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Article ; Online: Nutrition in the cause and prevention of cancer: An update.

Adhami, Vaqar Mustafa / Mukhtar, Hasan

2016 Volume 60, Issue 6, Page(s) 1226–1227

MeSH term(s)	Diet ; Humans ; Neoplasms ; Nutrients ; Nutritional Status
Chemical Substances	Nutrients
Language	English
Publishing date	2016-06-07
Publishing country	Germany
Document type	Editorial ; Comment
ZDB-ID	2160372-8
ISSN	1613-4133 ; 1613-4125
ISSN (online)	1613-4133
ISSN	1613-4125
DOI	10.1002/mnfr.201670064
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Article ; Online: Nanoencapsulated dietary polyphenols for cancer prevention and treatment: successes and challenges.

Tabrez, Shams / Jabir, Nasimudeen R / Adhami, Vaqar Mustafa / Khan, Mohammad Imran / Moulay, Mohammed / Kamal, Mohammad Amjad / Mukhtar, Hasan

Nanomedicine (London, England)

2020 Volume 15, Issue 11, Page(s) 1147–1162

Abstract: Many dietary polyphenols have been investigated for their therapeutic potential either as single agents or in combinations. Despite the significant anticancer potential of these polyphenols ... ...

Abstract	Many dietary polyphenols have been investigated for their therapeutic potential either as single agents or in combinations. Despite the significant anticancer potential of these polyphenols in
MeSH term(s)	Animals ; Catechin/pharmacology ; Curcumin/pharmacology ; Humans ; Neoplasms/drug therapy ; Neoplasms/prevention & control ; Polyphenols/pharmacology ; Quercetin ; Resveratrol
Chemical Substances	Polyphenols ; Catechin (8R1V1STN48) ; Quercetin (9IKM0I5T1E) ; Curcumin (IT942ZTH98) ; Resveratrol (Q369O8926L)
Language	English
Publishing date	2020-04-15
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2277839-1
ISSN	1748-6963 ; 1743-5889
ISSN (online)	1748-6963
ISSN	1743-5889
DOI	10.2217/nnm-2019-0398
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Zs.A 6617: Show issues

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Article ; Online: Cancer chemoprevention is not a failure.

Adhami, Vaqar Mustafa / Bailey, Howard H / Mukhtar, Hasan

Carcinogenesis

2014 Volume 35, Issue 9, Page(s) 2154–2155

MeSH term(s)	Chemoprevention ; Humans ; Neoplasms/prevention & control
Language	English
Publishing date	2014-09
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	603134-1
ISSN	1460-2180 ; 0143-3334
ISSN (online)	1460-2180
ISSN	0143-3334
DOI	10.1093/carcin/bgu141
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Zs.A 1558: Show issues

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Article ; Online: Dietary flavonoid fisetin for cancer prevention and treatment.

Lall, Rahul K / Adhami, Vaqar Mustafa / Mukhtar, Hasan

Molecular nutrition & food research

2016 Volume 60, Issue 6, Page(s) 1396–1405

Abstract: Cancer remains a major public health concern and a significant cause of death worldwide. Identification of bioactive molecules that have the potential to inhibit carcinogenesis continues to garner interest among the scientific community. In particular, ... ...

Abstract	Cancer remains a major public health concern and a significant cause of death worldwide. Identification of bioactive molecules that have the potential to inhibit carcinogenesis continues to garner interest among the scientific community. In particular, flavonoids from dietary sources are the most sought after because of their safety, cost-effectiveness, and feasibility of oral administration. Emerging data have provided newer insights into understanding the molecular mechanisms that are essential to identify novel mechanism-based strategies for cancer prevention and treatment. Dietary flavonoid fisetin (3,3',4',7-tetrahydroxyflavone) found in many fruits and vegetables has been shown in preclinical studies to inhibit cancer growth through alteration of cell cycle, inducing apoptosis, angiogenesis, invasion, and metastasis without causing any toxicity to normal cells. Although data from in-vitro and in-vivo studies look convincing, well-designed clinical trials in humans are needed to conclusively determine the efficacy across various cancers. This review highlights the chemopreventive and therapeutic effects, molecular targets, and mechanisms that contribute to the observed anticancer activity of fisetin against various cancers.
MeSH term(s)	Animals ; Anticarcinogenic Agents/pharmacology ; Carcinogenesis/drug effects ; Cell Line, Tumor ; Chemoprevention ; Female ; Flavonoids/pharmacology ; Fruit/chemistry ; Humans ; Male ; Neoplasms/drug therapy ; Neoplasms/prevention & control ; Polyphenols/pharmacology ; Vegetables/chemistry
Chemical Substances	Anticarcinogenic Agents ; Flavonoids ; Polyphenols ; fisetin (OO2ABO9578)
Language	English
Publishing date	2016-05-06
Publishing country	Germany
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	2160372-8
ISSN	1613-4133 ; 1613-4125
ISSN (online)	1613-4133
ISSN	1613-4125
DOI	10.1002/mnfr.201600025
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Article ; Online: Targeting epigenome with dietary nutrients in cancer: Current advances and future challenges.

