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Article: Identification of sleep and circadian alternative polyadenylation sites associated with APA-linked human brain disorders.

Flores, Carlos C / Pasetto, Nickolas A / Wang, Hongyang / Dimitrov, Alexander / Davis, Jon F / Jiang, Zhuhua / Davis, Christopher J / Gerstner, Jason R

Research square

2024

Abstract: Sleep and circadian rhythm disruptions are comorbid features of many pathologies and can negatively influence numerous health conditions, including degenerative diseases, metabolic illnesses, cancer, and various neurological disorders. Genetic ... ...

Abstract	Sleep and circadian rhythm disruptions are comorbid features of many pathologies and can negatively influence numerous health conditions, including degenerative diseases, metabolic illnesses, cancer, and various neurological disorders. Genetic association studies linking sleep and circadian disturbances with disease susceptibility have mainly focused on changes in gene expression due to mutations, such as single-nucleotide polymorphisms. Thus, associations between sleep and/or circadian rhythm and alternative polyadenylation (APA), particularly in the context of other health challenges, are largely undescribed. APA is a process that generates various transcript isoforms from the same gene, resulting in effects on mRNA translation, stability, localization, and subsequent function. Here, we have identified unique APAs in rat brain that exhibit time-of-day-dependent oscillations in expression as well as APAs that are altered by sleep deprivation and the subsequent recovery period. Genes affected by APA usage include
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3867797/v1
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Article ; Online: Behavioral and Neurobiological Consequences of Hedonic Feeding on Alcohol Drinking.

Brutman, Julianna / Davis, Jon F / Sirohi, Sunil

Current pharmaceutical design

2020 Volume 26, Issue 20, Page(s) 2309–2315

Abstract: A complex interplay of peripheral and central signaling mechanisms within the body of an organism maintains energy homeostasis. In addition, energy/food intake is modified by various external factors (e.g., palatability, food availability, social and ... ...

Abstract	A complex interplay of peripheral and central signaling mechanisms within the body of an organism maintains energy homeostasis. In addition, energy/food intake is modified by various external factors (e.g., palatability, food availability, social and environmental triggers). Highly palatable foods can provoke maladaptive feeding behavior, which in turn disrupts normal homeostatic regulation resulting in numerous health consequences. Furthermore, neuroendocrine peptides, traditionally considered to regulate appetite and energy homeostasis, also control the intake and reinforcing properties of alcohol and drugs of abuse. Therefore, dysregulated eating as a result of a hedonic/binge-like intake of hyper-palatable food may impact alcohol drinking behavior. Relevant in this case is the fact that eating disorders are highly comorbid with several neuropsychiatric conditions, including alcohol use disorder. The present review is intended to summarize the neurobiological and functional consequences of hedonic feeding on alcohol intake.
MeSH term(s)	Alcohol Drinking/adverse effects ; Appetite ; Binge-Eating Disorder ; Eating ; Feeding Behavior ; Feeding and Eating Disorders ; Humans
Language	English
Publishing date	2020-02-10
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612826666200206092231
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Zs.A 4714: Show issues

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Article ; Online: The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Rectal Cancer 2023 Supplement.

Langenfeld, Sean J / Davis, Bradley R / Vogel, Jon D / Davids, Jennifer S / Temple, Larissa K F / Cologne, Kyle G / Hendren, Samantha / Hunt, Steven / Garcia Aguilar, Julio / Feingold, Daniel L / Lightner, Amy L / Paquette, Ian M

Diseases of the colon and rectum

2023 Volume 67, Issue 1, Page(s) 18–31

MeSH term(s)	Humans ; Colon/surgery ; Rectal Neoplasms/surgery ; Rectum ; Surgeons ; United States
Language	English
Publishing date	2023-08-20
Publishing country	United States
Document type	Journal Article ; Practice Guideline
ZDB-ID	212581-x
ISSN	1530-0358 ; 0012-3706
ISSN (online)	1530-0358
ISSN	0012-3706
DOI	10.1097/DCR.0000000000003057
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Uk I Zs.237: Show issues

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Article ; Online: Recent Advances in the Neurobiology of Altered Motivation Following Bariatric Surgery.

