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  1. Article ; Online: Natural Antibodies Mediate Protection Against Acinetobacter baumannii Respiratory Infections.

    Islam, Aminul / Actis, Luis A / Wilson, Timothy J

    The Journal of infectious diseases

    2023  Volume 228, Issue 3, Page(s) 353–363

    Abstract: Background: Acinetobacter baumannii causes a wide range of dangerous infections due to the emergence of pandrug-resistant strains. Therefore, there is a need for alternative therapeutics to treat these infections, including those targeting the host ... ...

    Abstract Background: Acinetobacter baumannii causes a wide range of dangerous infections due to the emergence of pandrug-resistant strains. Therefore, there is a need for alternative therapeutics to treat these infections, including those targeting the host immune responses. However, immune responses, especially the humoral response against this pathogen, are poorly understood.
    Methods: This study investigated the lymphocyte-mediated innate immune resistance to A. baumannii AB5075 pulmonary infection using B- and T-cell-deficient (Rag2-/-) mice, the protective effect of natural antibodies (NAbs), and the expression of complement-mediated responses using a mouse pneumonia model.
    Results: Our results showed that intranasally infected Rag2-/- mice are impaired in clearing bacteria from lung, liver, and spleen at 24 hours postinfection compared to wildtype mice. Animal pretreatment with normal mouse serum or purified antibodies from naive mice rescued Rag2-/- mice from infection. Analysis of C3 complement protein binding demonstrated that NAbs increased C3 protein deposition on A. baumannii cells, indicating the activation of the classical complement pathway by NAbs.
    Conclusions: Overall, our study shows that NAbs mediate innate immune resistance against A. baumannii, a finding that may lead to the development of effective therapies against human infections caused by this antibiotic-resistant A. baumannii.
    MeSH term(s) Humans ; Animals ; Mice ; Acinetobacter baumannii ; Pneumonia/microbiology ; Lung/microbiology ; Respiratory Tract Infections ; Anti-Bacterial Agents/pharmacology ; Antibodies
    Chemical Substances Anti-Bacterial Agents ; Antibodies
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Influence of Blue Light and the BlsA Photoreceptor on the Oxidative Stress Resistance Mechanisms of

    Squire, Mariah S / Townsend, Hope A / Actis, Luis A

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 856953

    Abstract: Acinetobacter ... ...

    Abstract Acinetobacter baumannii
    MeSH term(s) Acinetobacter baumannii/genetics ; Bacterial Proteins/metabolism ; Biofilms ; Catalase/metabolism ; Humans ; Iron/metabolism ; Oxidative Stress
    Chemical Substances Bacterial Proteins ; Iron (E1UOL152H7) ; Catalase (EC 1.11.1.6)
    Language English
    Publishing date 2022-03-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.856953
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  3. Article ; Online: Light Regulates

    Squire, Mariah S / Townsend, Hope A / Islam, Aminul / Actis, Luis A

    Journal of bacteriology

    2022  Volume 204, Issue 6, Page(s) e0003222

    Abstract: The opportunistic pathogen A. baumannii has a remarkable capacity to persist in the hospital environment and cause devastating human infections. This capacity can be attributed partly to the sensing and regulatory systems that enable this pathogen to ... ...

    Abstract The opportunistic pathogen A. baumannii has a remarkable capacity to persist in the hospital environment and cause devastating human infections. This capacity can be attributed partly to the sensing and regulatory systems that enable this pathogen to modify its physiology based on environmental cues. One of the signals that A. baumannii senses and responds to is light through the sensing and regulatory roles of the BlsA photoreceptor protein in cells cultured at temperatures below 30°C. This report presents evidence that a light stimulon is operational at 37°C, a condition at which the BlsA production and activity are drastically impaired. Global transcriptional analysis showed that the 37°C light stimulon includes the differential expression of chromosomal genes encoding a wide range of functions that are known to be involved in the adaptation to different metabolic conditions, as well as virulence and persistence in the host and the medical environment. Unexpectedly, the 37°C light stimulon also includes the differential expression of conjugation functions encoded by pAB3 plasmid genes. Our work further demonstrates that the TetR1 and H-NS regulators encoded by this conjugative plasmid control the expression of H
    MeSH term(s) Acinetobacter baumannii/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biofilms ; Hydrogen Peroxide/metabolism ; Plasmids/genetics ; Temperature ; Virulence/genetics
    Chemical Substances Bacterial Proteins ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2022-05-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/jb.00032-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Isolation and Characterization of the Acinetobactin and Baumannoferrin Siderophores Produced by Acinetobacter baumannii.

