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Article ; Online: Insights for increased risk of failed fibrinolytic therapy and stent thrombosis associated with COVID-19 in ST-segment elevation myocardial infarction patients.

Lacour, Thibaud / Semaan, Carl / Genet, Thibaud / Ivanes, Fabrice

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

2020 Volume 97, Issue 2, Page(s) E241–E243

Abstract: Important health resources are dedicated worldwide to the management of COVID-19. This new disease, due to its large diffusion, may significantly hamper the prognosis of other pathologies, such as ST-segment elevation myocardial infarction (STEMI) ... ...

Abstract	Important health resources are dedicated worldwide to the management of COVID-19. This new disease, due to its large diffusion, may significantly hamper the prognosis of other pathologies, such as ST-segment elevation myocardial infarction (STEMI) because of (a) a possible direct negative impact and (b) shortage of first response medical resources and increased delays to reperfusion. We report the case of a 68-year-old man admitted for anterior STEMI and asymptomatic COVID-19. Due to extended transportation delays to a cathlab, he received intravenous fibrinolytic therapy, which failed. Reperfusion was achieved with rescue coronary angioplasty, but the patient experienced two episodes of acute stent thrombosis at 2- and 36-hr following admission and despite optimal medical therapy. He finally died because of cardiogenic shock. This raises concerns about a possible increase in platelet aggregability associated with COVID-19 leading to an increased risk of stent thrombosis, particularly in the context of STEMI. This pleads for the promotion of primary coronary angioplasty as the first-choice revascularization technique in this population and the use of new generation P2Y12 inhibitors. In addition, the use of GPIIb/IIIa inhibitors may be considered in every STEMI patient with COVID-19 to prevent the risk of acute stent thrombosis.
MeSH term(s)	Aged ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/therapy ; Coronary Thrombosis/diagnosis ; Coronary Thrombosis/etiology ; Coronary Thrombosis/therapy ; Fibrinolytic Agents/therapeutic use ; Graft Occlusion, Vascular/diagnosis ; Graft Occlusion, Vascular/etiology ; Graft Occlusion, Vascular/therapy ; Humans ; Male ; ST Elevation Myocardial Infarction/complications ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/therapy ; Stents/adverse effects ; Thrombolytic Therapy ; Treatment Failure
Chemical Substances	Fibrinolytic Agents
Keywords	covid19
Language	English
Publishing date	2020-04-30
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/ccd.28948
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Article ; Online: Insights for increased risk of failed fibrinolytic therapy and stent thrombosis associated with COVID ‐19 in ST ‐segment elevation myocardial infarction patients

Lacour, Thibaud / Semaan, Carl / Genet, Thibaud / Ivanes, Fabrice

Catheterization and Cardiovascular Interventions ; ISSN 1522-1946 1522-726X

2020

Keywords	Radiology Nuclear Medicine and imaging ; Cardiology and Cardiovascular Medicine ; General Medicine ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
DOI	10.1002/ccd.28948
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Article: Insights for increased risk of failed fibrinolytic therapy and stent thrombosis associated with COVID-19 in ST-segment elevation myocardial infarction patients

Lacour, Thibaud / Semaan, Carl / Genet, Thibaud / Ivanes, Fabrice

Catheter. cardiovasc. interv

Abstract	Important health resources are dedicated worldwide to the management of COVID-19. This new disease, due to its large diffusion, may significantly hamper the prognosis of other pathologies, such as ST-segment elevation myocardial infarction (STEMI) because of (a) a possible direct negative impact and (b) shortage of first response medical resources and increased delays to reperfusion. We report the case of a 68-year-old man admitted for anterior STEMI and asymptomatic COVID-19. Due to extended transportation delays to a cathlab, he received intravenous fibrinolytic therapy, which failed. Reperfusion was achieved with rescue coronary angioplasty, but the patient experienced two episodes of acute stent thrombosis at 2- and 36-hr following admission and despite optimal medical therapy. He finally died because of cardiogenic shock. This raises concerns about a possible increase in platelet aggregability associated with COVID-19 leading to an increased risk of stent thrombosis, particularly in the context of STEMI. This pleads for the promotion of primary coronary angioplasty as the first-choice revascularization technique in this population and the use of new generation P2Y12 inhibitors. In addition, the use of GPIIb/IIIa inhibitors may be considered in every STEMI patient with COVID-19 to prevent the risk of acute stent thrombosis.
Keywords	covid19
Publisher	WHO
Document type	Article
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Database	COVID19

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Article ; Online: How to upgrade a leadless pacemaker to cardiac resynchronization therapy.