Brutman, Julianna N / Sirohi, Sunil / Davis, Jon F

Current psychiatry reports

2019 Volume 21, Issue 11, Page(s) 117

Abstract: Purpose of review: There is compelling evidence in the clinical population that long-term weight loss secondary to bariatric surgery is mitigated by the reemergence of maladaptive feeding behaviors and in some cases new onset substance abuse.: Recent ... ...

Abstract	Purpose of review: There is compelling evidence in the clinical population that long-term weight loss secondary to bariatric surgery is mitigated by the reemergence of maladaptive feeding behaviors and in some cases new onset substance abuse. Recent findings: A review of the current literature suggests that physical restructuring of the GI tract during WLS alters secretion of feeding peptides and nutrient-sensing mechanisms that directly target the brain's endogenous reward system, the mesolimbic dopamine system. Post-surgical changes in GI physiology augment activation of the mesolimbic system. In some patients, this process may contribute to a reduced appetite for palatable food whereas in others it may support maladaptive motivated behavior for food and chemical drugs. It is concluded that future studies are required to detail the timing and duration of surgical-induced changes in GI-mesolimbic communication to more fully understand this phenomenon.
MeSH term(s)	Appetite ; Bariatric Surgery/adverse effects ; Dopamine/metabolism ; Feeding Behavior ; Humans ; Motivation ; Neurobiology ; Reward
Chemical Substances	Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2019-11-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2055376-6
ISSN	1535-1645 ; 1523-3812
ISSN (online)	1535-1645
ISSN	1523-3812
DOI	10.1007/s11920-019-1084-2
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Zs.A 5520: Show issues

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Article ; Online: Vertical Sleeve Gastrectomy Attenuates Hedonic Feeding Without Impacting Alcohol Drinking in Rats.

Sirohi, Sunil / Skripnikova, Elena / Davis, Jon F

Obesity (Silver Spring, Md.)

2019 Volume 27, Issue 4, Page(s) 603–611

Abstract: Objective: Roux-en-Y gastric bypass surgery and vertical sleeve gastrectomy (VSG) are the most commonly performed bariatric procedures. Whereas studies report new-onset alcohol misuse following Roux-en-Y gastric bypass, the impact of VSG on alcohol ... ...

Abstract	Objective: Roux-en-Y gastric bypass surgery and vertical sleeve gastrectomy (VSG) are the most commonly performed bariatric procedures. Whereas studies report new-onset alcohol misuse following Roux-en-Y gastric bypass, the impact of VSG on alcohol intake is less clear. Hedonic feeding, alcohol drinking, and hypothalamic obesity-related gene expression following VSG were evaluated. Methods: Male Long-Evans rats underwent VSG or sham surgery. To evaluate hedonic feeding, rats received a high-fat diet following behavioral satiation on chow. Alcohol (5%-10% v/v) drinking was assessed in a two-bottle choice paradigm. Finally, polymerase chain reaction array evaluated gene expression. Results: VSG induced moderate but significant weight loss. Sham rats significantly escalated high-fat diet intake following behavioral satiation, an effect significantly reduced in VSG rats. A moderate decrease in alcohol intake was observed in VSG rats at low (5%) alcohol concentration. However, overall, no significant between-group differences were evident. Key hypothalamic orexigenic transcripts linked to stimulation of food and alcohol intake were significantly decreased in VSG rats. Conclusions: VSG attenuated hedonic feeding without impacting alcohol drinking, an effect potentially mediated by alterations in genetic information flow within the hypothalamus. Importantly, these data highlight VSG as an effective bariatric procedure with a potentially reduced risk of developing alcohol use disorder.
MeSH term(s)	Alcohol Drinking/genetics ; Alcohol Drinking/pathology ; Animals ; Appetite Regulation/genetics ; Diet, High-Fat ; Feeding Behavior/physiology ; Gastrectomy/methods ; Gastric Bypass/methods ; Gene Expression ; Hypothalamus/metabolism ; Hypothalamus/pathology ; Male ; Obesity/complications ; Obesity/genetics ; Obesity/pathology ; Obesity/surgery ; Rats ; Rats, Long-Evans ; Weight Loss/physiology
Language	English
Publishing date	2019-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2230457-5
ISSN	1930-739X ; 1071-7323 ; 1930-7381
ISSN (online)	1930-739X
ISSN	1071-7323 ; 1930-7381
DOI	10.1002/oby.22415
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Zs.A 4061: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Examining the Impact of Estrogen on Binge Feeding, Food-Motivated Behavior, and Body Weight in Female Rats.

