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Article ; Online: Launching Liver Exchange and the First 3-Way Liver Paired Donation.

Salman, Saad / Arsalan, Muhammad / Dar, Faisal Saud

2022 Volume 158, Issue 2, Page(s) 210–211

MeSH term(s)	Humans ; Tissue and Organ Procurement ; Living Donors ; Liver
Language	English
Publishing date	2022-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2701841-6
ISSN	2168-6262 ; 2168-6254
ISSN (online)	2168-6262
ISSN	2168-6254
DOI	10.1001/jamasurg.2022.5440
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Article: Anomalous branching of the middle meningeal artery from the basilar artery: a systematic review.

Salman, Maryam A / Mallah, Saad I / Almadi, Faris Soloman / Almayman, Talal / Corbally, Martin

Frontiers in neurology

2024 Volume 14, Page(s) 1301426

Abstract: Background: Anomalous origin of the middle meningeal artery (MMA) from the basilar artery is a rare congenital neurological variant that has been detected in both children and adults with diagnoses ranging from intracranial haemorrhage to ependymoma. ... ...

Abstract	Background: Anomalous origin of the middle meningeal artery (MMA) from the basilar artery is a rare congenital neurological variant that has been detected in both children and adults with diagnoses ranging from intracranial haemorrhage to ependymoma. This review aims to investigate the anatomical course of an anomalous basilar-middle meningeal artery and its clinical presentation. Methods: A systematic search was performed in PubMed using the keywords (middle meningeal artery) and (basilar artery). Ninety-four papers were identified, of which seven were included. One paper was further identified through cross-referencing. Results: The average age of presentation was 43 years with a male predominance (7/9). In most cases, the MMA arose between the superior cerebellar artery and the anterior inferior cerebellar artery (8/9) (versus 1 case between the anterior inferior cerebellar artery and the posterior inferior cerebellar artery). The anomaly mostly presented on the left side (6/11), but was bilateral in one case. Most of the cases showed a pontine artery branching from the basilar artery arising 5 mm to 10 mm proximal to the superior cerebellar artery, which would then assume the trajectory of the MMA. In three cases, the vessel increased in calibre near the trigeminal ganglion. Foramen spinosum absence in the anomalous side was noted in 3/6 of the patients. Conclusion: To avoid unexpected complications during neurosurgical and neuroradiointerventional procedures, it is essential to have a clear understanding of the anomalous routes of the MMA. This is especially important when it proves to be the only available route for embolization.
Language	English
Publishing date	2024-01-23
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1301426
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Article ; Online: Impact of authentic leadership on nurses' well-being and quality of care in the acute care settings.

Alhalal, Eman / Alharbi, Johara Fahad / Alharbi, Sabah Turyhib / Alotaibi, Sarah Saad / Albagami, Norah Saleh / Alruwaili, Salman Mutarid / Alshammari, Saad Aqeel

Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing

2024

Abstract: Introduction: Both nurses' well-being and quality of care are top priorities of the healthcare system. Yet, there is still a gap in understanding the extent and how authentic leadership influences them. This information is needed to inform the ... ...

Abstract	Introduction: Both nurses' well-being and quality of care are top priorities of the healthcare system. Yet, there is still a gap in understanding the extent and how authentic leadership influences them. This information is needed to inform the development of effective interventions, organizational practices, and policies. Thus, this study aimed to test the mechanism by which nurses' perception of their managers' authentic leadership impacts nurses' well-being and perception of quality of care, given the role of the nursing practice environment and nurses' psychological capital. Design: A cross-sectional design was used. Methods: This study recruited a random sample of 680 nurses from six hospitals in Saudi Arabia. A final sample of 415 completed the surveys, with a response rate of 61%. Structural equation modeling was performed to test the hypothesized model. Results: The study showed that nurses' perceptions of authentic leadership in their managers positively and directly affect their perceptions of quality of care but do not directly affect nurses' well-being. Both the nursing practice environment and psychological capital fully mediated the relationship between authentic leadership and nurses' well-being. However, the nursing practice environment partially mediated the relationship between authentic leadership and perceptions of quality of care. Conclusion: The findings contribute to understanding the crucial role of authentic leaders' style in nurses' well-being and quality of care through its positive impact on the nursing practice environment and psychological capital. Clinical relevance: Designing interventions and policies that specifically target nursing managers' authentic leadership style has implications for enhancing nurses' well-being and the quality of patient care. Institutional measures are needed to help leaders practice an authentic leadership style to create a positive nursing practice environment and cultivate nurses' psychological capital, both of which contribute to nurses' well-being and attaining a better quality of care. Further work is required to highlight the outcomes of implementing an authentic leadership style relevant to other leadership styles.
Language	English
Publishing date	2024-05-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2008214-9
ISSN	1547-5069 ; 1527-6546
ISSN (online)	1547-5069
ISSN	1527-6546
DOI	10.1111/jnu.12978
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Article ; Online: SARS-CoV-2-induced phosphorylation and its pharmacotherapy backed by artificial intelligence and machine learning

