LIVIVO - Search results -

Search results

Result 1 - 10 of total 1142

Search options

Article ; Online: Author Correction: Mebendazole augments sensitivity to sorafenib by targeting MAPK and BCL-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma.

Younis, Nancy S / Ghanim, Amal M H / Saber, Sameh

2022 Volume 12, Issue 1, Page(s) 13607

Language	English
Publishing date	2022-08-10
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-17580-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Tuning the Properties of Tetracene-Based Nanoribbons by Fluorination and N-Doping.

Younis, Umer / Muhammad, Imran / Kawazoe, Yoshiyuki / Sun, Qiang

Chemphyschem : a European journal of chemical physics and physical chemistry

2019 Volume 20, Issue 21, Page(s) 2799–2805

Abstract: The structural stabilities and electronic properties are studied for the recently synthesized one-dimensional (1-D) tetracene-based nanoribbons with four-membered rings by using first-principles calculation. All three configurations (named as straight, ... ...

Abstract	The structural stabilities and electronic properties are studied for the recently synthesized one-dimensional (1-D) tetracene-based nanoribbons with four-membered rings by using first-principles calculation. All three configurations (named as straight, zigzag, and armchair) are stable and exhibit an indirect band gap of 1.46, 0.73, and 0.32 eV, respectively. The band gaps can be effectively tuned by substituting hydrogen with fluorine atoms and by doping with nitrogen atoms. Substituting hydrogen with fluorine atoms leads to gradual decrease of the electronic band gaps of all configurations. Nitrogen doping changes the band gap from indirect to direct, displaying flexibility of tuning the band structure.
Language	English
Publishing date	2019-09-09
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1439-7641
ISSN (online)	1439-7641
DOI	10.1002/cphc.201900803
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article ; Online: Mebendazole augments sensitivity to sorafenib by targeting MAPK and BCL-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma.

Younis, Nancy S / Ghanim, Amal M H / Saber, Sameh

Scientific reports

2019 Volume 9, Issue 1, Page(s) 19095

Abstract: ... other than its anti-tubulin activity. MBZ (100 mg/kg/day, P.O.) was administered to N-nitrosodiethylamine-induced HCC ...

Abstract	Sorafenib (SO) is a multi-kinase inhibitor that targets upstream signals in the MAPK pathway. Drug resistance and transient survival benefits are the main obstacles associated with SO treatment in Hepatocellular carcinoma (HCC) patients. Mebendazole (MBZ), an anthelmintic agent, has demonstrated activity against various cancer types. Therefore, we aimed to investigate the possible mechanisms of MBZ other than its anti-tubulin activity. MBZ (100 mg/kg/day, P.O.) was administered to N-nitrosodiethylamine-induced HCC mice as a monotherapeutic agent or in combination with SO. Our results revealed that MBZ decreased AFP levels, improved liver function and histology and increased survival in HCC mice, particularly when administered in combination with SO. MBZ also reduced hepatic inflammation and fibrogenesis as evidenced by reductions in TNF-α and TGF-β1 levels, respectively. Increased hepatic caspases-3 and -9 and decreased BCL-2 levels suggest induced-cell death. In addition, MBZ demonstrated anti-angiogenic, anti-metastatic, and anti-proliferative effects, as indicated by reduced VEGF levels, MMP-2:TIMP-1 ratios, and reduced cyclin D1 levels and Ki67 immunostaining, respectively. Our main finding was that MBZ targeted downstream signal of the MAPK pathway by inhibiting ERK1/2 phosphorylation. Targeting downstream MAPK signalling by MBZ and upstream signalling by SO is a novel approach to minimizing resistance and prolonging survival.
MeSH term(s)	Alanine Transaminase/metabolism ; Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Carcinoma, Hepatocellular/blood ; Carcinoma, Hepatocellular/drug therapy ; Cyclin D1/genetics ; Cyclin D1/metabolism ; Diethylnitrosamine ; Hep G2 Cells ; Humans ; Kaplan-Meier Estimate ; Ki-67 Antigen/metabolism ; Liver Neoplasms/blood ; Liver Neoplasms/drug therapy ; MAP Kinase Signaling System/drug effects ; Male ; Matrix Metalloproteinase 2/metabolism ; Mebendazole/pharmacology ; Mebendazole/therapeutic use ; Mice ; Mitogen-Activated Protein Kinases/metabolism ; Molecular Targeted Therapy ; Phosphorylation/drug effects ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Signal Transduction ; Sorafenib/pharmacology ; Sorafenib/therapeutic use ; Tissue Inhibitor of Metalloproteinase-1/metabolism ; Tumor Burden/drug effects ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Antineoplastic Agents ; Ki-67 Antigen ; Proto-Oncogene Proteins c-bcl-2 ; RNA, Messenger ; Tissue Inhibitor of Metalloproteinase-1 ; Vascular Endothelial Growth Factor A ; Cyclin D1 (136601-57-5) ; Diethylnitrosamine (3IQ78TTX1A) ; Mebendazole (81G6I5V05I) ; Sorafenib (9ZOQ3TZI87) ; Alanine Transaminase (EC 2.6.1.2) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Matrix Metalloproteinase 2 (EC 3.4.24.24)
Language	English
Publishing date	2019-12-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-55666-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: (E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by α7 nicotinic acetylcholine receptor potentiation.

