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  1. Article ; Online: Inquiring Into Benefits of Independent Activation of Nonclassical Renin-angiotensin System in the Clinical Prognosis and Reduction of COVID-19 Mortality.

    Álvarez-Aragón, Luis Miguel / Cuesta-Muñoz, Antonio Luis / Álvarez-López, Inmaculada

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 71, Issue 15, Page(s) 894–895

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Prognosis ; Renin-Angiotensin System ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa402
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  2. Article: Inquiring Into Benefits of Independent Activation of Nonclassical Renin-angiotensin System in the Clinical Prognosis and Reduction of COVID-19 Mortality

    Álvarez-Aragón, Luis Miguel / Cuesta-Muñoz, Antonio Luis / Álvarez-López, Inmaculada

    Clin Infect Dis

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #47952
    Database COVID19

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  3. Article ; Online: Inquiring Into Benefits of Independent Activation of Nonclassical Renin-angiotensin System in the Clinical Prognosis and Reduction of COVID-19 Mortality

    Álvarez-Aragón, Luis Miguel / Cuesta-Muñoz, Antonio Luis / Álvarez-López, Inmaculada

    Clinical Infectious Diseases

    2020  Volume 71, Issue 15, Page(s) 894–895

    Keywords Microbiology (medical) ; Infectious Diseases ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa402
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

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  4. Article ; Online: A Previously Unrecognized Molecular Landscape of Lynch Syndrome in the Mexican Population.

    Padua-Bracho, Alejandra / Velázquez-Aragón, José A / Fragoso-Ontiveros, Verónica / Nuñez-Martínez, Paulina María / Mejía Aguayo, María de la Luz / Sánchez-Contreras, Yuliana / Ramirez-Otero, Miguel Angel / De la Fuente-Hernández, Marcela Angélica / Vidal-Millán, Silvia / Wegman-Ostrosky, Talia / Pedroza-Torres, Abraham / Arriaga-Canon, Cristian / Herrera-Montalvo, Luis A / Alvarez-Gómez, Rosa Maria

    International journal of molecular sciences

    2022  Volume 23, Issue 19

    Abstract: Lynch syndrome (LS) is the main hereditary colorectal cancer syndrome. There have been few reports regarding the clinical and molecular characteristics of LS patients in Latin America; this is particularly true in the Mexican population, where no ... ...

    Abstract Lynch syndrome (LS) is the main hereditary colorectal cancer syndrome. There have been few reports regarding the clinical and molecular characteristics of LS patients in Latin America; this is particularly true in the Mexican population, where no information is available. The present study aims to describe the clinical and molecular spectrum of variants in a cohort of patients diagnosed with LS in Mexico. We present a retrospective analysis of 412 patients with suspected LS, whose main site of cancer diagnosis was the colon (58.25%), followed by the endometrium (18.93%). Next-generation sequencing analysis, with an extensive multigene panel, showed that 27.1% (112/414) had a variant in one of the genes of the mismatch repair pathway (MMR); 30.4% (126/414) had a variant in non-MMR genes such as
    MeSH term(s) Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis ; Colorectal Neoplasms, Hereditary Nonpolyposis/epidemiology ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; DNA Mismatch Repair/genetics ; DNA-Binding Proteins/genetics ; Female ; Germ-Line Mutation ; Humans ; Immune Checkpoint Inhibitors ; Mexico/epidemiology ; MutS Homolog 2 Protein/genetics ; Retrospective Studies
    Chemical Substances DNA-Binding Proteins ; Immune Checkpoint Inhibitors ; MutS Homolog 2 Protein (EC 3.6.1.3)
    Language English
    Publishing date 2022-09-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms231911549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mexican BRCA1 founder mutation: Shortening the gap in genetic assessment for hereditary breast and ovarian cancer patients.

    Fragoso-Ontiveros, Veronica / Velázquez-Aragón, Jose Antonio / Nuñez-Martínez, Paulina Maria / de la Luz Mejía-Aguayo, Maria / Vidal-Millán, Silvia / Pedroza-Torres, Abraham / Sánchez-Contreras, Yuliana / Ramírez-Otero, Miguel Angel / Muñiz-Mendoza, Rodolfo / Domínguez-Ortíz, Julieta / Wegman-Ostrosky, Talia / Bargalló-Rocha, Juan Enrique / Gallardo-Rincón, Dolores / Reynoso-Noveron, Nancy / Arriaga-Canon, Cristian / Meneses-García, Abelardo / Herrera-Montalvo, Luis Alonso / Alvarez-Gomez, Rosa Maria

    PloS one

    2019  Volume 14, Issue 9, Page(s) e0222709

    Abstract: The deletion of exons 9 to 12 of BRCA1 (9-12 del BRCA1) is considered a founder mutation in the Mexican population. We evaluate the usefulness of the target detection of 9-12 del BRCA1 as the first molecular diagnostic strategy in patients with ... ...

