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Article ; Online: Role of vitamins beyond vitamin D

Skalny, Anatoly V / Aschner, Michael / Tsatsakis, Aristidis / Rocha, Joao B T / Santamaria, Abel / Spandidos, Demetrios A / Martins, Airton C / Lu, Rongzhu / Korobeinikova, Tatiana V / Chen, Wen / Chang, Jung-Su / Chao, Jane C J / Li, Chong / Tinkov, Alexey A

International journal of molecular medicine

2023 Volume 53, Issue 1

Abstract: The objective of the present review was to summarize the molecular mechanisms associated with the effects of the vitamins A, C, E and K, and group B vitamins on bone and their potential roles in the development of osteoporosis. Epidemiological findings ... ...

Abstract	The objective of the present review was to summarize the molecular mechanisms associated with the effects of the vitamins A, C, E and K, and group B vitamins on bone and their potential roles in the development of osteoporosis. Epidemiological findings have demonstrated an association between vitamin deficiency and a higher risk of developing osteoporosis; vitamins are positively related to bone health upon their intake at the physiological range. Excessive vitamin intake can also adversely affect bone formation, as clearly demonstrated for vitamin A. Vitamins E (tocopherols and tocotrienols), K2 (menaquinones 4 and 7) and C have also been shown to promote osteoblast development through bone morphogenetic protein (BMP)/Smad and Wnt/β‑catenin signaling, as well as the TGFβ/Smad pathway (α‑tocopherol). Vitamin A metabolite (all‑trans retinoic acid) exerts both inhibitory and stimulatory effects on BMP‑ and Wnt/β‑catenin‑mediated osteogenesis at the nanomolar and micromolar range, respectively. Certain vitamins significantly reduce receptor activator of nuclear factor kappa‑B ligand (RANKL) production and RANKL/RANK signaling, while increasing the level of osteoprotegerin (OPG), thus reducing the RANKL/OPG ratio and exerting anti‑osteoclastogenic effects. Ascorbic acid can both promote and inhibit RANKL signaling, being essential for osteoclastogenesis. Vitamin K2 has also been shown to prevent vascular calcification by activating matrix Gla protein through its carboxylation. Therefore, the maintenance of a physiological intake of vitamins should be considered as a nutritional strategy for the prevention of osteoporosis.
MeSH term(s)	Humans ; Vitamins/pharmacology ; Cholecalciferol/pharmacology ; beta Catenin/metabolism ; Vitamin A ; Bone Density ; Osteoporosis/metabolism ; Vitamin K ; Bone Morphogenetic Proteins ; Wnt Signaling Pathway
Chemical Substances	Vitamins ; Cholecalciferol (1C6V77QF41) ; beta Catenin ; Vitamin A (11103-57-4) ; Vitamin K (12001-79-5) ; Bone Morphogenetic Proteins
Language	English
Publishing date	2023-12-08
Publishing country	Greece
Document type	Review ; Journal Article
ZDB-ID	1444428-8
ISSN	1791-244X ; 1107-3756
ISSN (online)	1791-244X
ISSN	1107-3756
DOI	10.3892/ijmm.2023.5333
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Article ; Online: 2,4-D Herbicide-Induced Hepatotoxicity: Unveiling Disrupted Liver Functions and Associated Biomarkers.

Martins, Rafael Xavier / Carvalho, Matheus / Maia, Maria Eduarda / Flor, Bruno / Souza, Terezinha / Rocha, Thiago Lopes / Félix, Luís M / Farias, Davi

Toxics

2024 Volume 12, Issue 1

Abstract: 2,4-dichlorophenoxyacetic acid (2,4-D) is a widely used herbicide worldwide and is frequently found ... of 2,4-D, focusing on morphological damages, toxicity biomarkers and affected liver functions. Searches ... xenobiotic metabolism were also identified. Furthermore, studies about the effects of 2,4-D in mixtures ...

