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Article ; Online: Correction to: A New Approach for Dry Eye Management by Mucoadhesive In situ Gel of Vitamin B12: Formulation, In vitro and In vivo Assessment.

Mohamad, Soad A / Alaaeldin, Eman / Abdallah, Raafat M A / Mansour, Heba F

2021 Volume 22, Issue 3, Page(s) 124

Language	English
Publishing date	2021-04-06
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2052070-0
ISSN	1530-9932 ; 1530-9932
ISSN (online)	1530-9932
ISSN	1530-9932
DOI	10.1208/s12249-021-01991-2
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Article ; Online: Insulin fast-dissolving film for intranasal delivery via olfactory region, a promising approach for the treatment of anosmia in COVID-19 patients: Design, in-vitro characterization and clinical evaluation.

Mohamad, Soad A / Badawi, Ahmed M / Mansour, Heba F

International journal of pharmaceutics

2021 Volume 601, Page(s) 120600

Abstract: The present work aimed to formulate intranasal insulin fast-dissolving films for treatment of anosmia in patients post COVID-19 infection. Variant films were prepared employing the casting method and using hydroxypropyl methyl cellulose and polyvinyl ... ...

Abstract	The present work aimed to formulate intranasal insulin fast-dissolving films for treatment of anosmia in patients post COVID-19 infection. Variant films were prepared employing the casting method and using hydroxypropyl methyl cellulose and polyvinyl alcohol. The formulated films were investigated for insulin content, weight variation, surface pH, thickness, folding endurance and disintegration time. In vitro release study was conducted for the selected formulations (F6, F7, F8). A drug/polymer interaction was investigated in the optimized formulation (F7) employing Fourier transform infrared spectroscopy. Clinical study was accomplished for F7 on 20 patients. Sniffin's and olfactory discrimination tests were used for assessing patients. The formulated films displayed appropriate physical characteristics. F7 showed the shortest disintegration time (50 ± 7 s) and fastest release. It displayed compatibility between the drug and the used polymers. The results of the clinical study revealed a significant increase in the olfactory detection scores and olfactory discrimination values in the intervention group (7.9 ± 1.2, 6.7 ± 0.5 respectively) compared to placebo group (3 ± 0.8, 2.8 ± 1).. Intervention group showed significant differences between these scores before and after treatment while the placebo group did not display any significant differences. Thus, the optimized film can be considered as an auspicious approach for managing post COVID-19 anosmia.
MeSH term(s)	Anosmia ; COVID-19 ; Humans ; Insulin ; SARS-CoV-2 ; Solubility
Chemical Substances	Insulin
Language	English
Publishing date	2021-04-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2021.120600
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Article: In Vitro Anti-Diabetic, Anti-Inflammatory, Antioxidant Activities and Toxicological Study of Optimized

Syed Mohamad, Sharifah Nurul Akilah / Khatib, Alfi / So'ad, Siti Zaiton Mat / Ahmed, Qamar Uddin / Ibrahim, Zalikha / Nipun, Tanzina Sharmin / Humaryanto, Humaryanto / AlAjmi, Mohamed F / Khalifa, Shaden A M / El-Seedi, Hesham R

Pharmaceuticals (Basel, Switzerland)

2023 Volume 16, Issue 12

Abstract: Psychotria ... ...

Abstract	Psychotria malayana
Language	English
Publishing date	2023-12-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph16121692
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Article ; Online: Anti-otomycotic potential of nanoparticles of

Maher Zahran, Eman / Mohamad, Soad A / Yahia, Ramadan / Badawi, Ahmed M / Sayed, Ahmed M / Ramadan Abdelmohsen, Usama

Food & function

2022 Volume 13, Issue 21, Page(s) 11083–11096

Abstract: Otomycosis is a serious superficial mycotic infection of the outer ear canal caused by some pathogenic species ... ...

Abstract	Otomycosis is a serious superficial mycotic infection of the outer ear canal caused by some pathogenic species of
MeSH term(s)	Humans ; Otomycosis ; Moringa oleifera ; Nystatin/pharmacology ; Antifungal Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Nanoparticles ; Plant Extracts/pharmacology
Chemical Substances	Nystatin (1400-61-9) ; Antifungal Agents ; Anti-Infective Agents ; Plant Extracts
Language	English
Publishing date	2022-10-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d2fo02382b
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Article ; Online: A New Approach for Dry Eye Management By Mucoadhesive In situ Gel of Vitamin B12: Formulation, In vitro and In vivo Assessment.