Khan, Mohammad Imran / Rath, Suvasmita / Adhami, Vaqar Mustafa / Mukhtar, Hasan

Pharmacological research

2017 Volume 129, Page(s) 375–387

Abstract: Tumorigenesis and epigenetic are closely linked with each other. Epigenetic changes are potential regulators of gene expression without involving any change in the DNA itself. More interestingly, epigenetic changes are reversible heritable changes which ... ...

Abstract	Tumorigenesis and epigenetic are closely linked with each other. Epigenetic changes are potential regulators of gene expression without involving any change in the DNA itself. More interestingly, epigenetic changes are reversible heritable changes which pass through generations. Many dietary bioactive ingredients regulate epigenetic control of cells and influence biochemical processes. Correlation between epigenetic regulation and cancer onset has been well established. Recent studies provide important information on the role of bioactive dietary components in cancer prevention and therapy. Several bioactive components are responsible for modification of the epigenome by affecting DNA methylation, histone modification, micro RNAs (miRNAs) and long non-coding RNAs (lncRNAs). This review summarizes recent advancements in this field and describes the role of many bioactive components in regulating human epigenome and how these modifications can be exploited for prevention and treatment of cancer.
MeSH term(s)	Animals ; Diet ; Epigenesis, Genetic ; Humans ; Neoplasms/genetics ; Neoplasms/therapy ; Nutrients/pharmacology ; Nutrients/therapeutic use
Chemical Substances	Nutrients
Language	English
Publishing date	2017-12-09
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2017.12.008
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Zs.A 721: Show issues

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Article: Human cancer chemoprevention: hurdles and challenges.

Adhami, Vaqar Mustafa / Mukhtar, Hasan

Topics in current chemistry

2013 Volume 329, Page(s) 203–220

Abstract: Cancer is considered a disease of aging since the risk for developing the disease considerably increases with age. It is estimated that 77% of all cancers are diagnosed in people who fall within the age group of 55 or older. Also, it takes several years ... ...

Abstract	Cancer is considered a disease of aging since the risk for developing the disease considerably increases with age. It is estimated that 77% of all cancers are diagnosed in people who fall within the age group of 55 or older. Also, it takes several years from initiation to the development of detectable cancer. One advantage of the long latency is that it provides numerous opportunities for intervention. While intervention approaches cannot be geared towards a whole population, they can nevertheless be directed towards a defined group of people who have a greater relative risk for developing the disease. The idea of cancer prevention through the use of nontoxic agents, preferably from dietary sources, has therefore emerged as an appropriate strategy for controlling the disease. An important aspect of chemoprevention is that agents can be designed for intervention at any stage during the multistage process of carcinogenesis. This process of slowing the progression of cancer is applicable to many cancers with long latency, including prostate cancer. Over the past two decades we have put considerable effort into identifying dietary substances in the form of extracts and pure compounds that can be used for the prevention of prostate and other cancers. Although cancer chemoprevention has proven to be a successful strategy in animals and, to some extent, we can say that the mission has been accomplished, its application to humans has met with limited success. This chapter will discuss various challenges associated with chemoprevention of cancer with the focus on studies with green tea and prostate cancer.
MeSH term(s)	Animals ; Chemoprevention ; Humans ; Middle Aged ; Neoplasms/prevention & control
Language	English
Publishing date	2013
Publishing country	Germany
Document type	Journal Article ; Review
ISSN	0340-1022
ISSN	0340-1022
DOI	10.1007/128_2012_342
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Article ; Online: Hypoxia driven glycation: Mechanisms and therapeutic opportunities.

Khan, Mohammad Imran / Rath, Suvasmita / Adhami, Vaqar Mustafa / Mukhtar, Hasan

Seminars in cancer biology

2017 Volume 49, Page(s) 75–82

Abstract: Tumor masses are deprived of oxygen and characterized by enhanced glucose uptake followed by glycolysis. Elevated glucose levels induce non-enzymatic glycosylation or glycation of proteins which leads to accumulation of advanced glycation end products ( ... ...