Abstract	2,4-dichlorophenoxyacetic acid (2,4-D) is a widely used herbicide worldwide and is frequently found in water samples. This knowledge has prompted studies on its effects on non-target organisms, revealing significant alterations to liver structure and function. In this review, we evaluated the literature on the hepatotoxicity of 2,4-D, focusing on morphological damages, toxicity biomarkers and affected liver functions. Searches were conducted on PubMed, Web of Science and Scopus and 83 articles were selected after curation. Among these studies, 72% used in vivo models and 30% used in vitro models. Additionally, 48% used the active ingredient, and 35% used commercial formulations in exposure experiments. The most affected biomarkers were related to a decrease in antioxidant capacity through alterations in the activities of catalase, superoxide dismutase and the levels of malondialdehyde. Changes in energy metabolism, lipids, liver function, and xenobiotic metabolism were also identified. Furthermore, studies about the effects of 2,4-D in mixtures with other pesticides were found, as well as hepatoprotection trials. The reviewed data indicate the essential role of reduction in antioxidant capacity and oxidative stress in 2,4-D-induced hepatotoxicity. However, the mechanism of action of the herbicide is still not fully understood and further research in this area is necessary.
Language	English
Publishing date	2024-01-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics12010035
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Article ; Online: Genotype Prevalence of Lactose Deficiency, Vitamin D Deficiency, and the Vitamin D Receptor in a Chilean Inflammatory Bowel Disease Cohort: Insights from an Observational Study.

International journal of molecular sciences

2023 Volume 24, Issue 19

Abstract: Lactose intolerance (LI) and vitamin D deficiency (VDD) have been linked ... Vitamin D Receptor (VDR) gene variants. Blood samples were analyzed using Illumina's Infinium Global Screening Array ...

Abstract	Lactose intolerance (LI) and vitamin D deficiency (VDD) have been linked to inflammatory bowel disease (IBD). We conducted an observational study in 192 Chilean IBD patients to investigate the prevalence of a specific gene variant (LCT-13910 CC genotype) associated with LI and the prevalence of VDD/Vitamin D Receptor (VDR) gene variants. Blood samples were analyzed using Illumina's Infinium Global Screening Array. The LCT-13910 CC genotype was found in 61% of IBD patients, similar to Chilean Hispanic controls and lower than Chilean Amerindian controls. The frequency of the LCT-13910-C allele in Chilean IBD patients (0.79) was comparable to the general population and higher than Europeans (0.49). Regarding VDR and VDD variants, in our study, the rs12785878-GG variant was associated with an increased risk of IBD (OR = 2.64, CI = 1.61-4.32;
MeSH term(s)	Humans ; Chile/epidemiology ; Genetic Predisposition to Disease ; Genotype ; Inflammatory Bowel Diseases/epidemiology ; Inflammatory Bowel Diseases/genetics ; Inflammatory Bowel Diseases/complications ; Lactose/deficiency ; Polymorphism, Single Nucleotide ; Prevalence ; Receptors, Calcitriol/genetics ; Vitamin D ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology ; Vitamin D Deficiency/genetics
Chemical Substances	Lactose (J2B2A4N98G) ; Receptors, Calcitriol ; Vitamin D (1406-16-2)
Language	English
Publishing date	2023-10-03
Publishing country	Switzerland
Document type	Observational Study ; Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241914866
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Article ; Online: Daily Vitamin D Supplementation Improves Vitamin D Deficiency in Patients With Chronic Liver Disease.

Mariano da Rocha, Carolina Roos / Guaragna-Filho, Guilherme / Kieling, Carlos Oscar / Adami, Marina Rossato / Guedes, Renata Rostirola / Gonçalves Vieira, Sandra Maria

Journal of pediatric gastroenterology and nutrition

2023 Volume 76, Issue 6, Page(s) 723–730

Abstract: ... cholecalciferol (OC) treatment in children with chronic liver disease (CLD) and 25(OH)D deficiency.: Methods ... for serum 25(OH)D, liver function, bone metabolism, Child-Pugh classification, and anthropometry. Patients ... with 25(OH)D deficiency (defined as 25(OH)D < 20 ng/mL) who received 6000 IU/day of OC were analyzed pre ...

