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Article ; Online: Reduction in blood pressure following acute dietary nitrate ingestion is correlated with increased red blood cell S-nitrosothiol concentrations.

Wei, Chenguang / Vanhatalo, Anni / Kadach, Stefan / Stoyanov, Zdravko / Abu-Alghayth, Mohammed / Black, Matthew I / Smallwood, Miranda J / Rajaram, Raghini / Winyard, Paul G / Jones, Andrew M

Nitric oxide : biology and chemistry

2023 Volume 138-139, Page(s) 1–9

Abstract: Dietary nitrate ( ... ...

Abstract	Dietary nitrate (NO
MeSH term(s)	Humans ; Blood Pressure ; Nitrates ; Nitrites ; Nitrogen Dioxide ; Nitric Oxide/pharmacology ; Dietary Supplements ; Hypotension ; Erythrocytes ; S-Nitrosothiols/pharmacology ; Eating ; Beta vulgaris ; Double-Blind Method
Chemical Substances	Nitrates ; Nitrites ; Nitrogen Dioxide (S7G510RUBH) ; Nitric Oxide (31C4KY9ESH) ; S-Nitrosothiols
Language	English
Publishing date	2023-05-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1362794-6
ISSN	1089-8611 ; 1089-8603
ISSN (online)	1089-8611
ISSN	1089-8603
DOI	10.1016/j.niox.2023.05.008
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Article ; Online: Importance and vulnerability of the world’s water towers

Immerzeel, W.W. / Lutz, A.F. / Andrade, M. / Bahl, A. / Biemans, H. / Bolch, T. / Hyde, S. / Brumby, S. / Davies, B.J. / Elmore, A.C. / Emmer, A. / Feng, M. / Fernández, A. / Haritashya, U. / Kargel, J.S. / Koppes, M. / Kraaijenbrink, P.D.A. / Kulkarni, A.V. / Mayewski, P.A. /

Nepal, S. / Pacheco, P. / Painter, T.H. / Pellicciotti, F. / Rajaram, H. / Rupper, S. / Sinisalo, A. / Shrestha, A.B. / Viviroli, D. / Wada, Y. / Xiao, C. / Yao, T. / Baillie, J.E.M.

Nature

2020 Volume 577, Issue 7790

Abstract: ... to safeguard the future of the world’s most important and vulnerable water towers. ...

Abstract	Mountains are the water towers of the world, supplying a substantial part of both natural and anthropogenic water demands1,2. They are highly sensitive and prone to climate change3,4, yet their importance and vulnerability have not been quantified at the global scale. Here we present a global water tower index (WTI), which ranks all water towers in terms of their water-supplying role and the downstream dependence of ecosystems and society. For each water tower, we assess its vulnerability related to water stress, governance, hydropolitical tension and future climatic and socio-economic changes. We conclude that the most important (highest WTI) water towers are also among the most vulnerable, and that climatic and socio-economic changes will affect them profoundly. This could negatively impact 1.9 billion people living in (0.3 billion) or directly downstream of (1.6 billion) mountainous areas. Immediate action is required to safeguard the future of the world’s most important and vulnerable water towers.
Keywords	Life Science
Subject code	333
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Laterally Closed Tunnel Approach with A-PRF for Isolated Miller’s Class II Gingival Recession

Mary Jose Nisha / Nalina Kumari Burnice / Kumar S Ashok / Mahendra Jaideep / Rajaram Vijayalakshmi

Journal of Clinical and Diagnostic Research, Vol 14, Iss 2, Pp ZD05-ZD

A Case Report

2020 Volume 07

Abstract: The displacement of the gingival margin below the level of Cementoenamel Junction (CEJ) is referred to as gingival recession. The main indication to treat isolated gingival recession is to increase soft tissue thickness and stability to facilitate plaque ...