    Abstract The deletion of exons 9 to 12 of BRCA1 (9-12 del BRCA1) is considered a founder mutation in the Mexican population. We evaluate the usefulness of the target detection of 9-12 del BRCA1 as the first molecular diagnostic strategy in patients with Hereditary Breast and Ovarian Cancer (HBOC). We performed the genetic assessment of 637 patients with suspected HBOC. The region corresponding to the breakpoints for the 9-12 del BRCA1 was amplified by polymerase chain reaction (PCR). An analysis of the clinical data of the carriers and non-carriers was done, searching for characteristics that correlated with the deletion. The 9-12 del BRCA1 was detected in 5% of patients with suspected HBOC (30/637). In patients diagnosed with ovarian cancer, 13 of 30 were 9-12 del BRCA1 carriers, which represents 43%. We found a significant association between the 9-12 del BRCA1 carriers with triple negative breast cancer and high-grade papillary serous ovarian cancer. We concluded that the detection of the 9-12 del BRCA1 is useful as a first molecular diagnostic strategy in the Mexican population. In particular, it shortens the gap in genetic assessment in patients with triple negative breast cancer and ovarian cancer.
    MeSH term(s) Adult ; BRCA1 Protein/genetics ; Breast Neoplasms/diagnosis ; Breast Neoplasms/genetics ; Exons/genetics ; Family Health ; Female ; Founder Effect ; Genetic Predisposition to Disease/genetics ; Genetic Testing ; Germ-Line Mutation ; Humans ; Mexico ; Middle Aged ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/genetics ; Sequence Deletion ; Young Adult
    Chemical Substances BRCA1 Protein ; BRCA1 protein, human
    Language English
    Publishing date 2019-09-23
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0222709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study

    Abuín-Fernández, Jose / Tapia-Guerrero, María José / López-Urdiales, Rafael / Herranz-Antolín, Sandra / García-Almeida, Jose Manuel / García-Malpartida, Katherine / Ferrer-Gómez, Mercedes / Cancer-Minchot, Emilia / Luengo-Pérez, Luis Miguel / Álvarez-Hernández, Julia / Aragón Valera, Carmen / Ocón-Bretón, Julia / García-Manzanares, Álvaro / Bretón-Lesmes, Irene / Serrano-Aguayo, Pilar / Pérez-Ferre, Natalia / López-Gómez, Juan José / Olivares-Alcolea, Josefina / Arraiza-Irigoyen, Carmen /
    Tejera-Pérez, Cristina / Martínez-González, Jorge Daniel / Urioste-Fondo, Ana / Abad-González, Ángel Luis / Molina-Puerta, María José / Zugasti-Murillo, Ana / Parra-Barona, Juan / López-Cobo, Irela / Olveira, Gabriel

    Nutrients. 2020 May 27, v. 12, no. 6

    2020  

    Abstract: There are no studies that have specifically assessed the role of intravenous lipid emulsions (ILE) enriched with fish oil in people with diabetes receiving total parenteral nutrition (TPN). The objective of this study was to assess the metabolic control ( ...

    Abstract There are no studies that have specifically assessed the role of intravenous lipid emulsions (ILE) enriched with fish oil in people with diabetes receiving total parenteral nutrition (TPN). The objective of this study was to assess the metabolic control (glycemic and lipid) and in-hospital complications that occurred in non-critically ill inpatients with TPN and type 2 diabetes with regard to the use of fish oil emulsions compared with other ILEs. We performed a post-hoc analysis of the Insulin in Parenteral Nutrition (INSUPAR) trial that included patients who started with TPN for any cause and that would predictably continue with TPN for at least five days. The study included 161 patients who started with TPN for any cause. There were 80 patients (49.7%) on fish oil enriched ILEs and 81 patients (50.3%) on other ILEs. We found significant decreases in triglyceride levels in the fish oil group compared to the other patients. We did not find any differences in glucose metabolic control: mean capillary glucose, glycemic variability, and insulin dose, except in the number of mild hypoglycemic events that was significantly higher in the fish oil group. We did not observe any differences in other metabolic, liver or infectious complications, in-hospital length of stay or mortality.
    Keywords dosage ; fish oils ; glucose ; insulin ; intravenous injection ; length ; liver ; mortality ; noninsulin-dependent diabetes mellitus ; people ; total parenteral nutrition ; triacylglycerols ; variability
    Language English
    Dates of publication 2020-0527
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12061566
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study.