Abstract	Tumor masses are deprived of oxygen and characterized by enhanced glucose uptake followed by glycolysis. Elevated glucose levels induce non-enzymatic glycosylation or glycation of proteins which leads to accumulation of advanced glycation end products (AGE). These AGE molecules bind to their respective receptors called the receptor for advanced glycation end products (RAGE) and initiate several aberrant signaling pathways leading to onset of diseases such as diabetes, Alzheimer's, atherosclerosis, heart failure and cancer. The role of AGE in cancer progression is being extensively studied in recent years. As cancer cells are hypoxic in nature and adapted to glycolysis, which induces glycation, its effects need to be understood in greater detail. Since AGE-RAGE signaling is involved in cancer progression, inhibition of AGE-RAGE interaction could be a potential therapeutic target. The purpose of this review is to highlight the role of AGE-RAGE interaction in hypoxic cancer cells.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Cell Transformation, Neoplastic/drug effects ; Cell Transformation, Neoplastic/metabolism ; Glycation End Products, Advanced/antagonists & inhibitors ; Glycation End Products, Advanced/metabolism ; Glycosylation/drug effects ; Humans ; Hypoxia/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Molecular Targeted Therapy ; Protein Binding/drug effects ; Receptor for Advanced Glycation End Products/genetics ; Receptor for Advanced Glycation End Products/metabolism ; Signal Transduction/drug effects
Chemical Substances	Antineoplastic Agents ; Glycation End Products, Advanced ; Hypoxia-Inducible Factor 1, alpha Subunit ; Receptor for Advanced Glycation End Products
Language	English
Publishing date	2017-05-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	1033980-2
ISSN	1096-3650 ; 1044-579X
ISSN (online)	1096-3650
ISSN	1044-579X
DOI	10.1016/j.semcancer.2017.05.008
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Zs.A 2922: Show issues

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Article: Dietary flavonoid fisetin for cancer prevention and treatment

Lall, Rahul K / Adhami, Vaqar Mustafa / Mukhtar, Hasan

Molecular nutrition & food research. 2016 June, v. 60, no. 6

2016

Abstract	Cancer remains a major public health concern and a significant cause of death worldwide. Identification of bioactive molecules that have the potential to inhibit carcinogenesis continues to garner interest among the scientific community. In particular, flavonoids from dietary sources are the most sought after because of their safety, cost‐effectiveness, and feasibility of oral administration. Emerging data have provided newer insights into understanding the molecular mechanisms that are essential to identify novel mechanism‐based strategies for cancer prevention and treatment. Dietary flavonoid fisetin (3,3′,4′,7‐tetrahydroxyflavone) found in many fruits and vegetables has been shown in preclinical studies to inhibit cancer growth through alteration of cell cycle, inducing apoptosis, angiogenesis, invasion, and metastasis without causing any toxicity to normal cells. Although data from in‐vitro and in‐vivo studies look convincing, well‐designed clinical trials in humans are needed to conclusively determine the efficacy across various cancers. This review highlights the chemopreventive and therapeutic effects, molecular targets, and mechanisms that contribute to the observed anticancer activity of fisetin against various cancers.
Keywords	carcinogenesis ; death ; fruits ; oral administration ; humans ; neoplasms ; public health ; antineoplastic activity ; chemoprevention ; clinical trials ; metastasis ; dietary nutrient sources ; flavonoids ; cost effectiveness ; vegetables ; cell cycle ; toxicity ; angiogenesis ; apoptosis
Language	English
Dates of publication	2016-06
Size	p. 1396-1405.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	REVIEW ; 2019-12-06
ZDB-ID	2160372-8
ISSN	1613-4133 ; 1613-4125
ISSN (online)	1613-4133
ISSN	1613-4125
DOI	10.1002/mnfr.201600025
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Targeting microtubules by natural agents for cancer therapy.

Mukhtar, Eiman / Adhami, Vaqar Mustafa / Mukhtar, Hasan

Molecular cancer therapeutics

2014 Volume 13, Issue 2, Page(s) 275–284

Abstract: Natural compounds that target microtubules and disrupt the normal function of the mitotic spindle have proven to be one of the best classes of cancer chemotherapeutic drugs available in clinics to date. There is increasing evidence showing that even ... ...