Mohamad, Soad A / Alaaeldin, Eman / Abdallah, Raafat M A / Mansour, Heba F

AAPS PharmSciTech

2021 Volume 22, Issue 3, Page(s) 87

Abstract: The commitment of the existent study was to develop a mucoadhesive in situ gel systems of vitamin B12 for the management of dry eye disease. The gels were prepared using pluronic F-127 and either of chitosan, carbapol 971P, sodium alginate, or hydroxy ... ...

Abstract	The commitment of the existent study was to develop a mucoadhesive in situ gel systems of vitamin B12 for the management of dry eye disease. The gels were prepared using pluronic F-127 and either of chitosan, carbapol 971P, sodium alginate, or hydroxy propyl methyl cellulose. Drug-excipients compatibility was investigated by means of differential scanning calorimetry and Fourier transform infrared spectroscopy. The gels were characterized for pH, clarity, gelling capacity, viscosity, and adhesion. In vitro release of vitamin B12 from the selected gels was investigated. In vivo effectiveness of the selected gel was determined in rabbit models using Schirmer's and fluorescein tests. The compatibility studies revealed the possibility of incidence of drug/polymer interaction in some formulations. F2-containing pluronic F127 and hydroxypropyl methyl cellulose showed the most appropriate physical characterization and in vitro release profile. The prepared gels showed prolonged drug release with drug release mechanism of combined diffusion and erosion. The in vivo study revealed good effectiveness of the prepared mucoadhesive in situ gel system of vitamin B12 in the treatment of dry eye disease that was comparable to that of the marketed drops.
MeSH term(s)	Adhesives ; Animals ; Drug Compounding ; Drug Delivery Systems ; Drug Liberation ; Dry Eye Syndromes/drug therapy ; Excipients ; Female ; Gels ; Hypromellose Derivatives ; Male ; Mucous Membrane ; Poloxamer ; Rabbits ; Viscosity ; Vitamin B 12/administration & dosage ; Vitamin B 12/therapeutic use ; Vitamins/administration & dosage ; Vitamins/therapeutic use
Chemical Substances	Adhesives ; Excipients ; Gels ; Vitamins ; Poloxamer (106392-12-5) ; Hypromellose Derivatives (3NXW29V3WO) ; Vitamin B 12 (P6YC3EG204)
Language	English
Publishing date	2021-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2052070-0
ISSN	1530-9932 ; 1530-9932
ISSN (online)	1530-9932
ISSN	1530-9932
DOI	10.1208/s12249-021-01957-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Study of Different Local Treatments of Post COVID-19 Smell Dysfunction.

Mohamad, Soad A / Badawi, Ahmed M / El-Sabaa, Ramy M / Ahmad, Hosam M / Mohamed, Asmaa S

Iranian journal of otorhinolaryngology

2022 Volume 34, Issue 125, Page(s) 281–288

Abstract: Introduction: This study was designed to differentiate between the impact of the topical nasal spray of corticosteroids, antihistamines, a combination of them, and normal 0.2% saline in treating patients with post-coronavirus disease 2019 (COVID-19) ... ...

Abstract	Introduction: This study was designed to differentiate between the impact of the topical nasal spray of corticosteroids, antihistamines, a combination of them, and normal 0.2% saline in treating patients with post-coronavirus disease 2019 (COVID-19) smell dysfunction. Materials and methods: Patients with hyposmia or anosmia (n = 240), who recently recovered from COVID-19, were enrolled in this trial and were randomly assigned to four parallel groups. Group I (G1) received a combination of topical corticosteroid and antihistamine nasal spray (n = 60). Group II (G2) received topical corticosteroid nasal spray (n = 60). Group III (G3) received antihistamine nasal spray (n = 60). Group IV (G4) received 0.2% normal nasal saline nasal spray (n = 60). The treatments were used in all groups for 3 weeks. The sense of smell was assessed using the butanol threshold and discrimination tests. The smell tests were evaluated weekly for 3 weeks. Results: The mean age of the patients was 51.9 ± 7.1 years; moreover, 83.8% and 16.2% were male and female, respectively. The results of the smell tests in the first week significantly improved with those in the third week (P< 0.001). The greatest degree of improvement was found in the first group, followed by the second, third, and fourth groups. Conclusions: The results suggest the ability of combination therapy of corticosteroid and antihistamine nasal spray to manage post-COVID-19 hyposmia or anosmia; however, this combination therapy was not superior to corticosteroid nasal spray. Trial registration ID: UMIN000043537.
Language	English
Publishing date	2022-02-04
Publishing country	Iran
Document type	Journal Article
ZDB-ID	3018470-8
ISSN	2251-726X ; 2251-7251
ISSN (online)	2251-726X
ISSN	2251-7251
DOI	10.22038/IJORL.2022.58339.3012
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Article ; Online: Cholecalciferol-load films for the treatment of nasal burns caused by cauterization of the hypertrophied inferior turbinate: formulation, in vivo study, and clinical assessment.