Abstract	Objective: The objective of this article is to evaluate the response to 6000 IU oral cholecalciferol (OC) treatment in children with chronic liver disease (CLD) and 25(OH)D deficiency. Methods: This historical cohort included non-transplanted CLD patients younger than 18 years old, which were analyzed for serum 25(OH)D, liver function, bone metabolism, Child-Pugh classification, and anthropometry. Patients with 25(OH)D deficiency (defined as 25(OH)D < 20 ng/mL) who received 6000 IU/day of OC were analyzed pre- and post-intervention, and considered responders if 25(OH)D > 20 ng/mL after at least 60 days. We compared clinical and laboratory data from patients with and without 25(OH)D deficiency, responders and nonresponders. Results: We studied 96 patients, of which 57.2% had biliary atresia. The prevalence of 25(OH)D deficiency was 67.7% (65/96). These patients were younger ( P < 0.001), had higher Child-Pugh scores ( P < 0.001), higher levels of total bilirubin (TB) ( P < 0.001), gamma-glutamyl transferase ( P < 0.001), and alkaline phosphatase ( P = 0.002), as well as lower levels of phosphorus ( P = 0.009) compared with patients without 25(OH)D deficiency. The median treatment length was 126 days (70-307 days). At the end of treatment, we observed a higher median of 25(OH)D ( P < 0.001), and lower median of parathyroid hormone (PTH) ( P = 0.023). Nine patients (29%) restored 25(OH)D to normal range; they had lower Child-Pugh score ( P = 0.001), lower TB levels ( P = 0.001), and higher level of phosphorus ( P = 0.003) after treatment. Conclusion: Despite an increase in 25(OH)D and decrease in PTH levels, 6000 IU/day of OC was not sufficient to restore 25(OH)D deficiency in most of the patients in this study.
MeSH term(s)	Humans ; Adolescent ; Vitamin D ; Vitamins ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/drug therapy ; Cholecalciferol/therapeutic use ; Liver Diseases/complications ; Liver Diseases/drug therapy ; Parathyroid Hormone/therapeutic use ; Dietary Supplements ; Phosphorus
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins ; Cholecalciferol (1C6V77QF41) ; Parathyroid Hormone ; Phosphorus (27YLU75U4W)
Language	English
Publishing date	2023-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000003769
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Article ; Online: Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 disease severity.

Freitas, Ana Teresa / Calhau, Conceição / Antunes, Gonçalo / Araújo, Beatriz / Bandeira, Matilde / Barreira, Sofia / Bazenga, Filipa / Braz, Sandra / Caldeira, Daniel / Santos, Susana Constantino Rosa / Faria, Ana / Faria, Daniel / Fraga, Marta / Nogueira-Garcia, Beatriz / Gonçalves, Lúcia / Kovalchuk, Pavlo / Lacerda, Luísa / Lopes, Hugo / Luís, Daniel /

Medeiros, Fábio / Melo, Ana M P / Melo-Cristino, José / Miranda, Ana / Pereira, Clara / Pinto, Ana Teresa / Pinto, João / Proença, Helena / Ramos, Angélica / Rato, João P R / Rocha, Filipe / Rocha, Júlio César / Moreira-Rosário, André / Vazão, Helena / Volovetska, Yuliya / Guimarães, João-Tiago / Pinto, Fausto J

Scientific reports

2021 Volume 11, Issue 1, Page(s) 20837

Abstract: Vitamin D is a fundamental regulator of host defences by activating genes related to innate and ... adaptive immunity. Previous research shows a correlation between the levels of vitamin D in patients infected ... background related to vitamin D pathways on COVID-19 severity. For the first time, the Portuguese population ...

Abstract	Vitamin D is a fundamental regulator of host defences by activating genes related to innate and adaptive immunity. Previous research shows a correlation between the levels of vitamin D in patients infected with SARS-CoV-2 and the degree of disease severity. This work investigates the impact of the genetic background related to vitamin D pathways on COVID-19 severity. For the first time, the Portuguese population was characterized regarding the prevalence of high impact variants in genes associated with the vitamin D pathways. This study enrolled 517 patients admitted to two tertiary Portuguese hospitals. The serum concentration of 25 (OH)D, was measured in the hospital at the time of patient admission. Genetic variants, 18 variants, in the genes AMDHD1, CYP2R1, CYP24A1, DHCR7, GC, SEC23A, and VDR were analysed. The results show that polymorphisms in the vitamin D binding protein encoded by the GC gene are related to the infection severity (p = 0.005). There is an association between vitamin D polygenic risk score and the serum concentration of 25 (OH)D (p = 0.04). There is an association between 25 (OH)D levels and the survival and fatal outcomes (p = 1.5e-4). The Portuguese population has a higher prevalence of the DHCR7 RS12785878 variant when compared with its prevalence in the European population (19% versus 10%). This study shows a genetic susceptibility for vitamin D deficiency that might explain higher severity degrees in COVID-19 patients. These results reinforce the relevance of personalized strategies in the context of viral diseases.Trial registration: NCT04370808.
MeSH term(s)	Aged ; Biomarkers ; COVID-19/blood ; COVID-19/diagnosis ; Cholestanetriol 26-Monooxygenase/genetics ; Cytochrome P450 Family 2/genetics ; Female ; Genetic Predisposition to Disease ; Hospitalization ; Humans ; Male ; Middle Aged ; Oxidoreductases Acting on CH-CH Group Donors/genetics ; Polymorphism, Genetic ; Portugal/epidemiology ; Prevalence ; Severity of Illness Index ; Vesicular Transport Proteins/genetics ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D/genetics ; Vitamin D Deficiency/blood ; Vitamin D-Binding Protein/genetics ; Vitamin D3 24-Hydroxylase/genetics
Chemical Substances	Biomarkers ; GC protein, human ; SEC23A protein, human ; Vesicular Transport Proteins ; Vitamin D-Binding Protein ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H) ; Cytochrome P450 Family 2 (EC 1.14.14.1) ; CYP2R1 protein, human (EC 1.14.14.24) ; Cholestanetriol 26-Monooxygenase (EC 1.14.15.15) ; CYP24A1 protein, human (EC 1.14.15.16) ; Vitamin D3 24-Hydroxylase (EC 1.14.15.16) ; Oxidoreductases Acting on CH-CH Group Donors (EC 1.3.-) ; 7-dehydrocholesterol reductase (EC 1.3.1.21)
Language	English
Publishing date	2021-10-21
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-99952-z
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Article ; Online: Toxicological and behavioral analyses indicates the safety of a biofertilizer in the non-target D. melanogaster.

