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Article: Judgements of Social Dominance From Faces and Related Variables.

Pandeirada, Josefa N S / Madeira, Mariana / Fernandes, Natália Lisandra / Marinho, Patrícia / Vasconcelos, Marco

2022 Volume 13, Page(s) 873147

Language	English
Publishing date	2022-04-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.873147
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Can I Trust This Person? Evaluations of Trustworthiness From Faces and Relevant Individual Variables.

Pandeirada, Josefa N S / Fernandes, Natália Lisandra / Madeira, Mariana / Marinho, Patrícia I / Vasconcelos, Marco

Frontiers in psychology

2022 Volume 13, Page(s) 857511

Language	English
Publishing date	2022-05-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.857511
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: 2-Styrylchromones Prevent IL-1β-Induced Pro-Inflammatory Activation of Fibroblast-like Synoviocytes while Increasing COX-2 Expression.

Rufino, Ana Teresa / Lucas, Mariana / Silva, Artur M S / Ribeiro, Daniela / Fernandes, Eduarda

Pharmaceutics

2023 Volume 15, Issue 3

Abstract: Rheumatoid arthritis (RA) is characterized by systemic immune and chronic inflammatory features, leading to the destruction of the joints. Presently, there are no effective drugs able to control synovitis and catabolism in the process of RA. 2- ... ...

Abstract	Rheumatoid arthritis (RA) is characterized by systemic immune and chronic inflammatory features, leading to the destruction of the joints. Presently, there are no effective drugs able to control synovitis and catabolism in the process of RA. 2-Styrylchromones (2-SC) are a small group of compounds characterized by the attachment of a styryl group to the chromone core that have already been associated to a wide range of biological activities, including antioxidant and anti-inflammatory activities. The present study investigated the effect of a set of six 2-SC on the interleukin-1β (IL-1β)-induced increase of nitric oxide (
Language	English
Publishing date	2023-02-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15030780
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Simultaneous Bilateral Patellar Tendon Rupture: A Systematic Review.

Fernandes, André / Rufino, Mariana / Hamal, Divakar / Mousa, Amr / Fossett, Emma / Cheema, Kamalpreet S

Cureus

2023 Volume 15, Issue 7, Page(s) e41512

Abstract: The extensor mechanism of the knee can be damaged due to various modes of injury, which, in most cases, will require urgent surgical intervention for repair. Single patellar tendon ruptures are uncommon, but simultaneous bilateral events are even rarer ... ...

Abstract	The extensor mechanism of the knee can be damaged due to various modes of injury, which, in most cases, will require urgent surgical intervention for repair. Single patellar tendon ruptures are uncommon, but simultaneous bilateral events are even rarer and have been scarcely reviewed in English literature. Research in this area is mainly confined to case series, with some literature reviews but no evidence of more substantial analysis. Therefore, this systematic review was done to analyse the existing literature on bilateral simultaneous patellar tendon ruptures and propose a systematic and standardised approach to diagnosing and managing these injuries. A systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The search terms included 'bilateral patellar tendon rupture', 'bilateral', 'patellar', 'tendon' and 'rupture'. Three independent reviewers conducted searches in PubMed, OvidSP for Medline, Embase and the Cochrane Library using the same search strategy. The eligibility criteria included studies on bilateral concomitant patellar tendon rupture published in English. Bilateral simultaneous patellar tendon ruptures of traumatic and atraumatic origin in human patients were included. The study types comprised case reports and literature reviews. The key limitation of this study was the low number of patients covered by the eligible literature. Patellar tendon ruptures are a rare and scarcely documented injury, and there is a need for studies with a high level of evidence, especially regarding surgical treatment choice and methods, as well as post-operative management, which could potentially lead to improved outcomes in the management of this injury.
Language	English
Publishing date	2023-07-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.41512
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Isoniazid-Induced Acute Liver Failure Requiring Liver Transplantation.

Almeida, Mariana S / Gomes, Francisco / Ginga, Maria do Rosário / Fernandes, Martinho / Cartucho, Joana

Cureus

2022 Volume 14, Issue 12, Page(s) e32905

Abstract: Tuberculosis (TB) is a contagious disease caused by the ... ...

Abstract	Tuberculosis (TB) is a contagious disease caused by the bacilli
Language	English
Publishing date	2022-12-24
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.32905
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: M1 cholinergic signaling in the brain modulates cytokine levels and splenic cell sub-phenotypes following cecal ligation and puncture.

Abraham, Mabel N / Nedeljkovic-Kurepa, Ana / Fernandes, Tiago D / Yaipen, Omar / Brewer, Mariana R / Leisman, Daniel E / Taylor, Matthew D / Deutschman, Clifford S

Molecular medicine (Cambridge, Mass.)

2024 Volume 30, Issue 1, Page(s) 22

Abstract: Background: The contribution of the central nervous system to sepsis pathobiology is incompletely understood. In previous studies, administration of endotoxin to mice decreased activity of the vagus anti-inflammatory reflex. Treatment with the centrally- ...

Abstract	Background: The contribution of the central nervous system to sepsis pathobiology is incompletely understood. In previous studies, administration of endotoxin to mice decreased activity of the vagus anti-inflammatory reflex. Treatment with the centrally-acting M1 muscarinic acetylcholine (ACh) receptor (M1AChR) attenuated this endotoxin-mediated change. We hypothesize that decreased M1AChR-mediated activity contributes to inflammation following cecal ligation and puncture (CLP), a mouse model of sepsis. Methods: In male C57Bl/6 mice, we quantified basal forebrain cholinergic activity (immunostaining), hippocampal neuronal activity, serum cytokine/chemokine levels (ELISA) and splenic cell subtypes (flow cytometry) at baseline, following CLP and following CLP in mice also treated with the M1AChR agonist xanomeline. Results: At 48 h. post-CLP, activity in basal forebrain cells expressing choline acetyltransferase (ChAT) was half of that observed at baseline. Lower activity was also noted in the hippocampus, which contains projections from ChAT-expressing basal forebrain neurons. Serum levels of TNFα, IL-1β, MIP-1α, IL-6, KC and G-CSF were higher post-CLP than at baseline. Post-CLP numbers of splenic macrophages and inflammatory monocytes, TNFα Conclusion: Our findings indicate that M1AChR-mediated responses modulate CLP-induced alterations in serum levels of some, but not all, cytokines/chemokines and affected splenic immune response phenotypes.
MeSH term(s)	Male ; Mice ; Animals ; Cytokines/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Interleukin-6 ; CD8-Positive T-Lymphocytes/metabolism ; Chemokine CCL3 ; Chemokines ; Punctures ; Endotoxins ; Brain/metabolism ; Ligation ; Cholinergic Agents ; Granulocyte Colony-Stimulating Factor ; Sepsis ; Mice, Inbred C57BL ; Cecum/metabolism ; Disease Models, Animal ; Pyridines ; Thiadiazoles
Chemical Substances	Cytokines ; xanomeline (9ORI6L73CJ) ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Chemokine CCL3 ; Chemokines ; Endotoxins ; Cholinergic Agents ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Pyridines ; Thiadiazoles
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1283676-x
ISSN	1528-3658 ; 1076-1551
ISSN (online)	1528-3658
ISSN	1076-1551
DOI	10.1186/s10020-024-00787-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Haemophilus influenzae

Bajanca-Lavado, Maria Paula / Cavaco, Luís / Fernandes, Mariana / Touret, Tiago / Candeias, Catarina / Simões, Alexandra S / Sá-Leão, Raquel

Microorganisms

2022 Volume 10, Issue 10

Abstract: Haemophilus ... ...

Abstract	Haemophilus influenzae
Language	English
Publishing date	2022-10-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10101964
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives.

Fernandes, Sílvia / Vieira, Mariana / Prudêncio, Cristina / Ferraz, Ricardo

International journal of molecular sciences

2024 Volume 25, Issue 4

Abstract: Betulinic acid is a naturally occurring compound that can be obtained through methanolic or ethanolic extraction from plant sources, as well as through chemical synthesis or microbial biotransformation. Betulinic acid has been investigated for its ... ...

Abstract	Betulinic acid is a naturally occurring compound that can be obtained through methanolic or ethanolic extraction from plant sources, as well as through chemical synthesis or microbial biotransformation. Betulinic acid has been investigated for its potential therapeutic properties, and exhibits anti-inflammatory, antiviral, antimalarial, and antioxidant activities. Notably, its ability to cross the blood-brain barrier addresses a significant challenge in treating neurological pathologies. This review aims to compile information about the impact of betulinic acid as an antitumor agent, particularly in the context of glioblastoma. Importantly, betulinic acid demonstrates selective antitumor activity against glioblastoma cells by inhibiting proliferation and inducing apoptosis, consistent with observations in other cancer types. Compelling evidence published highlights the acid's therapeutic action in suppressing the Akt/NFκB-p65 signaling cascade and enhancing the cytotoxic effects of the chemotherapeutic agent temozolomide. Interesting findings with betulinic acid also suggest a focus on researching the reduction of glioblastoma's invasiveness and aggressiveness profile. This involves modulation of extracellular matrix components, remodeling of the cytoskeleton, and secretion of proteolytic proteins. Drawing from a comprehensive review, we conclude that betulinic acid formulations as nanoparticles and/or ionic liquids are promising drug delivery approaches with the potential for translation into clinical applications for the treatment and management of glioblastoma.
MeSH term(s)	Humans ; Glioblastoma/drug therapy ; Glioblastoma/pathology ; Triterpenes/pharmacology ; Triterpenes/therapeutic use ; Triterpenes/chemistry ; Pentacyclic Triterpenes/therapeutic use ; Betulinic Acid ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/chemistry
Chemical Substances	Triterpenes ; Pentacyclic Triterpenes ; Betulinic Acid (4G6A18707N) ; Antineoplastic Agents
Language	English
Publishing date	2024-02-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25042108
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Is the List of Ingredients a Source of Nutrition and Health Information in Food Labeling? A Scoping Review.

Kraemer, Mariana V S / Fernandes, Ana Carolina / Chaddad, Maria Cecília C / Uggioni, Paula L / Bernardo, Greyce L / Proença, Rossana P C

Nutrients

2023 Volume 15, Issue 21

Abstract: Nutrition labelling is any description intended to inform consumers about the nutritional properties of a food product and has focused primarily on nutrients. However, literature has shown that the nutritional quality of packaged foods is not limited to ... ...

Abstract	Nutrition labelling is any description intended to inform consumers about the nutritional properties of a food product and has focused primarily on nutrients. However, literature has shown that the nutritional quality of packaged foods is not limited to the amount of nutrients, considering that individuals do not consume only nutrients separately, but rather the entire food matrix. Therefore, to analyze the nutritional quality of a packaged food, it is necessary to read its ingredients. This scoping review aims to discuss (1) the list of ingredients as a source of health and nutrition information in food labelling; (2) opportunities to improve the nutrition labeling policies around the world. The study was carried out through a systematic search on Codex Alimentarius meeting reports. Results show that the list of ingredients is used as a source of nutritional and health information on food labelling; however, this label item is not considered in the regulatory field as a nutrition labelling requirement. It is suggested that nutrition labelling be discussed as a tool for food choices in the context of public health from a broader, consistent, convergent perspective, considering the list of ingredients as an item of nutrition labelling requirement to be included in public policies around the world.
MeSH term(s)	Humans ; Food Labeling ; Nutritional Status ; Food ; Food Preferences ; Public Health ; Nutritive Value
Language	English
Publishing date	2023-10-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15214513
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Fishers, Let Us Talk: Validating Métiers in a Multi-Gear Coastal Fishing Fleet

Szynaka, Monika J. / Fernandes, Mariana / Anjos, Mariana / Erzini, Karim / Gonçalves, Jorge M. S. / Campos, Aida

Fishes. 2022 July 19, v. 7, no. 4

2022

Abstract: In the multi-gear coastal fleet in the Algarve (South Portugal), fishers own licenses for various fishing gears. However, they generally do not use all these licenses, and therefore, it is difficult to estimate the impacts this fleet has on the local ... ...

Abstract	In the multi-gear coastal fleet in the Algarve (South Portugal), fishers own licenses for various fishing gears. However, they generally do not use all these licenses, and therefore, it is difficult to estimate the impacts this fleet has on the local environment. In this study, two types of questionnaires were used directed to the local fishers from the multi-gear fleet during interviews carried out between November 2019 and July 2021 with the objective to validate the métiers proposed for this fleet in a previous study using multivariate analysis on past landing profiles. A total of 10 out of the 11 proposed métiers were validated, including four métiers with gillnets, three with dredges, two with trammel nets, and one with traps. Additional métiers were identified not found in the previous study. The results obtained with the two types of questionnaires are presented, and their usefulness in validating the gear used and the seasonality of fishing activities are discussed, as well as their contribution to a clearer distinction between target species and commercial by-catch.
Keywords	bycatch ; gillnets ; multivariate analysis ; Portugal
Language	English
Dates of publication	2022-0719
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ISSN	2410-3888
DOI	10.3390/fishes7040174
Database	NAL-Catalogue (AGRICOLA)

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