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  1. Book: Precision approaches to heterogeneity in asthma

    Brasier, Allan R. / Jarjour, Nizar N.

    (Advances in experimental medicine and biology ; 1426)

    2023  

    Author's details Allan R. Brasier, Nizar N. Jarjour editors
    Series title Advances in experimental medicine and biology ; 1426
    Collection
    Keywords Asthma ; Asthma/Diagnosis ; Asthma/Treatment ; Precision medicine
    Subject code 616.238
    Language English
    Size x, 418 Seiten, Illustrationen, 24 cm
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT030078048
    ISBN 978-3-031-32258-7 ; 9783031322594 ; 3-031-32258-4 ; 3031322592
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -1426- not available for loan Lesesaal EG

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  2. Article: Orchestrating epigenetic readers: Progress in understanding the functions of bromodomain-containing protein 4 complexes.

    Brasier, Allan R

    Molecular therapy. Nucleic acids

    2023  Volume 32, Page(s) 340–342

    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type News
    ZDB-ID 2662631-7
    ISSN 2162-2531
    ISSN 2162-2531
    DOI 10.1016/j.omtn.2023.03.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Heterogeneity in asthma

    Brasier, Allan R.

    (Advances in experimental medicine and biology ; 795)

    2014  

    Author's details Allan R. Brasier ed
    Series title Advances in experimental medicine and biology ; 795
    Collection
    Language English
    Size XIV, 354 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017906301
    ISBN 978-1-4614-8602-2 ; 9781461486039 ; 1-4614-8602-5 ; 1461486033
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -795- not available for loan Zeitschriften-Lesesaal

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  4. Article: Innate Immunity, Epithelial Plasticity, and Remodeling in Asthma.

    Brasier, Allan R

    Advances in experimental medicine and biology

    2023  Volume 1426, Page(s) 265–285

    Abstract: Innate immune responses (IIR) of the epithelium play a critical role in the initiation and progression of asthma. The core of the IIR is an intracellular signaling pathway activated by pattern recognition receptors (PRRs) to limit the spread of ... ...

    Abstract Innate immune responses (IIR) of the epithelium play a critical role in the initiation and progression of asthma. The core of the IIR is an intracellular signaling pathway activated by pattern recognition receptors (PRRs) to limit the spread of infectious organisms. This chapter will focus on the epithelium as the major innate sentinel cell and its role in acute exacerbations (AEs). Although the pathways of how the IIR activates the NFκB transcription factor, triggering cytokine secretion, dendritic cell activation, and Th2 polarization are well-described, recent exciting work has developed mechanistic insights into how chronic activation of the IIR is linked to mucosal adaptive responses. These adaptations include changes in cell state, now called epithelial-mesenchymal plasticity (EMP). EMP is a coordinated, genomic response to airway injury disrupting epithelial barrier function, expanding the basal lamina, and producing airway remodeling. EMP is driven by activation of the unfolded protein response (UPR), a transcriptional response producing metabolic shunting of glucose through the hexosamine biosynthetic pathway (HBP) to protein N-glycosylation. NFκB signaling and UPR activation pathways potentiate each other in remodeling the basement membrane. Understanding of injury-repair process of epithelium provides new therapeutic targets for precision approaches to the treatment of asthma exacerbations and their sequelae.
    MeSH term(s) Humans ; Inflammation/metabolism ; Immunity, Innate ; Asthma ; NF-kappa B/metabolism ; Signal Transduction
    Chemical Substances NF-kappa B
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410187-X
    ISSN 0065-2598
    ISSN 0065-2598
    DOI 10.1007/978-3-031-32259-4_13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3192: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Einzelsignatur: Show issues

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  5. Article: Next steps in precision approaches for asthma-proteomics and asthma endotypes.

    Brasier, Allan R

    Annals of translational medicine

    2022  Volume 10, Issue 19, Page(s) 1047

    Language English
    Publishing date 2022-10-24
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-22-4198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Special Issue "Next-Generation Technologies to Understand Mechanisms of Virus Infections".

    Brasier, Allan R

    Viruses

    2022  Volume 15, Issue 1

    Abstract: RNA viruses are responsible for substantial morbidity and health burden [ ... ]. ...

    Abstract RNA viruses are responsible for substantial morbidity and health burden [...].
    MeSH term(s) Humans ; Virus Diseases ; RNA Viruses/genetics ; High-Throughput Nucleotide Sequencing
    Language English
    Publishing date 2022-12-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15010033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Reporter System Using Firefly Luciferase: Introduction or DNA into Mammalian Cells.

    Brasier, Allan R

    Current protocols in molecular biology

    2021  Volume 12, Issue 1, Page(s) 9.6.11–9.6.15

    Language English
    Publishing date 2021-07-13
    Publishing country United States
    Document type Journal Article
    ISSN 1934-3647
    ISSN (online) 1934-3647
    DOI 10.1002/j.1934-3647.1990.tb00199.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  8. Article ; Online: Reporter System Using Firefly Luciferase: Introduction of DNA into Mammalian Cells.