Brutman, Julianna N / Sirohi, Sunil / Davis, Jon F

Obesity (Silver Spring, Md.)

2019 Volume 27, Issue 10, Page(s) 1617–1626

Abstract: Objective: Binge-eating disorder is associated with diminished self-control, emotional distress, and obesity. In this context, women are nearly twice as likely to develop binge-eating disorder and depression relative to men. Here, the physiological, ... ...

Abstract	Objective: Binge-eating disorder is associated with diminished self-control, emotional distress, and obesity. In this context, women are nearly twice as likely to develop binge-eating disorder and depression relative to men. Here, the physiological, psychological, and endocrine parameters were characterized in female rats subjected to a binge-eating protocol. Methods: Nonrestricted female Long Evans rats (n = 8/group) received 2-hour restricted access to a high-fat diet (HFD) (4.54 kcal/g) every day or every third day. The progression of estrous cycling, the functional relevance of estrogen signaling for binge feeding, and binge-induced changes in food motivation were measured. Results: Female rats developed a binge pattern of feeding that included alternation between caloric overconsumption and compensatory voluntary restriction without impacting estrous cycling. Notably, rats that received daily HFD exposure progressively decreased binge meals. Estrogen replacement in normal cycling or ovariectomized rats mimicked the reduction in body weight in female rats that received daily HFD access. Operant responding was unaffected by binge feeding; however, estrogen augmented operant performance in HFD-exposed rats. Conclusions: Collectively, these data suggest that estrogen protects against binge-induced increases in body weight gain without affecting food motivation in female rats.
MeSH term(s)	Animals ; Body Weight/drug effects ; Bulimia/pathology ; Bulimia/physiopathology ; Bulimia/psychology ; Diet, High-Fat ; Estradiol/pharmacology ; Feeding Behavior/drug effects ; Feeding Behavior/psychology ; Female ; Meals ; Motivation/drug effects ; Obesity/etiology ; Obesity/physiopathology ; Obesity/psychology ; Rats ; Rats, Long-Evans ; Weight Gain/drug effects
Chemical Substances	Estradiol (4TI98Z838E)
Language	English
Publishing date	2019-08-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2230457-5
ISSN	1930-739X ; 1071-7323 ; 1930-7381
ISSN (online)	1930-739X
ISSN	1071-7323 ; 1930-7381
DOI	10.1002/oby.22582
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Zs.A 4061: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Obesity and its effects on the esophageal mucosal barrier.

Paris, Shere / Ekeanyanwu, Rebecca / Jiang, Yuwei / Davis, Daniel / Spechler, Stuart Jon / Souza, Rhonda F

American journal of physiology. Gastrointestinal and liver physiology

2021 Volume 321, Issue 3, Page(s) G335–G343

Abstract: Obesity is associated with gastroesophageal reflux disease (GERD) and its complications including reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma. Traditionally, these associations have been attributed to the mechanical effect of ... ...