Abstract	The displacement of the gingival margin below the level of Cementoenamel Junction (CEJ) is referred to as gingival recession. The main indication to treat isolated gingival recession is to increase soft tissue thickness and stability to facilitate plaque control, improve the patient aesthetics and prevent further periodontal breakdown. Though various root coverage techniques are available with numerous regenerative materials, autologous material such as Advanced Plasma Rich Fibrin (A-PRF) along with latest approach by Laterally Closed Tunnel (LCT) technique has been used in present case report as a predictable approach for the treatment of isolated gingival recessions.
Keywords	advanced plasma rich fibrin ; periodontal regeneration ; root coverage ; Medicine ; R
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Advanced-Platelet Rich Fibrin Assisted Papilla Reconstruction by Modified Beagle’s Technique- A Novel Approach

Rajaram Vijayalakshmi / Ravi Sathyapriya / Prakash Prashanthi / Chellathurai Burnice

Journal of Clinical and Diagnostic Research, Vol 14, Iss 4, Pp ZD07-ZD

2020 Volume 09

Abstract: ... lateral food impaction. This case report deals with a variant method of Beagle’s technique 37-year-old ...

Abstract	The loss of key papilla in an unaesthetic zone and the presence of a “black triangle” depicts the requirement for papillary reconstruction. The complete reconstruction of lost papilla is unpredictable; therefore, retention of papilla is very important for aesthetics. There are many causes for loss of papillae and the establishment of “black triangle” between teeth. However, the most common cause is loss of periodontal support due to plaque-associated lesions. However, abnormaility in tooth shape, improper contours of the prosthetic restorations and traumatic oral hygienic procedures may also impact the interdental papilla. The loss of interdental papilla soft tissue causes difficulties in phonetics, aesthetic appearance and lateral food impaction. This case report deals with a variant method of Beagle’s technique 37-year-old systemically healthy male patient with the chief complaint of black space between the upper front teeth region, causing displeasing smile and food entrapment. Intraoral examination done with periodontal probe revealed the loss of 2 mm of interdental papilla. Patient was treated surgically with Advanced Platelet Rich Fibrin (A-PRF) membrane for papilla reconstruction in the upper anterior aesthetic zone.
Keywords	aesthetics ; black triangle ; interdental papilla ; Medicine ; R
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Occlusal Contact Points, Areas and Bite Force Distribution in Angle’s Class I, II and III Patients using T-scan

Laya Thayyi / Poornima Jnaneshwar / Krishnaraj Rajaram / Sangeetha Duraisamy / Ravi Kannan

Journal of Clinical and Diagnostic Research, Vol 15, Iss 11, Pp ZC37-ZC

2021 Volume 42

Abstract: ... of occlusal contacts and areas, bite force distribution in Angle’s Class I, II, III subjects using T-scan and ... groups of 15 subjects each based on Angle’s classification of malocclusion with teeth in normal line ... <0.001) and bite forces (p=0.0032) were statistically highly significant in Angle’s class I group ...

Abstract	Introduction: Number of occlusal contacts and uniform bite force distribution during maximum intercuspation are determinants of a good functional occlusion. Distribution of posterior contacts in the three malocclusion groups along with force distribution has been a topic of research. Aim: To quantify the number of occlusal contacts and areas, bite force distribution in Angle’s Class I, II, III subjects using T-scan and to identify the centre of force trajectory. Materials and Methods: This cross-sectional, observational study was conducted in the Department of Orthodontics, SRM College, Chennai, Tamil Nadu, India, from June 2018 to December 2018. Total 45 subjects in the age group of 18 to 24 years were divided into three groups of 15 subjects each based on Angle’s classification of malocclusion with teeth in normal line of occlusion. T-Scan system sensor and software were used to record and store data. The collected data were analysed with IBM Statistical Package for the Social Sciences (SPSS) software version 23.0. The descriptive statistics were performed, followed by Analysis of Variance (ANOVA). Post hoc Tukey test was done to find the difference between the groups. Chi-square test was done for the categorical data and the Paired t-test for determining the significant difference between the bivariate samples in paired groups. Level of significance was set at p<0.05. Results: Out of three study groups, mean contact points (p<0.001), contact areas (p<0.001) and bite forces (p=0.0032) were statistically highly significant in Angle’s class I group when compared to the other groups. Statistically, the right and the left side differences in force distribution of the three groups were significant with the forces predominantly being higher on the right side. Conclusion: Subjects with Angle’s Class I molar relation had greater contacts, contact area and better bite force distribution. There was preference to the right side in bite force distribution in all the three groups. Centre of force trajectory was concentrated between first and second molars in all the groups.
Keywords	centre of force trajectory ; dental occlusion ; digital occlusal analyser ; Medicine ; R
Subject code	796
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exploiting the Potential of VGI Metadata to Develop A Data-Driven Framework for Predicting User’s Proficiency in OpenStreetMap Context