    Brasier, Allan R

    Current protocols in molecular biology

    2021  Volume 14, Issue 1, Page(s) 9.6.10–9.6.14

    Language English
    Publishing date 2021-07-13
    Publishing country United States
    Document type Journal Article
    ISSN 1934-3647
    ISSN (online) 1934-3647
    DOI 10.1002/j.1934-3647.1991.tb00213.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  9. Article ; Online: Cooperative interaction of interferon regulatory factor -1 and bromodomain-containing protein 4 on RNA polymerase activation for intrinsic innate immunity.

    Xu, Xiaofang / Qiao, Dianhua / Brasier, Allan R

    Frontiers in immunology

    2024  Volume 15, Page(s) 1366235

    Abstract: Introduction: The human orthopneumovirus, Respiratory Syncytial Virus (RSV), is the causative agent of severe lower respiratory tract infections (LRTI) and exacerbations of chronic lung diseases. In immune competent hosts, RSV productively infects ... ...

    Abstract Introduction: The human orthopneumovirus, Respiratory Syncytial Virus (RSV), is the causative agent of severe lower respiratory tract infections (LRTI) and exacerbations of chronic lung diseases. In immune competent hosts, RSV productively infects highly differentiated epithelial cells, where it elicits robust anti-viral, cytokine and remodeling programs. By contrast, basal cells are relatively resistant to RSV infection, in part, because of constitutive expression of an intrinsic innate immune response (IIR) consisting of a subgroup of interferon (IFN) responsive genes. The mechanisms controlling the intrinsic IIR are not known.
    Methods: Here, we use human small airway epithelial cell hSAECs as a multipotent airway stem cell model to examine regulatory control of an intrinsic IIR pathway.
    Results: We find hSAECs express patterns of intrinsic IIRs, highly conserved with pluri- and multi-potent stem cells. We demonstrate a core intrinsic IIR network consisting of Bone Marrow Stromal Cell Antigen 2 (
    Conclusions: We conclude that the IRF1 functions in two modes- in absence of infection, ambient IRF1 mediates constitutive expression of the intrinsic IIR, whereas in response to RSV infection, the BRD4 CRC independently activates pSer2 Pol II to mediates robust expression of the intrinsic IIR. These data provide insight into molecular control of anti-viral defenses of airway basal cells.
    MeSH term(s) Humans ; Antiviral Agents ; Bromodomain Containing Proteins ; Cell Cycle Proteins ; Immunity, Innate ; Nuclear Proteins/metabolism ; Respiratory Syncytial Virus Infections ; Respiratory Syncytial Virus, Human ; RNA Polymerase II/genetics ; RNA Polymerase II/metabolism ; Transcription Factors
    Chemical Substances Antiviral Agents ; BRD4 protein, human ; Bromodomain Containing Proteins ; Cell Cycle Proteins ; Nuclear Proteins ; RNA Polymerase II (EC 2.7.7.-) ; Transcription Factors ; IRF1 protein, human
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1366235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: RSV Reprograms the CDK9•BRD4 Chromatin Remodeling Complex to Couple Innate Inflammation to Airway Remodeling.

    Brasier, Allan R

    Viruses

    2020  Volume 12, Issue 4

    Abstract: Respiratory syncytial virus infection is responsible for seasonal upper and lower respiratory tract infections worldwide, causing substantial morbidity. Self-inoculation of the virus into the nasopharynx results in epithelial replication and distal ... ...

    Abstract Respiratory syncytial virus infection is responsible for seasonal upper and lower respiratory tract infections worldwide, causing substantial morbidity. Self-inoculation of the virus into the nasopharynx results in epithelial replication and distal spread into the lower respiratory tract. Here, respiratory syncytial virus (RSV) activates sentinel cells important in the host inflammatory response, resulting in epithelial-derived cytokine and interferon (IFN) expression resulting in neutrophilia, whose intensity is associated with disease severity. I will synthesize key findings describing how RSV replication activates intracellular NFκB and IRF signaling cascades controlling the innate immune response (IIR). Recent studies have implicated a central role for
    MeSH term(s) Airway Remodeling ; Biomarkers ; Cell Cycle Proteins ; Chromatin Assembly and Disassembly ; Cyclin-Dependent Kinase 9 ; Disease Susceptibility ; Gene Expression Profiling ; Gene Expression Regulation ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Paracrine Communication ; Respiratory Mucosa/immunology ; Respiratory Mucosa/metabolism ; Respiratory Mucosa/pathology ; Respiratory Mucosa/virology ; Respiratory Syncytial Virus Infections/etiology ; Respiratory Syncytial Virus Infections/pathology ; Respiratory Syncytial Virus, Human/physiology ; Signal Transduction ; Transcription Factors ; Virus Replication
    Chemical Substances BRD4 protein, human ; Biomarkers ; Cell Cycle Proteins ; Transcription Factors ; CDK9 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinase 9 (EC 2.7.11.22)
    Language English
    Publishing date 2020-04-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v12040472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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