Abstract	Obesity is associated with gastroesophageal reflux disease (GERD) and its complications including reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma. Traditionally, these associations have been attributed to the mechanical effect of abdominal fat in increasing intra-abdominal pressure, thereby promoting gastroesophageal reflux and causing disruption of antireflux mechanisms at the esophagogastric junction. However, recent studies suggest that visceral adipose tissue (VAT) produces numerous cytokines that can cause esophageal inflammation and impair esophageal mucosal barrier integrity through reflux-independent mechanisms that render the esophageal mucosa especially susceptible to GERD-induced injury. In this report, we review mechanisms of esophageal mucosal defense, the genesis and remodeling of visceral adipose tissue during obesity, and the potential role of substances produced by VAT, especially the VAT that encircles the esophagogastric junction, in the impairment of esophageal mucosal barrier integrity that leads to the development of GERD complications.
MeSH term(s)	Barrett Esophagus/metabolism ; Barrett Esophagus/pathology ; Esophageal Mucosa/metabolism ; Esophageal Mucosa/pathology ; Esophagitis, Peptic/metabolism ; Esophagitis, Peptic/pathology ; Esophagus/pathology ; Gastroesophageal Reflux/metabolism ; Gastroesophageal Reflux/pathology ; Humans ; Obesity/metabolism ; Obesity/pathology
Language	English
Publishing date	2021-08-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	603840-2
ISSN	1522-1547 ; 0193-1857
ISSN (online)	1522-1547
ISSN	0193-1857
DOI	10.1152/ajpgi.00199.2021
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Article ; Online: Amylin Modulates a Ventral Tegmental Area-to-Medial Prefrontal Cortex Circuit to Suppress Food Intake and Impulsive Food-Directed Behavior.

Geisler, Caroline E / Décarie-Spain, Léa / Loh, Maxine K / Trumbauer, Wolf / Gaisinsky, Jane / Klug, Molly E / Pelletier, Caitlyn / Davis, Jon F / Schmidt, Heath D / Roitman, Mitchell F / Kanoski, Scott E / Hayes, Matthew R

Biological psychiatry

2023

Abstract: Background: A better understanding of the neural mechanisms regulating impaired satiety to palatable foods is essential to treat hyperphagia linked with obesity. The satiation hormone amylin signals centrally at multiple nuclei including the ventral ... ...

Abstract	Background: A better understanding of the neural mechanisms regulating impaired satiety to palatable foods is essential to treat hyperphagia linked with obesity. The satiation hormone amylin signals centrally at multiple nuclei including the ventral tegmental area (VTA). VTA-to-medial prefrontal cortex (mPFC) projections encode food reward information to influence behaviors including impulsivity. We hypothesized that modulation of VTA-to-mPFC neurons underlies amylin-mediated decreases in palatable food-motivated behaviors. Methods: We used a variety of pharmacological, behavioral, genetic, and viral approaches (n = 4-16/experiment) to investigate the anatomical and functional circuitry of amylin-controlled VTA-to-mPFC signaling in rats. Results: To first establish that VTA amylin receptor (calcitonin receptor) activation can modulate mPFC activity, we showed that intra-VTA amylin decreased food-evoked mPFC cFos. VTA amylin delivery also attenuated food-directed impulsive behavior, implicating VTA amylin signaling as a regulator of mPFC functions. Palatable food activates VTA dopamine and mPFC neurons. Accordingly, dopamine receptor agonism in the mPFC blocked the hypophagic effect of intra-VTA amylin, and VTA amylin injection reduced food-evoked phasic dopamine levels in the mPFC, supporting the idea that VTA calcitonin receptor activation decreases dopamine release in the mPFC. Surprisingly, calcitonin receptor expression was not found on VTA-to-mPFC projecting neurons but was instead found on GABAergic (gamma-aminobutyric acidergic) interneurons in the VTA that provide monosynaptic inputs to this pathway. Blocking intra-VTA GABA signaling, through GABA receptor antagonists and DREADD (designer receptor exclusively activated by designer drugs)-mediated GABAergic neuronal silencing, attenuated intra-VTA amylin-induced hypophagia. Conclusions: These results indicate that VTA amylin signaling stimulates GABA-mediated inhibition of dopaminergic projections to the mPFC to mitigate impulsive consumption of palatable foods.
Language	English
Publishing date	2023-07-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	209434-4
ISSN	1873-2402 ; 0006-3223
ISSN (online)	1873-2402
ISSN	0006-3223
DOI	10.1016/j.biopsych.2023.07.011
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Article ; Online: A point-prevalence study on community and inpatient

Viprey, Virginie F / Davis, Georgina L / Benson, Anthony D / Ewin, Duncan / Spittal, William / Vernon, Jon J / Rupnik, Maja / Banz, Alice / Allantaz, Florence / Cleuziat, Philippe / Wilcox, Mark H / Davies, Kerrie A

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2022 Volume 27, Issue 26

Abstract: BackgroundThere is a paucity of data on community- ... ...

Abstract	BackgroundThere is a paucity of data on community-based
MeSH term(s)	Adult ; Clostridioides difficile/genetics ; Clostridium Infections/diagnosis ; Clostridium Infections/drug therapy ; Clostridium Infections/epidemiology ; Cross Infection/epidemiology ; Cross-Sectional Studies ; Europe/epidemiology ; Humans ; Inpatients ; Prevalence ; Ribotyping
Language	English
Publishing date	2022-06-28
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2022.27.26.2100704
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Zs.A 5066: Show issues

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Article ; Online: Cannabis Sativa targets mediobasal hypothalamic neurons to stimulate appetite.

Wheeler, Emma C / Choi, Pique / De Howitt, Joanne / Gill, Sumeen / Watson, Shane / Yu, Sue / Wahl, Peyton / Diaz, Cecilia / Mohr, Claudia / Zinski, Amy / Jiang, Zhihua / Rossi, David / Davis, Jon F

Scientific reports

2023 Volume 13, Issue 1, Page(s) 22970

Abstract: The neurobiological mechanisms that regulate the appetite-stimulatory properties of cannabis sativa are unresolved. This work examined the hypothesis that cannabinoid-1 receptor (CB1R) expressing neurons in the mediobasal hypothalamus (MBH) regulate ... ...

Abstract	The neurobiological mechanisms that regulate the appetite-stimulatory properties of cannabis sativa are unresolved. This work examined the hypothesis that cannabinoid-1 receptor (CB1R) expressing neurons in the mediobasal hypothalamus (MBH) regulate increased appetite following cannabis vapor inhalation. Here we utilized a paradigm where vaporized cannabis plant matter was administered passively to rodents. Initial studies in rats characterized meal patterns and operant responding for palatable food following exposure to air or vapor cannabis. Studies conducted in mice used a combination of in vivo optical imaging, electrophysiology and chemogenetic manipulations to determine the importance of MBH neurons for cannabis-induced feeding behavior. Our data indicate that cannabis vapor increased meal frequency and food seeking behavior without altering locomotor activity. Importantly, we observed augmented MBH activity within distinct neuronal populations when mice anticipated or consumed food. Mechanistic experiments demonstrated that pharmacological activation of CB1R attenuated inhibitory synaptic tone onto hunger promoting Agouti Related Peptide (AgRP) neurons within the MBH. Lastly, chemogenetic inhibition of AgRP neurons attenuated the appetite promoting effects of cannabis vapor. Based on these results, we conclude that MBH neurons contribute to the appetite stimulatory properties of inhaled cannabis.
MeSH term(s)	Mice ; Rats ; Animals ; Appetite ; Cannabis/metabolism ; Agouti-Related Protein/metabolism ; Eating/physiology ; Hypothalamus/metabolism ; Neurons/metabolism ; Hallucinogens/pharmacology
Chemical Substances	Agouti-Related Protein ; Hallucinogens
Language	English
Publishing date	2023-12-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-50112-5
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