Abstract	Natural compounds that target microtubules and disrupt the normal function of the mitotic spindle have proven to be one of the best classes of cancer chemotherapeutic drugs available in clinics to date. There is increasing evidence showing that even minor alteration of microtubule dynamics can engage the spindle checkpoint, arresting cell-cycle progression at mitosis and subsequently leading to cell death. Our improved understanding of tumor biology and our continued appreciation for what the microtubule targeting agents (MTAs) can do have helped pave the way for a new era in the treatment of cancer. The effectiveness of these agents for cancer therapy has been impaired, however, by various side effects and drug resistance. Several new MTAs have shown potent activity against the proliferation of various cancer cells, including resistance to the existing MTAs. Sustained investigation of the mechanisms of action of MTAs, development and discovery of new drugs, and exploring new treatment strategies that reduce side effects and circumvent drug resistance could provide more effective therapeutic options for patients with cancer. This review focuses on the successful cancer chemotherapy from natural compounds in clinical settings and the challenges that may abort their usefulness.
MeSH term(s)	Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Biological Products/adverse effects ; Biological Products/therapeutic use ; Cell Cycle Checkpoints/drug effects ; Humans ; Microtubules/metabolism ; Models, Biological ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Treatment Outcome ; Tubulin Modulators/adverse effects ; Tubulin Modulators/therapeutic use
Chemical Substances	Antineoplastic Agents ; Biological Products ; Tubulin Modulators
Language	English
Publishing date	2014-01-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2063563-1
ISSN	1538-8514 ; 1535-7163
ISSN (online)	1538-8514
ISSN	1535-7163
DOI	10.1158/1535-7163.MCT-13-0791
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Zs.A 5750: Show issues

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Article ; Online: Dietary flavonoid fisetin binds to β-tubulin and disrupts microtubule dynamics in prostate cancer cells.

Mukhtar, Eiman / Adhami, Vaqar Mustafa / Sechi, Mario / Mukhtar, Hasan

Cancer letters

2015 Volume 367, Issue 2, Page(s) 173–183

Abstract: Microtubule targeting based therapies have revolutionized cancer treatment; however, resistance and side effects remain a major limitation. Therefore, novel strategies that can overcome these limitations are urgently needed. We made a novel discovery ... ...

Abstract	Microtubule targeting based therapies have revolutionized cancer treatment; however, resistance and side effects remain a major limitation. Therefore, novel strategies that can overcome these limitations are urgently needed. We made a novel discovery that fisetin, a hydroxyflavone, is a microtubule stabilizing agent. Fisetin binds to tubulin and stabilizes microtubules with binding characteristics far superior than paclitaxel. Surface plasmon resonance and computational docking studies suggested that fisetin binds to β-tubulin with superior affinity compared to paclitaxel. Fisetin treatment of human prostate cancer cells resulted in robust up-regulation of microtubule associated proteins (MAP)-2 and -4. In addition, fisetin treated cells were enriched in α-tubulin acetylation, an indication of stabilization of microtubules. Fisetin significantly inhibited PCa cell proliferation, migration, and invasion. Nudc, a protein associated with microtubule motor dynein/dynactin complex that regulates microtubule dynamics, was inhibited with fisetin treatment. Further, fisetin treatment of a P-glycoprotein overexpressing multidrug-resistant cancer cell line NCI/ADR-RES inhibited the viability and colony formation. Our results offer in vitro proof-of-concept for fisetin as a microtubule targeting agent. We suggest that fisetin could be developed as an adjuvant for treatment of prostate and other cancer types.
MeSH term(s)	Acetylation ; Animals ; Binding Sites ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Flavonoids/chemistry ; Flavonoids/metabolism ; Flavonoids/pharmacology ; Male ; Microtubule-Associated Proteins/metabolism ; Microtubules/drug effects ; Microtubules/metabolism ; Molecular Docking Simulation ; Neoplasm Invasiveness ; Nuclear Proteins/metabolism ; Paclitaxel/pharmacology ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Protein Binding ; Protein Conformation ; Protein Processing, Post-Translational ; Protein Stability ; Signal Transduction/drug effects ; Surface Plasmon Resonance ; Time Factors ; Tubulin/chemistry ; Tubulin/metabolism ; Tubulin Modulators/metabolism ; Tubulin Modulators/pharmacology
Chemical Substances	Cell Cycle Proteins ; Flavonoids ; MAP2 protein, human ; MAP4 protein, human ; Microtubule-Associated Proteins ; NUDC protein, human ; Nuclear Proteins ; Tubulin ; Tubulin Modulators ; fisetin (OO2ABO9578) ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2015-10-28
Publishing country	Ireland
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2015.07.030
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