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  1. Article: In Vitro

    Indira, Mikkili / Peele, Karlapudi Abraham / Krupanidhi, Srirama / Prabhakar, Kodali Vidya / Vimala, K B S / Kavya, P Satya / Sravya, I / Venkateswarulu, T C

    Tropical life sciences research

    2023  Volume 34, Issue 3, Page(s) 197–215

    Abstract: ... Citrus ... ...

    Abstract Citrus medica
    Language English
    Publishing date 2023-09-30
    Publishing country Malaysia
    Document type Journal Article
    ZDB-ID 2607038-8
    ISSN 2180-4249 ; 1985-3718
    ISSN (online) 2180-4249
    ISSN 1985-3718
    DOI 10.21315/tlsr2023.34.3.11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Design of multi-epitope vaccine candidate against SARS-CoV-2: a

    Abraham Peele, K / Srihansa, T / Krupanidhi, S / Ayyagari, Vijaya Sai / Venkateswarulu, T C

    Journal of biomolecular structure & dynamics

    2020  Volume 39, Issue 10, Page(s) 3793–3801

    Abstract: The best therapeutic strategy to find an effective vaccine against SARS-CoV-2 is to explore the target structural protein. In the present study, a novel multi-epitope vaccine is designed ... ...

    Abstract The best therapeutic strategy to find an effective vaccine against SARS-CoV-2 is to explore the target structural protein. In the present study, a novel multi-epitope vaccine is designed using
    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines ; Epitopes, B-Lymphocyte/immunology ; Epitopes, T-Lymphocyte/immunology ; Humans ; Molecular Docking Simulation ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/immunology ; Vaccines, Subunit
    Chemical Substances COVID-19 Vaccines ; Epitopes, B-Lymphocyte ; Epitopes, T-Lymphocyte ; Spike Glycoprotein, Coronavirus ; Vaccines, Subunit ; spike protein, SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2020.1770127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Insilico drug repurposing using FDA approved drugs against Membrane protein of SARS-CoV-2.

    Peele, K Abraham / Kumar, Vikas / Parate, Shraddha / Srirama, Krupanidhi / Lee, Keun Woo / Venkateswarulu, T C

    Journal of pharmaceutical sciences

    2021  Volume 110, Issue 6, Page(s) 2346–2354

    Abstract: The novel coronavirus (SARS-CoV-2) outbreak has started taking away the millions of lives worldwide. Identification of known and approved drugs against novel coronavirus disease (COVID-19) seems to be an urgent need for the repurposing of the existing ... ...

    Abstract The novel coronavirus (SARS-CoV-2) outbreak has started taking away the millions of lives worldwide. Identification of known and approved drugs against novel coronavirus disease (COVID-19) seems to be an urgent need for the repurposing of the existing drugs. So, here we examined a safe strategy of using approved drugs of SuperDRUG2 database against modeled membrane protein (M-protein) of SARS-CoV-2 which is essential for virus assembly by using molecular docking-based virtual screening. A total of 3639 drugs from SuperDRUG2 database and additionally 14 potential drugs reported against COVID-19 proteins were selected. Molecular docking analyses revealed that nine drugs can bind the active site of M-protein with desirable molecular interactions. We therefore applied molecular dynamics simulations and binding free energy calculation using MM-PBSA to analyze the stability of the compounds. The complexes of M-protein with the selected drugs were simulated for 50 ns and ranked according to their binding free energies. The binding mode of the drugs with M-protein was analyzed and it was observed that Colchicine, Remdesivir, Bafilomycin A1 from COVID-19 suggested drugs and Temozolomide from SuperDRUG2 database displayed desirable molecular interactions and higher binding affinity towards M-protein. Interestingly, Colchicine was found as the top most binder among tested drugs against M-protein. We therefore additionally identified four Colchicine derivatives which can bind efficiently with M-protein and have better pharmacokinetic properties. We recommend that these drugs can be tested further through in vitro studies against SARS-CoV-2 M-protein.
    MeSH term(s) Antiviral Agents/pharmacology ; COVID-19 ; Drug Repositioning ; Humans ; Membrane Proteins ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Pharmaceutical Preparations ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Membrane Proteins ; Pharmaceutical Preparations
    Language English
    Publishing date 2021-03-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3151-3
    ISSN 1520-6017 ; 0022-3549
    ISSN (online) 1520-6017
    ISSN 0022-3549
    DOI 10.1016/j.xphs.2021.03.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article: Bioactive molecules of probiotic bacteria and their mechanism of action: a review.

    Indira, M / Venkateswarulu, T C / Abraham Peele, K / Nazneen Bobby, Md / Krupanidhi, S

    3 Biotech

    2019  Volume 9, Issue 8, Page(s) 306

    Abstract: The bacteria residing in the gut environment do play a pivotal role in metabolic activities of the host. The metabolites produced by these bacteria affect the physiology and health of the host. The gut bacteria are exposed to environmental conditions ... ...

    Abstract The bacteria residing in the gut environment do play a pivotal role in metabolic activities of the host. The metabolites produced by these bacteria affect the physiology and health of the host. The gut bacteria are exposed to environmental conditions where multiple factors such as lifestyle, stress, antibiotics, host genetics and infections have an influence on them. In case of pathogenesis of a disease, the gut bacterial composition is altered which leads to a diseased state. This stage is due to colonization of bacterial pathogens in the gut environment. The pathological condition can be alleviated by administering probiotic strains into the gut environment. The probiotic strains produce therapeutic molecules such as amino acids, vitamins, bacteriocins, enzymes, immunomodulatory compounds and short-chain fatty acids. This review discusses recent evidences of the impact of bioactive molecules produced by probiotic bacteria and their mechanism of action in the gut environment to maintain homeostasis and health of the host without any effect on beneficial bacteria sharing the same niche. In addition, the manufacturing challenges of probiotic products for various applications are discussed here.
    Language English
    Publishing date 2019-07-24
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-019-1841-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Design of multi-epitope vaccine candidate against SARS-CoV-2

    Abraham Peele, K. / Srihansa, T. / Krupanidhi, S. / Ayyagari, Vijaya Sai / Venkateswarulu, T. C.

    Journal of Biomolecular Structure and Dynamics

    a in-silico study

    2020  , Page(s) 1–9

    Keywords Molecular Biology ; Structural Biology ; General Medicine ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2020.1770127
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Design of a multi-epitope-based vaccine targeting M-protein of SARS-CoV2: an immunoinformatics approach.

    Ayyagari, Vijaya Sai / T C, Venkateswarulu / K, Abraham Peele / Srirama, Krupanidhi

    Journal of biomolecular structure & dynamics

    2020  Volume 40, Issue 7, Page(s) 2963–2977

    Abstract: In the present study, one of the targets present on the envelopes of coronaviruses, membrane glycoprotein (M) was chosen for the design of a multi-epitope vaccine by Immunoinformatics approach. The B-cell and T-cell epitopes used for the construction of ... ...

    Abstract In the present study, one of the targets present on the envelopes of coronaviruses, membrane glycoprotein (M) was chosen for the design of a multi-epitope vaccine by Immunoinformatics approach. The B-cell and T-cell epitopes used for the construction of vaccine were antigenic, nonallergic and nontoxic. An adjuvant, β-defensin and PADRE sequence were included at the N-terminal end of the vaccine. All the epitopes were joined by linkers for decreasing the junctional immunogenicity. Various physicochemical parameters of the vaccine were evaluated. Secondary and tertiary structures were predicted for the vaccine construct. The tertiary structure was further refined, and various parameters related to the refinement of the protein structure were validated by using different tools. Humoral immunity induced by B-cells relies upon the identification of antigenic determinants on the surface of the vaccine construct. In this regard, the vaccine construct was found to consist of several B-cell epitopes in its three-dimensional conformation. Molecular docking of the vaccine was carried out with TLR-3 receptor to study their binding and its strength. Further, protein-protein interactions in the docked complex were visualized using LigPlot+. Population coverage analysis had shown that the multi-epitope vaccine covers 94.06% of the global population. The vaccine construct was successfully cloned
    MeSH term(s) COVID-19/prevention & control ; Computational Biology/methods ; Epitopes, B-Lymphocyte ; Epitopes, T-Lymphocyte ; Humans ; Molecular Docking Simulation ; RNA, Viral ; SARS-CoV-2 ; Vaccines, Subunit
    Chemical Substances Epitopes, B-Lymphocyte ; Epitopes, T-Lymphocyte ; RNA, Viral ; Vaccines, Subunit
    Language English
    Publishing date 2020-11-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2020.1850357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Sustainable nutritional supplementation for green economy through hydroponics system

    Bobby, Md. Nazneen / Indira, M. / Peele, K. Abraham / Venkateswarulu, T.C. / Krupanidhi, S.

    Indian journal of ecology. 2021 Feb., v. 48, no. 1

    2021  

    Abstract: Hydroponics is a cultivation of plants without soil with formulated nutrient medium growing in a fabricated set of unit. The present study focused on the nine different medicinal and ornamental plants. They were grown in the hydroponics unit supplied ... ...

    Abstract Hydroponics is a cultivation of plants without soil with formulated nutrient medium growing in a fabricated set of unit. The present study focused on the nine different medicinal and ornamental plants. They were grown in the hydroponics unit supplied with macro and micro nutrients of three different treatments ranges from 200ppm to 450ppm. Experiment was laid to study the length of plants, number of shoot lets th th and number of days of experimentation with replicates. Dieffenbachia bowmannii showed highest length of 38 to 50 cm at 4ᵗʰ & 5ᵗʰ week compared to the remaining plants grown in hydroponics unit. Number of multiple shoots was increased in Mentha arvensis grown to the length of 19-45cm with 15-37 numbers of shoots and Table top plant with 25-38 shoots after five weeks of nutritional treatment. Mostly in the process of hydroponics the growth rate and shoots number increased followed by Table top, Mentha arvensi, Capsicum annum. This study gives the comparative values of growth rate in selected plants through hydroponics system.
    Keywords Capsicum annuum ; Dieffenbachia ; Mentha arvensis ; diet therapy ; dietary supplements ; ecology ; economic sustainability ; hydroponics ; soil
    Language English
    Dates of publication 2021-02
    Size p. 85-90.
    Publishing place Indian Ecological Society
    Document type Article
    ZDB-ID 193796-0
    ISSN 0304-5250
    ISSN 0304-5250
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 7625: Show issues

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  8. Article: Emulsifying activity of a biosurfactant produced by a marine bacterium.

    Peele, K Abraham / Ch, V Ravi Teja / Kodali, Vidya P

    3 Biotech

    2016  Volume 6, Issue 2, Page(s) 177

    Abstract: Biosurfactants produced by biofilm-forming bacteria have great applications in biotechnology, pharmaceutical, food engineering, bioremediation, and biohydrometallurgy industries. This study aimed to find out the bacteria that produce novel exopolymers ( ... ...

    Abstract Biosurfactants produced by biofilm-forming bacteria have great applications in biotechnology, pharmaceutical, food engineering, bioremediation, and biohydrometallurgy industries. This study aimed to find out the bacteria that produce novel exopolymers (EPSs) which can find potential role in oil biodegradation. A screening procedure was performed to detect EPS-producing bacteria. The EPS producing isolate was identified as Acinetobacter species by 16S rDNA analysis. The polymer produced by the isolate has shown significant emulsification and surfactant activities, and the activities were compared to some of the commercial emulsifiers. The EPS has been partially characterized by FTIR analysis and has been proved to be a glycolipoprotein. This is one of the very few reports on Acinetobacter species producing EPS with surfactant properties.
    Language English
    Publishing date 2016-08-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-016-0494-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Design of multi-epitope vaccine candidate against SARS-CoV-2: a in-silico study

    Abraham Peele, K / Srihansa, T / Krupanidhi, S / Vijaya Sai, A / Venkateswarulu, T C

    J Biomol Struct Dyn

    Abstract: The best therapeutic strategy to find an effective vaccine against SARS-CoV-2 is to explore the target structural protein. In the present study, a novel multi-epitope vaccine is designed using in silico tools that potentially trigger both CD4 and CD8 T- ... ...

    Abstract The best therapeutic strategy to find an effective vaccine against SARS-CoV-2 is to explore the target structural protein. In the present study, a novel multi-epitope vaccine is designed using in silico tools that potentially trigger both CD4 and CD8 T-cell immune responses against the novel Coronavirus. The vaccine candidate was designed using B and T-cell epitopes that can act as an immunogen and elicits immune response in the host system. NCBI was used for the retrieval of surface spike glycoprotein, of novel corona virus (SARS-CoV-2) strains. VaxiJen server screens the most important immunogen of all the proteins and IEDB server gives the prediction and analysis of B and T cell epitopes. Final vaccine construct was designed in silico composed of 425 amino acids including the 50S ribosomal protein adjuvant and the construct was computationally validated in terms of antigenicity, allergenicity and stability on considering all critical parameters into consideration. The results subjected to the modeling and docking studies of vaccine were validated. Molecular docking study revealed the protein-protein binding interactions between the vaccine construct and TLR-3 immune receptor. The MD simulations confirmed stability of the binding pose. The immune simulation results showed significant response for immune cells. The findings of the study confirmed that the final vaccine construct of chimeric peptide could able to enhance the immune response against nCoV-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #379808
    Database COVID19

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  10. Article: Design of multi-epitope vaccine candidate against SARS-CoV-2: a in-silico study

    Abraham Peele, K / Srihansa, T / Krupanidhi, S / Ayyagari, Vijaya Sai / Venkateswarulu, T C

    J Biomol Struct Dyn

    Abstract: The best therapeutic strategy to find an effective vaccine against SARS-CoV-2 is to explore the target structural protein. In the present study, a novel multi-epitope vaccine is designed using in silico tools that potentially trigger both CD4 and CD8 T- ... ...

    Abstract The best therapeutic strategy to find an effective vaccine against SARS-CoV-2 is to explore the target structural protein. In the present study, a novel multi-epitope vaccine is designed using in silico tools that potentially trigger both CD4 and CD8 T-cell immune responses against the novel Coronavirus. The vaccine candidate was designed using B and T-cell epitopes that can act as an immunogen and elicits immune response in the host system. NCBI was used for the retrieval of surface spike glycoprotein, of novel corona virus (SARS-CoV-2) strains. VaxiJen server screens the most important immunogen of all the proteins and IEDB server gives the prediction and analysis of B and T cell epitopes. Final vaccine construct was designed in silico composed of 425 amino acids including the 50S ribosomal protein adjuvant and the construct was computationally validated in terms of antigenicity, allergenicity and stability on considering all critical parameters into consideration. The results subjected to the modeling and docking studies of vaccine were validated. Molecular docking study revealed the protein-protein binding interactions between the vaccine construct and TLR-3 immune receptor. The MD simulations confirmed stability of the binding pose. The immune simulation results showed significant response for immune cells. The findings of the study confirmed that the final vaccine construct of chimeric peptide could able to enhance the immune response against nCoV-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #379808
    Database COVID19

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