    Abuín-Fernández, Jose / Tapia-Guerrero, María José / López-Urdiales, Rafael / Herranz-Antolín, Sandra / García-Almeida, Jose Manuel / García-Malpartida, Katherine / Ferrer-Gómez, Mercedes / Cancer-Minchot, Emilia / Luengo-Pérez, Luis Miguel / Álvarez-Hernández, Julia / Valera, Carmen Aragón / Ocón-Bretón, Julia / García-Manzanares, Álvaro / Bretón-Lesmes, Irene / Serrano-Aguayo, Pilar / Pérez-Ferre, Natalia / López-Gómez, Juan José / Olivares-Alcolea, Josefina / Arraiza-Irigoyen, Carmen /
    Tejera-Pérez, Cristina / Martínez-González, Jorge Daniel / Urioste-Fondo, Ana / Abad-González, Ángel Luis / Molina-Puerta, María José / Zugasti-Murillo, Ana / Parra-Barona, Juan / López-Cobo, Irela / Olveira-Fuster, And Gabriel

    Nutrients

    2020  Volume 12, Issue 6

    Abstract: There are no studies that have specifically assessed the role of intravenous lipid emulsions (ILE) enriched with fish oil in people with diabetes receiving total parenteral nutrition (TPN). The objective of this study was to assess the metabolic control ( ...

    Abstract There are no studies that have specifically assessed the role of intravenous lipid emulsions (ILE) enriched with fish oil in people with diabetes receiving total parenteral nutrition (TPN). The objective of this study was to assess the metabolic control (glycemic and lipid) and in-hospital complications that occurred in non-critically ill inpatients with TPN and type 2 diabetes with regard to the use of fish oil emulsions compared with other ILEs. We performed a post-hoc analysis of the Insulin in Parenteral Nutrition (INSUPAR) trial that included patients who started with TPN for any cause and that would predictably continue with TPN for at least five days. The study included 161 patients who started with TPN for any cause. There were 80 patients (49.7%) on fish oil enriched ILEs and 81 patients (50.3%) on other ILEs. We found significant decreases in triglyceride levels in the fish oil group compared to the other patients. We did not find any differences in glucose metabolic control: mean capillary glucose, glycemic variability, and insulin dose, except in the number of mild hypoglycemic events that was significantly higher in the fish oil group. We did not observe any differences in other metabolic, liver or infectious complications, in-hospital length of stay or mortality.
    MeSH term(s) Aged ; Aged, 80 and over ; Blood Glucose ; Diabetes Mellitus, Type 2/drug therapy ; Fat Emulsions, Intravenous/therapeutic use ; Fatty Acids, Omega-3/therapeutic use ; Female ; Fish Oils/therapeutic use ; Humans ; Hypoglycemic Agents ; Insulin ; Liver/metabolism ; Male ; Middle Aged ; Parenteral Nutrition ; Parenteral Nutrition, Total/adverse effects ; Triglycerides/blood ; Triglycerides/metabolism
    Chemical Substances Blood Glucose ; Fat Emulsions, Intravenous ; Fatty Acids, Omega-3 ; Fish Oils ; Hypoglycemic Agents ; Insulin ; Triglycerides
    Language English
    Publishing date 2020-05-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12061566
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Mexican BRCA1 founder mutation

    Veronica Fragoso-Ontiveros / Jose Antonio Velázquez-Aragón / Paulina Maria Nuñez-Martínez / Maria de la Luz Mejía-Aguayo / Silvia Vidal-Millán / Abraham Pedroza-Torres / Yuliana Sánchez-Contreras / Miguel Angel Ramírez-Otero / Rodolfo Muñiz-Mendoza / Julieta Domínguez-Ortíz / Talia Wegman-Ostrosky / Juan Enrique Bargalló-Rocha / Dolores Gallardo-Rincón / Nancy Reynoso-Noveron / Cristian Arriaga-Canon / Abelardo Meneses-García / Luis Alonso Herrera-Montalvo / Rosa Maria Alvarez-Gomez

    PLoS ONE, Vol 14, Iss 9, p e

    Shortening the gap in genetic assessment for hereditary breast and ovarian cancer patients.

    2019  Volume 0222709

    Abstract: The deletion of exons 9 to 12 of BRCA1 (9-12 del BRCA1) is considered a founder mutation in the Mexican population. We evaluate the usefulness of the target detection of 9-12 del BRCA1 as the first molecular diagnostic strategy in patients with ... ...

    Abstract The deletion of exons 9 to 12 of BRCA1 (9-12 del BRCA1) is considered a founder mutation in the Mexican population. We evaluate the usefulness of the target detection of 9-12 del BRCA1 as the first molecular diagnostic strategy in patients with Hereditary Breast and Ovarian Cancer (HBOC). We performed the genetic assessment of 637 patients with suspected HBOC. The region corresponding to the breakpoints for the 9-12 del BRCA1 was amplified by polymerase chain reaction (PCR). An analysis of the clinical data of the carriers and non-carriers was done, searching for characteristics that correlated with the deletion. The 9-12 del BRCA1 was detected in 5% of patients with suspected HBOC (30/637). In patients diagnosed with ovarian cancer, 13 of 30 were 9-12 del BRCA1 carriers, which represents 43%. We found a significant association between the 9-12 del BRCA1 carriers with triple negative breast cancer and high-grade papillary serous ovarian cancer. We concluded that the detection of the 9-12 del BRCA1 is useful as a first molecular diagnostic strategy in the Mexican population. In particular, it shortens the gap in genetic assessment in patients with triple negative breast cancer and ovarian cancer.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616 ; 610
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain

    Berenguer, Juan / Ryan, Pablo / Rodríguez-Baño, Jesús / Jarrín, Inmaculada / Carratalà, Jordi / Pachón, Jerónimo / Yllescas, María / Arriba, José Ramón / Aznar Muñoz, Esther / Gil Divasson, Pedro / González Muñiz, Patricia / Muñoz Aguirre, Clara / López, Juan Carlos / Ramírez-Schacke, Margarita / Gutiérrez, Isabel / Tejerina, Francisco / Aldámiz-Echevarría, Teresa / Díez, Cristina / Fanciulli, Chiara /
    Pérez-Latorre, Leire / Parras, Francisco / Catalán, Pilar / García-Leoni, María E. / Pérez-Tamayo, Isabel / Puente, Luis / Cedeño, Jamil / Díaz Menéndez, Marta / de la Calle Prieto, Fernando / Arsuaga Vicente, Marta / Trigo Esteban, Elena / Lago Núñez, Mª del Mar / de Miguel Buckley, Rosa / Cadiñaños Loidi, Julen / Busca Arenzana, Carmen / Mican, Alfredo / Mora Rillo, Marta / Ramos Ramos, Juan Carlos / Loeches Yagüe, Belén / Bernardino de la Serna, José Ignacio / García Rodríguez, Julio / Arribas López, José Ramón / Such Diaz, Ana / Álvaro Alonso, Elena / Izquierdo García, Elsa / Torres Macho, Juan / Cuevas Tascon, Guillermo / Troya García, Jesús / Mestre Gómez, Beatriz / Jiménez González de Buitrago, Eva / Fernández Jiménez, Inés / Tebar Martínez, Ana Josefa / Brañas Baztán, Fátima / Valencia de la Rosa, Jorge / Pérez Butragueño, Mario / Alvarado Blasco, Marta / Sepúlveda Berrocal, Mª Antonia / Yera Bergua, Carmen / Toledano Sierra, Pilar / Cano Llorente, Verónica / Zafar Iqubal-Mirza, Sadaf / Muñiz, Gema / Martín Pérez, Inmaculada / Mozas Moriñigo, Helena / Alguacil, Ana / García Butenegro, María Paz / Peláez Ballesta, Ana Isabel / Morcillo Rodríguez, Elena / Goikoetxea Agirre, Josune / Blanco Vidal, María José / Nieto Arana, Javier / del Álamo Martínez de Lagos, Mikel / Pérez Hernández, Isabel A. / Pérez Zapata, Inés / Silvariño Fernández, Rafael / Ugalde Espiñeira, Jon / Asensi Álvarez, Víctor / Suárez Pérez, Lucia / Suárez Diaz, Silvia / Yllera Gutiérrez, Carmen / Boix, Vicente / Díez Martínez, Marcos / Carreres Candela, Melissa / Gómez-Ayerbe, Cristina / Sánchez-Lora, Javier / Velasco Garrido, José Luis / López-Jódar, María / Santos González, Jesús / Ruiz Aragón, Jesús / Virto Peña, Ianire / Alende Castro, Vanessa / Brea Aparicio, Ruth / Vega Molpeceres, Sonia / Pons Viñas, Estel / del Río Pérez, Oscar / Valero Rovira, Silvia / Villar-García, Judit / Gómez-Junyent, Joan / Knobel, Hernando / Cánepa, María Cecilia / Castañeda Espinosa, Silvia / Sorli Redò, Luisa / Güerri-Fernández, Roberto / Milagro Montero, María / Horcajada, Juan Pablo / García Vázquez, Elisa / Moral Escudero, Encarnación / Hernández Torres, Alicia / García Almodóvar, Esther / Sáez Barberá, Carmen / Karroud, Zineb / Hernández Quero, José / Vinuesa García, David / García Fogeda, José Luis / Peregrina, José Antonio / Novella Mena, María / Hernández Gutiérrez, Cristina / Sanz Moreno, José / Pérez Tanoira, Ramón / Sierra Rodríguez, Rodrigo / Alonso Menchén, David / Gutiérrez García, Aida / Arranz Caso, Alberto / Cuadros González, Juan / Álvarez de Mon Soto, Melchor / Díaz de Brito Fernández, Vicente Ferrer / Sanmarti Vilamala, Montserrat / Gabarrell Pascuet, Aina / Molina Morant, Daniel / España Cueto, Sergio / Cámara Fernández, Jonathan / Sabater Gil, Albert / Muñoz López, Laura / Sáez Escolano, Paula / Bejarano Tello, Esperanza / Sempere Alcocer, Marco Antonio / Álvarez Martin, Salvador / De los Santos Gil, Ignacio / García-Fraile, Lucio / Sampedro Núñez, Miguel / Barrios Blandino, Ana / Rodríguez Franco, Carlos / Useros Brañas, Daniel / Villa Martí, Almudena / Oliver Ortega, Javier / Costanza Espiño Álvarez, Alexia / Sanz Sanz, Jesús / Rexach Fumaña, María / Abascal Cambras, Ivette / Pérez Jaén, Ana del Cielo / Sala Jofre, Clara / Casas Rodríguez, Susana / Tortajada Alamilla, Cecilia / Oltra, Carmina / Masiá Canuto, Mar / Gutiérrez Rodero, Félix / Ferrer Ribera, Ana / Bea Serrano, Carlos / Pedromingo Kus, Miguel / Garcinuño, María Ángeles / Fiorante, Silvana / Pérez Pinto, Sergio / Hernández Machín, Pilar / Alastrué Violeta, Alba / Fariñas Álvarez, María Carmen / González Rico, Claudia / Arnaiz de las Revillas, Francisco / Calvo, Jorge / Gozalo, Mónica / Mora Gómez, Francisco / Milagro Beamonte, Ana / Latorre-Millán, Miriam / Rezusta López, Antonio / Martínez Sapiña, Ana / Meije, Yolanda / Duarte Borges, Alejandra / Pareja Coca, Julia / Clemente Presas, Mercedes / Losa García, Juan Emilio / Vegas Serrano, Ana / Pérez-Rodríguez, M. Teresa / Pérez González, Alexandre / Belhassen-García, Moncef / Rodríguez-Alonso, Beatriz / López-Bernus, Amparo / Carbonell, Cristina / Torres Perea, Rafael / Cantón de Seoane, Juan / Alonso, Blanca / Kamal, Sara Lidia / Cajuela, Lucia / Roa, David / Cervero, Miguel / Oreja, Alberto / Avilés, Juan Pablo / Martín, Lidia / Pelegrín Senent, Iván / Rouco Esteves Marques, Rosana / Parra Ruiz, Jorge / Ramos Sesma, Violeta / Abadia Otero, Jessica / Salillas Hernando, Juan / Torres Sánchez del Arco, Robert / Torralba González de Suso, Miguel / Serrano Martínez, Alberto / Gilaberte Reyzábal, Sergio / Pacheco Martínez-Atienza, Marina / Liébana Gómez, Mónica / Fernández Rodríguez, Sara / Varela Plaza, Álvaro / Calvo Sánchez, Henar / Martínez Martín, Patricia / González- Ruano, Patricia / Malmierca Corral, Eduardo / Rábago Lorite, Isabel / Pérez-Monte Mínguez, Beatriz / García Flores, Ángeles / Comas Casanova, Pere / Sirisi, Merce / Rojas, Richard / Díaz de Tuesta del Arco, José Luis / Figueroa Cerón, Ruth / González Sarria, Ander / Alemán Valls, Remedios / Alonso Socas, María del Mar / Sanz Peláez, Oscar / Mohamed Ramírez, Karim / Riera Jaume, Melchor / Vilchez, Helem Haydee / Albertí, Francesc / Cañabate, Ana Isabel / Moreno Cuerda, Víctor J. / Álvarez Kaelis, Silvia / Álvarez Zapatero, Beatriz / García García, Alejandro / Isaba Ares, Elena / Morcate Fernández, Covadonga / Pérez Rodríguez, Andrea / Ramos Merino, Lucía / Castelo Corral, Laura / Rodríguez Mahía, María / González Bardanca, Mónica / Sánchez Vidal, Efrén / Míguez Rey, Enrique / De la Torre Lima, Javier / García de Lomas Guerrero, José Mª / Morte, Elena / Loscos, Silvia / Camón, Ana / Gómez García, Lucía / Boix Palop, Lucia / Dietl Gómez-Luengo, Beatriz / Pedrola Gorrea, Iris / Blasco Claramunt, Amparo / López Mestanza, Cristina / Fraile Villarejo, Esther / Tosco Núñez, Tomás / Aroca Ferri, María / Algado Rabasa, José Tomas / Garijo Saiz, Ana María / Amador Prous, Concepción / Baño, Jesús Rodriguez / Retamar, Pilar / Valiente, Adoración / López-Cortés, Luis E. / Sojo, Jesús / Gutiérrez-Gutiérrez, Belén / Bravo-Ferrer, José / Salamanca, Elena / Palacios, Zaira R. / Pérez-Palacios, Patricia / Peral, Enrique / Pérez de León, José Antonio / Sánchez-Gómez, Jesús / Marín-Barrera, Lucía / García-Jiménez, Domingo / Abelenda-Alonso, Gabriela / Ardanuy, Carmen / Bergas, Alba / Cuervo, Guillermo / Domínguez, María Ángeles / Fernández-Huerta, Miguel / Gudiol, Carlota / Lorenzo-Esteller, Laia / Niubó, Jordi / Pérez-Recio, Sandra / Podzamczer, Daniel / Pujol, Miquel / Rombauts, Alexander / Trullen, Núria / Salavert Lletí, Miguel / Castro Hernández, Iván / Hernández Belmonte, Adriana / Martínez Goñi, Raquel / Navarro Vilasaró, Marta / Calzado Isbert, Sonia / Cervantes García, Manuel / Gomila Grange, Aina / Gasch Blasi, Oriol / Machado Sicilia, María Luisa / Van den Eynde Otero, Eva / Falgueras López, Luis / Navarro Sáez, María del Carmen / Martínez, Esteban / Marcos, Mª Ángeles / Mosquera, Mar / Blanco, José Luis / Laguno, Montserrat / Rojas, Jhon / González-Cordón, Ana / Inciarte, Alexy / Torres, Berta / De la Mora, Lorena / Soriano, Alex / Martínez Macias, Olalla / Pérez Doñate, Virginia / Cabello Úbeda, Alfonso / Carrasco Antón, Nerea / Álvarez Álvarez, Beatriz / Petkova Saiz, Elizabet / Górgolas Hernández-Mora, Miguel / Prieto Pérez, Laura / Carrillo Acosta, Irene / Heili Frades, Sara / Villar Álvarez, Felipe / Fernández Roblas, Ricardo / Milicua Muñoz, José María / Fernández Espinilla, Virginia / Dueñas Gutiérrez, Carlos Jesús / Hernán García, Cristina / González-Romo, Fernando / Merino Amador, Paloma / Rueda López, Alba / Martínez Jordán, Jorge / Medrano Pardo, Sara / Díaz de la Torre, Irene / Posada Franco, Yolanda / Delgado-Iribarren, Alberto / López-Contreras González, Joaquín / Pascual Alonso, Pablo / Pomar Solchaga, Virginia / Rabella García, Nuria / Benito Hernández, Natividad / Domingo Pedrol, Pere / Bonfill Cosp, Xavier / Padrós Selma, Rafael / Puig Campmany, Mireia / Mancebo Cortés, Jordi / Gurguí Ferrer, Mercè / Íñigo Pestaña, Melania / Pérez García, Alejandra / Sorní Moreno, Patricia / Izko Gartzia, Nora / Membrillo de Novales, Francisco Javier / Simón Sacristán, María / Zamora Cintas, Maribel / Martínez Martínez, Yolanda / Fernández-González, Pablo / Alcántara Nicolás, Francisco / Aguirre Vila-Cora, Alejandro / López Tizón, Elena / Ramírez-Olivencia, Germán / Estébanez Muñoz, Miriam / Sáez de Adana Arróniz, Ester / Portu Zapirain, Joseba / Gainzarain Arana, Juan Carlos / Ortiz de Zárate Ibarra, Zuriñe / Moran Rodríguez, Miguel Ángel / Canut Blasco, Andrés / Hernáez Crespo, Silvia / Balerdi Sarasola, Leire / Morales García, Cristina / Corral Saracho, Miguel / Valcarce González, Zeltia / Arenal Andrés, Noelia / Rodríguez Tarazona, Raquel Elisa / Iglesias Llorente, Laura / Loureiro Rodríguez, Beatriz / Sánchez Montalvá, Adrián / Espinosa Pereiro, Juan / Almirante, Benito / Miarons, Marta / Sellarés, Júlia / Larrosa, María / García, Sonia / Marzo, Blanca / Villamarín, Miguel / Fernández, Nuria / Pérez-Jorge Peremarch, Conchita / Resino Foz, Elena / Espigares Correa, Andrea / Álvarez de Espejo Montiel, Teresa / Navas Clemente, Iván / Quijano Contreras, María Isabel / Nieto Fernández del Campo, Luis Alberto / Jiménez Álvarez, Guillermo / Guillamón Sánchez, Mercedes / García García, Josefina / Muñoz Hornero, Constanza / Mariño Callejo, Ana / Valcarce Pardeiro, Nieves / Smithson Amat, Alex / Chico Chumillas, Cristina / Sánchez Serrano, Adriana / García Villalba, Eva Pilar / Jiménez Martínez, Isabel / Estrada Fernández, Guillermo / Lorén Vargas, María / Parra Arribas, Nuria / Martínez Cilleros, Carmen / Villasante de la Puente, Aránzazu / García Delange, Teresa / Ruiz Rodríguez, María José / Robledo del Prado, Marta / Abad Almendro, Juan Carlos / Muñoz del Rey, José Román / Jiménez Álvaro, Montaña / Coy Coy, Javier / Poquet Catala, Inmaculada / Santos Peña, Marta / Naranjo Velasco, Virginia / Manso Gómez, Tamara / Quilez Ágreda, Delia / Barbeito Castiñeiras, Gema / Domínguez