    Penwell, William F / Actis, Luis A

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 1946, Page(s) 259–270

    Abstract: Siderophores are high-affinity iron chelators produced and used by bacteria to prosper under iron-limiting conditions they normally encounter in the environment and hosts. In this chapter, we describe the isolation and purification of the siderophores ... ...

    Abstract Siderophores are high-affinity iron chelators produced and used by bacteria to prosper under iron-limiting conditions they normally encounter in the environment and hosts. In this chapter, we describe the isolation and purification of the siderophores acinetobactin and baumannoferrin produced by the bacterial pathogen Acinetobacter baumannii using XAD-7 batch adsorption and high-pressure liquid chromatography (HPLC). We also describe chemical tests and biological assays used to detect the presence of catechol and hydroxamate siderophores in culture supernatants, XAD-7 extracts, and HPLC fractions.
    MeSH term(s) Acinetobacter baumannii/metabolism ; Catechols/chemistry ; Catechols/isolation & purification ; Chemistry Techniques, Analytical ; Chromatography ; Chromatography, High Pressure Liquid ; Imidazoles/chemistry ; Imidazoles/isolation & purification ; Imidazoles/metabolism ; Oxazoles/chemistry ; Oxazoles/isolation & purification ; Oxazoles/metabolism ; Siderophores/chemistry ; Siderophores/isolation & purification ; Siderophores/metabolism
    Chemical Substances Catechols ; Imidazoles ; Oxazoles ; Siderophores ; acinetobactin (160472-93-5) ; catechol (LF3AJ089DQ)
    Language English
    Publishing date 2019-02-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9118-1_24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Iron Content of Human Serum Albumin Modulates the Susceptibility of

    Escalante, Jenny / Nishimura, Brent / Tuttobene, Marisel R / Subils, Tomás / Mezcord, Vyanka / Actis, Luis A / Tolmasky, Marcelo E / Bonomo, Robert A / Ramirez, María Soledad

    Biomedicines

    2023  Volume 11, Issue 2

    Abstract: The mortality rates of patients infected ... ...

    Abstract The mortality rates of patients infected with
    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11020639
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  6. Article ; Online: Insight into innovative approaches to battle Acinetobacter baumannii infection therapy struggles.

    Actis, Luis A

    Virulence

    2011  Volume 1, Issue 1, Page(s) 6–7

    MeSH term(s) Acinetobacter Infections/drug therapy ; Acinetobacter baumannii/drug effects ; Acinetobacter baumannii/pathogenicity ; Animals ; Anti-Bacterial Agents/metabolism ; Anti-Bacterial Agents/therapeutic use ; Chelating Agents/therapeutic use ; Disease Models, Animal ; Drug Resistance, Multiple, Bacterial ; Humans ; Mice ; Nanoparticles/therapeutic use ; Nitric Oxide/metabolism ; Photochemotherapy/methods ; Wound Infection/drug therapy
    Chemical Substances Anti-Bacterial Agents ; Chelating Agents ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2011-03-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.4161/viru.1.1.10210
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  7. Article ; Online: Draft Genome Sequences of Two Acinetobacter baumannii Isolates from a Fatal Case of Necrotizing Fasciitis.

