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Article ; Online: RNF135 promotes cell proliferation and autophagy in lung adenocarcinoma by promoting the phosphorylation of ULK1.

Zhuang, Lichun / Shi, Guanhui / Sun, Yuejun

2024 Volume 52, Issue 2, Page(s) 3–9

Abstract: Objective: To detect the expression of RING finger protein 135 (RNF135) in lung adenocarcinoma tissues and explore its role in the progression of lung adenocarcinoma.: Methods: Bioinformation analysis, quantitative polymerase chain reaction, and ... ...

Abstract	Objective: To detect the expression of RING finger protein 135 (RNF135) in lung adenocarcinoma tissues and explore its role in the progression of lung adenocarcinoma. Methods: Bioinformation analysis, quantitative polymerase chain reaction, and immunoblotting technique discovered the expression of RNF135 in lung adenocarcinoma tissues. Cell counting kit-8 and colony formation, immunostaining, and immunoblot assays examined the effects of RNF135 on cell growth and autophagy. Co-immunoprecipitation (Co-IP), immunostaining, and immuoblotting were conducted to confirm the mechanism. Results: RNF135 was highly expressed in lung adenocarcinoma. In addition, RNF135 promoted lung adenocarcinoma cell growth. Further, data confirmed that RNF135 promoted autophagy in lung adenocarcinoma cells. Mechanically, RNF135 directly interacted with Unc-51-like autophagy activating kinase 1 (ULK1) to promote its phosphorylation level. Conclusion: RNF135 promoted cell growth and autophagy in lung adenocarcinoma by promoting the phosphorylation of ULK1.
MeSH term(s)	Humans ; Adenocarcinoma of Lung ; Autophagy ; Autophagy-Related Protein-1 Homolog/metabolism ; Cell Proliferation ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Intracellular Signaling Peptides and Proteins/pharmacology ; Lung Neoplasms/pathology ; Phosphorylation ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitin-Protein Ligases/pharmacology
Chemical Substances	Autophagy-Related Protein-1 Homolog (EC 2.7.11.1) ; Intracellular Signaling Peptides and Proteins ; RNF135 protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; ULK1 protein, human (EC 2.7.11.1)
Language	English
Publishing date	2024-03-01
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193144-1
ISSN	1578-1267 ; 0301-0546
ISSN (online)	1578-1267
ISSN	0301-0546
DOI	10.15586/aei.v52i2.1048
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Zs.A 1165: Show issues

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Article ; Online: The role of cardiac microenvironment in cardiovascular diseases: implications for therapy.

Yao, Jiayu / Chen, Yuejun / Huang, Yuqing / Sun, Xiaoou / Shi, Xingjuan

Human cell

2024 Volume 37, Issue 3, Page(s) 607–624

Abstract: Due to aging populations and changes in lifestyle, cardiovascular diseases including cardiomyopathy, hypertension, and atherosclerosis, are the leading causes of death worldwide. The heart is a complicated organ composed of multicellular types, including ...

Abstract	Due to aging populations and changes in lifestyle, cardiovascular diseases including cardiomyopathy, hypertension, and atherosclerosis, are the leading causes of death worldwide. The heart is a complicated organ composed of multicellular types, including cardiomyocytes, fibroblasts, endothelial cells, vascular smooth muscle cells, and immune cells. Cellular specialization and complex interplay between different cell types are crucial for the cardiac tissue homeostasis and coordinated function of the heart. Mounting studies have demonstrated that dysfunctional cells and disordered cardiac microenvironment are closely associated with the pathogenesis of various cardiovascular diseases. In this paper, we discuss the composition and the homeostasis of cardiac tissues, and focus on the role of cardiac environment and underlying molecular mechanisms in various cardiovascular diseases. Besides, we elucidate the novel treatment for cardiovascular diseases, including stem cell therapy and targeted therapy. Clarification of these issues may provide novel insights into the prevention and potential targets for cardiovascular diseases.
MeSH term(s)	Humans ; Cardiovascular Diseases/therapy ; Cardiovascular Diseases/pathology ; Endothelial Cells/metabolism ; Myocytes, Cardiac/pathology ; Atherosclerosis ; Aging
Language	English
Publishing date	2024-03-18
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	1149134-6
ISSN	1749-0774 ; 0914-7470
ISSN (online)	1749-0774
ISSN	0914-7470
DOI	10.1007/s13577-024-01052-3
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Zs.A 3676: Show issues

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Article ; Online: Capability of Au nano-rhombic dodecahedra in a label-free colorimetric assay: application in the determination of S

Shi, Yali / Chen, Qianyuan / Liu, Yuejun / Wang, Guoqing

The Analyst

2022 Volume 147, Issue 15, Page(s) 3578–3584

Abstract: Anisotropic nanoparticles possess high sensitivity to the environmental refractive index that is strongly dependent on their active facets. As a polyhedron exclusively enclosed by active facets, Au nano-rhombic dodecahedra (AuNRDs) with multiple tips and ...