Mohamad, Soad A / Badwi, Ahmed M / Elrehany, Mahmoud / Ali, Sherif / Helmy, Abdelrahman M

Drug delivery and translational research

2022 Volume 13, Issue 4, Page(s) 1102–1115

Abstract: Nasal turbinate hypertrophy is among the most common nasal obstruction disorders, affecting the patient's quality of life significantly. Endoscopic submucosal diathermy is a prevalent cauterization procedure for treating turbinate hypertrophy. ... ...

Abstract	Nasal turbinate hypertrophy is among the most common nasal obstruction disorders, affecting the patient's quality of life significantly. Endoscopic submucosal diathermy is a prevalent cauterization procedure for treating turbinate hypertrophy. Regrettably, the nasal burn associated with diathermy typically heals slowly causing facial pain and nasal bleeding and possibly resulting in synechiae formation. In the current study, we have developed, for the first time, a polymeric film loaded with cholecalciferol for local treatment of nasal burns. The casting method was used to prepare films of different compositions of polymers such as chitosan, polyvinyl alcohol (PVA), Carbopol 971p (CP971p), and hydroxypropyl methylcellulose (HPMC) as well as a plasticizer. Several characterizations were performed for the cholecalciferol-loaded films (e.g. weight, thickness, content uniformity, surface pH, folding endurance, disintegration time, and in vitro release) to select the optimal formulation. The optimal formulation (F4) displayed compatibility between the used polymers and the drug. In vivo animal study was carried out to assess the healing efficacy of the formulated cholecalciferol-loaded film. The rabbits treated with the cholecalciferol-loaded film demonstrated significantly higher mRNA expression of the growth factor TGF-β and significantly lower mRNA expression of the proinflammatory cytokine TNF-α and IL-1β compared to the plain film treated group and the untreated control group. A randomized, single-blinded, parallel, controlled clinical trial was conducted on 20 patients scheduled to undergo endoscopic submucous diathermy. The results of the clinical study demonstrated significant reductions in facial pain and nasal bleeding scores for the nostrils treated with cholecalciferol-loaded films in comparison to the nostrils treated with plain films. Furthermore, the endoscopic examination showed good healing for 95% of the cholecalciferol-loaded film-treated nostrils. In conclusion, the optimized film can be considered an opportune approach for enhancing the healing rate of nasal burns and thus reducing the downsides of the diathermy procedure.
MeSH term(s)	Animals ; Rabbits ; Burns ; Cautery/methods ; Epistaxis ; Hypertrophy/surgery ; Polymers ; Quality of Life ; RNA, Messenger ; Turbinates ; Humans
Chemical Substances	Polymers ; RNA, Messenger
Language	English
Publishing date	2022-12-12
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2590155-2
ISSN	2190-3948 ; 2190-393X
ISSN (online)	2190-3948
ISSN	2190-393X
DOI	10.1007/s13346-022-01275-7
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Article ; Online: Vitis vinifera

Elmaidomy, Abeer H / Mohamad, Soad A / Abdelnaser, Mahmoud / Yahia, Ramadan / Mokhtar, Fatma A / Alsenani, Faisal / Badr, Moutaz Y / Almaghrabi, Safa Y / Altemani, Faisal H / Alzubaidi, Mubarak A / Saber, Entesar Ali / Elrehany, Mahmoud A / Abdelmohsen, Usama Ramadan / Sayed, Ahmed M

Food & function

2023 Volume 14, Issue 15, Page(s) 7156–7175

Abstract: ... Vitis ... ...

Abstract	Vitis vinifera
MeSH term(s)	Vitis ; Wound Healing ; Anti-Bacterial Agents/chemistry ; Liposomes/chemistry ; Gels ; Phytochemicals/pharmacology ; Plant Extracts/chemistry
Chemical Substances	carboxypolymethylene (0A5MM307FC) ; Anti-Bacterial Agents ; Liposomes ; Gels ; Phytochemicals ; Plant Extracts
Language	English
Publishing date	2023-07-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d2fo03212k
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Article ; Online: Bucco-Adhesive Film as a Pediatric Proper Dosage Form for Systemic Delivery of Propranolol Hydrochloride: In-vitro and in-vivo Evaluation.