    Arivett, Brock A / Charnot-Katsikas, Angella / Bethel, Cindy / Fiester, Steven E / Actis, Luis A

    Microbiology resource announcements

    2020  Volume 9, Issue 13

    Abstract: Carbapenem- ... ...

    Abstract Carbapenem-resistant
    Language English
    Publishing date 2020-03-26
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00047-20
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  8. Article ; Online: Human serum albumin-induced modification of Ton-B-dependent receptor expression in cefiderocol-exposed carbapenem-resistant Acinetobacter baumannii.

    Nishimura, Brent / Escalante, Jenny / Mezcord, Vyanka / Tuttobene, Marisel R / Subils, Tomás / Actis, Luis A / Pasteran, Fernando / Tolmasky, Marcelo E / Bonomo, Robert A / Ramirez, María Soledad

    International journal of antimicrobial agents

    2023  Volume 62, Issue 5, Page(s) 106950

    MeSH term(s) Humans ; Acinetobacter baumannii ; Cephalosporins/pharmacology ; Anti-Bacterial Agents/pharmacology ; Carbapenems/pharmacology ; Microbial Sensitivity Tests ; Cefiderocol
    Chemical Substances Cephalosporins ; Anti-Bacterial Agents ; Carbapenems
    Language English
    Publishing date 2023-08-18
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2023.106950
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    Zs.A 3368: Show issues Location:
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    Zs.MO 500: Show issues

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  9. Article ; Online: An Update on the Acinetobacter baumannii Regulatory Circuitry.

    Wood, Cecily R / Mack, Lydia E / Actis, Luis A

    Trends in microbiology

    2018  Volume 26, Issue 7, Page(s) 560–562

    Abstract: Acinetobacter baumannii adapts to different environmental conditions by expressing complex regulatory circuitry. Recent studies revealed that this circuitry includes regulatory factors that control the emergence of distinct bacterial subpopulations, ... ...

    Abstract Acinetobacter baumannii adapts to different environmental conditions by expressing complex regulatory circuitry. Recent studies revealed that this circuitry includes regulatory factors that control the emergence of distinct bacterial subpopulations, which are critical for the capacity of this pathogen to persist in medical settings and cause infections in compromised hosts.
    MeSH term(s) Acinetobacter Infections/microbiology ; Acinetobacter baumannii/drug effects ; Acinetobacter baumannii/genetics ; Acinetobacter baumannii/pathogenicity ; Acinetobacter baumannii/physiology ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial ; Gene Expression Regulation, Bacterial ; Genes, Bacterial ; Genome, Bacterial ; Host Specificity ; Virulence ; Virulence Factors
    Chemical Substances Anti-Bacterial Agents ; Virulence Factors
    Language English
    Publishing date 2018-05-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2018.05.005
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    Zs.A 3738: Show issues Location:
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  10. Article ; Online: A Light-Regulated Type I Pilus Contributes to Acinetobacter baumannii Biofilm, Motility, and Virulence Functions.

    Wood, Cecily R / Ohneck, Emily J / Edelmann, Richard E / Actis, Luis A

    Infection and immunity

    2018  Volume 86, Issue 9

    Abstract: Transcriptional analyses ... ...

    Abstract Transcriptional analyses of
    MeSH term(s) A549 Cells ; Acinetobacter baumannii/genetics ; Acinetobacter baumannii/pathogenicity ; Adhesins, Bacterial/genetics ; Animals ; Bacterial Adhesion ; Bacterial Proteins/genetics ; Biofilms/growth & development ; Fimbriae, Bacterial/genetics ; Fimbriae, Bacterial/radiation effects ; Gene Expression Profiling ; Gene Expression Regulation, Bacterial ; Humans ; Larva/microbiology ; Light ; Moths ; Operon ; Temperature ; Virulence/genetics
    Chemical Substances Adhesins, Bacterial ; Bacterial Proteins
    Language English
    Publishing date 2018-08-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.00442-18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 684: Show issues Location:
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