Fouzia Qamar / Zubair Sharif / Jawaria Idrees / Asif Wasim / Sana Haider / Saad Salman

Future Science OA (2024)

2024

Abstract: Aims: To investigate the role of phosphorylation in SARS-CoV-2 infection, potential therapeutic targets and its harmful genetic sequences. Materials & Methods: Data mining techniques were employed to identify upregulated kinases responsible for proteomic ...

Abstract	Aims: To investigate the role of phosphorylation in SARS-CoV-2 infection, potential therapeutic targets and its harmful genetic sequences. Materials & Methods: Data mining techniques were employed to identify upregulated kinases responsible for proteomic changes induced by SARS-CoV-2. Spike and nucleocapsid proteins' sequences were analyzed using predictive tools, including SNAP2, MutPred2, PhD-SNP, SNPs&Go, MetaSNP, Predict-SNP and PolyPhen-2. Missense variants were identified using ensemble-based algorithms and homology/structure-based models like SIFT, PROVEAN, Predict-SNP and MutPred-2. Results: Eight missense variants were identified in viral sequences. Four damaging variants were found, with SNPs&Go and PolyPhen-2. Promising therapeutic candidates, including gilteritinib, pictilisib, sorafenib, RO5126766 and omipalisib, were identified. Conclusion: This research offers insights into SARS-CoV-2 pathogenicity, highlighting potential treatments and harmful variants in viral proteins.
Keywords	monoclonal antibodies ; nucleocapsid protein ; phosphorylation ; proteomics ; spike protein ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	572
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Future Science Ltd
Document type	Article ; Online
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Article ; Online: Diabetic ketoacidosis: knowledge and practice among patients with diabetes attending three specialized diabetes clinics in Khartoum, Sudan.

Elhassan, Almutasim Billah Elbagir / Saad, Marwa Mohammed Elrasheed / Salman, Mohammed Suliman Tawer / Ibrahim, Abazr / Ali, Almigdad / Alla, Asmaa Abd Elaal Abd / Saad, Fadwa Mohammed

The Pan African medical journal

2022 Volume 41, Page(s) 299

Abstract: Introduction: diabetic Ketoacidosis is the leading cause of mortality in children and adolescents with T1DM and accounts for about 50% of all deaths in patients younger than 24 years with diabetes. It affects 8 out of 1000 people with diabetes annually, ...

Abstract	Introduction: diabetic Ketoacidosis is the leading cause of mortality in children and adolescents with T1DM and accounts for about 50% of all deaths in patients younger than 24 years with diabetes. It affects 8 out of 1000 people with diabetes annually, with a worldwide mortality rate of 2-10%. The purpose of this study is to assess the knowledge and practice towards DKA among patients with diabetes attending three diabetes clinics in Khartoum. Methods: we conducted a cross-sectional institution-based study. It included all patients with diabetes attending three diabetes clinics in Khartoum state over the period July - September 2016. A self-administered questionnaire was used to assess and score knowledge and practice towards DKA among patients with diabetes. Data were analyzed using SPSS 23.0. Results: one hundred and ten patients participated in the study, of whom 86 had heard of DKA and were questioned further. Fifty-six point nine percent of participants had poor knowledge (0-8 out of 24) and low practice scores (0-2 out of 6). There was a strong association between knowledge scores and attended clinics. Conclusion: there was an evident lack of knowledge and poor practice towards DKA among patients with diabetes attending diabetes clinics in Khartoum, Sudan.
MeSH term(s)	Adolescent ; Ambulatory Care Facilities ; Child ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/complications ; Diabetic Ketoacidosis ; Humans ; Sudan
Language	English
Publishing date	2022-04-13
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2022.41.299.31129
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Article ; Online: Learning From COVID-19: What Would It Take to Be Better Prepared in the Eastern Mediterranean Region?