Mohamad, Soad A / Salem, Hesham / Yassin, Heba A / Mansour, Heba F

Drug design, development and therapy

2020 Volume 14, Page(s) 4277–4289

Abstract: Objective: To formulate and assess bucco-adhesive films of propranolol hydrochloride for pediatric use.: Methods: Different films were formulated adopting mucin, polyvinyl alcohol, chitosan and carbopol. A drug/polymer compatibility study was ... ...

Abstract	Objective: To formulate and assess bucco-adhesive films of propranolol hydrochloride for pediatric use. Methods: Different films were formulated adopting mucin, polyvinyl alcohol, chitosan and carbopol. A drug/polymer compatibility study was conducted adopting differential scanning calorimetry and Fourier transform infrared spectroscopy. The prepared films were physically investigated for variation of weight, propranolol content, thickness, surface pH, proportion of moisture, folding endurance and mucoadhesion. In vitro drug release study and kinetic analysis of the corresponding data have been conducted. The optimized formulation was selected for a bioavailability study using albino rabbits and adopting a developed HPLC method. The pharmacokinetic parameters of the drug were calculated following administration of the optimized film and the corresponding marketed oral tablets to albino rabbits. Key finding: The compatibility study revealed the absence of drug/polymer interaction. The film formulations had suitable mucoadhesive and mechanical properties. The optimized formulation exhibited reasonable drug release that followed Higuchi diffusion pattern. The calculated AUC0-8h presented an enhancement in the bioavailability of propranolol hydrochloride from the selected film formulation by 1.9 times relative to the marketed propranolol oral tablets. Conclusion: These findings support that propranolol hydrochloride bucco-adhesive film can be considered as a proper effective dosage form for pediatric delivery.
MeSH term(s)	Adhesiveness ; Adhesives ; Administration, Buccal ; Adrenergic beta-Antagonists/administration & dosage ; Adrenergic beta-Antagonists/chemistry ; Adrenergic beta-Antagonists/pharmacology ; Animals ; Area Under Curve ; Biological Availability ; Cheek ; Child ; Chromatography, High Pressure Liquid ; Dosage Forms ; Drug Compounding ; Excipients ; Humans ; Hydrogen-Ion Concentration ; Infant ; Propranolol/administration & dosage ; Propranolol/pharmacokinetics ; Propranolol/pharmacology ; Rabbits
Chemical Substances	Adhesives ; Adrenergic beta-Antagonists ; Dosage Forms ; Excipients ; Propranolol (9Y8NXQ24VQ)
Language	English
Publishing date	2020-10-15
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S267317
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Article ; Online: New Acaciin-Loaded Self-Assembled Nanofibers as M

Mohamad, Soad A / Zahran, Eman Maher / Abdel Fadeel, Maha Raafat / Albohy, Amgad / Safwat, Mohamed A

International journal of nanomedicine

2021 Volume 16, Page(s) 1789–1804

Abstract: Background: SARS-COVID-2 has recently been one of the most life-threatening problems which urgently needs new therapeutic antiviral agents, especially those of herbal origin.: Purpose: The study aimed to load acaciin (ACA) into the new self-assembled ...

Abstract	Background: SARS-COVID-2 has recently been one of the most life-threatening problems which urgently needs new therapeutic antiviral agents, especially those of herbal origin. Purpose: The study aimed to load acaciin (ACA) into the new self-assembled nanofibers (NFs) followed by investigating their possible antiviral effect against bovine coronavirus (BCV) as a surrogate model for SARS-COV-2. Methods: ACA was identified using Results: Core/shell NFs, ranging between 80-330 nm with tiny thorn-like branches, were formed which attained an enhanced encapsulation efficiency (97.5 ± 0.53%, P<0.05) and a dual controlled release (a burst release of 65% at 1 h and a sustained release up to >24 h). The antiviral investigation of the formed NFs revealed a significant inhibition of 98.88 ± 0.16% (P<0.05) with IC Conclusion: The results introduced a new, time/cost-saving strategy for the synthesis of biodegradable NFs without the need for electric current or hazardous cross-linking agents. Moreover, it provided an innovative avenue for the discovery of drugs of herbal origin for the fight against SARS-CoV-2 infection.
MeSH term(s)	Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; COVID-19/virology ; Cell Line ; Coronavirus, Bovine/drug effects ; Glycosides/chemistry ; Glycosides/isolation & purification ; Glycosides/pharmacology ; Glycosides/therapeutic use ; Humans ; Ligands ; Models, Biological ; Molecular Docking Simulation ; Nanofibers/chemistry ; Nanofibers/ultrastructure ; SARS-CoV-2/drug effects ; Solvents ; Ultraviolet Rays ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents ; Glycosides ; Ligands ; Solvents ; linarin (HBH2I685IU)
Language	English
Publishing date	2021-03-02
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S298900
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