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Article ; Online: Uterine necrosis: we do not know it enough.

Karoui, Abir / Abouda, Hassine Saber / Ben Marzouk, Sofiène

American journal of obstetrics and gynecology

2022 Volume 228, Issue 1, Page(s) 117

MeSH term(s)	Female ; Humans ; Uterus/diagnostic imaging ; Uterine Diseases ; Necrosis ; Uterine Neoplasms
Language	English
Publishing date	2022-08-18
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/j.ajog.2022.08.028
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Article ; Online: Insights into the potential role of alpha1-antitrypsin in COVID-19 patients: Mechanisms, current update, and future perspectives.

Marzouk, Saber / Attia, Noha / Mashal, Mohamed

The clinical respiratory journal

2021 Volume 15, Issue 9, Page(s) 1019–1024

Abstract: In this work, we provide an up-to-date summary of the available molecular- and cell-related mechanisms by which alpha1-antitrypsin (AAT) protein could be of benefit in treating COVID-19 patients. As well, we demonstrate the current status in terms of the ...

Abstract	In this work, we provide an up-to-date summary of the available molecular- and cell-related mechanisms by which alpha1-antitrypsin (AAT) protein could be of benefit in treating COVID-19 patients. As well, we demonstrate the current status in terms of the ongoing clinical trials using AAT in COVID-19 patients. Finally, we touch on the potential role gene therapy and stem cell-based gene therapy could have in such emerging and serious condition caused by the SARS-CoV-2 virus.
MeSH term(s)	COVID-19 ; Humans ; SARS-CoV-2 ; alpha 1-Antitrypsin/genetics ; alpha 1-Antitrypsin Deficiency/genetics ; alpha 1-Antitrypsin Deficiency/therapy
Chemical Substances	alpha 1-Antitrypsin
Language	English
Publishing date	2021-07-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2442214-9
ISSN	1752-699X ; 1752-6981
ISSN (online)	1752-699X
ISSN	1752-6981
DOI	10.1111/crj.13406
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Article ; Online: [No title information]

Marzouk, Mahmoud / Nasri, Oussama / Hammami, Rabeb / Ben Messaoud, Chadha / Thamlaoui, Saber / Baffoun, Nader / Kaabachi, Olfa / Kaddour, Chokri

La Tunisie medicale

2023 Volume 101, Issue 3, Page(s) 351–355

Abstract: Introduction: The placement of central venous catheters (CVC) is a frequent procedure in intensive care. It is not devoid of complications, the diagnosis of which relied for a long time on the chest X-ray. Currently, ultrasound appears to be an ... ...

Title translation	Exclusion of complications of central venous catheters: Ultrasound versus X-ray.
Abstract	Introduction: The placement of central venous catheters (CVC) is a frequent procedure in intensive care. It is not devoid of complications, the diagnosis of which relied for a long time on the chest X-ray. Currently, ultrasound appears to be an interesting alternative. Aim: To report the impact of the use of ultrasound on the time to exclusion of mechanical complications after CVC placement. Methods: This is a prospective, multicenter, comparative, double-blind study. Were included the patients in whom the placement of a CVC was decided. After placement, a chest X-ray was ordered and an ultrasound was performed to look for signs of misplacement and pneumothorax. The two examinations were interpreted by two different doctors. The primary endpoint between the ultrasound group and the RTX group was the time "T1" represented by the time required to exclude complications. Results: 30 patients were included in our study. The mean ultrasound T1time was significantly lower than the mean radiological T1time (p=0.000). Only one case of pneumothorax was observed. It was first detected by ultrasound. For the 29 other patients, exclusion of pneumothorax was confirmed by ultrasound and chest X-ray. No misplacement type complications detected. This was confirmed by ultrasound and radiological exclusions. Conclusion: Ultrasound is a faster tool than RTX in excluding mechanical complications after CVC placement. It guarantees a non-irradiating examination as efficient as chest X-ray for intensive care patients.
MeSH term(s)	Humans ; Central Venous Catheters ; Pneumothorax ; Prospective Studies ; Radiography ; X-Rays ; Double-Blind Method
Language	French
Publishing date	2023-03-05
Publishing country	Tunisia
Document type	Comparative Study ; English Abstract ; Journal Article ; Multicenter Study
ZDB-ID	128627-4
ISSN	2724-7031 ; 0041-4131
ISSN (online)	2724-7031
ISSN	0041-4131
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Article: Effect of saffron (Crocus sativus L.) on sodium valporate induced cytogenetic and testicular alterations in albino rats.

Sakr, Saber A / Zowail, Mohamed E / Marzouk, Amera M

Anatomy & cell biology

2014 Volume 47, Issue 3, Page(s) 171–179

Abstract: The present study investigated the cytogenetic and testicular damage induced by the antiepileptic drug, sodium valporate (SVP) in albino rats and the effect of saffron aqueous extracts. Treating rats with SVP caused a significant increase in the ... ...