Rieder, G S / Zamberlan, D C / Silva, L F O / Borin, B C / Schuch, A P / da Rocha, J B T

The Science of the total environment

2023 Volume 873, Page(s) 162150

Abstract: ... in vitro and had no toxicity to the non-target D. melanogaster after in vivo exposure. Thus, in addition ...

Abstract	The demand for food to feed the growing world population has been promoting the indiscriminate use of chemical fertilizers, which can be detrimental to the environment. In order to maintain high crop productivity without damaging the ecosystem, biofertilizers have emerged as alternative to reduce the use of chemical fertilizers. So, environmentally safer biofertilizer can replace the exploitation of more toxic chemical fertilizer. Here, the fly Drosophila melanogaster was used to study the potential toxicity of the biofertilizer Beifort®. Flies were exposed to high concentrations of Beifort® in the diet (1.8 mL/L, 9.0 mL/L and 18 mL/L), and morphological and behavioral endpoints of toxicity were analyzed (development from egg to adult age, flies longevity, climbing performance, memory and learning of an associative learning, larvae digestive tract damage and plasmid DNA break). Beifort® did not modify flies development, survival, digestive track cell damage, locomotor activity or memory. Beifort® did not induce DNA breakage in vitro and had no toxicity to the non-target D. melanogaster after in vivo exposure. Thus, in addition of promoting the sustainable use of agricultural wastes, the exploitation of Beifort® can contribute to decrease the use of chemical fertilizers.
MeSH term(s)	Animals ; Drosophila melanogaster ; Ecosystem ; Fertilizers/toxicity ; Fertilizers/analysis ; Agriculture ; Crop Production
Chemical Substances	Fertilizers
Language	English
Publishing date	2023-02-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.162150
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Article ; Online: A 3-D-printed synaptic puzzle contributes to students' synaptic transmission comprehension.

Carrazoni, Guilherme Salgado / Chaves, Amanda Dalla'corte / da Rocha, Claudio Felipe Kolling / Mello-Carpes, Pâmela Billig

Advances in physiology education

2023 Volume 47, Issue 2, Page(s) 307–317

Abstract: We created the "3-dimensional synaptic puzzle" (3Dsp) as an educational resource for the physiology teaching of synaptic transmission (ST). In this study, we aimed to apply and evaluate the use of 3Dsp. For this, we divided 175 university students from ... ...

Abstract	We created the "3-dimensional synaptic puzzle" (3Dsp) as an educational resource for the physiology teaching of synaptic transmission (ST). In this study, we aimed to apply and evaluate the use of 3Dsp. For this, we divided 175 university students from public and private universities into two groups:
MeSH term(s)	Humans ; Comprehension ; Educational Measurement/methods ; Learning ; Students ; Synaptic Transmission
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1024917-5
ISSN	1522-1229 ; 1043-4046
ISSN (online)	1522-1229
ISSN	1043-4046
DOI	10.1152/advan.00091.2022
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Article ; Online: An α-D-galactan and a β-D-glucan from the mushroom Amanita muscaria: Structural characterization and antitumor activity against melanoma.

Zavadinack, Matheus / de Lima Bellan, Daniel / da Rocha Bertage, Jessica Loren / da Silva Milhorini, Shayane / da Silva Trindade, Edvaldo / Simas, Fernanda Fogagnoli / Sassaki, Guilherme Lanzi / Cordeiro, Lucimara M C / Iacomini, Marcello

Carbohydrate polymers

2021 Volume 274, Page(s) 118647

Abstract: Polysaccharides α-D-galactan (GAL-Am) and β-D-glucan (GLC-Am) were obtained from Amanita muscaria ...