Santalla, María Jesús / Mao Martín, Laura / Alonso Navarro, Rodrigo / Ampuero Martinich, Jose David / Barrós González, Raquel / Galindo Martín, María Aránzazu / Herrera Pacheco, Lourdes / Martínez Avilés, Rocío / Rodrigo González, Sara / Rodríguez Leal, Cristóbal Manuel / Romay Lema, Eva María / Suárez Gil, Roi / Ibarguren Pinilla, Maialen / Marimón Ortiz de Zárate, José María / Vidaur Tello, Loreto / Kortajarena Urkola, Xabier / García Gómez, Miriam / Aranguren Arostegui, Asier / Álvarez de Castro, Maria / Martínez Mateu, Cintia María / Rodríguez Gómez, Francisco / Muñoz Beamud, Francisco / Chamarro Martí, Elena / Cardona Rivera, Merce / Zakariya-Yousef Breval, Ismail / Rico Rodríguez, Marta / Llenas García, Jara / Sánchez Arenas, Mª Carmen / Fernández Cruz, Ana / Calderón Parra, Jorge / López Dosil, Marcos / Ramos Martínez, Antonio / Múñez Rubio, Elena / Callejas Díaz, Alejandro / Vázquez Comendador, José Manuel / Diego Yagüe, Itziar / Expósito Palomo, Esther / Anel Pedroche, Jorge / Álvarez Franco, Raquel / Fernández de Orueta, Lucía / Vates Gómez, Roberto / Cardona Arias, Andrés Felipe / Marguenda Contreras, Pablo / Gaspar Alonso-Vega, Gabriel / Aranda Rife, Elena María / Martínez Cifre, Blanca / Roger Zapata, Daniel / Martín Rubio, Irene / Barbosa Ventura, André / Piñero, Iván / Bahamonde Carrasco, Alberto / Runza Buznego, Paula / Talavera García, Eva / Lamata Subero, Marta / Urrutia Losada, Ainhoa / Arteche Eguizabal, Lorea / Delgado Sánchez, Elisabet / Molina Peinado, Virginia / Caro Bragado, Sarah / Domínguez de Pablos, Gema / Roldán Fontana, Carolina / Herrero Rodríguez, Carmen / Force Sanmartín, Luis / Aranega, Raquel / Mera Fidalgo, Arantzazu / Toda Savall, María Roca / Merchante Gutiérrez, Nicolas / León Jiménez, Eva María / Del Pozo León, José Luís / Serralta Buades, Josefa / Cabrera Tejada, Ginger Giorgiana / Fernández-Ruiz, Mario / Aguado, José María / Maestro de la Calle, Guillermo / Cisneros, José Miguel / Aguilar-Guisado, Manuela / Aldabó, Teresa / Avilés, María Dolores / Bueno, Claudio / Cordero-Matía, Elisa / Escoresca, Ana / Gálvez-Benítez, Lydia / Infante, Carmen / Martín, Guillermo / Praena, Julia / Roca, Cristina / Salamanca, Celia / Suárez-Benjumea, Alejandro / Vizcarra, Pilar / Quereda, Carmen / Rodriguez Dominguez, Mario José / Gioia, Francesca / Norman, Francesca / Del Campo, Santos / Cantón Moreno, Rafael / Oteo Revuelta José, Antonio / Santibáñez Sáenz, Paula / Cervera Acedo, Cristina / Ruiz Martínez, Carlos / Blanco Ramos, José R. / Azcona Gutiérrez, José M. / García García, Concepción / Alba Fernández, Jorge / Ibarra Cucalón, Valvanera / San Franco, Mercedes / Metola Sacristán, Luis / Meijide Míguez, Héctor / Paulos Viñas, Silvia / Menéndez, Justo / Villares Fernández, Paula / Montes Andújar, Lara / Navarro Batet, Álvaro / Ferrer Santolaria, Anna / Padilla Salazar, María de la Luz / Abella Vázquez, Lucy / Hayek Peraza, Marcelino / García Pardo, Antonio / Hernández Carballo, Carolina / Ruiz Fernández, Andrés Javier / Barrio López, Isabel / Martakoush, Alí / Rojas-Vieyra, Agustín / García Calvo, Sonia / Villarreal García-Lomas, Mercedes / Vizcaíno Callejón, Marta / García García, María Pilar / Lérida Urteaga, Ana / Carrasco Fons, Natalia / María Sanjuan, Beatriz / Martín González, Lydia / Sanz Zamudio, Camilo / Alejos, Belén / Moreno, Cristina / Rava, Marta / Iniesta, Carlos / Izquierdo, Rebeca / Suárez-García, Inés / Díaz, Asunción / Ruiz-Alguero, Marta / Hernando, Victoria

    Clinical Microbiology and Infection

    2020  Volume 26, Issue 11, Page(s) 1525–1536

    Keywords Microbiology (medical) ; Infectious Diseases ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2020.07.024
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Effectiveness of a cognitive behavioral intervention in patients with medically unexplained symptoms: cluster randomized trial.

    López-García-Franco, Alberto / del-Cura-González, Ma Isabel / Caballero-Martinez, Luis / Sanz-Cuesta, Teresa / Díaz-García, Marta Isabel / Rodriguez-Monje, Ma Teresa / Chahua, Marcela / Muñoz-Sanchez, Inmaculada / Serrano-González, Dolores / Rollán-Llanderas, Teresa / Nieto-Blanco, Esther / Losada-Cucco, Liliana / Caballero-Martínez, Fernando / Sanz-García, Nuria / Pose-García, Belén / Jurado-Sueiro, Montserrat / Rey, Manuela Luque / de Blas González, Francisca García / Abanto, Ma Angeles Miguel /
    Bayona, Teresa Sanz / Ayllón-Camargo, Rafaela / Lopez, Inmaculada Santamaría / Hernando, María Luisa Santiago / Beltran-Alvarez, Rosario / Aguilar-Gutierrez, Ana Isabel / Mota-Rodriguez, Jose Luis / Cosculluela-Pueyo, Rafaél / López-Martín-Aragón, Teresa / Bonilla-Sanchez, Rosa / Aritieda-González-Granda, Ma Carmen / Razola-Rincón, Raquel / Sanchez-de-la-Ventana, Ma Angeles / Martinez-Guinea, Concepción / Huerta-Galindo, Luis / Barrio-Ovalle, Ana Belén / Miguel-Martín, Susana / Portero-Fraile, Paz / Pensado-Freire, Higinio / Herrera-Garcia, Ma Luisa / Azcoaga-Lorenzo, Amaya / Gómez-García, Inés / Llamas-Sandino, Nuria / López-Borja, Isabel / Maldonado-Castro, Hortensia / Lumbreras-Villarán, Patricia / Ascanio-Durán, Carlos

    BMC family practice

    2012  Volume 13, Page(s) 35

    Abstract: Background: Medically unexplained symptoms are an important mental health problem in primary care and generate a high cost in health services.Cognitive behavioral therapy and psychodynamic therapy have proven effective in these patients. However, there ... ...

    Abstract Background: Medically unexplained symptoms are an important mental health problem in primary care and generate a high cost in health services.Cognitive behavioral therapy and psychodynamic therapy have proven effective in these patients. However, there are few studies on the effectiveness of psychosocial interventions by primary health care. The project aims to determine whether a cognitive-behavioral group intervention in patients with medically unexplained symptoms, is more effective than routine clinical practice to improve the quality of life measured by the SF-12 questionary at 12 month.
    Methods/design: This study involves a community based cluster randomized trial in primary healthcare centres in Madrid (Spain). The number of patients required is 242 (121 in each arm), all between 18 and 65 of age with medically unexplained symptoms that had seeked medical attention in primary care at least 10 times during the previous year. The main outcome variable is the quality of life measured by the SF-12 questionnaire on Mental Healthcare. Secondary outcome variables include number of consultations, number of drug (prescriptions) and number of days of sick leave together with other prognosis and descriptive variables. Main effectiveness will be analyzed by comparing the percentage of patients that improve at least 4 points on the SF-12 questionnaire between intervention and control groups at 12 months. All statistical tests will be performed with intention to treat. Logistic regression with random effects will be used to adjust for prognostic factors. Confounding factors or factors that might alter the effect recorded will be taken into account in this analysis.
    Discussion: This study aims to provide more insight to address medically unexplained symptoms, highly prevalent in primary care, from a quantitative methodology. It involves intervention group conducted by previously trained nursing staff to diminish the progression to the chronicity of the symptoms, improve quality of life, and reduce frequency of medical consultations.
    Trial registration: The trial was registered with ClinicalTrials.gov, number NCT01484223 [http://ClinicalTrials.gov].
    MeSH term(s) Adolescent ; Adult ; Aged ; Cognitive Behavioral Therapy/methods ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Primary Health Care/methods ; Psychotherapy, Group/methods ; Quality of Life ; Referral and Consultation/statistics & numerical data ; Sick Leave/statistics & numerical data ; Somatoform Disorders/therapy ; Spain ; Surveys and Questionnaires ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2012-05-02
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ISSN 1471-2296
    ISSN (online) 1471-2296
    DOI 10.1186/1471-2296-13-35
    Database MEDical Literature Analysis and Retrieval System OnLINE

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