Kufoof, Lara / Hajjeh, Rana / Al Nsour, Mohannad / Saad, Randa / Bélorgeot, Victoria / Abubakar, Abdinasir / Khader, Yousef / Rawaf, Salman

JMIR public health and surveillance

2024 Volume 10, Page(s) e40491

Abstract: The COVID-19 transmission in the Eastern Mediterranean Region (EMR) was influenced by various factors such as conflict, demographics, travel and social restrictions, migrant workers, weak health systems, and mass gatherings. The countries that responded ... ...

Abstract	The COVID-19 transmission in the Eastern Mediterranean Region (EMR) was influenced by various factors such as conflict, demographics, travel and social restrictions, migrant workers, weak health systems, and mass gatherings. The countries that responded well to COVID-19 had high-level political commitment, multisectoral coordination, and existing infrastructures that could quickly mobilize. However, some EMR countries faced challenges due to political instability and fragile health systems, which hindered their response strategies. The pandemic highlighted the region's weak health systems and preparedness, fragmented surveillance systems, and lack of trust in information sharing. COVID-19 exposed the disruption of access and delivery of essential health services as a major health system fragility. In 2020, the World Health Organization (WHO) conducted a global pulse survey, which demonstrated that the EMR experienced the highest disruption in health services compared to other WHO regions. However, thanks to prioritization by the WHO and its member states, significant improvement was observed in 2021 during the second round of the WHO's National Pulse Survey. The pandemic underscored the importance of political leadership, community engagement, and trust and emphasized that investing in health security benefits everyone. Increasing vaccine coverage, building regional capacities, strengthening health systems, and working toward universal health coverage and health security are all priorities in the EMR. Emergency public health plays a key role in preparing for and responding to pandemics and biological threats. Integrating public health into primary care and investing in public health workforce capacity building is essential to reshaping public health and health emergency preparedness.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Public Health ; World Health Organization ; Mediterranean Region/epidemiology
Language	English
Publishing date	2024-02-15
Publishing country	Canada
Document type	Journal Article
ISSN	2369-2960
ISSN (online)	2369-2960
DOI	10.2196/40491
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Article ; Online: Long-term clinical outcomes of intravascular imaging-guided percutaneous coronary intervention versus angiography-guided percutaneous coronary intervention in complex coronary lesions: a systematic review and meta-analysis.

Ashraf, Danish Ali / Ahmed, Usman / Khan, Zainab Zaib / Mushtaq, Fiza / Bano, Shehar / Khan, Ali Raza / Azam, Saad / Haroon, Abdullah / Malik, Salman Ahmed / Aslam, Raza / Kumar, Jai / Khan, Farva Zaib / Faheem, Amna / Kumar, Sarwan / Hassan, Saad

Future cardiology

2024

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-04-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2274267-0
ISSN	1744-8298 ; 1479-6678
ISSN (online)	1744-8298
ISSN	1479-6678
DOI	10.2217/fca-2023-0124
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Article ; Online: Molecular characterization of mecA gene in Methicillin-Resistant Staphylococcus aureus

Saad Salman Hamim

مجلة علوم ذي قار, Vol 6, Iss

2019 Volume 1

Abstract: Background & objectives: It is clear now that methicillin-resistant Staphylococcus aureus (MRSA) strains considered as one of the most bacteria responsible for different diseases among humans and animals. The present study aimed to detect the molecular ... ...