Bagdas, Deniz / Sevdar, Gulce / Gul, Zulfiye / Younis, Rabha / Cavun, Sinan / Tae, Han-Shen / Ortells, Marcelo O / Arias, Hugo R / Gurun, Mine Sibel

Neurological research

2021 Volume 43, Issue 12, Page(s) 1056–1068

Abstract: Clinical intervention of pain is often accompanied by changes in affective behaviors, so both assays of affective and sensorial aspects of nociception play an important role in the development of novel analgesics. Although positive allosteric modulation ( ...

Abstract	Clinical intervention of pain is often accompanied by changes in affective behaviors, so both assays of affective and sensorial aspects of nociception play an important role in the development of novel analgesics. Although positive allosteric modulation (PAM) of α7 nicotinic acetylcholine receptors (nAChRs) has been recognized as a novel approach for the relief of sensorial aspects of pain, their effects on affective components of pain remain unclear. Therefore, we investigated whether PAM-4, a highly selective α7-nAChR PAM, attenuates inflammatory and neuropathic pain, as well as the concomitant depressive/anxiety comorbidities. The anti-nociceptive activity of PAM-4 was assessed in mice using the formalin test and chronic constriction injury (CCI)-induced neuropathic pain model. The anxiolytic- and antidepressant-like activity of PAM-4 was evaluated using the marble burying test and forced swimming test. Acute systemic administration of PAM-4 dose-dependently reversed formalin-induced paw licking behavior and CCI-induced mechanical allodynia without development of any motor impairment. PAM-4 reversed the decreased swimming time and number of buried marbles in CCI-treated mice, suggesting that this ligand attenuates chronic pain-induced depression-like behavior and anxiogenic-like effects. The effects of PAM-4 were inhibited by the α7-selective antagonist methyllycaconitine, indicating molecular mechanism mediated by α7-nAChRs. Indeed, electrophysiological recordings showed the PAM-4 enhances human α7 nAChRs with higher potency and efficacy compared to rat α7 nAChRs. These findings suggest that PAM-4 reduces both sensorial and affective behaviors induced by chronic pain in mice by α7-nAChR potentiation. PAM-4 deserves further investigations for the management of chronic painful conditions with comorbidities.
MeSH term(s)	Acrylamides/pharmacology ; Analgesics/pharmacology ; Animals ; Anxiety/etiology ; Behavior, Animal/drug effects ; Depression/etiology ; Male ; Mice ; Mice, Inbred BALB C ; Neuralgia/metabolism ; Neuralgia/psychology ; Nociception/drug effects ; alpha7 Nicotinic Acetylcholine Receptor/agonists
Chemical Substances	Acrylamides ; Analgesics ; N-phenylacrylamide ; alpha7 Nicotinic Acetylcholine Receptor
Language	English
Publishing date	2021-07-19
Publishing country	England
Document type	Journal Article
ZDB-ID	424428-x
ISSN	1743-1328 ; 0161-6412
ISSN (online)	1743-1328
ISSN	0161-6412
DOI	10.1080/01616412.2021.1949684
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1491: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Analytical studies on the 2-naphthoyl substituted-1-n-pentylindoles: Regioisomeric synthetic cannabinoids.