Abstract	The present study investigated the cytogenetic and testicular damage induced by the antiepileptic drug, sodium valporate (SVP) in albino rats and the effect of saffron aqueous extracts. Treating rats with SVP caused a significant increase in the chromosomal aberrations either structural or numerical and decreased the mitotic index. Besides, animals administered SVP showed DNA damage appeared in the single strand breaks (comet assay). Testis of SVP-treated rats showed many histopathological changes. A significant decrease in seminiferous tubules and their epithelial heights diameters and inhibition of spermatogenesis was recorded. In addition, the number of sperm head abnormalities was increased. Biochemical results revealed an increase in malondialdhyde (MDA) which is lipid peroxidation marker and a significant decrease in the level of serum antioxidant enzyme, catalase (CAT) and reducing antioxidant power (RAP). Animals given SVP and saffron showed an improvement in chromosomal aberrations, mitotic index, DNA damage and testicular alterations caused by SVP. Moreover, MDA decreased and CAT and RAP increased. It is concluded from the present results that the ameliorative effects of saffron extract against SVP-induced cytogenetic and testicular damage in albino rats may be due to the presence of one or more antioxidant components of saffron.
Language	English
Publishing date	2014-09-23
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2590173-4
ISSN	2093-3673 ; 2093-3665
ISSN (online)	2093-3673
ISSN	2093-3665
DOI	10.5115/acb.2014.47.3.171
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Article ; Online: L'hemorragie grave du peripartum en milieu de reanimation dans un centre universitaire tunisien de niveau 3: épidémiologie et facteurs de risque de mortalité maternelle.

Ben Nasr, Laidi / Ben Marzouk, Sofiene / Kehila, Mehdi / Jabri, Hamed / Thamleoui, Saber / Maghrebi, Hayen

The Pan African medical journal

2015 Volume 21, Page(s) 277

Title translation	Severe hemorrhage in the peripartum in intensive care unit in a level 3 Tunisian university center: epidemiology and risk factors for maternal mortality.
MeSH term(s)	APACHE ; Adult ; Female ; Humans ; Intensive Care Units ; Maternal Mortality ; Postpartum Hemorrhage/epidemiology ; Postpartum Hemorrhage/etiology ; Postpartum Hemorrhage/mortality ; Pregnancy ; Retrospective Studies ; Risk Factors ; Tunisia/epidemiology
Language	French
Publishing date	2015
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2015.21.277.6147
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Article ; Online: L'hemorragie grave du peripartum en milieu de reanimation dans un centre universitaire tunisien de niveau 3

Laidi Ben Nasr / Sofiene Ben Marzouk / Mehdi Kehila / Hamed Jabri / Saber Thamleoui / Hayen Maghrebi

The Pan African Medical Journal, Vol 21, Iss

épidémiologie et facteurs de risque de mortalité maternelle

2015 Volume 277

Abstract: L'hémorragie grave du péripartum demeure une des causes principales de mortalité maternelle. L'objectif de notre étude était de décrire le profil épidémiologique des patientes qui ont été prises en charge en milieu de réanimation suite à une hémorragie ... ...

Abstract	L'hémorragie grave du péripartum demeure une des causes principales de mortalité maternelle. L'objectif de notre étude était de décrire le profil épidémiologique des patientes qui ont été prises en charge en milieu de réanimation suite à une hémorragie grave du péripartum et de rechercher d'éventuels facteurs de risque de mortalité. Notre étude est rétrospective descriptive et analytique. Nous avons inclus tous les cas d'hémorragie du péripartum ayant séjourné en unité de réanimation obstétricale du centre de maternité et de néonatologie de Tunis (CMNT) au cours de la période allant de janvier 2010 à Décembre 2013. Nous avons recueilli les paramètres démographiques, obstétricaux, ceux relatifs à la prise en charge chirurgicale et réanimatoire, les scores de gravité SAPS obstétrical et APACHEII, ainsi que la morbi-mortalité. Au total nous avons colligé 322 cas sur quatre ans. La répartition annuelle des patientes ainsi que les caractéristiques démographiques et obstétricales étaient comparables dans leur globalité sur les quatre années. Les pratiques thérapeutiques étaient également comparables. Le taux global de mortalité par hémorragie dans notre unité était à 4,7%, avec un taux annuel de mortalité stable. L'analyse des facteurs de risque de mortalité par hémorragie en milieu de réanimation a montré une association statistiquement significative entre la survenue du décès et les facteurs suivants: recours aux catécholamines, survenue de sepsis, èdème pulmonaire aigu, coagulation intravasculaire disséminée, insuffisance rénale aiguë avec recours à l'hémodialyse, SDRA ou TRALI, atteinte neurologique grave, défaillance multiviscérale et arrêt cardiaque récupéré.
Keywords	mortalité maternelle ; hémorragie du péripartum ; réanimation ; morbidité ; Medicine ; R
Language	English
Publishing date	2015-08-01T00:00:00Z
Publisher	The Pan African Medical Journal
Document type	Article ; Online
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Article: Regional effect on essential oil composition and antimicrobial activity of Thymus capitatus L

