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  1. Article ; Online: At the heart of artificial intelligence: the future might well be based on synthetic cells.

    Adão, Rui / Bijnens, Bart

    Cardiovascular research

    2022  Volume 118, Issue 12, Page(s) e82–e84

    MeSH term(s) Artificial Cells ; Artificial Intelligence ; Cardiology ; Forecasting ; Machine Learning
    Language English
    Publishing date 2022-08-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvac129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 565: Show issues Location:
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  2. Article ; Online: Highlights of American Heart Association Scientific Sessions 2020: a virtual experience.

    Adão, Rui / Marian, Ali J

    Cardiovascular research

    2022  Volume 117, Issue 1, Page(s) e10–e12

    MeSH term(s) American Heart Association ; COVID-19/complications ; COVID-19/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/therapy ; Humans ; SARS-CoV-2 ; United States
    Language English
    Publishing date 2022-04-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvaa346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 565: Show issues Location:
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  3. Article ; Online: Corrigendum to: Scientist on the spot: Exploring the cause and cure for pulmonary arterial hypertension.

    Adão, Rui / Archer, Stephen L

    Cardiovascular research

    2021  Volume 117, Issue 9, Page(s) 2068

    Language English
    Publishing date 2021-07-05
    Publishing country England
    Document type Published Erratum
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvab191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Therapeutic Approaches in Pulmonary Arterial Hypertension with Beneficial Effects on Right Ventricular Function-Preclinical Studies.

    Balsa, André / Adão, Rui / Brás-Silva, Carmen

    International journal of molecular sciences

    2023  Volume 24, Issue 21

    Abstract: Pulmonary hypertension (PH) is a progressive condition that affects the pulmonary vessels, but its main prognostic factor is the right ventricle (RV) function. Many mice/rat models are used for research in PAH, but results fail to translate to clinical ... ...

    Abstract Pulmonary hypertension (PH) is a progressive condition that affects the pulmonary vessels, but its main prognostic factor is the right ventricle (RV) function. Many mice/rat models are used for research in PAH, but results fail to translate to clinical trials. This study reviews studies that test interventions on pulmonary artery banding (PAB), a model of isolated RV disfunction, and PH models. Multiple tested drugs both improved pulmonary vascular hemodynamics in PH models and improved RV structure and function in PAB animals. PH models and PAB animals frequently exhibited similar results (73.1% concordance). Macitentan, sildenafil, and tadalafil improved most tested pathophysiological parameters in PH models, but almost none in PAB animals. Results are frequently not consistent with other studies, possibly due to the methodology, which greatly varied. Some research groups start treating the animals immediately, and others wait up to 4 weeks from model induction. Treatment duration and choice of anaesthetic are other important differences. This review shows that many drugs currently under research for PAH have a cardioprotective effect on animals that may translate to humans. However, a uniformization of methods may increase comparability between studies and, thus, improve translation to clinical trials.
    MeSH term(s) Humans ; Mice ; Rats ; Animals ; Pulmonary Arterial Hypertension/drug therapy ; Ventricular Function, Right ; Pulmonary Artery ; Familial Primary Pulmonary Hypertension ; Hypertension, Pulmonary/drug therapy ; Disease Models, Animal
    Language English
    Publishing date 2023-10-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242115539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Inside the heart of COVID-19.

    Adão, Rui / Guzik, Tomasz J

    Cardiovascular research

    2020  Volume 116, Issue 6, Page(s) e59–e61

    MeSH term(s) Betacoronavirus ; COVID-19 ; China ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-08
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvaa086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 565: Show issues Location:
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  6. Article ; Online: Scientists on the Spot: Inflammation in atherosclerosis.

    Adão, Rui / Ait-Oufella, Hafid

    Cardiovascular research

    2020  Volume 117, Issue 1, Page(s) e7–e8

    MeSH term(s) Adaptive Immunity ; Atherosclerosis/history ; Atherosclerosis/immunology ; Biomedical Research/history ; History, 21st Century ; Humans ; Inflammation/history ; Inflammation/immunology
    Language English
    Publishing date 2020-12-01
    Publishing country England
    Document type Biography ; Historical Article ; Interview ; Portrait ; Video-Audio Media
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvaa314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Therapeutic Approaches in Pulmonary Arterial Hypertension with Beneficial Effects on Right Ventricular Function—Preclinical Studies

    André Balsa / Rui Adão / Carmen Brás-Silva

    International Journal of Molecular Sciences, Vol 24, Iss 21, p

    2023  Volume 15539

    Abstract: Pulmonary hypertension (PH) is a progressive condition that affects the pulmonary vessels, but its main prognostic factor is the right ventricle (RV) function. Many mice/rat models are used for research in PAH, but results fail to translate to clinical ... ...

