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Article: The Protective Effects of a Modified Xiaohua Funing Decoction against Acute Liver Failure in Mice Induced by D-Gal and LPS.

Zhao, Jindong / Liu, Lili / Xin, Ling / Lu, Yunxia / Yang, Xiaojun / Hou, Yong / Shi, Mei / Han, Sha / Zhou, Hao / Liu, Yonghua / Fang, Zhaohui / Li, Yan / Zhang, Guoliang

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 6611563

Abstract: Objective: The aim of this study was to evaluate the effects of a modified Xiaohua Funing ...

Abstract	Objective: The aim of this study was to evaluate the effects of a modified Xiaohua Funing decoction (Xfd) on acute liver failure (ALF) and determine whether the protective mechanisms are related to alterations in the gut microbiota. Methods: An animal model of ALF was induced by intraperitoneal injection of D-galactosamine (D-Gal, 0.5 g/kg) and lipopolysaccharide (LPS, 100 Results: D-Gal/LPS treatment caused severe ALF, illustrating that the ALF model was successfully established. The administration of Sil and Xfd greatly reduced the serum ALT and AST levels and improved the pathological signs of liver injury. However, no significant difference was found between the two groups. In contrast to the Mod group, the Sil and Xfd groups showed a shift toward the Con group in terms of the gut microbiota structure. The abundances of Firmicutes and Bacteroidetes and the Bacteroidetes/Firmicutes ratio in the Mod group significantly differed from those in the Con group. The Sil and Xfd groups showed restoration of the disordered microbiota. Significantly increased relative abundances of Lachnospiraceae_NK4A136_group and Candidatus_Saccharimonas and a markedly decreased Muribaculaceae abundance were found in the Sil and Xfd mice compared with those in the Mod mice ( Conclusion: In summary, our results indicate that Xfd may protect the liver and modify the gut microbiota in ALF mice.
Language	English
Publishing date	2022-01-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/6611563
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Article ; Online: The Protective Effects of a Modified Xiaohua Funing Decoction against Acute Liver Failure in Mice Induced by D-Gal and LPS

Jindong Zhao / Lili Liu / Ling Xin / Yunxia Lu / Xiaojun Yang / Yong Hou / Mei Shi / Sha Han / Hao Zhou / Yonghua Liu / Zhaohui Fang / Yan Li / Guoliang Zhang

Evidence-Based Complementary and Alternative Medicine, Vol

2022 Volume 2022

Abstract: Objective. The aim of this study was to evaluate the effects of a modified Xiaohua Funing decoction ...

Abstract	Objective. The aim of this study was to evaluate the effects of a modified Xiaohua Funing decoction (Xfd) on acute liver failure (ALF) and determine whether the protective mechanisms are related to alterations in the gut microbiota. Methods. An animal model of ALF was induced by intraperitoneal injection of D-galactosamine (D-Gal, 0.5 g/kg) and lipopolysaccharide (LPS, 100 μg/kg). Male BALB/c mice were randomly divided into the following 4 groups: the control group (saline, Con), model group (D-Gal/LPS, Mod), silymarin pretreatment group (200 mg/kg, Sil), and modified Xfd pretreatment group (650 mg/kg, Xfd). The Sil and Xfd groups received the respective intervention orally for 14 days and 2 h before D-Gal/LPS treatment. The liver injury markers included alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and liver histology. 16S rRNA gene sequencing was performed to assess the effects on the caecum content. Results. D-Gal/LPS treatment caused severe ALF, illustrating that the ALF model was successfully established. The administration of Sil and Xfd greatly reduced the serum ALT and AST levels and improved the pathological signs of liver injury. However, no significant difference was found between the two groups. In contrast to the Mod group, the Sil and Xfd groups showed a shift toward the Con group in terms of the gut microbiota structure. The abundances of Firmicutes and Bacteroidetes and the Bacteroidetes/Firmicutes ratio in the Mod group significantly differed from those in the Con group. The Sil and Xfd groups showed restoration of the disordered microbiota. Significantly increased relative abundances of Lachnospiraceae_NK4A136_group and Candidatus_Saccharimonas and a markedly decreased Muribaculaceae abundance were found in the Sil and Xfd mice compared with those in the Mod mice (P<0.01, P<0.05). Interestingly, a negative correlation was observed between the abundances of the gut microbiota constituents, specifically Clostridia_UCG-014, and ALT and AST levels. Conclusion. In ...
Keywords	Other systems of medicine ; RZ201-999
Subject code	630
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Corrigendum to "Elimination of Microcystis aeruginosa through Leuconostoc mesenteroides DH and its underlying mechanism" [Sci. Total Environ. 908 (2024) 168290].

