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  1. Article ; Online: Safety and efficacy of catheter ablation for atrial fibrillation in cancer survivors: a systematic review and meta-analysis.

    Costa, Thomaz Alexandre / Felix, Nicole / Clemente, Mariana / Teixeira, Larissa / Braga, Marcelo Antonio Pinheiro / Silva, Livia Teixeira Martins

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

    2023  Volume 67, Issue 1, Page(s) 211–219

    Abstract: Background: Cancer survivors are at increased risk for atrial fibrillation (AF). However, data on the efficacy and safety of catheter ablation (CA) in this population remain limited. Therefore, we aimed to perform a systematic review and meta-analysis ... ...

    Abstract Background: Cancer survivors are at increased risk for atrial fibrillation (AF). However, data on the efficacy and safety of catheter ablation (CA) in this population remain limited. Therefore, we aimed to perform a systematic review and meta-analysis comparing outcomes after CA for AF in patients with versus without prior or active cancer.
    Methods: We systematically searched PubMed, Cochrane Library, and Embase from inception to April 2023 for studies comparing the safety and efficacy of CA for AF in cancer survivors. Outcomes of interest were bleeding events, late AF recurrence, and need for repeat ablation. Statistical analyses were performed using Review Manager 5.4.1. We pooled odds ratios (OR) with 95% confidence intervals (CI) for binary endpoints.
    Results: We included 5 retrospective cohort studies comprising 998 patients, of whom 41.4% had a history of cancer. Cancer survivors were at significantly higher risk of clinically relevant bleeding (OR 2.17; 95% CI 1.17-4.0; p=0.01) as compared with those without cancer. The efficacy of CA for AF was similar between groups. Late AF recurrence at 12 months was not significantly different between patients with vs. without a history of cancer (OR 1.29; 95% CI 0.78-2.13; p=0.32). Similar findings were observed in the outcome of repeat ablations (OR 0.71; 95% CI 0.37-1.37; p=0.31).
    Conclusions: These findings suggest that cancer survivors have an increased risk of bleeding after CA for AF relative to patients without cancer, with no significant difference in the efficacy of CA for maintenance of sinus rhythm between groups.
    Study registration: This systematic review is registered in the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD42023394538.
    MeSH term(s) Humans ; Atrial Fibrillation ; Cancer Survivors ; Catheter Ablation/adverse effects ; Hemorrhage/epidemiology ; Neoplasms/surgery ; Recurrence ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2023-11-11
    Publishing country Netherlands
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 1329179-8
    ISSN 1572-8595 ; 1383-875X
    ISSN (online) 1572-8595
    ISSN 1383-875X
    DOI 10.1007/s10840-023-01677-8
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  2. Article ; Online: Lifestyle and Sense of Coherence

    João Paulo Costa Braga / Eduardo Wolfgram / João Paulo Batista de Souza / Larissa Gabriele Fausto Silva / Yonel Estavien / Roberto de Almeida / Cezar Rangel Pestana

    PLoS ONE, Vol 18, Iss

    A comparative analysis among university students in different areas of knowledge

    2023  Volume 9

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
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  3. Article ; Online: Lifestyle and Sense of Coherence: A comparative analysis among university students in different areas of knowledge.

    Braga, João Paulo Costa / Wolfgram, Eduardo / Batista de Souza, João Paulo / Fausto Silva, Larissa Gabriele / Estavien, Yonel / de Almeida, Roberto / Pestana, Cezar Rangel

    PloS one

    2023  Volume 18, Issue 9, Page(s) e0288624

    Abstract: Background: The concept of health has undergone profound changes. Lifestyle Medicine consists of therapeutic approaches that focus on the prevention and treatment of diseases. It follows that the quality of life of university students directly affects ... ...

    Abstract Background: The concept of health has undergone profound changes. Lifestyle Medicine consists of therapeutic approaches that focus on the prevention and treatment of diseases. It follows that the quality of life of university students directly affects their health and educational progress.
    Experimental methodology: Socioeconomic, lifestyle (LS), and Salutogenesis Theory/sense of coherence (SOC) questionnaires were administered to college students from three different areas. The results were analyzed for normality and homogeneity, followed by ANOVA variance analysis and Dunn and Tukey post hoc test for multiple comparisons. Spearman's correlation coefficient evaluated the correlation between lifestyle and sense of coherence; p values < 0.05 were considered statistically significant.
    Results: The correlation between LS and SOC was higher among males and higher among Medical and Human sciences students compared to Exact sciences. Medical students' scores were higher than Applied sciences and Human sciences students on the LS questionnaire. Exact science students' scores on the SOC questionnaire were higher than Human sciences students. In the LS areas related to alcohol intake, sleeping quality, and behavior, there were no differences between the areas. However, women scored better in the nutrition domain and alcohol intake. The SOC was also higher in men compared to women.
    Conclusion: The results obtained demonstrate in an unprecedented way in the literature that the correlation between the LS and SOC of college students varies according to gender and areas of knowledge, reflecting the importance of actions on improving students' quality of life and enabling better academic performance.
    MeSH term(s) Male ; Humans ; Female ; Sense of Coherence ; Quality of Life ; Universities ; Life Style ; Students ; Surveys and Questionnaires
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0288624
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  4. Article ; Online: Renin-angiotensin system in normal pregnancy and in preeclampsia: A comprehensive review.

    Leal, Caio Ribeiro Vieira / Costa, Larissa Braga / Ferreira, Guilherme Costa / Ferreira, Alexandre de Melo / Reis, Fernando M / Simões E Silva, Ana Cristina

    Pregnancy hypertension

    2022  Volume 28, Page(s) 15–20

    Abstract: The activation of the Renin Angiotensin System (RAS) is required during pregnancy and it seems that RAS dysfunction has some important effects on pathological pregnancy conditions, including preeclampsia (PE). The objective of this review is to summarize ...

    Abstract The activation of the Renin Angiotensin System (RAS) is required during pregnancy and it seems that RAS dysfunction has some important effects on pathological pregnancy conditions, including preeclampsia (PE). The objective of this review is to summarize and to discuss the role of the RAS in normal pregnancy and in PE. We found evidence that the RAS is important for the evolution of pregnancy under physiological conditions and plays an important role in the pathogenesis of PE. In normal gestation, almost all circulating components of RAS are increased and there is a general state of non-reactivity to the vasoconstrictor actions of Angiotensin (Ang) II. In PE, changes in the circulating levels of RAS components occur, especially with an intense decrease in the levels of Ang I, Ang II and Ang-(1-7). Our findings endorse the idea that PE is a disease whose cornerstone relies on altered placental physiology. There are high tissue levels of Ang II type 1 receptor (AT1R) in the musculature of the blood vessels and in the placenta, generating a state of increased sensitivity to the vasoconstrictor action of Ang II. AT1R autoantibodies (AT1R-AA) might be one of the key points for the vicious cycle of PE, as these molecules are synthesized in situations of hypoxia and enhance placental vasoconstriction, causing even more hypoxia. Further studies are needed to investigate the role of circulating RAS, uteroplacental RAS and local RAS molecules from other tissues related to the pathogenesis of PE.
    MeSH term(s) Angiotensin II ; Female ; Humans ; Hypoxia/metabolism ; Placenta/metabolism ; Pre-Eclampsia ; Pregnancy ; Renin-Angiotensin System ; Vasoconstrictor Agents/metabolism
    Chemical Substances Vasoconstrictor Agents ; Angiotensin II (11128-99-7)
    Language English
    Publishing date 2022-02-04
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2584464-7
    ISSN 2210-7797 ; 2210-7789
    ISSN (online) 2210-7797
    ISSN 2210-7789
    DOI 10.1016/j.preghy.2022.01.011
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  5. Article ; Online: Molecular and serological detection of Anaplasma spp. in small ruminants in an area of Cerrado Biome in northeastern Brazil.

    Silva, Ellainy Maria Conceição / Marques, Ingrid Carolinne Lopes / de Mello, Victória Valente Califre / Amaral, Renan Bressianini do / Gonçalves, Luiz Ricardo / Braga, Maria do Socorro Costa Oliveira / Ribeiro, Larissa Sarmento Dos Santos / Machado, Rosangela Zacarias / André, Marcos Rogério / Neta, Alcina Vieira de Carvalho

    Ticks and tick-borne diseases

    2023  Volume 15, Issue 1, Page(s) 102254

    Abstract: Anaplasmosis, caused by bacteria of the genus Anaplasma, is an important tick-borne disease that causes economic losses to livestock farms in many countries. Even though Anaplasma spp. have been detected in goats and sheep worldwide, few studies ... ...

    Abstract Anaplasmosis, caused by bacteria of the genus Anaplasma, is an important tick-borne disease that causes economic losses to livestock farms in many countries. Even though Anaplasma spp. have been detected in goats and sheep worldwide, few studies investigate the occurrence and genetic identity of these agents in small ruminants from Brazil. Thus, this work aimed to detect and determine the genetic identity of Anaplasma spp. in small ruminants from the Baixo Parnaíba region, state of Maranhão, northeastern Brazil. For this purpose, blood samples were collected from 161 animals (91 goats; 70 sheep) from 4 municipalities in the Baixo Parnaíba region. Sheep and goat serum samples were subjected to recombinant membrane surface protein (MSP5)-based iELISA. Whole blood samples were subject to DNA extraction and molecular diagnosis using PCR assays for Anaplasma spp. targeting msp1β, msp1α, 16S rRNA and msp4 genes. Positive samples were sequenced and then subjected to Anaplasma marginale msp1α genetic diversity analysis and phylogenetic inferences based on the 16S rRNA and msp4 genes. The serological survey detected the presence of anti-A. marginale IgG antibodies in 18 animals (11.1%): 2.9% (2/70) sheep and 17.4% (16/91) goats. Anaplasma marginale DNA was detected in 2 goats (1.2%) using qPCR based on the msp1β gene. Two distinct A. marginale msp1α strains, namely α β and α β ΓγΓγΓγΓγ were found in the infected goats, each one found in a different animal, both belonging to the H genotype. Phylogenetic analysis based on the 16S rRNA gene showed the sequences positioned in three different clades and grouped with sequences from 'Candidatus Anaplasma boleense', A. platys and A. marginale. Phylogenetic inferences based on the msp4 gene positioned the sequence variants in the A. marginale clade. The present work represents the first molecular detection of sequence variants phylogenetic associated to 'Candidatus Anaplasma boleense' and A. platys and α β and α β ΓγΓγΓγΓγ in goats from Brazil.
    MeSH term(s) Animals ; Sheep ; Anaplasma/genetics ; RNA, Ribosomal, 16S/genetics ; Brazil/epidemiology ; Phylogeny ; Anaplasmosis/microbiology ; Ruminants ; Anaplasma marginale/genetics ; Membrane Proteins/genetics ; Goats/microbiology ; DNA ; Goat Diseases/epidemiology ; Sheep Diseases/epidemiology ; Sheep Diseases/microbiology
    Chemical Substances RNA, Ribosomal, 16S ; Membrane Proteins ; DNA (9007-49-2)
    Language English
    Publishing date 2023-11-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2541872-5
    ISSN 1877-9603 ; 1877-959X
    ISSN (online) 1877-9603
    ISSN 1877-959X
    DOI 10.1016/j.ttbdis.2023.102254
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  6. Article ; Online: Affordances in the home environment of children at risk of developmental delay.

    Santos, Janaína Araujo Teixeira / Lima, Amanda Larissa Oliveira / Silva, Letícia Dias Dos Santos / Braga, Fernanda da Costa / Alécio, Marcelo Machado / Chagas, Paula Silva de Carvalho / Defilipo, Érica Cesário / Toledo, Aline Martins de / Gutierres Filho, Paulo José Barbosa / Ayupe, Kênnea Martins Almeida

    Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo

    2023  Volume 41, Page(s) e2022104

    Abstract: Objective: The aim of this study was to verify the adequacy of affordances in the home environment of children at risk of developmental delay and to identify factors associated with their frequency.: Methods: The cross-sectional study included 97 ... ...

    Abstract Objective: The aim of this study was to verify the adequacy of affordances in the home environment of children at risk of developmental delay and to identify factors associated with their frequency.
    Methods: The cross-sectional study included 97 families who responded to the Affordances in the Home Environment for Motor Development - Infant Scale (AHEMD-IS) for 3-18 months (n=63), or AHEMD - Self-Report (AHEMD-SR) for 18-42 months (n=34). The Mann-Whitney U test was used to identify the differences between the frequencies of affordances between the groups. Multiple linear regression was used to verify the association between the child's sex, mother's marital status, education, socioeconomic level, child and mother's ages, house residents' number, per capita income, and AHEMD scores (α=0.05).
    Results: The home affordances' frequency in the AHEMD-IS ranged from less than adequate to excellent, while in the AHEMD-SR, the highest predominance was medium. The offer of stimuli in the AHEMD-IS was significantly higher. Higher socioeconomic level and house residents' number were associated with greater affordances.
    Conclusions: The higher the socioeconomic level and house residents' number, the greater the affordances in the homes of children at risk of delay. It is necessary to provide families with some alternatives to make their home environments richer in affordances that favor child development.
    MeSH term(s) Infant ; Humans ; Child ; Home Environment ; Cross-Sectional Studies ; Child Development ; Social Class ; Educational Status
    Language English
    Publishing date 2023-05-15
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2560228-7
    ISSN 1984-0462 ; 1984-0462
    ISSN (online) 1984-0462
    ISSN 1984-0462
    DOI 10.1590/1984-0462/2023/41/2022104
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  7. Article ; Online: Relationship between zinc-related nutritional status and the progression of multiple sclerosis.

    Castro, Ádila da Silva / Albuquerque, Larissa da Silva / Melo, Maria Luísa Pereira de / D'Almeida, José Artur Costa / Braga, Ribanna Aparecida Marques / Assis, Renata Carmo de / Marreiro, Dilina do Nascimento / Matos, Wladiana Oliveira / Maia, Carla Soraya Costa

    Multiple sclerosis and related disorders

    2022  Volume 66, Page(s) 104063

    Abstract: Background: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system.: Objective: To investigate plasma and erythrocyte zinc status and its relationship to MS.: Methods: Cross-sectional study, including ...

    Abstract Background: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system.
    Objective: To investigate plasma and erythrocyte zinc status and its relationship to MS.
    Methods: Cross-sectional study, including 98 participants, distributed in groups: case (MS, n = 49), diagnosed with MS and control (n = 49), matched by age and sex with the case group. Zinc was analyzed by flame atomic absorption spectrophotometry, and superoxide dismutase (SOD) activity by spectrophotometry.
    Results: Mean plasma zinc was 94.6 (22.1) μg/dL for MS patients and 81.5 (31.3) μg/dL for control group, with statistical difference (p = 0.023). The mean erythrocyte zinc was 83.6 (41.6) µg/gHb for case group and 72.6 (31.5) µg/gHb for control. Erythrocyte SOD activity was above reference values, significantly different for MS patients (p = 0.003). There was a significant direct correlation between erythrocyte zinc and SOD (r = 0.835; p < 0.001). SOD showed inverse correlation with MS outbreaks (r = -0.317; p = 0.027).
    Conclusion: Patients with MS have normal plasma and elevated erythrocyte zinc. Erythrocyte zinc showed positive correlation with SOD, which correlated inversely to outbreaks.
    MeSH term(s) Cross-Sectional Studies ; Humans ; Multiple Sclerosis ; Nutritional Status ; Sodium Oxybate ; Superoxide Dismutase ; Zinc
    Chemical Substances Sodium Oxybate (7G33012534) ; Superoxide Dismutase (EC 1.15.1.1) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2022-07-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2022.104063
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  8. Article ; Online: Do we have enough evidence to use chloroquine/hydroxychloroquine as a public health panacea for COVID-19?

    Vitória Andrade Palmeira / Larissa Braga Costa / Lucas Giandoni Perez / Victor Teatini Ribeiro / Katharina Lanza / Ana Cristina Simões e Silva

    Clinics, Vol

    2020  Volume 75

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Elsevier España
    Document type Article ; Online
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  9. Book ; Online: Do we have enough evidence to use chloroquine/hydroxychloroquine as a public health panacea for COVID-19?

    Palmeira, Vitória Andrade / Costa, Larissa Braga / Perez, Lucas Giandoni / Ribeiro, Victor Teatini / Lanza, Katharina / Silva, Ana Cristina Simões e

    Clinics v.75 2020

    2020  

    Keywords covid19
    Language English
    Publishing date 2020-01-01
    Publisher Faculdade de Medicina / USP
    Publishing country br
    Document type Book ; Online
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  10. Article ; Online: 2020 update on the renin-angiotensin-aldosterone system in pediatric kidney disease and its interactions with coronavirus.

    Simões E Silva, Ana Cristina / Lanza, Katharina / Palmeira, Vitória Andrade / Costa, Larissa Braga / Flynn, Joseph T

    Pediatric nephrology (Berlin, Germany)

    2020  Volume 36, Issue 6, Page(s) 1407–1426

    Abstract: The last decade was crucial for our understanding of the renin-angiotensin-aldosterone system (RAAS) as a two-axis, counter-regulatory system, divided into the classical axis, formed by angiotensin-converting enzyme (ACE), angiotensin II (Ang II), and ... ...

    Abstract The last decade was crucial for our understanding of the renin-angiotensin-aldosterone system (RAAS) as a two-axis, counter-regulatory system, divided into the classical axis, formed by angiotensin-converting enzyme (ACE), angiotensin II (Ang II), and the angiotensin type 1 receptor (AT1R), and the alternative axis comprising angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7) (Ang-(1-7)), and the Mas receptor. Breakthrough discoveries also took place, with other RAAS endopeptides being described, including alamandine and angiotensin A. In this review, we characterize the two RAAS axes and the role of their components in pediatric kidney diseases, including childhood hypertension (HTN), pediatric glomerular diseases, congenital abnormalities of the kidney and urinary tract (CAKUT), and chronic kidney disease (CKD). We also present recent findings on potential interactions between the novel coronavirus, SARS-CoV-2, and components of the RAAS, as well as potential implications of coronavirus disease 2019 (COVID-19) for pediatric kidney diseases.
    MeSH term(s) COVID-19/physiopathology ; Child ; Humans ; Kidney Diseases/physiopathology ; Renin-Angiotensin System/physiology
    Keywords covid19
    Language English
    Publishing date 2020-09-29
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-020-04759-1
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