Thaxton-Weissenfluh, Amber / Alsegiani, Amsha S / Abiedalla, Younis / DeRuiter, Jack / Smith, Forrest / Clark, C Randall

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2018 Volume 1077-1078, Page(s) 77–84

Abstract: The six 1-n-pentyl-2-, 3-, 4-, 5-, 6- and 7-(2-naphthoyl)-indoles each have the same substituents ...

Abstract	The six 1-n-pentyl-2-, 3-, 4-, 5-, 6- and 7-(2-naphthoyl)-indoles each have the same substituents attached to the indole ring, identical elemental composition (C
MeSH term(s)	Cannabinoids/analysis ; Cannabinoids/chemistry ; Gas Chromatography-Mass Spectrometry ; Indoles/analysis ; Indoles/chemistry ; Isomerism ; Models, Molecular ; Naphthalenes/analysis ; Naphthalenes/chemistry
Chemical Substances	1-pentyl-3-(1-naphthoyl)indole ; Cannabinoids ; Indoles ; Naphthalenes
Language	English
Publishing date	2018-03-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1180823-8
ISSN	1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
ISSN (online)	1873-376X
ISSN	0378-4347 ; 1570-0232 ; 1387-2273
DOI	10.1016/j.jchromb.2018.01.036
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 813: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: The effect of intravenous infusion of N-acetyl cysteine in cirrhotic patients undergoing liver resection: A randomized controlled trial.

Sayed, Eman / Gaballah, Khaled / Younis, Eman / Yassen, Khaled / El-Einen, Abo K

Journal of anaesthesiology, clinical pharmacology

2017 Volume 33, Issue 4, Page(s) 450–456

Abstract: ... to evaluate the effect of N-acetyl cysteine (NAC) on liver enzymes (alanine aminotransferase [ALT] and ...

Abstract	Background and aims: Liver resection can lead to hepatocellular dysfunction. The aim was to evaluate the effect of N-acetyl cysteine (NAC) on liver enzymes (alanine aminotransferase [ALT] and aspartate aminotransferase [AST]), international normalized ratio (INR), C-reactive protein (CRP), and intercellular adhesion molecule 1 (ICAM 1) in cirrhotic patients undergoing liver resection. Material and methods: A randomized controlled trial (RCT), Pan African Clinical Trial registry (PACTR201508001251260). 60 Child A patients were studied. NAC group ( Results: ALT and AST were significantly elevated after surgery, but to a less extent with NAC versus C (day 3; 118.3 ± 18.6 vs. 145.4 ± 14.0 U/L. P < 0.01) and (121.5 ± 19.5 vs. 146.6 ± 15.1 U/L, Conclusion: Prophylactic NAC in hepatic patients undergoing liver surgery attenuated postoperative increase in transaminases, ICAM 1, and CRP blood levels. The impact of these findings and the cost benefit of reduced hospital stay on enhanced recovery after surgery needs to be evaluated.
Language	English
Publishing date	2017-02-15
Publishing country	India
Document type	Journal Article
ZDB-ID	1401760-x
ISSN	0970-9185
ISSN	0970-9185
DOI	10.4103/joacp.JOACP_70_17
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4830: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Evaluation of The Nuclear Data on(Î±,n)Reaction for Natural Molybdenum

H.M.T. Hamadani / T.A. Younis / S. A. Ebrahiem

Ibn Al-Haitham Journal for Pure and Applied Sciences, Vol 23, Iss

2017 Volume 3

Abstract: The cross section evaluation for (Î±,n) reaction was calculated according to the available ... n) cross sections which was used to calculate the neutron yield for (Mo) for the first time ...