Li, Yi / Qin, Mengyuan / Han, Shuo / Wang, Yuqi / Gao, Chao / Niu, Wenfang / Xia, Xiaohua

The Science of the total environment

2024 Volume 927, Page(s) 172209

Language	English
Publishing date	2024-04-10
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.172209
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Article: Identification of CXC Chemokine Receptor 2 (CXCR2) as a Novel Eosinophils-Independent Diagnostic Biomarker of Pediatric Eosinophilic Esophagitis by Integrated Bioinformatic and Machine-Learning Analysis.

Wu, Junhao / Duan, Caihan / Han, Chaoqun / Hou, Xiaohua

ImmunoTargets and therapy

2024 Volume 13, Page(s) 55–74

Abstract: Background: Eosinophilic esophagitis (EoE) is a complex allergic condition frequently accompanied by various atopic comorbidities in children, which significantly affects their life qualities. Therefore, this study aimed to evaluate pivotal molecular ... ...

Abstract	Background: Eosinophilic esophagitis (EoE) is a complex allergic condition frequently accompanied by various atopic comorbidities in children, which significantly affects their life qualities. Therefore, this study aimed to evaluate pivotal molecular markers that may facilitate the diagnosis of EoE in pediatric patients. Methods: Three available EoE-associated gene expression datasets in children: GSE184182, GSE 197702, GSE55794, along with GSE173895 were downloaded from the GEO database. Differentially expressed genes (DEGs) identified by "limma" were intersected with key module genes identified by weighted gene co-expression network analysis (WGCNA), and the shared genes went through functional enrichment analysis. The protein-protein interaction (PPI) network and the machine learning algorithms: least absolute shrinkage and selection operator (LASSO), random forest (RF), and XGBoost were used to reveal candidate diagnostic markers for EoE. The receiver operating characteristic (ROC) curve showed the efficacy of differential diagnosis of this marker, along with online databases predicting its molecular regulatory network. Finally, we performed gene set enrichment analysis (GSEA) and assessed immune cell infiltration of EoE/control samples by using the CIBERSORT algorithm. The correlations between the key diagnostic biomarker and immune cells were also investigated. Results: The intersection of 936 DEGs and 1446 key module genes in EoE generated 567 genes, which were primarily enriched in immune regulation. Following the construction of the PPI network and filtration by machine learning, CXCR2 served as a potential diagnostic biomarker of pediatric EoE with a perfect diagnostic efficacy (AUC = ~1.00) in regional tissue/peripheral whole blood samples. Multiple infiltrated immune cells were observed to participate in disrupting the homeostasis of esophageal epithelium to varying degrees. Conclusion: The immune-correlated CXCR2 gene was proved to be a promising diagnostic indicator for EoE, and dysregulated regulatory T cells (Tregs)/neutrophils might play a crucial role in the pathogenesis of EoE in children.
Language	English
Publishing date	2024-02-02
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2706272-7
ISSN	2253-1556
ISSN	2253-1556
DOI	10.2147/ITT.S439289
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Article ; Online: Supplementary Control for Quantized Discrete-Time Nonlinear Systems Under Goal Representation Heuristic Dynamic Programming.

Wang, Xueli / Ding, Derui / Ge, Xiaohua / Han, Qing-Long

IEEE transactions on neural networks and learning systems

2024 Volume 35, Issue 3, Page(s) 3202–3214

Abstract: This article is concerned with supplementary control of discrete-time nonlinear systems with multiple controllers in the framework of goal representation heuristic dynamic programming (GrHDP), where a logarithmic quantizer is used to govern the network ... ...