Abstract	Anisotropic nanoparticles possess high sensitivity to the environmental refractive index that is strongly dependent on their active facets. As a polyhedron exclusively enclosed by active facets, Au nano-rhombic dodecahedra (AuNRDs) with multiple tips and edges have been less explored with respect to their capability in surface plasmon resonance (SPR) sensing. Here, we report on the use of AuNRDs in the colorimetric detection of S
MeSH term(s)	Colorimetry/methods ; Gold/chemistry ; Mercury ; Metal Nanoparticles/chemistry ; Surface Plasmon Resonance/methods
Chemical Substances	Gold (7440-57-5) ; Mercury (FXS1BY2PGL)
Language	English
Publishing date	2022-07-22
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d2an00852a
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Zs.A 2423: Show issues

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Article ; Online: Feline infectious peritonitis virus ORF7a is a virulence factor involved in inflammatory pathology in cats.

Jiao, Zhe / Wang, Pengpeng / Hu, Xiaoshuai / Chen, Yixi / Xu, Juan / Zhang, Jintao / Wu, Benyuan / Luo, Ruxue / Shi, Yuejun / Peng, Guiqing

Antiviral research

2024 Volume 222, Page(s) 105794

Abstract: A hyperinflammatory response is a prominent feature of feline infectious peritonitis (FIP), but the mechanisms behind the feline infectious peritonitis virus (FIPV)-induced cytokine storm in the host have not been clarified. Studies have shown that ... ...

Abstract	A hyperinflammatory response is a prominent feature of feline infectious peritonitis (FIP), but the mechanisms behind the feline infectious peritonitis virus (FIPV)-induced cytokine storm in the host have not been clarified. Studies have shown that coronaviruses encode accessory proteins that are involved in viral replication and associated with viral virulence, the inflammatory response and immune regulation. Here, we found that FIPV ORF7a gene plays a key role in viral infection and host proinflammatory responses. The recombinant FIPV strains lacking ORF7a (rQS-79Δ7a) exhibit low replication rates in macrophages and do not induce dramatic upregulation of inflammatory factors. Furthermore, through animal experiments, we found that the rQS-79Δ7a strain is nonpathogenic and do not cause symptoms of FIP in cats. Unexpectedly, after three vaccinations with rQS-79Δ7a strain, humoral and cellular immunity was increased and provided protection against virulent strains in cats, and the protection rate reaches 40%. Importantly, our results demonstrated that ORF7a is a key virulence factor that exacerbates FIPV infection and inflammatory responses. Besides, our findings will provide novel implications for future development of live attenuated FIPV vaccines.
MeSH term(s)	Cats ; Animals ; Coronavirus, Feline/genetics ; Virulence Factors/genetics ; Coronavirus Infections ; Feline Infectious Peritonitis ; Virulence
Chemical Substances	Virulence Factors
Language	English
Publishing date	2024-01-03
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	306628-9
ISSN	1872-9096 ; 0166-3542
ISSN (online)	1872-9096
ISSN	0166-3542
DOI	10.1016/j.antiviral.2024.105794
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Zs.A 1627: Show issues

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Article ; Online: Association between chronic obstructive pulmonary disease and cardiovascular disease in adults aged 40 years and above: data from NHANES 2013-2018.

Chen, Hong / Luo, Xiaojia / Du, Yuejun / He, Chenyun / Lu, Yanjun / Shi, Zixuan / Zhou, Jin

BMC pulmonary medicine

2023 Volume 23, Issue 1, Page(s) 318

Abstract: Background: Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) are two major age-related diseases prevalent in the elderly. However, it is unclear whether there is a higher prevalence of one or more CVDs in COPD patients ... ...