Abstract	Polysaccharides α-D-galactan (GAL-Am) and β-D-glucan (GLC-Am) were obtained from Amanita muscaria fruiting bodies. They were purified using different methodologies, such as Fehling precipitation (for both fractions), freeze-thawing process and ultrafiltration (for GLC-Am). Results showed that the GAL-Am has (1 → 6)-linked Galp main chain branched at O-2 by terminal Galp units and has not been previously reported. Besides, GLC-Am has (1 → 3)-linked Glcp in the main chain, substituted at O-6 by (1 → 6)-linked β-Glcp units. Both are water-soluble, with 9.0 × 10
MeSH term(s)	Amanita/metabolism ; Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; BALB 3T3 Cells ; Cell Proliferation/drug effects ; Galactans/chemistry ; Galactans/pharmacology ; Glucans/chemistry ; Glucans/pharmacology ; Melanoma, Experimental/drug therapy ; Mice
Chemical Substances	Antineoplastic Agents ; Galactans ; Glucans
Language	English
Publishing date	2021-09-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2021.118647
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Article ; Online: Vitamin D status in active and inactive noninfectious uveitis - data from a reference university hospital in Rio de Janeiro, Brazil.

Moraes, Henrique Maciel Vieira de / Silva, Juliana Rocha de Mendonça da / Rangel, Milena Ribeiro / Riche, Marcelle Raschik / Moraes Junior, Haroldo Vieira de

Arquivos brasileiros de oftalmologia

2024 Volume 87, Issue 4, Page(s) e2023

Abstract: Purpose: This study aimed to investigate the correlation between serum vitamin D levels and ... 29) groups, along with 51 healthy controls. Serum 25-hydroxy vitamin D [25(OH)D] levels were measured ... The uveitis group also completed a questionnaire regarding sunlight exposure habits and vitamin D ...

Abstract	Purpose: This study aimed to investigate the correlation between serum vitamin D levels and disease activity in patients with noninfectious uveitis. Methods: We conducted a prospective case-control study, assessing 51 patients with noninfectious uveitis, categorized into active (n=22) and inactive (n=29) groups, along with 51 healthy controls. Serum 25-hydroxy vitamin D [25(OH)D] levels were measured. The uveitis group also completed a questionnaire regarding sunlight exposure habits and vitamin D supplementation. Results: Patients with inflammation-related uveitis exhibited low serum 25(OH)D levels in 68% of cases. The median 25(OH)D level in patients with active uveitis was 17.8 ng/mL (interquartile range [IQR], 15-21 ng/mL), significantly lower compared to the 31.7 ng/mL (IQR, 25-39 ng/mL) in patients with inactive uveitis (p<0.001) and the 27 ng/mL (IQR, 23-31 ng/mL) in the Control Group (p<0.001). Significantly, nearly all patients with uveitis taking vitamin D supplementation were in the Inactive Group (p<0.005). Moreover, reduced sunlight exposure was associated with active uveitis (p<0.003). Furthermore, patients with 25(OH)D levels below 20 ng/mL had ten times higher odds of developing active uveitis (p=0.001). Conclusions: This study revealed a prevalent 25(OH)D deficiency among patients with noninfectious uveitis and suggested a link between low 25(OH)D levels and disease activity. To prevent future episodes of intraocular inflammation, vitamin D supplementation and controlled sunlight exposure could be viable options.
MeSH term(s)	Humans ; Vitamin D/blood ; Vitamin D/analogs & derivatives ; Male ; Uveitis/blood ; Female ; Adult ; Case-Control Studies ; Brazil/epidemiology ; Middle Aged ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology ; Prospective Studies ; Sunlight ; Hospitals, University ; Young Adult ; Surveys and Questionnaires
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2024-04-19
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	603915-7
ISSN	1678-2925 ; 0004-2749
ISSN (online)	1678-2925
ISSN	0004-2749
DOI	10.5935/0004-2749.2023-0141
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Article: Interplay between diphenyl diselenide and copper: Impact on D. melanogaster survival, behavior, and biochemical parameters.

Rieder, G S / Duarte, T / Delgado, C P / Rodighiero, A / Nogara, P A / Orian, L / Aschner, M / Dalla Corte, C L / Da Rocha, J B T

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

2024 Volume 281, Page(s) 109899

Abstract: ... Copper ( ... ...

Abstract	Copper (Cu
Language	English
Publishing date	2024-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	189285-x
ISSN	1532-0456 ; 0306-4492 ; 0742-8413
ISSN	1532-0456 ; 0306-4492 ; 0742-8413
DOI	10.1016/j.cbpc.2024.109899
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