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  1. Article ; Online: Medical Expulsive Therapy for Urinary Stone Disease in Children.

    Goka, Selasie Q / Copelovitch, Lawrence

    Indian pediatrics

    2020  Volume 57, Issue 10, Page(s) 940–943

    Abstract: The rising incidence of urinary stone disease in children requires pediatric practitioners to keep abreast of management recommendations which are generally geared towards adults. Medical expulsive therapy (MET) is a non-surgical therapeutic option that ... ...

    Abstract The rising incidence of urinary stone disease in children requires pediatric practitioners to keep abreast of management recommendations which are generally geared towards adults. Medical expulsive therapy (MET) is a non-surgical therapeutic option that can be trialed in patients who present with uncomplicated symptomatic ureteral stones. Seminal articles published and indexed in Medline on the topic of MET were extracted and reviewed. Studies suggest a potential benefit of alpha-blockade for the expulsion of distal ureteral stones that are >5 mm but ≤10 mm in adults and possibly >4 mm in children. Conversely, there does not seem to be any added benefit for MET in smaller stones (<5 mm) in which the spontaneous passage rate is high. Conclusions: The off-label use of these medications is one of the several barriers which contribute to the underutilization of MET in children. However, these may be a reasonable option in particular for older children and adolescents with the appropriate-sized stones.
    MeSH term(s) Adolescent ; Adult ; Child ; Humans ; Treatment Outcome ; Ureteral Calculi/drug therapy
    Language English
    Publishing date 2020-08-07
    Publishing country India
    Document type Journal Article
    ZDB-ID 402594-5
    ISSN 0974-7559 ; 0019-6061
    ISSN (online) 0974-7559
    ISSN 0019-6061
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  2. Article ; Online: Reply.

    Vajravelu, Ravy K / Copelovitch, Lawrence / Denburg, Michelle R

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2020  Volume 19, Issue 9, Page(s) 1994

    Language English
    Publishing date 2020-11-20
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2020.11.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prevention of recurrent urinary stone disease.

    Goka, Selasie Q / Copelovitch, Lawrence

    Current opinion in pediatrics

    2019  Volume 32, Issue 2, Page(s) 295–299

    Abstract: Purpose of review: Urinary stone disease (USD) is increasing in prevalence and recurrence is common. In pediatrics, most stones are composed primarily of calcium with the highest incidence observed in adolescents. Given the morbidity associated with USD, ...

    Abstract Purpose of review: Urinary stone disease (USD) is increasing in prevalence and recurrence is common. In pediatrics, most stones are composed primarily of calcium with the highest incidence observed in adolescents. Given the morbidity associated with USD, an in depth review of current management strategies is of paramount importance to highlight the data supporting the recommended treatments and the knowledge gaps which still exist.
    Recent findings: Several interventions for the management of recurrent calcium USD in children have been recommended based on primarily adult studies. These interventions include modification of diet and fluid intake in addition to the utilization of medications such as thiazide diuretics and citrates when supportive care is inadequate. Overall there is conflicting data in the adult literature which is further complicated by our attempts to extrapolate these data to children.
    Summary: Based on the currently available literature the management of USD in pediatrics should be individualized to each patient and focused on the particular metabolic risk factors that are identified during the course of their evaluation. Several interventions may be required or trialed in a particular patient to show an effect. Well designed trials to assess the efficacy of each intervention in the pediatric population are needed.
    MeSH term(s) Adolescent ; Adult ; Child ; Diet/adverse effects ; Humans ; Kidney Calculi/diagnosis ; Kidney Calculi/prevention & control ; Kidney Calculi/therapy ; Nephrolithiasis/diet therapy ; Nephrolithiasis/prevention & control ; Recurrence ; Risk Factors ; Risk Reduction Behavior ; Secondary Prevention/methods ; Treatment Outcome ; Urinary Calculi/diagnosis ; Urinary Calculi/prevention & control ; Urinary Calculi/therapy
    Language English
    Publishing date 2019-11-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1049374-8
    ISSN 1531-698X ; 1040-8703
    ISSN (online) 1531-698X
    ISSN 1040-8703
    DOI 10.1097/MOP.0000000000000852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Uncommon cribfellows: an infant with hypercalcemia, nephrocalcinosis, and acidosis: Questions.

    Ehlayel, Abdulla M / Copelovitch, Lawrence

    Pediatric nephrology (Berlin, Germany)

    2018  Volume 33, Issue 10, Page(s) 1695

    MeSH term(s) Acidosis/blood ; Acidosis/diagnosis ; Acidosis/drug therapy ; Acidosis/etiology ; Bicarbonates/blood ; Failure to Thrive/drug therapy ; Failure to Thrive/etiology ; Female ; Humans ; Hypercalcemia/blood ; Hypercalcemia/diagnosis ; Hypercalcemia/drug therapy ; Hypercalcemia/etiology ; Infant ; Infant, Newborn ; Kidney/diagnostic imaging ; Nephrocalcinosis/blood ; Nephrocalcinosis/diagnosis ; Nephrocalcinosis/etiology ; Nephrocalcinosis/urine ; Potassium Citrate/administration & dosage ; Ultrasonography ; Vomiting/drug therapy ; Vomiting/etiology
    Chemical Substances Bicarbonates ; Potassium Citrate (EE90ONI6FF)
    Language English
    Publishing date 2018-02-19
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-018-3887-5
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  5. Article ; Online: Uncommon cribfellows: an infant with hypercalcemia, nephrocalcinosis, and acidosis: Answers.