Gangothri Rajaram / KR Manjula

ISPRS International Journal of Geo-Information, Vol 8, Iss 11, p

2019 Volume 492

Abstract: ... voluntarily that helps to enhance geospatial databases. VGI’s significant limitations are trustworthiness and ... with 95.5% accuracy. Our conclusions recognize the potential of OSM metadata to illustrate the user’s ... contribution behavior without the knowledge of the user’s profile information. ...

Abstract	Volunteered geographic information (VGI) encourages citizens to contribute geographic data voluntarily that helps to enhance geospatial databases. VGI’s significant limitations are trustworthiness and reliability concerning data quality due to the anonymity of data contributors. We propose a data-driven model to address these issues on OpenStreetMap (OSM), a particular case of VGI in recent times. This research examines the hypothesis of evaluating the proficiency of the contributor to assess the credibility of the data contributed. The proposed framework consists of two phases, namely, an exploratory data analysis phase and a learning phase. The former explores OSM data history to perform feature selection, resulting in “OSM Metadata” summarized using principal component analysis. The latter combines unsupervised and supervised learning through K-means for user-clustering and multi-class logistic regression for user classification. We identified five major classes representing user-proficiency levels based on contribution behavior in this study. We tested the framework with India OSM data history, where 17% of users are key contributors, and 27% are unexperienced local users. The results for classifying new users are satisfactory with 95.5% accuracy. Our conclusions recognize the potential of OSM metadata to illustrate the user’s contribution behavior without the knowledge of the user’s profile information.
Keywords	openstreetmap ; vgi ; metadata ; principal component analysis ; k-means ; multiclass logistic regression ; Geography (General) ; G1-922
Subject code	004
Language	English
Publishing date	2019-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: FRBR and Ranganathan’s Colon Book Numbers

Shyama Rajaram

DESIDOC Journal of Library & Information Technology, Vol 33, Iss 4, Pp 323-

Exploring a Symbiotic Relationship

2013 Volume 329

Abstract: ... the Colon Book Numbers of S.R. Ranganathan. Subsequently, it explores a symbiotic relationship between ...

Abstract	Library catalogues are significant surrogates of the documents in the library collection. This paper sfirst describes the conceptual model of FRBR. Then it shifts its focus and goes on to describe the Colon Book Numbers of S.R. Ranganathan. Subsequently, it explores a symbiotic relationship between Functional Requirements for Bibliographic Records (FRBR) and Colon Book Numbers. The study reveals that many of the features of FRBR are already present in Colon Book Numbers. The paper concludes that catalogues adopting FRBR model can go for a full-fledged book numbering system like Colon Book Numbers, so that, a simple call number search can also bring together all the entity relationships in the retrievals
Keywords	Functional Requirements for Bibliographic Records ; Bibliography. Library science. Information resources ; Z
Language	English
Publishing date	2013-07-01T00:00:00Z
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: FRBR and Ranganathan’s Colon Book Numbers

Shyama Rajaram

DESIDOC Journal of Library & Information Technology, Vol 33, Iss

Exploring a Symbiotic Relationship

2013 Volume 4

Abstract: ... the Colon Book Numbers of S.R. Ranganathan. Subsequently, it explores a symbiotic relationship between ...

Abstract	Library catalogues are significant surrogates of the documents in the library collection. This paper sfirst describes the conceptual model of FRBR. Then it shifts its focus and goes on to describe the Colon Book Numbers of S.R. Ranganathan. Subsequently, it explores a symbiotic relationship between Functional Requirements for Bibliographic Records (FRBR) and Colon Book Numbers. The study reveals that many of the features of FRBR are already present in Colon Book Numbers. The paper concludes that catalogues adopting FRBR model can go for a full-fledged book numbering system like Colon Book Numbers, so that, a simple call number search can also bring together all the entity relationships in the retrievals. http://dx.doi.org/10.14429/djlit.33.5006
Keywords	Functional Requirements for Bibliographic Records ; Bibliography. Library science. Information resources ; Z
Language	English
Publishing date	2013-07-01T00:00:00Z
Publisher	DESIDOC, Ministry of Defence, India
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Structural and functional studies of S-adenosyl-L-methionine binding proteins: a ligand-centric approach.