Abstract	The cross section evaluation for (Î±,n) reaction was calculated according to the available International Atomic Energy Agency (IAEA) and other experimental published data . These cross section are the most recent data , while the well known international libraries like ENDF , JENDL , JEFF , etc. We considered an energy range from threshold to 25 MeV in interval (1 MeV). The average weighted cross sections for all available experimental and theoretical(JENDL) data and for all the considered isotopes was calculated . The cross section of the element is then calculated according to the cross sections of the isotopes of that element taking into account their abundance . A mathematical representative equation for each of the element and their isotopes are "formulated" they represent the variation of the cross section with energy . The evaluated (Î±,n) cross sections which was used to calculate the neutron yield for (Mo) for the first time ,which are very important in nuclear technology .
Keywords	Science ; Q
Language	English
Publishing date	2017-05-01T00:00:00Z
Publisher	University of Baghdad
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Mebendazole augments sensitivity to sorafenib by targeting MAPK and BCL-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma

Nancy S. Younis / Amal M. H. Ghanim / Sameh Saber

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 16

Abstract: ... of MBZ other than its anti-tubulin activity. MBZ (100 mg/kg/day, P.O.) was administered to N ...

Abstract	Abstract Sorafenib (SO) is a multi-kinase inhibitor that targets upstream signals in the MAPK pathway. Drug resistance and transient survival benefits are the main obstacles associated with SO treatment in Hepatocellular carcinoma (HCC) patients. Mebendazole (MBZ), an anthelmintic agent, has demonstrated activity against various cancer types. Therefore, we aimed to investigate the possible mechanisms of MBZ other than its anti-tubulin activity. MBZ (100 mg/kg/day, P.O.) was administered to N-nitrosodiethylamine-induced HCC mice as a monotherapeutic agent or in combination with SO. Our results revealed that MBZ decreased AFP levels, improved liver function and histology and increased survival in HCC mice, particularly when administered in combination with SO. MBZ also reduced hepatic inflammation and fibrogenesis as evidenced by reductions in TNF-α and TGF-β1 levels, respectively. Increased hepatic caspases-3 and -9 and decreased BCL-2 levels suggest induced-cell death. In addition, MBZ demonstrated anti-angiogenic, anti-metastatic, and anti-proliferative effects, as indicated by reduced VEGF levels, MMP-2:TIMP-1 ratios, and reduced cyclin D1 levels and Ki67 immunostaining, respectively. Our main finding was that MBZ targeted downstream signal of the MAPK pathway by inhibiting ERK1/2 phosphorylation. Targeting downstream MAPK signalling by MBZ and upstream signalling by SO is a novel approach to minimizing resistance and prolonging survival.
Keywords	Medicine ; R ; Science ; Q
Subject code	570 ; 616
Language	English
Publishing date	2019-12-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Hydroamination of diphenylbutadiyne with secondary N-methyl-anilines using the dipotassium tetrakis(2,6-diisopropylanilino)calciate precatalyst.

Younis, Fadi M / Krieck, Sven / Görls, Helmar / Westerhausen, Matthias

Dalton transactions (Cambridge, England : 2003)

2016 Volume 45, Issue 14, Page(s) 6241–6250

Abstract: The approved precatalyst [K2Ca{N(H)Dipp}4] was employed to study the hydroamination ... of diphenylbutadiyne with N-methyl-anilines in tetrahydrofuran at room temperature. The hydroamination occurs ... regioselectively within a few hours yielding (N-methyl)-(N-aryl)-1,4-diphenylbut-1-ene-3-yne-1-ylamine with phenyl ...