    Ehlayel, Abdulla M / Copelovitch, Lawrence

    Pediatric nephrology (Berlin, Germany)

    2018  Volume 33, Issue 10, Page(s) 1697–1699

    MeSH term(s) Acidosis, Renal Tubular/blood ; Acidosis, Renal Tubular/diagnosis ; Acidosis, Renal Tubular/drug therapy ; Acidosis, Renal Tubular/genetics ; Bicarbonates/blood ; Diagnosis, Differential ; Failure to Thrive/drug therapy ; Failure to Thrive/etiology ; Female ; Humans ; Hypercalcemia/blood ; Hypercalcemia/diagnosis ; Hypercalcemia/drug therapy ; Hypercalcemia/genetics ; Infant ; Infant, Newborn ; Kidney/diagnostic imaging ; Mutation ; Nephrocalcinosis/blood ; Nephrocalcinosis/diagnosis ; Nephrocalcinosis/genetics ; Nephrocalcinosis/urine ; Potassium Citrate/administration & dosage ; Treatment Outcome ; Ultrasonography ; Vacuolar Proton-Translocating ATPases/genetics ; Vomiting/drug therapy ; Vomiting/etiology
    Chemical Substances Bicarbonates ; ATP6V0A4 protein, human (EC 3.6.1.-) ; Vacuolar Proton-Translocating ATPases (EC 3.6.1.-) ; Potassium Citrate (EE90ONI6FF)
    Language English
    Publishing date 2018-02-19
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-018-3912-8
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  6. Article ; Online: Update on Dent Disease.

    Ehlayel, Abdulla M / Copelovitch, Lawrence

    Pediatric clinics of North America

    2018  Volume 66, Issue 1, Page(s) 169–178

    Abstract: Dent disease is an X-linked form of chronic kidney disease characterized by hypercalciuria, low molecular weight proteinuria, nephrocalcinosis, and proximal tubular dysfunction. Clinical presentation is highly variable. Male patients may present with ... ...

    Abstract Dent disease is an X-linked form of chronic kidney disease characterized by hypercalciuria, low molecular weight proteinuria, nephrocalcinosis, and proximal tubular dysfunction. Clinical presentation is highly variable. Male patients may present with early-onset rickets, recurrent nephrolithiasis, or insidiously with asymptomatic proteinuria or chronic kidney disease. Mutations in both the CLCN5 and OCRL1 genes have been associated with the Dent phenotype and are now classified as Dent-1 and Dent-2, respectively. This article describes the clinical presentation, laboratory evaluation, genetics, pathophysiology, management, and future therapies of Dent disease.
    MeSH term(s) Child ; Dent Disease/diagnosis ; Dent Disease/genetics ; Dent Disease/physiopathology ; Dent Disease/therapy ; Diagnosis, Differential ; Disease Progression ; Humans
    Language English
    Publishing date 2018-09-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215711-1
    ISSN 1557-8240 ; 0031-3955
    ISSN (online) 1557-8240
    ISSN 0031-3955
    DOI 10.1016/j.pcl.2018.09.003
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  7. Article ; Online: Urolithiasis in children: medical approach.

    Copelovitch, Lawrence

    Pediatric clinics of North America

    2012  Volume 59, Issue 4, Page(s) 881–896

    Abstract: Childhood urolithiasis is an evolving condition with an increasing incidence and prevalence over the last 2 decades. Over that time the underlying cause has shifted from predominantly infectious to metabolic in nature. This review describes the ... ...

    Abstract Childhood urolithiasis is an evolving condition with an increasing incidence and prevalence over the last 2 decades. Over that time the underlying cause has shifted from predominantly infectious to metabolic in nature. This review describes the pathophysiology, underlying metabolic abnormalities, clinical presentation, evaluation, and management of childhood urolithiasis. A comprehensive metabolic evaluation is essential for all children with renal calculi, given the high rate of recurrence and the importance of excluding inherited progressive conditions.
    MeSH term(s) Calcium Oxalate/metabolism ; Calcium Oxalate/urine ; Calcium Phosphates/metabolism ; Calcium Phosphates/urine ; Child ; Child, Preschool ; Citric Acid/urine ; Cystinuria/complications ; Diagnostic Imaging ; Female ; Humans ; Hypercalciuria/complications ; Hyperoxaluria/complications ; Infant ; Infant, Newborn ; Male ; Risk Factors ; Urinalysis ; Urolithiasis/diagnosis ; Urolithiasis/metabolism ; Urolithiasis/physiopathology ; Urolithiasis/therapy
    Chemical Substances Calcium Phosphates ; Calcium Oxalate (2612HC57YE) ; Citric Acid (2968PHW8QP) ; calcium phosphate (97Z1WI3NDX)
    Language English
    Publishing date 2012-06-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215711-1
    ISSN 1557-8240 ; 0031-3955
    ISSN (online) 1557-8240
    ISSN 0031-3955
    DOI 10.1016/j.pcl.2012.05.009
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  8. Article ; Online: Long-term outcome among females with Alport syndrome from a single pediatric center.

    Goka, Selasie / Copelovitch, Lawrence / Levy Erez, Daniella

    Pediatric nephrology (Berlin, Germany)

    2020  Volume 36, Issue 4, Page(s) 945–951

    Abstract: Background: Alport syndrome (AS) is a multisystem condition which can result in progressive kidney disease, hearing loss, and ocular changes. X-linked inheritance is observed in 85% of affected individuals. As a result, most prior studies have focused ... ...

    Abstract Background: Alport syndrome (AS) is a multisystem condition which can result in progressive kidney disease, hearing loss, and ocular changes. X-linked inheritance is observed in 85% of affected individuals. As a result, most prior studies have focused on males. Girls with AS can also be symptomatic although historically thought to have few clinical manifestations in childhood. The objective of the study was to describe the clinical presentation and course of females with AS.
    Methods: A single-center retrospective study of all young females with AS between January 1, 1987, and May 20, 2019. Subjects were identified using ICD-9/10 diagnosis codes for AS, familial hematuria, or nephritis. Clinical data were extracted by retrospective chart review.
    Results: Thirty-six female patients were included in the analysis. Mean age at presentation was 5.58 ± 3.0 years, and mean follow-up was 5.9 ± 3.9 years. Twenty-nine patients (80%) had a family history of AS. At end of the follow-up period, gross hematuria was observed in 15 patients (42%), 20 (56%) developed proteinuria, and 2 (6.7%) had an estimated glomerular filtration rate (eGFR) < 90 ml/min/1.73m
    Conclusions: Known family histories of AS or gross hematuria were the most common reasons for the initial presentation in our cohort. Development of proteinuria, eGFR < 90 ml/min/1.73m
    MeSH term(s) Child ; Child, Preschool ; Collagen Type IV/genetics ; Female ; Hematuria/etiology ; Humans ; Nephritis, Hereditary/complications ; Nephritis, Hereditary/diagnosis ; Nephritis, Hereditary/genetics ; Proteinuria/etiology ; Retrospective Studies
    Chemical Substances Collagen Type IV
    Language English
    Publishing date 2020-10-13
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-020-04748-4
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  9. Article ; Online: New insights into the pathogenesis of Streptococcus pneumoniae-associated hemolytic uremic syndrome.

    Scobell, Rebecca R / Kaplan, Bernard S / Copelovitch, Lawrence

    Pediatric nephrology (Berlin, Germany)

    2019  Volume 35, Issue 9, Page(s) 1585–1591

    Abstract: The purpose of this review is to describe Streptococcus pneumoniae-associated hemolytic uremic syndrome (P-HUS) with emphasis on new insights into the pathophysiology and management over the past 10 years. Even though awareness of this clinico- ... ...

    Abstract The purpose of this review is to describe Streptococcus pneumoniae-associated hemolytic uremic syndrome (P-HUS) with emphasis on new insights into the pathophysiology and management over the past 10 years. Even though awareness of this clinico-pathological entity has increased, it likely remains under-recognized. Recent observations indicate that although neuraminidase activity and exposure of the T-antigen are necessary for development of P-HUS, they are not sufficient; activation of the alternate pathway of complement may also contribute. It is unclear, however, whether or not eculizumab and/or plasmapheresis are of value.
    MeSH term(s) Child ; Complement Activation/immunology ; Hemolytic-Uremic Syndrome/etiology ; Hemolytic-Uremic Syndrome/microbiology ; Hemolytic-Uremic Syndrome/physiopathology ; Hemolytic-Uremic Syndrome/therapy ; Humans ; Pneumonia, Pneumococcal/complications ; Pneumonia, Pneumococcal/microbiology ; Streptococcus pneumoniae/immunology ; Streptococcus pneumoniae/isolation & purification
    Language English
    Publishing date 2019-09-13
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-019-04342-3
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  10. Article ; Online: Salt, sweat, and unclear? Diaphoresis and hypernatremia in end-stage kidney disease: Answers.

    Levy Erez, Daniella / Copelovitch, Lawrence / Denburg, Michele

    Pediatric nephrology (Berlin, Germany)

    2017  Volume 33, Issue 2, Page(s) 253–254

    MeSH term(s) Humans ; Hypernatremia ; Kidney Failure, Chronic ; Sodium Chloride ; Sodium Chloride, Dietary ; Sweat
    Chemical Substances Sodium Chloride, Dietary ; Sodium Chloride (451W47IQ8X)
    Language English
    Publishing date 2017-04-27
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-017-3668-6
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