    Abstract Pulmonary hypertension (PH) is a progressive condition that affects the pulmonary vessels, but its main prognostic factor is the right ventricle (RV) function. Many mice/rat models are used for research in PAH, but results fail to translate to clinical trials. This study reviews studies that test interventions on pulmonary artery banding (PAB), a model of isolated RV disfunction, and PH models. Multiple tested drugs both improved pulmonary vascular hemodynamics in PH models and improved RV structure and function in PAB animals. PH models and PAB animals frequently exhibited similar results (73.1% concordance). Macitentan, sildenafil, and tadalafil improved most tested pathophysiological parameters in PH models, but almost none in PAB animals. Results are frequently not consistent with other studies, possibly due to the methodology, which greatly varied. Some research groups start treating the animals immediately, and others wait up to 4 weeks from model induction. Treatment duration and choice of anaesthetic are other important differences. This review shows that many drugs currently under research for PAH have a cardioprotective effect on animals that may translate to humans. However, a uniformization of methods may increase comparability between studies and, thus, improve translation to clinical trials.
    Keywords pulmonary arterial hypertension ; pulmonary arterial banding ; right ventricle ; preclinical studies ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Avalanching nanoparticles bring new light to cardiovascular imaging.

    Adão, Rui / Stoddart, Paul R / Peter, Karlheinz

    Cardiovascular research

    2021  Volume 117, Issue 5, Page(s) e60–e63

    MeSH term(s) Nanoparticles
    Language English
    Publishing date 2021-04-19
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvab092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 565: Show issues Location:
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  9. Article ; Online: Scientist on the Spot: Exploring the cause and cure for pulmonary arterial hypertension.

    da Costa Adão, Rui Miguel / Archer, Stephen L

    Cardiovascular research

    2021  Volume 117, Issue 6, Page(s) e82–e83

    MeSH term(s) Biomedical Research ; Cardiology ; Humans ; Pulmonary Arterial Hypertension/etiology ; Pulmonary Arterial Hypertension/metabolism ; Pulmonary Arterial Hypertension/physiopathology ; Pulmonary Arterial Hypertension/therapy
    Language English
    Publishing date 2021-05-21
    Publishing country England
    Document type Interview
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvab091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cardiovascular effects of relaxin-2: therapeutic potential and future perspectives.

    Almeida-Pinto, Nísia / Dschietzig, Thomas Bernd / Brás-Silva, Carmen / Adão, Rui

    Clinical research in cardiology : official journal of the German Cardiac Society

    2023  

    Abstract: The hormone relaxin-2 has emerged as a promising player in regulating the physiology of the cardiovascular system. Through binding to the relaxin family peptide receptor 1 (RXFP1), this hormone elicits multiple physiological responses including ... ...

    Abstract The hormone relaxin-2 has emerged as a promising player in regulating the physiology of the cardiovascular system. Through binding to the relaxin family peptide receptor 1 (RXFP1), this hormone elicits multiple physiological responses including vasodilation induction, reduction of inflammation and oxidative stress, and angiogenesis stimulation. The role of relaxin-2, or its recombinant human form known as serelaxin, has been investigated in preclinical and clinical studies as a potential therapy for cardiovascular diseases, especially heart failure, whose current therapy is still unoptimized. However, evidence from past clinical trials has been inconsistent and further research is needed to fully understand the potential applications of relaxin-2. This review provides an overview of serelaxin use in clinical trials and discusses future directions in the development of relaxin-2 mimetics, which may offer new therapeutic options for patients with heart failure.
    Language English
    Publishing date 2023-09-18
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2213295-8
    ISSN 1861-0692 ; 1861-0684
    ISSN (online) 1861-0692
    ISSN 1861-0684
    DOI 10.1007/s00392-023-02305-1
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