.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19 Testing ; Case-Control Studies ; COVID-19 ; Mutation ; Antibodies, Neutralizing ; Codon ; Hospitalization ; Transplant Recipients ; Organ Transplantation ; Spike Glycoprotein, Coronavirus/genetics ; Antibodies, Viral
    Chemical Substances Antibodies, Neutralizing ; Codon ; Spike Glycoprotein, Coronavirus ; Antibodies, Viral ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28885
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  5. Article: Factors Associated with Infectious Diseases Fellowship Academic Success.

    Khodadadi, Ryan B / Yetmar, Zachary A / Domonoske, Cynthia L / Razonable, Raymund R

    Research square

    2023  

    Abstract: Background: A multitude of factors are considered in an infectious diseases (ID) training program's meticulous selection process of ID fellows but their correlation to pre and in-fellowship academic success as well as post-fellowship academic success ... ...

    Abstract Background: A multitude of factors are considered in an infectious diseases (ID) training program's meticulous selection process of ID fellows but their correlation to pre and in-fellowship academic success as well as post-fellowship academic success and short-term outcomes is poorly understood. Our goal was to investigate factors associated with subsequent academic success in fellowship as well as post-fellowship short-term outcomes.
    Methods: In 2022, we retrospectively analyzed deidentified academic records from 39 graduates of the Mayo Clinic Rochester ID Fellowship Program (July 1, 2013- June 30, 2022). Data abstracted included demographics, degrees, honor society membership, visa/citizenship status, medical school, residency training program, United States Medical Licensure Exam (USMLE) scores, letters of recommendation, in-training examination (ITE) scores, fellowship track, academic rank, career choice, number of honors, awards, and abstracts/publications prior to fellowship, during training, and within 2 years of graduation.
    Results: Younger fellows had higher USMLE step 1 scores, pre and in-fellowship scholarly productivity, and higher ITE performance. Female fellows had significantly higher USMLE step 3 scores. Prior research experience translated to greater in-fellowship scholarly productivity. Higher USMLE scores were associated with higher ID ITE performance during multiple years of fellowship, but USMLE step 2 clinical knowledge and 3 scores were associated with higher pre and in-fellowship scholarly productivity and receiving an award during fellowship. USMLE step 1 score did not correlate with fellowship performance beyond year 1 and 2 ITE scores.
    Conclusions: Multiple aspects of a prospective fellow's application must be considered as part of a holistic reviewprocess for fellowship selection. USMLE step 2 CK and 3 scores may predict fellowship performance across multiple domains.
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3140095/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Prototheca

    Cullen, Grace D / Yetmar, Zachary A / Fida, Madiha / Abu Saleh, Omar M

    Open forum infectious diseases

    2023  Volume 10, Issue 6, Page(s) ofad294

    Abstract: ... ...

    Abstract Prototheca
    Language English
    Publishing date 2023-06-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad294
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  7. Article ; Online: Antispike monoclonal antibodies for prevention and treatment of coronavirus disease-2019 in solid organ transplant recipients.

    Yetmar, Zachary A / Bhaimia, Eric / Razonable, Raymund R

    Current opinion in organ transplantation

    2022  Volume 27, Issue 4, Page(s) 269–276

    Abstract: Purpose of review: Coronavirus disease-2019 (COVID-19) disproportionately causes severe outcomes in solid organ transplant recipients (SOTR). Antispike monoclonal antibodies have been authorized for therapy and prophylaxis for COVID-19. Here, we review ... ...

    Abstract Purpose of review: Coronavirus disease-2019 (COVID-19) disproportionately causes severe outcomes in solid organ transplant recipients (SOTR). Antispike monoclonal antibodies have been authorized for therapy and prophylaxis for COVID-19. Here, we review the current state of antispike monoclonal antibodies and their role for SOTRs.
    Recent findings: Bamlanivimab with or without etesevimab, casirivimab-imdevimab and sotrovimab have reduced the rates of hospitalization and severe disease in high-risk patients with mild-to-moderate COVID-19. Multiple retrospective studies have also demonstrated monoclonal antibodies are effective in SOTR populations. However, the evolution of resistant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concerns has resulted in revocation of the authorization of bamlanivimab with or without etesevimab, and casirivimab-imdevimab as treatment and postexposure prophylaxis (PEP). Sotrovimab and bebtelovimab are currently authorized for treatment of the predominant circulating SARS-CoV-2 B.1.1.529 (Omicron), but not as pre or PEP. Tixagevimab-cilgavimab, a long-acting antibody combination preparation, is authorized for preexposure prophylaxis in high-risk immunocompromised populations, including SOTRs, who are less likely to mount an effective immune response following vaccination series and booster.
    Summary: Antispike monoclonal antibodies are useful for the prevention and treatment of mild-to-moderate COVID-19 in SOTRs. However, their clinical use should be determined by the evolving epidemiology of SARS-CoV-2 variants in the community.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19/prevention & control ; Retrospective Studies ; Antibodies, Monoclonal/adverse effects ; Organ Transplantation/adverse effects ; Transplant Recipients
    Chemical Substances imdevimab (2Z3DQD2JHM) ; casirivimab (J0FI6WE1QN) ; sotrovimab (1MTK0BPN8V) ; etesevimab (N7Q9NLF11I) ; tixagevimab ; bamlanivimab (45I6OFJ8QH) ; cilgavimab (1KUR4BN70F) ; bebtelovimab (8YL4SYR6CU) ; Antibodies, Monoclonal
    Language English
    Publishing date 2022-11-10
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1390429-2
    ISSN 1531-7013 ; 1087-2418
    ISSN (online) 1531-7013
    ISSN 1087-2418
    DOI 10.1097/MOT.0000000000000981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Mediastinal Infection After Endobronchial Ultrasound-guided Transbronchial Needle Aspiration: An Uncommon Complication.