Abstract	Background: Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) are two major age-related diseases prevalent in the elderly. However, it is unclear whether there is a higher prevalence of one or more CVDs in COPD patients compared to those without COPD, and the magnitude of this increased prevalence. Methods: This population-based cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 2013-2018 among American adults aged 40 years and above. Multivariable logistic regression models (including unadjusted model, minimally adjusted model, and fully adjusted model) were conducted to investigate the association between COPD and the prevalence of one or more CVDs, including coronary heart disease, heart failure, angina pectoris, heart attack, diabetes, and stroke. Results: This study included 11,425 participants, consisting of 661 participants with COPD and 10,764 participants without COPD. COPD patients had a significantly higher prevalence of CVD than those without COPD (59.6% vs. 28.4%). After adjusting for covariates, COPD was significantly associated with the prevalence of one CVD (OR = 2.2, 95% CI = 1.6-3.0, p < 0.001), two or more CVDs (OR = 3.3, 95% CI = 2.2-5.0, p < 0.001), and three or more CVDs (OR = 4.3, 95% CI = 2.9-6.5, p < 0.001). Conclusions: Patients with COPD have a higher prevalence of one or more CVDs compared with those without COPD. Our findings highlight the importance of CVD prevention and management in patients with COPD.
MeSH term(s)	Aged ; Humans ; Adult ; Cardiovascular Diseases/epidemiology ; Nutrition Surveys ; Cross-Sectional Studies ; Heart Failure ; Pulmonary Disease, Chronic Obstructive/epidemiology
Language	English
Publishing date	2023-08-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-023-02606-1
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Article ; Online: Solution-phase sample-averaged single-particle spectroscopy of quantum emitters with femtosecond resolution.

Shi, Jiaojian / Shen, Yuejun / Pan, Feng / Sun, Weiwei / Mangu, Anudeep / Shi, Cindy / McKeown-Green, Amy / Moradifar, Parivash / Bawendi, Moungi G / Moerner, W E / Dionne, Jennifer A / Liu, Fang / Lindenberg, Aaron M

Nature materials

2024

Abstract: The development of many quantum optical technologies depends on the availability of single quantum emitters with near-perfect coherence. Systematic improvement is limited by a lack of understanding of the microscopic energy flow at the single-emitter ... ...

Abstract	The development of many quantum optical technologies depends on the availability of single quantum emitters with near-perfect coherence. Systematic improvement is limited by a lack of understanding of the microscopic energy flow at the single-emitter level and ultrafast timescales. Here we utilize a combination of fluorescence correlation spectroscopy and ultrafast spectroscopy to capture the sample-averaged dynamics of defects with single-particle sensitivity. We employ this approach to study heterogeneous emitters in two-dimensional hexagonal boron nitride. From milliseconds to nanoseconds, the translational, shelving, rotational and antibunching features are disentangled in time, which quantifies the normalized two-photon emission quantum yield. Leveraging the femtosecond resolution of this technique, we visualize electron-phonon coupling and discover the acceleration of polaronic formation on multi-electron excitation. Corroborated with theory, this translates to the photon fidelity characterization of cascaded emission efficiency and decoherence time. Our work provides a framework for ultrafast spectroscopy in heterogeneous emitters, opening new avenues of extreme-scale characterization for quantum applications.
Language	English
Publishing date	2024-04-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2088679-2
ISSN	1476-4660 ; 1476-1122
ISSN (online)	1476-4660
ISSN	1476-1122
DOI	10.1038/s41563-024-01855-7
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Article ; Online: Correction for Tan et al., "Trypsin-Enhanced Infection with Porcine Epidemic Diarrhea Virus Is Determined by the S2 Subunit of the Spike Glycoprotein".

Tan, Yubei / Sun, Limeng / Wang, Gang / Shi, Yuejun / Dong, Wanyu / Fu, Yanan / Fu, Zhen / Chen, Huanchun / Peng, Guiqing

Journal of virology

2022 Volume 96, Issue 10, Page(s) e0040522

Language	English
Publishing date	2022-05-03
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.00405-22
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Zs.A 609: Show issues

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Article: New Paradigms in Catalysis Inspired by Cytochromes P450

Gao, Yanqun / Cheng, Lu / Shi, Wei / Ouyang, Yuejun / Han, Wei

Synlett

2023 Volume 35, Issue 05, Page(s) 552–564

Abstract: Cytochromes P450 (P450s or CYPs) are versatile biocatalysts capable of realizing a broad range of synthetically challenging reactions. The development of synthetic catalysts/catalytic systems that model enzyme functions is a goal that has long been ... ...