Tammar, Sonia / Nidhal Salem / Ines Bettaieb Rebey / Jazia Sriti / Majdi Hammami / Saber Khammassi / Brahim Marzouk / Riadh Ksouri / Kamel Msaada

Journal of essential oil research. 2019 Mar. 4, v. 31, no. 2

2019

Abstract: A biochemical characterization and a geographic variability of Thymus capitatus L. essential oils were undertaken. Chromatographic analysis using gas chromatography-ﬂame ionization detector and gas chromatography-mass spectrometry of essential oils ... ...

Abstract	A biochemical characterization and a geographic variability of Thymus capitatus L. essential oils were undertaken. Chromatographic analysis using gas chromatography-ﬂame ionization detector and gas chromatography-mass spectrometry of essential oils extracted from thyme aerial parts from four Tunisian regions (Kef, Bizerte, Boukornine and Grombalia) showed the predominance of carvacrol (75.79 ± 2.07%) in Boukornine region, thyme essential oils being carvacrol chemotype. Obtained results of antimicrobial activities showed that thyme essential oil has important antibacterial activity which was strongly related to the organoleptic quality of the oil which appeared strongly region-dependent. The inhibitory effect of thyme essential oils on the bacteria and fungi development showed that Bacillus cereus and Fusarium solani were the most sensitive bacteria and fungi, respectively. From these results, we have concluded that thyme essential oil could be used to cure mycotic infections and may have role as pharmaceutical and preservative agents.
Keywords	Bacillus cereus ; Coridothymus capitatus ; Fusarium solani ; aerial parts ; antibacterial properties ; bacteria ; carvacrol ; chemotypes ; essential oils ; fungi ; gas chromatography-mass spectrometry ; geographical variation ; ionization ; oils ; sensory properties ; thyme
Language	English
Dates of publication	2019-0304
Size	p. 129-137.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2197652-1
ISSN	2163-8152 ; 1041-2905
ISSN (online)	2163-8152
ISSN	1041-2905
DOI	10.1080/10412905.2018.1539415
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Sortie précoce en post-partum: résultats et facteurs de risque de ré hospitalization.

Kehila, Mehdi / Magdoud, Khaoula / Touhami, Omar / Abouda, Hassine Saber / Jeridi, Sara / Marzouk, Sofiène Ben / Mahjoub, Sami / Hmid, Rim Ben / Chanoufi, Mohamed Badis

The Pan African medical journal

2016 Volume 24, Page(s) 189

Abstract: The objective of this study is to evaluate the practice of early postpartum discharge by analyzing maternal readmission rates and identifying readmission risk factors. This is a prospective and analytical study of 1206 patients discharged from hospital ... ...

Title translation	Early postpartum discharge: outcomes and risk factors of readmission.
Abstract	The objective of this study is to evaluate the practice of early postpartum discharge by analyzing maternal readmission rates and identifying readmission risk factors. This is a prospective and analytical study of 1206 patients discharged from hospital on postpartum day 1. For each patient we collected the epidemiological data, the course of pregnancy and childbirth. We identified the causes of readmission and their evolution. Cesarean delivery rate was 42%. Maternal readmission rate was 0.99%. The average length of stay in hospital after readmission was 26 hours. Intestinal transit disorders were the most frequent reason for consultation (50% of cases) followed by fever (25% of cases). The readmission risk factors identified in our study were: cesarean section (p = 0.004), emergency cesarean section (p = 0.016) anemia (P < 0.001) and thrombopenia (p = 0.003). Early postpartum discharge seems a safe option for the mother and their newborn children subject to the ability to clearly communicate health information to the patient and to the compliance with selection criteria.
MeSH term(s)	Adolescent ; Adult ; Cesarean Section/statistics & numerical data ; Female ; Fever/epidemiology ; Fever/therapy ; Gastrointestinal Diseases/epidemiology ; Gastrointestinal Diseases/therapy ; Hospitalization/statistics & numerical data ; Humans ; Infant, Newborn ; Length of Stay ; Patient Discharge/statistics & numerical data ; Patient Readmission/statistics & numerical data ; Postpartum Period ; Pregnancy ; Prospective Studies ; Risk Factors ; Time Factors ; Young Adult
Language	French
Publishing date	2016
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2016.24.189.9371
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Article ; Online: Phenological stage effect on phenolic composition and repellent potential of Mentha pulegium against Tribolium castaneum and Lasioderma serricorne