Abstract	Background & objectives: It is clear now that methicillin-resistant Staphylococcus aureus (MRSA) strains considered as one of the most bacteria responsible for different diseases among humans and animals. The present study aimed to detect the molecular profile of methicillin-resistant S. aureus isolated from skin abscess patients in Nassyriah City, Southern Iraq. Methods: During the period of from June 2014 to February 2015, 120 S. aureus were isolated from abscess patient in two governmental hospitals, and subjected to conventional Polymerase Chain Reaction which used for the amplification of 310 bp mecA gene. Three PCR products of mecA were named primarily (THQR1, THQR2, and THQR3) were selected and subjected to partial DNA sequencing for the mecA gene to follow up their possible relationship between these local isolates and what recorded globally in Genbank. Results: Only 64 S. aureus isolates were diagnosed phenotypically as MRSA (53.33%), and 88/120 (73.33%) of S. aureus were positive for the targeted gene. The Three PCR products of mecA were registered in Genbank under the official accession numbers of (KY468502, KY468503 and KY468504, respectively). The constructed phylogenetic tree showed that S. aureus KY468502 and KY468504 were highly relative to each other in comparison with S. aureus KY468503 that revealed a close relatedness to S. aureus TN/CN/1/12, mecA gene beta-lactam, and mecA gene isolated in USA. Interpretation & conclusions: The present study results confirmed the importance of mecA gene in MRSA detection and highlighted the increasing manner of its prevalence in Iraq, furthermore, the importance of molecular techniques as an epidemiological tool.
Keywords	Gene sequencing ; Methicillin-resistant ; Staphylococcus aureus ; Phylogenetic tree ; mecA gene of S. aureus ; Physics ; QC1-999 ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	630
Language	English
Publishing date	2019-04-01T00:00:00Z
Publisher	University of Thi-Qar
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Cost-Savings Associated with Multi-Disciplinary Team Approach for Reducing Macrovascular and Microvascular Complications in Patients with Type 2 Diabetes: A Predictive Model.

Alshowair, Abdulmajeed / Altamimi, Saleh / Alruhaimi, Faisal A / Alshahrani, Saad / Alsuwailem, Fatima / Alkhaldi, Mona / Abdalla, Haiam / Alkhuraiji, Fahad Hamad / Alaqeel, Montaser Saad / Almureef, Salman Sulaiman / Alhawasy, Salman / Abdel-Azeem, Amro

ClinicoEconomics and outcomes research : CEOR

2024 Volume 16, Page(s) 211–223

Abstract: Purpose: This study aims to predict the expected cost savings associated with implementing a multidisciplinary team (MDT) approach to reduce macrovascular and microvascular complications among patients with type 2 diabetes mellitus (T2DM).: Methods: ... ...

Abstract	Purpose: This study aims to predict the expected cost savings associated with implementing a multidisciplinary team (MDT) approach to reduce macrovascular and microvascular complications among patients with type 2 diabetes mellitus (T2DM). Methods: This economic evaluation study was conducted in Riyadh First Health Cluster, Saudi Arabia as a predictive model conceptualized by the authors based on models used in previous studies, particularly the CORE Diabetes Model. Our model was designed based on 1) the level of glycemic control among 24,755 T2DM patients served by MDTs; 2) the expected incidence of diabetes-related complications without intervention; 3) the predicted risk reduction of developing diabetes-related complications with MDTs. Costs of complications and cost savings were then calculated and expressed as mean incremental annual cost savings adjusted for a 1% reduction in HbA1c, and a 10 mmHg reduction in systolic blood pressure (SBP). Results: Along with the expected reduction in all diabetes-related complications, the average incremental cost savings per diabetic patient is predicted to be ($38,878) with approximately ($11,108) in the year of complication onset and ($27,770) over the subsequent post-index 10-years. On adjustment of cost savings, the average incremental cost savings are predicted to be ($22,869) for each 1% reduction in HbA1c per diabetic patient and ($27,770) for every 10 mmHg reduction in SBP per diabetic patient. Conclusion: MDT as a model of care is effective in glycemic control among T2DM patients with a predicted significant reduction of all diabetes-related complications and in turn, a predicted significant cost savings.
Language	English
Publishing date	2024-04-04
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2520698-9
ISSN	1178-6981
ISSN	1178-6981
DOI	10.2147/CEOR.S451739
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Article: Ameliorative inhibition of sirtuin 6 by imidazole derivative triggers oxidative stress-mediated apoptosis associated with Nrf2/Keap1 signaling in non-small cell lung cancer cell lines.

Dindi, Uma Maheswara Rao / Al-Ghamdi, Sameer / Alrudian, Naif Abdurhman / Dayel, Salman Bin / Abuderman, Abdulwahab Ali / Saad Alqahtani, Mohammed / Bahakim, Nasraddin Othman / Ramesh, Thiyagarajan / Vilwanathan, Ravikumar

Frontiers in pharmacology

2024 Volume 14, Page(s) 1335305

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-01-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1335305
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