Abstract	The approved precatalyst [K2Ca{N(H)Dipp}4] was employed to study the hydroamination of diphenylbutadiyne with N-methyl-anilines in tetrahydrofuran at room temperature. The hydroamination occurs regioselectively within a few hours yielding (N-methyl)-(N-aryl)-1,4-diphenylbut-1-ene-3-yne-1-ylamine with phenyl (1a), 4-tolyl (1b) and 4-fluorophenyl groups (1c). In all cases a mixture of E- and Z-isomers is obtained. The second hydroamination step requires drastically extended reaction times and is successful only for the reaction of diphenylbutadiyne with N-methyl-aniline and N-methyl-4-fluoroaniline giving 1,4-diphenyl-1,4-bis(N-methyl-anilino)buta-1,3-diene [R = H (2a) and F (2c)]; a mixture of E,E-, E,Z- and Z,Z-isomers is obtained. The X-ray structures of E-1a, E-1b and E-1c show a slightly shortened N-C bond to the alkene moieties. Due to enhanced steric strain the anilino units of Z,Z-2c and Z,Z-3 turn away from the butadiene unit and consequently, the lone pair at the planar nitrogen atoms slightly interacts with the adjacent aryl groups.
Language	English
Publishing date	2016-04-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/c5dt03818a
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: GC-MS and GC-IR Analyses of the Methoxy-1-n-pentyl-3-(1-naphthoyl)-indoles: Regioisomeric Designer Cannabinoids.

Thaxton-Weissenfluh, Amber / Belal, Tarek S / DeRuiter, Jack / Smith, Forrest / Abiedalla, Younis / Neel, Logan / Abdel-Hay, Karim M / Clark, C Randall

Journal of chromatographic science

2018 Volume 56, Issue 9, Page(s) 779–788

Abstract: The indole ring regioisomeric methoxy-1-n-pentyl-3-(1-naphthoyl)-indoles represent indole ring ...

Abstract	The indole ring regioisomeric methoxy-1-n-pentyl-3-(1-naphthoyl)-indoles represent indole ring-substituted analogs of the synthetic cannabinoid JWH-018. The electron ionization mass spectra show equivalent regioisomeric major fragments resulting from cleavage of the groups attached to the central indole nucleus. The characteristic (M-17)+ fragment ion at m/z 354 resulting from the loss of OH group is significant in the mass spectra of all four compounds. Fragmentation of the naphthoyl and/or pentyl groups yields the cations at m/z 314, 300, 244 and 216. The vapor-phase infrared spectra provide a number of characteristic absorption bands to identify the individual isomers. Gas chromatographic separations on a capillary column containing a film of trifluoropropylmethyl polysiloxane (Rtx-200) provided excellent resolution of these compounds, their precursor indoles and intermediate pentylindoles. The elution order appears related to the degree of crowding of indole ring substituents.
MeSH term(s)	Cannabinoids/analysis ; Cannabinoids/chemistry ; Designer Drugs/analysis ; Designer Drugs/chemistry ; Gas Chromatography-Mass Spectrometry/methods ; Indoles/analysis ; Indoles/chemistry ; Isomerism ; Naphthalenes/analysis ; Naphthalenes/chemistry ; Spectrophotometry, Infrared/methods
Chemical Substances	Cannabinoids ; Designer Drugs ; Indoles ; Naphthalenes ; 1-pentyl-3-(1-naphthoyl)indole (G391998J57)
Language	English
Publishing date	2018-06-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	80141-0
ISSN	1945-239X ; 0021-9665
ISSN (online)	1945-239X
ISSN	0021-9665
DOI	10.1093/chromsci/bmy059
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 895: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito