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  1. Article ; Online: Early relational health: Innovations in child health for promotion, screening, and research.

    Willis, David W / Eddy, J Mark

    Infant mental health journal

    2022  Volume 43, Issue 3, Page(s) 361–372

    Abstract: Relational experiences during infancy and early childhood are key drivers for building health, social emotional development, and learning capacities, each vital for wellbeing. The U.S. child health sectors share a commitment to universal health promotion, ...

    Abstract Relational experiences during infancy and early childhood are key drivers for building health, social emotional development, and learning capacities, each vital for wellbeing. The U.S. child health sectors share a commitment to universal health promotion, prevention and early intervention, and a growing enthusiasm for the research-affirmed primacy of caregiver-child interactions during the critical first 1000 days of life. Given our nation's growing children's mental health crisis, racial justice awakening and the need to reimagine equitable supports for young families post-COVID19, the child health sectors seek new tools and clinical approaches that blend science-to-practice innovations with co-developed activities that are meaningful to families. This special section brings together papers about a journey of co-discovery between researchers, clinicians, and parents during the development and refinement of new video- and interview-based dyadic relational screening and monitoring tools. The collection of papers addresses a range of topics including early relational health (ERH), development and validation of the Early Relational Health Screen, its application within research and clinical settings, and thoughtful discussions from multiple perspectives. Informed by the diversity informed tenets, this journey highlights not only science-informed approaches, but also co-development with families of equitable approaches to understanding and serving children and their caregivers.
    MeSH term(s) COVID-19 ; Caregivers ; Child ; Child Health ; Child, Preschool ; Humans ; Mental Health ; Parents/psychology
    Language English
    Publishing date 2022-05-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 225602-2
    ISSN 1097-0355 ; 0163-9641
    ISSN (online) 1097-0355
    ISSN 0163-9641
    DOI 10.1002/imhj.21980
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Lack of reinforcement is hard to "bear": Assessing judgment bias in grizzly bears (

    Bernstein-Kurtycz, Laura M / Vonk, Jennifer / Carroscia, Joseph M / Koester, Diana C / Snyder, Rebecca J / Willis, Mark A / Lukas, Kristen E

    Journal of applied animal welfare science : JAAWS

    2024  , Page(s) 1–14

    Abstract: Cognitive biases reveal underlying affective state by indicating optimism and pessimism. This methodology may permit assessment of positive welfare in animals that have few validated positive welfare indicators, such as bears. Our goal was to validate a ... ...

    Abstract Cognitive biases reveal underlying affective state by indicating optimism and pessimism. This methodology may permit assessment of positive welfare in animals that have few validated positive welfare indicators, such as bears. Our goal was to validate a judgment bias test for assessing optimism in brown bears, using a touchscreen. After training the bears on a conditional discrimination, we compared responses to an ambiguous stimulus in a 2 × 2 nested design involving four experimental conditions representing presence or absence of a behind-the-scenes tour and presence or absence of a keeper training session with food reinforcement. We recorded bears' behavior during the conditions as a measure of convergent validity. Testing revealed the possibility of pessimism in the absence of reinforcement in one bear. More frustration behaviors were also observed during the no food reinforcement conditions. This is the first experimental demonstration of brown bears using a touchscreen and one of only three reports in which bears have been reported to perform a conditional discrimination. This method of assessing underlying affective state shows promise for the future.
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Journal Article
    ISSN 1532-7604
    ISSN (online) 1532-7604
    DOI 10.1080/10888705.2024.2315042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Ethyl acetate production from dilute bioethanol with low energy intensity

    Grisales Díaz, Víctor Hugo / Willis, Mark J.

    Journal of cleaner production. 2022 Nov. 20, v. 376

    2022  

    Abstract: Ethyl acetate production by esterification and bioethanol recovery from dilute solutions (11 wt %) are energy-intensive processes. Although ethanol is a raw material for ethyl acetate production, both technologies are usually studied independently. Here, ...

    Abstract Ethyl acetate production by esterification and bioethanol recovery from dilute solutions (11 wt %) are energy-intensive processes. Although ethanol is a raw material for ethyl acetate production, both technologies are usually studied independently. Here, a cleaning coupled process was proposed. The dilute stream of ethanol was fed to a reactive distillation column, so reflux and columns for dehydration of ethanol were not required. This increases the steam flow at the bottoms of the reactive zone. Steam was found to displace the equilibrium allowing a total recovery of products in the reactive distillation column, ethyl acetate (top) and water (bottoms). So, it was found that, counterintuitively, steam favors the recovery of ethyl acetate, avoiding the over-recycle of raw materials such as acetic acid. An extractive distillation scheme using dimethyl sulfoxide (DMSO) was also proposed to minimize the energy requirements for the purification of a mixture of ethanol, water, and ethyl acetate. The decision tree model was used to estimate the importance of operating variables on total annualized costs. The operating conditions were selected considering steady-state multiplicities. The energy intensity was further decreased by heat integration with vapor compression from 2.4 to 2.8 to 0.9–1.4 MJ/kg-ethyl acetate. The scheme proposed in this work was found to be a novel intensified process as the energy intensity of the scheme proposed was between three and seven times lower than that reported previously in the literature.
    Keywords acetic acid ; bioethanol ; decision support systems ; dimethyl sulfoxide ; distillation ; energy ; esterification ; ethanol ; ethyl acetate ; heat ; models ; raw materials ; steam
    Language English
    Dates of publication 2022-1120
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0959-6526
    DOI 10.1016/j.jclepro.2022.134137
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Global inequities and political borders challenge nature conservation under climate change.

    Titley, Mark A / Butchart, Stuart H M / Jones, Victoria R / Whittingham, Mark J / Willis, Stephen G

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 7

    Abstract: Underlying sociopolitical factors have emerged as important determinants of wildlife population trends and the effectiveness of conservation action. Despite mounting research into the impacts of climate change on nature, there has been little ... ...

    Abstract Underlying sociopolitical factors have emerged as important determinants of wildlife population trends and the effectiveness of conservation action. Despite mounting research into the impacts of climate change on nature, there has been little consideration of the human context in which these impacts occur, particularly at the global scale. We investigate this in two ways. First, by modeling the climatic niches of terrestrial mammals and birds globally, we show that projected species loss under climate change is greatest in countries with weaker governance and lower Gross Domestic Product, with loss of mammal species projected to be greater in countries with lower CO
    MeSH term(s) Animals ; Birds ; Climate Change ; Endangered Species/statistics & numerical data ; Greenhouse Effect ; Mammals ; Political Systems
    Language English
    Publishing date 2021-02-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2011204118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Multistressor global change drivers reduce hatch and viability of Lingcod embryos, a benthic egg layer in the California Current System.

    Willis-Norton, Ellen / Carr, Mark H / Hazen, Elliott L / Kroeker, Kristy J

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 21987

    Abstract: Early life history stages of marine fishes are often more susceptible to environmental stressors than adult stages. This vulnerability is likely exacerbated for species that lay benthic egg masses bound to substrate because the embryos cannot evade ... ...

    Abstract Early life history stages of marine fishes are often more susceptible to environmental stressors than adult stages. This vulnerability is likely exacerbated for species that lay benthic egg masses bound to substrate because the embryos cannot evade locally unfavorable environmental conditions. Lingcod (Ophiodon elongatus), a benthic egg layer, is an ecologically and economically significant predator in the highly-productive California Current System (CCS). We ran a flow-through mesocosm experiment that exposed Lingcod eggs collected from Monterey Bay, CA to conditions we expect to see in the central CCS by the year 2050 and 2100. Exposure to temperature, pH, and dissolved oxygen concentrations projected by the year 2050 halved the successful hatch of Lingcod embryos and significantly reduced the size of day-1 larvae. In the year 2100 treatment, viable hatch plummeted (3% of normal), larvae were undersized (83% of normal), yolk reserves were exhausted (38% of normal), and deformities were widespread (94% of individuals). This experiment is the first to expose marine benthic eggs to future temperature, pH, and dissolved oxygen conditions in concert. Lingcod are a potential indicator species for other benthic egg layers for which global change conditions may significantly diminish recruitment rates.
    MeSH term(s) Animals ; Female ; Pregnancy ; Perciformes ; Fishes ; Larva ; Parturition ; Temperature
    Language English
    Publishing date 2022-12-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-25553-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The context and development of the early relational health screen.

    Willis, David W / Condon, Marie-Celeste / Moe, Vibeke / Munson, Leslie / Smith, Lars / Eddy, J Mark

    Infant mental health journal

    2022  Volume 43, Issue 3, Page(s) 493–506

    Abstract: Early relational experiences are key drivers for developing social emotional capacities, educational achievement, mental health, physical health, and overall wellbeing. The child health sectors are committed to promotion, prevention, and early ... ...

    Abstract Early relational experiences are key drivers for developing social emotional capacities, educational achievement, mental health, physical health, and overall wellbeing. The child health sectors are committed to promotion, prevention, and early intervention that optimize children's health and development, often employing evidence-based screening as foundational practices. Despite a variety of validated parent-infant observational assessment tools, few are practical within busy practice settings, acceptable with all racial and ethnic groups and ready for universal adoption. In response to this need, a team of clinicians, early childhood educators, researchers and infant mental health specialists collaborated to develop and test a novel video-based, dyadic relational screening and monitoring tool, the Early Relational Health Screen (ERHS). This tool uniquely focuses on the early parent-child relationship (6-24 months), within the construct of early relational health (ERH). Initial testing demonstrated that the ERHS is a valid, reliable, feasible, and useful screening and monitoring tool for clinical applications. The ERHS was further developed within a population-based, prospective research study and adapted with brief video feedback for parents in the home visiting and child health sectors. The ERHS and its adaptations appear to advance ERH and equity within the transforming child health and public health care systems of today.
    MeSH term(s) Child, Preschool ; Female ; Humans ; Infant ; Infant Health ; Mental Health ; Parent-Child Relations ; Parents ; Prospective Studies
    Language English
    Publishing date 2022-05-10
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 225602-2
    ISSN 1097-0355 ; 0163-9641
    ISSN (online) 1097-0355
    ISSN 0163-9641
    DOI 10.1002/imhj.21986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Exploring the effect of case management in homelessness per components: A systematic review of effectiveness and implementation, with meta-analysis and thematic synthesis.

    Weightman, Alison L / Kelson, Mark J / Thomas, Ian / Mann, Mala K / Searchfield, Lydia / Willis, Simone / Hannigan, Ben / Smith, Robin J / Cordiner, Rhiannon

    Campbell systematic reviews

    2023  Volume 19, Issue 2, Page(s) e1329

    Abstract: Background: Adequate housing is a basic human right. The many millions of people experiencing homelessness (PEH) have a lower life expectancy and more physical and mental health problems. Practical and effective interventions to provide appropriate ... ...

    Abstract Background: Adequate housing is a basic human right. The many millions of people experiencing homelessness (PEH) have a lower life expectancy and more physical and mental health problems. Practical and effective interventions to provide appropriate housing are a public health priority.
    Objectives: To summarise the best available evidence relating to the components of case-management interventions for PEH via a mixed methods review that explored both the effectiveness of interventions and factors that may influence its impact.
    Search methods: We searched 10 bibliographic databases from 1990 to March 2021. We also included studies from Campbell Collaboration Evidence and Gap Maps and searched 28 web sites. Reference lists of included papers and systematic reviews were examined and experts contacted for additional studies.
    Selection criteria: We included all randomised and non-randomised study designs exploring case management interventions where a comparison group was used. The primary outcome of interest was homelessness. Secondary outcomes included health, wellbeing, employment and costs. We also included all studies where data were collected on views and experiences that may impact on implementation.
    Data collection and analysis: We assessed risk of bias using tools developed by the Campbell Collaboration. We conducted meta-analyses of the intervention studies where possible and carried out a framework synthesis of a set of implementation studies identified by purposive sampling to represent the most 'rich' and 'thick' data.
    Main results: We included 64 intervention studies and 41 implementation studies. The evidence base was dominated by studies from the USA and Canada. Participants were largely (though not exclusively) people who were literally homeless, that is, living on the streets or in shelters, and who had additional support needs. Many studies were assessed as having a medium or high risk of bias. However, there was some consistency in outcomes across studies that improved confidence in the main findings.
    Case management and housing outcomes: Case management of any description was superior to usual care for homelessness outcomes (standardised mean difference [SMD] = -0.51 [95% confidence interval [CI]: -0.71, -0.30];
    Case management and mental health outcomes: The overall evidence suggested that case management of any description was not more or less effective compared to usual care for an individual's mental health (SMD = 0.02 [-0.15, 0.18];
    Case management and other outcomes: Based on meta-analyses, case management was superior to usual care for capability and wellbeing outcomes up to 1 year (an improvement of around one-third of an SMD;
    Case management components: For homelessness outcomes, there was a non-significant trend for benefits to be greater in the medium term (≤3 years) compared to long term (>3 years) (SMD = -0.64 [-1.04, -0.24] vs. -0.27 [-0.53, 0];
    Characteristics of persons experiencing homelessness: No conclusions could be drawn from meta-analysis other than a trend for greater reductions in homelessness for persons with high complexity of need (two or more support needs in addition to homelessness) as compared to those with medium complexity of need (one additional support need); effect sizes were SMD = -0.61 [-0.91, -0.31] versus -0.36 [-0.68, -0.05];
    The broader context of delivery of case management programmes: Other major themes from the implementation studies included the importance of interagency partnership; provision for non-housing support and training needs of PEH (such as independent living skills), intensive community support following the move to new housing; emotional support and training needs of case managers; and an emphasis on housing safety, security and choice.
    Cost effectiveness: The 12 studies with cost data provided contrasting results and no clear conclusions. Some case management costs may be largely off-set by reductions in the use of other services. Cost estimates from three North American studies were $45-52 for each additional day housed.
    Authors' conclusions: Case management interventions improve housing outcomes for PEH with one or more additional support needs, with more intense interventions leading to greater benefits. Those with greater support needs may gain greater benefit. There is also evidence for improvements to capabilities and wellbeing. Current approaches do not appear to lead to mental health benefits. In terms of case management components, there is evidence in support of a team approach and in-person meetings and, from the implementation evidence, that conditions associated with service provision should be minimised. The approach within Housing First could explain the finding that overall benefits may be greater than for other types of case management. Four of its principles were identified as key themes within the implementation studies: No conditionality, offer choice, provide an individualised approach and support community building. Recommendations for further research include an expansion of the research base outside North America and further exploration of case management components and intervention cost-effectiveness.
    Language English
    Publishing date 2023-05-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2762761-5
    ISSN 1891-1803 ; 1891-1803
    ISSN (online) 1891-1803
    ISSN 1891-1803
    DOI 10.1002/cl2.1329
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Strategies to maintain an N95 respirator supply during a pandemic supply-chain shortage.

    Buchanan, Mark O / Sickbert-Bennett, Emily E / Selimos, Amy / Dean, Stephen M / Willis, Beth / Boone, William P / Mitchell, Ashley M / DiBiase, Lauren M / Shaheen, Nicholas J / Weber, David J

    Infection control and hospital epidemiology

    2023  Volume 45, Issue 5, Page(s) 688–689

    MeSH term(s) Humans ; N95 Respirators ; Pandemics ; COVID-19 ; SARS-CoV-2 ; Respiratory Protective Devices
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2023.252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: PROTOCOL: Exploring the effect of case management in homelessness per components: A systematic review of effectiveness and implementation, with meta-analysis and thematic synthesis.

    Weightman, Alison L / Kelson, Mark J / Thomas, Ian / Mann, Mala K / Searchfield, Lydia / Hannigan, Ben / Smith, Robin J / Willis, Simone / Cordiner, Rhiannon

    Campbell systematic reviews

    2022  Volume 18, Issue 1, Page(s) e1220

    Abstract: This is the protocol for a Campbell review. The objectives are as follows: To carry out a mixed methods review to summarise current evidence relating to the components of case-management interventions for people experiencing homelessness. ...

    Abstract This is the protocol for a Campbell review. The objectives are as follows: To carry out a mixed methods review to summarise current evidence relating to the components of case-management interventions for people experiencing homelessness.
    Language English
    Publishing date 2022-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2762761-5
    ISSN 1891-1803 ; 1891-1803
    ISSN (online) 1891-1803
    ISSN 1891-1803
    DOI 10.1002/cl2.1220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Eukaryotic Elongation Factor 2 Kinase Activity Is Required for the Phenotypes of the Rpl24

    Knight, John R P / Proud, Christopher G / Mallucci, Giovanna / von der Haar, Tobias / Smales, C Mark / Willis, Anne E / Sansom, Owen J

    The Journal of investigative dermatology

    2022  Volume 142, Issue 12, Page(s) 3346–3348.e1

    MeSH term(s) Animals ; Mice ; Elongation Factor 2 Kinase/genetics ; Elongation Factor 2 Kinase/metabolism ; Phenotype ; Phosphorylation ; Signal Transduction
    Chemical Substances Elongation Factor 2 Kinase (EC 2.7.11.20) ; ribosomal protein L24
    Language English
    Publishing date 2022-07-16
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2022.06.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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