Gana, Rajaram / Rao, Shruti / Huang, Hongzhan / Wu, Cathy / Vasudevan, Sona

BMC structural biology

2013 Volume 13, Page(s) 6

Abstract: ... structures in the PDB. Results of applying our approach to S-adenosyl-L-methionine (SAM) binding proteins are ...

Abstract	Background: The post-genomic era poses several challenges. The biggest is the identification of biochemical function for protein sequences and structures resulting from genomic initiatives. Most sequences lack a characterized function and are annotated as hypothetical or uncharacterized. While homology-based methods are useful, and work well for sequences with sequence identities above 50%, they fail for sequences in the twilight zone (<30%) of sequence identity. For cases where sequence methods fail, structural approaches are often used, based on the premise that structure preserves function for longer evolutionary time-frames than sequence alone. It is now clear that no single method can be used successfully for functional inference. Given the growing need for functional assignments, we describe here a systematic new approach, designated ligand-centric, which is primarily based on analysis of ligand-bound/unbound structures in the PDB. Results of applying our approach to S-adenosyl-L-methionine (SAM) binding proteins are presented. Results: Our analysis included 1,224 structures that belong to 172 unique families of the Protein Information Resource Superfamily system. Our ligand-centric approach was divided into four levels: residue, protein/domain, ligand, and family levels. The residue level included the identification of conserved binding site residues based on structure-guided sequence alignments of representative members of a family, and the identification of conserved structural motifs. The protein/domain level included structural classification of proteins, Pfam domains, domain architectures, and protein topologies. The ligand level included ligand conformations, ribose sugar puckering, and the identification of conserved ligand-atom interactions. The family level included phylogenetic analysis. Conclusion: We found that SAM bound to a total of 18 different fold types (I-XVIII). We identified 4 new fold types and 11 additional topological arrangements of strands within the well-studied Rossmann fold Methyltransferases (MTases). This extends the existing structural classification of SAM binding proteins. A striking correlation between fold type and the conformation of the bound SAM (classified as types) was found across the 18 fold types. Several site-specific rules were created for the assignment of functional residues to families and proteins that do not have a bound SAM or a solved structure.
MeSH term(s)	Amino Acid Motifs ; Binding Sites ; Databases, Protein ; Ligands ; Methyltransferases/chemistry ; Methyltransferases/metabolism ; Protein Binding ; Protein Folding ; Protein Structure, Tertiary ; Proteins/chemistry ; Proteins/metabolism ; S-Adenosylmethionine/chemistry ; S-Adenosylmethionine/metabolism ; Temperature
Chemical Substances	Ligands ; Proteins ; S-Adenosylmethionine (7LP2MPO46S) ; Methyltransferases (EC 2.1.1.-)
Language	English
Publishing date	2013-04-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2050440-8
ISSN	1472-6807 ; 1472-6807
ISSN (online)	1472-6807
ISSN	1472-6807
DOI	10.1186/1472-6807-13-6
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Article ; Online: Collective memory and the individual mind.

Rajaram, Suparna

Trends in cognitive sciences

2022 Volume 26, Issue 12, Page(s) 1056–1058

Abstract: How does social transmission of information shape individual and collective memory? Taking a cognitive-experimental perspective, I propose three critical research themes to tackle in the next 25 years: the dynamic reciprocity of influence between the ... ...

Abstract	How does social transmission of information shape individual and collective memory? Taking a cognitive-experimental perspective, I propose three critical research themes to tackle in the next 25 years: the dynamic reciprocity of influence between the individual and the collective; changes in the individual and collective memory structures; and the impact of culture.
MeSH term(s)	Humans ; Memory ; Cognitive Science
Language	English
Publishing date	2022-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2010989-1
ISSN	1879-307X ; 1364-6613
ISSN (online)	1879-307X
ISSN	1364-6613
DOI	10.1016/j.tics.2022.09.014
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