Abstract	This article is concerned with supplementary control of discrete-time nonlinear systems with multiple controllers in the framework of goal representation heuristic dynamic programming (GrHDP), where a logarithmic quantizer is used to govern the network communication. For the addressed problem, a neural network (NN)-based observer is first proposed to estimate the unknown system state in the simultaneous presence of quantized influence. In light of the estimated states and the ideal control inputs via a zero-sum game, a GrHDP algorithm with a reinforced term is developed to implement the supplementary control task, where some novel weight updating rules are constructed by virtue of an additional tunable parameter to improve the system performance. Furthermore, a set of conditions about the stability of estimated error dynamics of both observer states and updated NNs' weights are derived by resorting to the Lyapunov stability theory. Finally, the effectiveness of the developed method is verified by a power system and a numerical experiment.
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ISSN	2162-2388
ISSN (online)	2162-2388
DOI	10.1109/TNNLS.2022.3201521
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Article ; Online: Event-Triggered Cluster Consensus of Multi-Agent Systems via a Modified Genetic Algorithm.

Yang, Yanping / Li, Shenrong / Ge, Xiaohua / Han, Qing-Long

IEEE transactions on neural networks and learning systems

2024 Volume 35, Issue 5, Page(s) 6792–6805

Abstract: This article is concerned with the event-triggered output feedback cluster consensus of leader-following multi-agent systems (MASs) under limited communication resources. Specifically, the distributed agents are divided into several clusters to ... ...

Abstract	This article is concerned with the event-triggered output feedback cluster consensus of leader-following multi-agent systems (MASs) under limited communication resources. Specifically, the distributed agents are divided into several clusters to accomplish different collective tasks under diverse intracluster and intercluster communications. First, to alleviate excessive communication resource consumption, two sampled-data-based event-triggered schemes are developed to distinguish agent-to-agent communications within clusters and between clusters. Based on these schemes, an event-based cluster consensus control protocol is proposed to solve the problem. Then, sufficient criteria on asymptotic stability of the resulting closed-loop system are derived and expressed in terms of matrix inequalities. It is noteworthy that the derived criteria for controller design are nonlinear and nonconvex with respect to the output feedback control gains and triggering parameters. To handle this issue, a modified genetic algorithm (MGA) with multiple subpopulations is proposed, where the subpopulations are independent of each other. The key feature of the designed MGA lies in that the fitness value is described as an accumulation of initial value and weighing value of each matrix inequality. Finally, an application of satellite formation flying is exemplified to demonstrate the effectiveness of the derived theoretical results.
Language	English
Publishing date	2024-05-02
Publishing country	United States
Document type	Journal Article
ISSN	2162-2388
ISSN (online)	2162-2388
DOI	10.1109/TNNLS.2022.3212967
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Article: Identifying MS4A6A

Wu, Junhao / Wang, Jinsheng / Duan, Caihan / Han, Chaoqun / Hou, Xiaohua

Heliyon

2024 Volume 10, Issue 8, Page(s) e29340

Abstract: Purpose: Concrete epidemiological evidence has suggested the mutually-contributing effect respectively between nonalcoholic fatty liver disease (NAFLD), type 2 diabetes mellitus (T2DM), and periodontitis (PD); however, their shared crosstalk mechanism ... ...

Abstract	Purpose: Concrete epidemiological evidence has suggested the mutually-contributing effect respectively between nonalcoholic fatty liver disease (NAFLD), type 2 diabetes mellitus (T2DM), and periodontitis (PD); however, their shared crosstalk mechanism remains an open issue. Method: The NAFLD, PD, and T2DM-related datasets were obtained from the NCBI GEO repository. Their common differentially expressed genes (DEGs) were identified and the functional enrichment analysis performed by the DAVID platform determined relevant biological processes and pathways. Then, the STRING database established a PPI network of such DEGs and topological analysis through Cytoscape 3.7.1 software along with the machine-learning analysis by the least absolute shrinkage and selection operator (LASSO) algorithm screened out hub characteristic genes. Their efficacy was validated by external datasets using the receiver operating characteristic (ROC) curve, and gene expression and location of the most robust one was determined using single-cell sequencing and immunohistochemical staining. Finally, the promising drugs were predicted through the CTD database, and the CB-DOCK 2 and Pymol platform mimicked molecular docking. Result: Intersection of differentially expressed genes from three datasets identified 25 shared DEGs of the three diseases, which were enriched in MHC II-mediated antigen presenting process. PPI network and LASSO machine-learning analysis determined 4 feature genes, of which the MS4A6A gene mainly expressed by macrophages was the hub gene and key immune cell type. Molecular docking simulation chosen fenretinide as the most promising medicant for MS4A6A Conclusion: MS4A6A
Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e29340
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fucose ameliorates the proinflammatory property of

Duan, Caihan / Hou, Lingzhi / Deng, Xiaohua / Wu, Junhao / Qian, Wei / Han, Chaoqun / Hou, Xiaohua

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1190602

Abstract: Introduction: Previous studies reported that fucose plays a protective role in inhibiting pathogens. Fusobacterium nucleatum (Fn) was recently found to promote the progression of colitis. However, the effects of fucose on Fn are poorly understood. This ... ...