Nidhal Salem / Jazia Sriti / Olfa Bachrouch / Kamel Msaada / Saber Khammassi / Majdi Hammami / Saoussen Selmi / Emna Boushih / Marwa Ouertani / Nesrine Hachani / Manef Abderraba / Brahim Marzouk / Ferid Limam / Jouda Mediouni Ben Jemaa

Asian Pacific Journal of Tropical Biomedicine, Vol 8, Iss 4, Pp 207-

2018 Volume 216

Abstract: Objective: To elucidate for the first time the phenological stage effect on polyphenol, flavonoid and proanthocyanidin contents of pennyroyal (Mentha pulegium) as well as their antioxidant capacities and insecticidal potentials against Tribolium ... ...

Abstract	Objective: To elucidate for the first time the phenological stage effect on polyphenol, flavonoid and proanthocyanidin contents of pennyroyal (Mentha pulegium) as well as their antioxidant capacities and insecticidal potentials against Tribolium castaneum and Lasioderma serricorne. Methods: Crude methanol extracts from pennyroyal (Mentha pulegium) aerial parts were evaluated for their antiradical, reducing power activities and repellent potentials against selected coleopteran insects during different phenological stages. Results: Phenolic contents of pennyroyal aerial parts and their antioxidant effects were significantly dependent on maturity stage of the plant. The maximum of phenol production was reached during the full flowering stage. Apigenin was the major phenol in Mentha pulegium with an amount of 6.01 mg/g of dry vegetable matter during this period. Nevertheless, at fructification stage, the highest antioxidant activity was not related to high phenolic content. The repulsive effect of pennyroyal extract showed that Lasioderma serricorne was more susceptible to pennyroyal extract than Tribolium castaneum with corresponding median repellent dose values of 0.124 and 0.006 mg/mL respectively. Moreover, great differences in insect repulsion depending on extract concentrations, exposure time and developmental stage was observed. For the lowest concentration (0.125 mg/mL), the repellent effect against Tribolium reached its maximum (90%) during the fructification stage (after 24 h of exposure) while this repellent effect was 80% during the vegetative stage. Conclusions: Due to the strong insecticidal potential of pennyroyal extracts, this study highlights the therapeutic properties of this plant and encourages its use as a safer, environmental-friendly and efficient insecticide in food industry.
Keywords	apigenin lasioderma ; repellent activity ; full flowering stage ; Arctic medicine. Tropical medicine ; RC955-962 ; Biology (General) ; QH301-705.5
Subject code	500
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sortie précoce en post-partum

Mehdi Kehila / Khaoula Magdoud / Omar Touhami / Hassine Saber Abouda / Sara Jeridi / Sofiéne Ben Marzouk / Sami Mahjoub / Rim Ben Hmid / Mohamed Badis Chanoufi

The Pan African Medical Journal, Vol 24, Iss

résultats et facteurs de risque de ré hospitalisation

2016 Volume 189

Abstract: Cette étude nous permettra d'évaluer la pratique d'une sortie précoce en post-partum en analysant le taux de réadmission maternelle et en essayant d'identifier les facteurs de risque de ré hospitalisation. Il s'agit d'une étude prospective et analytique ... ...

Abstract	Cette étude nous permettra d'évaluer la pratique d'une sortie précoce en post-partum en analysant le taux de réadmission maternelle et en essayant d'identifier les facteurs de risque de ré hospitalisation. Il s'agit d'une étude prospective et analytique à propos de 1206 patientes sorties de l'hôpital à J1 du post-partum. Pour chaque patiente, nous avons noté les données épidémiologiques, le déroulement de la grossesse et de l'accouchement. Nous avons identifié les causes des ré hospitalisations ainsi que leur évolution. Le taux de césariennes était de 42%. Le taux de réadmissions maternelles était de 0,99%. La durée moyenne du séjour lors de la ré hospitalisation était de 26 heures. Les troubles du transit ont été le motif de consultation le plus fréquent (50% des cas) suivis par la fièvre (25% des cas). Les facteurs de risque de ré hospitalisation, identifiés dans notre étude étaient: la césarienne (p=0,004), la césarienne en urgence (p=0,016), l'anémie (p=0,001) et la thrombopénie (p=0,003). La sortie précoce en post-partum semble une option sure pour la maman et le nouveau-né sous réserve d'une information claire de la patiente et du respect des critères de sélection.
Keywords	post-partum ; hospitalisation ; accouchement ; sortie précoce ; Medicine ; R
Language	English
Publishing date	2016-07-01T00:00:00Z
Publisher	The Pan African Medical Journal
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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