Lacour, Thibaud / Bisson, Arnaud / Bernard, Anne / Fauchier, Laurent / Babuty, Dominique / Clementy, Nicolas

Journal of cardiovascular electrophysiology

2019 Volume 30, Issue 11, Page(s) 2578–2581

Abstract: Introduction: We sought to develop an efficient method to upgrade pacing-induced cardiomyopathy (PICM) patients from a leadless pacemaker (LPM) to cardiac resynchronization therapy.: Methods and results: Three consecutive patients with chronic atrial ...

Abstract	Introduction: We sought to develop an efficient method to upgrade pacing-induced cardiomyopathy (PICM) patients from a leadless pacemaker (LPM) to cardiac resynchronization therapy. Methods and results: Three consecutive patients with chronic atrial fibrillation, implanted with an LPM, with permanent right ventricular pacing, and who developed left ventricular systolic dysfunction due to PICM, were included. A conventional biventricular pacemaker with two different coronary sinus leads, one used for left lateral ventricular pacing, one for early right ventricular sensing, was implanted. It was then synchronized with the LPM working as the right ventricular pacing lead to provide biventricular pacing. The upgrading technique was feasible in all cases, without any perioperative complication. All patients had an improved clinical status during follow-up. Conclusion: This new upgrading technique allows efficient cardiac resynchronization therapy in LPM patients while preventing tricuspid valve crossing and providing an increased battery longevity.
MeSH term(s)	Aged ; Aged, 80 and over ; Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/therapy ; Cardiac Resynchronization Therapy/adverse effects ; Cardiac Resynchronization Therapy/methods ; Humans ; Male ; Pacemaker, Artificial ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/therapy
Language	English
Publishing date	2019-09-25
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1025989-2
ISSN	1540-8167 ; 1045-3873
ISSN (online)	1540-8167
ISSN	1045-3873
DOI	10.1111/jce.14169
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Article ; Online: Timing of Coronary Revascularization and Transcatheter Aortic Valve Replacement: An Observational Nationwide Cohort Analysis.

Lantelme, Pierre / Bisson, Arnaud / Lacour, Thibaud / Herbert, Julien / Ivanes, Fabrice / Bourguignon, Thierry / Angoulvant, Denis / Harbaoui, Brahim / Bonnet, Marc / Babuty, Dominique / Saint Etienne, Christophe / Deharo, Pierre / Fauchier, Laurent

JACC. Cardiovascular interventions

2020 Volume 14, Issue 4, Page(s) 484–486

MeSH term(s)	Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Cohort Studies ; Coronary Artery Disease/surgery ; Humans ; Risk Factors ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
Language	English
Publishing date	2020-10-29
Publishing country	United States
Document type	Letter ; Observational Study
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2020.11.040
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Article ; Online: Outcomes associated with pacemaker implantation following transcatheter aortic valve replacement: A nationwide cohort study.

Clementy, Nicolas / Bisson, Arnaud / Bodin, Alexandre / Herbert, Julien / Lacour, Thibaud / Etienne, Christophe Saint / Pierre, Bertrand / Deharo, Pierre / Babuty, Dominique / Fauchier, Laurent

Heart rhythm

2021 Volume 18, Issue 12, Page(s) 2027–2032

Abstract: Background: Conduction abnormalities following transcatheter aortic valve replacement (TAVR) often may require permanent pacemaker implantation (PPM).: Objective: The purpose of this study was to evaluate outcomes associated with PPM after a TAVR ... ...

Abstract	Background: Conduction abnormalities following transcatheter aortic valve replacement (TAVR) often may require permanent pacemaker implantation (PPM). Objective: The purpose of this study was to evaluate outcomes associated with PPM after a TAVR procedure in a large, nationwide-level population. Methods: Based on the administrative hospital discharge database, the incidence of all-cause death, cardiovascular death, and hospitalization for heart failure (HF) were retrospectively collected, based on the presence or absence of PPM, in the first 30 days following all TAVRs in France from 2010 to 2019. Results: Among 520,662 patients hospitalized for aortic stenosis, 49,201 were treated with TAVR. A total of 29,422 patients had follow-up ≥6 months (median 1.7 years), 22% already had PPM at baseline, and 22% underwent PPM within the first 30 days post-TAVR. Adjusted hazard ratios for the combined risk of all-cause death and hospitalization for HF, during the whole follow-up, were higher in both patients with a previous PPM and in those implanted within 30 days (hazard ratio [95% confidence interval] 1.12 [1.07-1.17] and 1.11 [1.06-1.16], respectively). Conclusion: PPM at baseline and within 30 days post-TAVR are independently associated with higher mortality and HF hospitalization during follow-up.
MeSH term(s)	Aged, 80 and over ; Aortic Valve Stenosis/surgery ; Arrhythmias, Cardiac/epidemiology ; Arrhythmias, Cardiac/etiology ; Arrhythmias, Cardiac/therapy ; Cardiac Pacing, Artificial/methods ; Female ; Follow-Up Studies ; France/epidemiology ; Heart Valve Prosthesis/adverse effects ; Humans ; Incidence ; Male ; Patient Readmission ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Retrospective Studies ; Risk Factors ; Transcatheter Aortic Valve Replacement/adverse effects
Language	English
Publishing date	2021-06-17
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2021.06.1175
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Article ; Online: Outcomes Following Aortic Stenosis Treatment (Transcatheter vs Surgical Replacement) in Women vs Men (From a Nationwide Analysis).

Deharo, Pierre / Cuisset, Thomas / Bisson, Arnaud / Herbert, Julien / Lacour, Thibaud / Etienne, Christophe Saint / Jaussaud, Nicolas / Morera, Pierre / Spychaj, Jean-Charles / Porto, Alizée / Collart, Frederic / Theron, Alexis / Bernard, Anne / Bourguignon, Thierry / Fauchier, Laurent

The American journal of cardiology

2021 Volume 154, Page(s) 67–77

Abstract: Gender-differences in survival following transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) have been suggested. The objective of this study was to analyze outcomes following TAVR according to gender and to compare ...

Abstract	Gender-differences in survival following transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) have been suggested. The objective of this study was to analyze outcomes following TAVR according to gender and to compare outcomes between TAVR and SAVR in women, at a nationwide level. Based on the French administrative hospital-discharge database, the study collected information for all consecutive patients treated with TAVR and SAVR between 2010 and 2019. Outcomes were analyzed according to gender and propensity score matching was used for the analysis of outcomes. In total 71,794 patients were identified in the database. After matching on baseline characteristics, we analyzed 12,336 women and 12,336 men treated with TAVR. In a second matched analysis, we compared 9,297 women treated with TAVR and 9,297 women treated with SAVR. Long term follow-up showed lower risk of all-cause death (12.7% vs 14.8%, hazard ratio (HR) 0.85, 95% CI 0.81 to 0.90) in women than men. Although the difference in cardiovascular death remained non-significant (5.8% vs 6.0%, HR 0.96, 95% CI 0.88 to 1.05), non-cardiovascular death was less frequent in women than in men following TAVR (6.9% vs 8.8% HR 0.78, 95%CI 0.72 to 0.84).When TAVR was compared with SAVR in women, long-term follow-up with TAVR showed higher rates of all-cause death (11.2% vs 6.5%, HR 1.91, 95%CI 1.78 to 2.05), cardiovascular death (5.0% vs 3.2%, HR 1.44, 95%CI 1.30 to 1.59), and non-cardiovascular death (6.2% vs 3.3%, HR 2.48, 95% CI 2.25 to 2.72). In conclusion, we observed that women undergoing TAVR have lower long-term all-cause mortality as compared with TAVR in men, driven by non-cardiovascular mortality. SAVR was associated with lower rates of long-term cardiovascular adverse events in women as compared with TAVR.
MeSH term(s)	Aged ; Aged, 80 and over ; Aortic Valve Stenosis/surgery ; Atrial Fibrillation/epidemiology ; Cardiovascular Diseases/mortality ; Cause of Death ; Cohort Studies ; Female ; France ; Heart Valve Prosthesis Implantation ; Hospitalization/statistics & numerical data ; Humans ; Longitudinal Studies ; Male ; Mortality ; Myocardial Infarction/epidemiology ; Pacemaker, Artificial ; Postoperative Hemorrhage/epidemiology ; Propensity Score ; Proportional Hazards Models ; Sex Factors ; Stroke/epidemiology ; Transcatheter Aortic Valve Replacement
Language	English
Publishing date	2021-07-10
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2021.05.046
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Article ; Online: Transcatheter Valve-in-Valve Aortic Valve Replacement as an Alternative to Surgical Re-Replacement.

Deharo, Pierre / Bisson, Arnaud / Herbert, Julien / Lacour, Thibaud / Etienne, Christophe Saint / Porto, Alizée / Theron, Alexis / Collart, Frederic / Bourguignon, Thierry / Cuisset, Thomas / Fauchier, Laurent

Journal of the American College of Cardiology

2020 Volume 76, Issue 5, Page(s) 489–499

Abstract: Background: Valve-in-valve (VIV) transcatheter aortic valve replacement (TAVR) and redo surgical aortic valve replacement (SAVR) represent the 2 treatments for aortic bioprosthesis failure. Clinical comparison of both therapies remains limited by the ... ...

Abstract	Background: Valve-in-valve (VIV) transcatheter aortic valve replacement (TAVR) and redo surgical aortic valve replacement (SAVR) represent the 2 treatments for aortic bioprosthesis failure. Clinical comparison of both therapies remains limited by the number of patients analyzed. Objectives: The purpose of this study was to analyze the outcomes of VIV TAVR versus redo SAVR at a nationwide level in France. Methods: Based on the French administrative hospital-discharge database, the study collected information for patients treated for aortic bioprosthesis failure with isolated VIV TAVR or redo SAVR between 2010 and 2019. Propensity score matching was used for the analysis of outcomes. Results: A total of 4,327 patients were found in the database. After matching on baseline characteristics, 717 patients were analyzed in each arm. At 30 days, VIV TAVR was associated with lower rates of the composite of all-cause mortality, all-cause stroke, myocardial infarction, and major or life-threatening bleeding (odds ratio: 0.62; 95% confidence interval: 0.44 to 0.88; p = 0.03). During follow-up (median 516 days), the combined endpoint of cardiovascular death, all-cause stroke, myocardial infarction, or rehospitalization for heart failure was not different between the 2 groups (odds ratio: 1.18; 95% confidence interval: 0.99 to 1.41; p = 0.26). Rehospitalization for heart failure and pacemaker implantation were more frequently reported in the VIV TAVR group. A time-dependent interaction between all-cause and cardiovascular mortality following VIV TAVR was reported (p-interaction <0.05). Conclusions: VIV TAVR was observed to be associated with better short-term outcomes than redo SAVR. Major cardiovascular outcomes were not different between the 2 treatments during long-term follow-up.
MeSH term(s)	Aged ; Aged, 80 and over ; Aortic Valve/surgery ; Aortic Valve Stenosis/mortality ; Aortic Valve Stenosis/surgery ; Bioprosthesis ; Female ; Follow-Up Studies ; France/epidemiology ; Heart Valve Prosthesis ; Humans ; Male ; Propensity Score ; Prosthesis Design ; Reoperation ; Retrospective Studies ; Risk Factors ; Survival Rate/trends ; Transcatheter Aortic Valve Replacement/methods ; Treatment Outcome
Language	English
Publishing date	2020-07-08
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2020.06.010
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Futility Risk Model for Predicting Outcome After Transcatheter Aortic Valve Implantation.

Lantelme, Pierre / Lacour, Thibaud / Bisson, Arnaud / Herbert, Julien / Ivanes, Fabrice / Bourguignon, Thierry / Quilliet, Laurent / Angoulvant, Denis / Harbaoui, Brahim / Babuty, Dominique / Etienne, Christophe Saint / Deharo, Pierre / Bernard, Anne / Fauchier, Laurent

The American journal of cardiology

2020 Volume 130, Page(s) 100–107

Abstract: Risk-benefit assessment for transcatheter aortic valve implantation (TAVI) is still a matter of debate. We aimed to identify patients with a bad outcome within 1 year after TAVI, and to develop a Futile TAVI Simple score (FTS). Based on the ... ...

Abstract	Risk-benefit assessment for transcatheter aortic valve implantation (TAVI) is still a matter of debate. We aimed to identify patients with a bad outcome within 1 year after TAVI, and to develop a Futile TAVI Simple score (FTS). Based on the administrative hospital-discharge database, all consecutive patients treated with percutaneous TAVI in France between 2010 and 2018 were included. A prediction model was derived and validated for 1-year all-cause death after TAVI (considered as futility) by using split-sample validation: 20,443 patients were included in the analysis (mean age 83 ± 7 years). 7,039 deaths were recorded (yearly incidence rate 15.5%), among which 3,702 (53%) occurred in first year after TAVI procedure. In the derivation cohort (n = 10,221), the final logistic regression model included male sex, history of hospital stay with heart failure, history of pulmonary oedema, atrial fibrillation, previous stroke, vascular disease, renal disease, liver disease, pulmonary disease, anaemia, history of cancer, metastasis, depression and denutrition. The area under the curve (AUC) for the FTS was 0.674 (95%CI 0.660 to 0.687) in the derivation cohort and 0.651 (95%CI 0.637 to 0.665) in the validation cohort (n = 10,222). The Hosmer-Lemeshow test had a p-value of 0.87 suggesting an accurate calibration. The FTS score outperformed EuroSCORE II, Charlson comorbidity index and frailty index for identifying futility. Based on FTS score, 7% of these patients were categorized at high risk with a 1-year mortality at 43%. In conclusion, the FTS score, established from a large nationwide cohort of patients treated with TAVI, may provide a relevant tool for optimizing healthcare decision.
MeSH term(s)	Aged ; Aged, 80 and over ; Aortic Valve Stenosis/surgery ; Female ; Humans ; Male ; Medical Futility ; Models, Statistical ; Prognosis ; Retrospective Studies ; Risk Assessment ; Transcatheter Aortic Valve Replacement
Language	English
Publishing date	2020-06-07
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2020.05.043
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Article ; Online: Valve-in-valve transcatheter aortic valve implantation after failed surgically implanted aortic bioprosthesis versus native transcatheter aortic valve implantation for aortic stenosis: Data from a nationwide analysis.

Deharo, Pierre / Bisson, Arnaud / Herbert, Julien / Lacour, Thibaud / Saint Etienne, Christophe / Jaussaud, Nicolas / Theron, Alexis / Collart, Frederic / Bourguignon, Thierry / Cuisset, Thomas / Fauchier, Laurent

Archives of cardiovascular diseases

2020 Volume 114, Issue 1, Page(s) 41–50

Abstract: Background: Valve-in-valve transcatheter aortic valve implantation (TAVI) has emerged as a treatment for aortic bioprosthesis failure in case of prohibitive risk for redo surgery. However, clinical evaluation of valve-in-valve TAVI remains limited by ... ...

Abstract	Background: Valve-in-valve transcatheter aortic valve implantation (TAVI) has emerged as a treatment for aortic bioprosthesis failure in case of prohibitive risk for redo surgery. However, clinical evaluation of valve-in-valve TAVI remains limited by the number of patients analysed. Aim: To evaluate outcomes of valve-in-valve TAVI compared with native aortic valve TAVI at a nationwide level in France. Methods: Based on the French administrative hospital discharge database, the study collected information for all consecutive patients treated with TAVI for aortic stenosis or with isolated valve-in-valve TAVI for aortic bioprosthesis failure between 2010 and 2019. Propensity score matching was used for the analysis of outcomes. Results: A total of 44,218 patients were found in the database. After matching on baseline characteristics, 2749 patients were analysed in each arm. At 30 days, no significant differences were observed regarding the occurrence of major clinical events (composite of cardiovascular mortality, all-cause stroke, myocardial infarction, major or life-threatening bleeding and conversion to open heart surgery) (odds ratio [OR] 0.83, 95% confidence interval [CI] 0.68-1.01; P=0.32). During follow-up (mean 516 days), the combined endpoint of cardiovascular death, all-cause stroke or rehospitalization for heart failure was not different between the valve-in-valve TAVI and native TAVI groups (RR 1.03, 95% CI 0.94-1.13; P=1.00). Conclusion: We observed that valve-in-valve TAVI was associated with good short- and long-term outcomes. No significant differences were observed compared with native valve TAVI regarding clinical follow-up.
MeSH term(s)	Aged ; Aged, 80 and over ; Aortic Valve/diagnostic imaging ; Aortic Valve/physiopathology ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/mortality ; Aortic Valve Stenosis/physiopathology ; Aortic Valve Stenosis/surgery ; Bioprosthesis ; Databases, Factual ; Female ; France ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/adverse effects ; Heart Valve Prosthesis Implantation/instrumentation ; Heart Valve Prosthesis Implantation/mortality ; Humans ; Longitudinal Studies ; Male ; Prosthesis Failure ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Transcatheter Aortic Valve Replacement/adverse effects ; Transcatheter Aortic Valve Replacement/instrumentation ; Transcatheter Aortic Valve Replacement/mortality ; Treatment Outcome
Language	English
Publishing date	2020-06-10
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Observational Study
ZDB-ID	2408778-6
ISSN	1875-2128 ; 1875-2136
ISSN (online)	1875-2128
ISSN	1875-2136
DOI	10.1016/j.acvd.2020.04.005
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