Abstract	Introduction: Previous studies reported that fucose plays a protective role in inhibiting pathogens. Fusobacterium nucleatum (Fn) was recently found to promote the progression of colitis. However, the effects of fucose on Fn are poorly understood. This study aimed to explore whether fucose could ameliorate the proinflammatory property of Fn in colitis and the underlying mechanisms. Methods: To validate our hypothesis, mice were administrated with Fn and fucose-treated Fn (Fnf) before dextran sulfate sodium (DSS) treatment to establish Fn related colitis model. The metabolism variation of Fn was detected by metabolomic analysis. To verify the effects of bacterial metabolites on intestinal epithelial cells (IECs), Caco-2 cells were treated with bacterial supernatant. Results: More severe inflammation, intestinal barrier damage, autophagy block, and apoptosis in the colon were noted in DSS mice that were administrated with Fn or Fnf. However, the severity degree in Fnf+DSS group was less compared to Fn+DSS group. Metabolic pathways of Fn were altered after fucose treatment and proinflammatory metabolites were decreased. The supernatant of Fnf induced a lower level of inflammation than Fn in Caco-2 cells. One of the decreased metabolites, homocysteine thiolactone (HT), was proven to induce inflammatory effects in Caco-2 cells. Discussion: In conclusion, fucose ameliorates the proinflammatory property of Fn via altering its metabolism and these findings provide evidence for the application of fucose as functional food or prebiotic in the treatment of Fn related colitis.
MeSH term(s)	Humans ; Animals ; Mice ; Fusobacterium nucleatum ; Fucose/metabolism ; Caco-2 Cells ; Colitis/chemically induced ; Colitis/metabolism ; Inflammation/metabolism ; Colon ; Dextran Sulfate/toxicity ; Mice, Inbred C57BL ; Disease Models, Animal ; Intestinal Mucosa/metabolism
Chemical Substances	Fucose (28RYY2IV3F) ; Dextran Sulfate (9042-14-2)
Language	English
Publishing date	2023-05-01
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1190602
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Article ; Online: Transcriptome Analysis of Resistant and Susceptible Pecan (

Chang, Jun / Wang, Kailiang / Zhang, Chengcai / Han, Xiaojiao / Zhang, Xiaodan / Ren, Huadong / Yao, Xiaohua

Journal of agricultural and food chemistry

2023 Volume 71, Issue 14, Page(s) 5812–5822

Abstract: Pecan, ...

Abstract	Pecan,
MeSH term(s)	Carya/genetics ; Disease Resistance ; Fruit ; Gene Expression Profiling
Language	English
Publishing date	2023-03-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.2c08434
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Article ; Online: Delay-Variation-Dependent Criteria on Extended Dissipativity for Discrete-Time Neural Networks With Time-Varying Delay.

Zhang, Xian-Ming / Han, Qing-Long / Ge, Xiaohua / Zhang, Bao-Lin

IEEE transactions on neural networks and learning systems

2023 Volume 34, Issue 3, Page(s) 1578–1587

Abstract: This article is concerned with the extended dissipativity of discrete-time neural networks (NNs) with time-varying delay. First, the necessary and sufficient condition on matrix-valued polynomial inequalities reported recently is extended to a general ... ...

Abstract	This article is concerned with the extended dissipativity of discrete-time neural networks (NNs) with time-varying delay. First, the necessary and sufficient condition on matrix-valued polynomial inequalities reported recently is extended to a general case, where the variable of the polynomial does not need to start from zero. Second, a novel Lyapunov functional with a delay-dependent Lyapunov matrix is constructed by taking into consideration more information on nonlinear activation functions. By employing the Lyapunov functional method, a novel delay and its variation-dependent criterion are obtained to investigate the effects of the time-varying delay and its variation rate on several performances, such as H
Language	English
Publishing date	2023-02-28
Publishing country	United States
Document type	Journal Article
ISSN	2162-2388
ISSN (online)	2162-2388
DOI	10.1109/TNNLS.2021.3105591
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