Abstract	Cytochromes P450 (P450s or CYPs) are versatile biocatalysts capable of realizing a broad range of synthetically challenging reactions. The development of synthetic catalysts/catalytic systems that model enzyme functions is a goal that has long been pursued. In this account, we mainly summarize our latest advances in the field of catalysis inspired by cytochromes P450, including reductive activation strategies for highly efficient oxidations and an unusual l -cystine-derived ligand as a model of P450s for highly efficient iron-catalyzed undirected arene C–H hydroxylation. These new paradigms highlight some of the catalytic properties of P450s, such as effective late-stage functionalization of complex targets, good reactive functional group tolerance, and high catalytic efficiency and selectivity. 1 Introduction 2 Reductive Activation Strategies for Oxygenation 3 An Fe/Cysteine-Based Ligand as a Biomimetic Model of Cytochromes P450 for Arene C–H Hydroxylation 4 Conclusion
Keywords	cytochromes P450 ; bio-inspired catalysis ; iron catalysis ; oxidation ; late-stage functionalization ; reductive activation strategy ; I-cystine-derived ligand
Language	English
Publishing date	2023-02-27
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2042012-2
ISSN	1437-2096 ; 0936-5214
ISSN (online)	1437-2096
ISSN	0936-5214
DOI	10.1055/a-2043-4479
Database	Thieme publisher's database

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Article ; Online: Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor.

Liao, Ziyan / Jiang, Jie / Wu, Wei / Shi, Jiaqi / Wang, Yanfang / Yao, Yuejun / Sheng, Tao / Liu, Feng / Liu, Wei / Zhao, Peng / Lv, Feifei / Sun, Jie / Li, Hongjun / Gu, Zhen

National science review

2024 Volume 11, Issue 4, Page(s) nwae018

Abstract: The limited infiltration and persistence of chimeric antigen receptor (CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T-cell ... ...

Abstract	The limited infiltration and persistence of chimeric antigen receptor (CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T-cell proliferation in lymph nodes. This scaffold gathers the function of loading, delivery, activation and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) by a microfluidic technique with the modification of T-cell stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion
Language	English
Publishing date	2024-01-11
Publishing country	China
Document type	Journal Article
ZDB-ID	2745465-4
ISSN	2053-714X ; 2053-714X
ISSN (online)	2053-714X
ISSN	2053-714X
DOI	10.1093/nsr/nwae018
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Article ; Online: Partially Neutralized Polyacrylic Acid as an Efficient Binder for Aqueous Ceramic-Coated Separators for Lithium-Ion Batteries.

Thang, Ai Qin / Shen, Yuejun / Shi, Zugui / Yao, Ge / Wong, Sun Yew / Liu, Zhaolin / Yan, Qingyu

Chemistry, an Asian journal

2023 Volume 18, Issue 18, Page(s) e202300538

Abstract: A partially neutralized polyacrylic acid (Pn-PAA) is used for coating sub-micron-sized α-alumina on a conventional microporous polyolefin separator, fabricating a ceramic-coated separator (CCS). Pn-PAA acts as a dispersant and binder by adsorbing itself ... ...

Abstract	A partially neutralized polyacrylic acid (Pn-PAA) is used for coating sub-micron-sized α-alumina on a conventional microporous polyolefin separator, fabricating a ceramic-coated separator (CCS). Pn-PAA acts as a dispersant and binder by adsorbing itself on alpha(α)-alumina surfaces under acidic condition through the columbic interaction, providing a repulsive force to disperse fine alumina in aqueous suspension, and binds alumina strongly on plasma-treated separator through hydrogen bonding. This CCS shows favorable wettability in carbonate-based liquid electrolyte and ionic conduction due to the high hydrophilicity of Pn-PAA and alumina. With that, this study found that Pn-PAA-made-CCS yields a substantial adhesion strength of ~106 N/m with enhanced cycle stability, a specific capacity of 145.0 mAh/g after 200 cycles at 1 C at room temperature in half cells (LFP/Li metal).
Language	English
Publishing date	2023-08-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2233006-9
ISSN	1861-471X ; 1861-4728
ISSN (online)	1861-471X
ISSN	1861-4728
DOI	10.1002/asia.202300538
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