    Marty, Paige K / Yetmar, Zachary A / Zhang, Zhenmei / Temesgen, Zelalem / Nelson, Darlene R

    Journal of bronchology & interventional pulmonology

    2023  Volume 30, Issue 3, Page(s) 307–310

    MeSH term(s) Humans ; Mediastinum/diagnostic imaging ; Endoscopic Ultrasound-Guided Fine Needle Aspiration/adverse effects ; Lymph Nodes/diagnostic imaging ; Lung Neoplasms ; Bronchoscopy/adverse effects
    Language English
    Publishing date 2023-07-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2478320-1
    ISSN 1948-8270 ; 1944-6586
    ISSN (online) 1948-8270
    ISSN 1944-6586
    DOI 10.1097/LBR.0000000000000909
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Impact of a change in universal gloving protocol on rates of central line-related bloodstream infection, Clostridioides difficile, and vancomycin-resistant Enterococcus.

    Yetmar, Zachary A / Miller, Vickie L / Sampathkumar, Priya / Beam, Elena

    American journal of infection control

    2022  Volume 51, Issue 6, Page(s) 720–722

    Abstract: In this retrospective cohort of adult hematology-oncology and transplant patients, discontinuation of universal gloving did not result in significant changes in rates of central line-associated bloodstream infection, Clostridioides difficile infection, ... ...

    Abstract In this retrospective cohort of adult hematology-oncology and transplant patients, discontinuation of universal gloving did not result in significant changes in rates of central line-associated bloodstream infection, Clostridioides difficile infection, or vancomycin-resistant Enterococcus colonization. Active surveillance and subsequent isolation may be a viable alternative strategy to universal precautions.
    MeSH term(s) Adult ; Humans ; Cross Infection/epidemiology ; Infection Control/methods ; Vancomycin/pharmacology ; Vancomycin/therapeutic use ; Clostridioides ; Retrospective Studies ; Vancomycin-Resistant Enterococci ; Clostridium Infections/epidemiology ; Clostridium Infections/prevention & control
    Chemical Substances Vancomycin (6Q205EH1VU)
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2022.10.001
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  10. Article ; Online: Clinical characteristics of central nervous system phaeohyphomycosis: A brief report of 20 years' experience.

    Chesdachai, Supavit / Yetmar, Zachary A / Tabaja, Hussam / Wengenack, Nancy L / Abu Saleh, Omar M

    Medical mycology

    2023  Volume 61, Issue 6

    Abstract: Central nervous system (CNS) phaeohyphomycosis is a rare and often fatal fungal infection. Our study reported a case series of eight CNS phaeohyphomycosis cases at our institution over the past 20 years. We did not observe the common pattern of risk ... ...

    Abstract Central nervous system (CNS) phaeohyphomycosis is a rare and often fatal fungal infection. Our study reported a case series of eight CNS phaeohyphomycosis cases at our institution over the past 20 years. We did not observe the common pattern of risk factors, abscess location, or number of abscesses among them. Most patients were immunocompetent without classic risk factors for fungal infection. Early diagnosis and aggressive management with surgical intervention and prolonged antifungal therapy can lead to a favorable outcome. The study highlights the need for further research to better understand the pathogenesis and optimal management of this challenging rare infection.
    MeSH term(s) Animals ; Phaeohyphomycosis/diagnosis ; Phaeohyphomycosis/drug therapy ; Phaeohyphomycosis/microbiology ; Phaeohyphomycosis/veterinary ; Cerebral Phaeohyphomycosis/diagnosis ; Cerebral Phaeohyphomycosis/drug therapy ; Cerebral Phaeohyphomycosis/veterinary ; Mycoses/drug therapy ; Mycoses/veterinary ; Risk Factors ; Antifungal Agents/therapeutic use
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2023-06-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1421796-x
    ISSN 1460-2709 ; 1369-3786
    ISSN (online) 1460-2709
    ISSN 1369-3786
    DOI 10.1093/mmy/myad060
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