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  1. Article ; Online: Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Peeters PH, Hjartåker A, Weiderpass E, Arriola L, Molina-Montes E, Duell EJ, Santiuste C, Alonso de la Torre R, Barricarte Gurrea A, Stocks T, Johansson M, Ljungberg B, Wareham N, Khaw KT, Travis RC, Cross AJ, Murphy N, Riboli E, Scelo G.Int J Cancer. 2015 Oct 15;137(8):1953-66. [Epub 2015 Apr 28]. doi: 10.1002/ijc.29559.

    Jay, Raman / Brennan, P / Brenner / Overvad, K / Olsen, A / Tjønneland, A / Boutron-Ruault, M C / Clavel-Chapelon, F / Fagherazzi / Katzke, V / Kühn, T / Boeing, H / Bergmann, M M / Steffen, A / Naska, A / Trichopoulou, A / Trichopoulos, D / Saieva, C / Grioni, S /
    Panico, S / Tumino, R / Vineis, P / Bueno-de-Mesquita, H B / Peeters, P H / Hjartåker, A / Weiderpass, E / Arriola, L / Molina-Montes, E / Duell, E J / Santiuste, C / Alonso de la Torre, R / Barricarte Gurrea, A / Stocks, T / Johansson, M / Ljungberg, B / Wareham, N / Khaw, K T / Travis, R C / Cross, A J / Murphy, N / Riboli, E / Scelo, G

    Urologic oncology

    2017  Volume 35, Issue 3, Page(s) 117

    Abstract: Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 to 2010, 477,325 men and women ...

    Abstract Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 to 2010, 477,325 men and women in the European Prospective Investigation into Cancer and Nutrition cohort were followed for incident renal cancers (n = 931). Baseline and lifetime alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. In multivariate analysis, total alcohol consumption at baseline was inversely associated with renal cancer; the HR and 95% CI for the increasing categories of total alcohol consumption at recruitment vs. the light drinkers category were 0.78 (0.62-0.99), 0.82 (0.64-1.04), 0.70 (0.55-0.90), and 0.91 (0.63-1.30), respectively, (ptrend = 0.001). A similar relationship was observed for average lifetime alcohol consumption and for all renal cancer subsites combined or for renal parenchyma subsite. The trend was not observed in hypertensive individuals and not significant in smokers. In conclusion, moderate alcohol consumption was associated with a decreased risk of renal cancer.
    MeSH term(s) Alcohol Drinking ; Female ; Humans ; Kidney Neoplasms ; Male ; Nutritional Status ; Proportional Hazards Models ; Prospective Studies ; Risk Factors
    Language English
    Publishing date 2017-02-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1336505-8
    ISSN 1873-2496 ; 1078-1439
    ISSN (online) 1873-2496
    ISSN 1078-1439
    DOI 10.1016/j.urolonc.2016.12.022
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  2. Book: Multicultural Care

    Comas-Díaz, Lillian / Murphy, Michael J

    A Clinician's Guide to Cultural Competence

    2023  

    Author's details Lillian Comas-Díaz, PhD, is a clinical psychologist in full-time private practice and a clinical professor in the George Washington University Department of Psychiatry and Behavioral Sciences. Previously, she was a faculty member of the Yale University Department of Psychiatry, where she also directed its Hispanic Clinic. The author of more than 100 publications, Dr. Comas-Díaz is the coeditor of Clinical Guidelines in Cross-Cultural Mental Health (with Ezra Griffith, 1988), Women of Color: Integrating Ethnic and Gender Identities in Psychotherapy (with Beverly Greene, 1994), WomanSoul: The Inner Life of Women's Spirituality (with Carole A. Rayburn, 2008), and Women Psychotherapists: Journeys in Healing (with Marcella Bakur Weiner, 2011). She is the founding editor of Cultural Diversity and Ethnic Minority Psychology, the official journal of the Society for the Psychological Study of Ethnic Minorities Issues (Division 45 of APA). In addition, she serves on several editorial boards a
    Language English
    Size 317 p.
    Publisher American Psychological Association (APA)
    Document type Book
    Note PDA Manuell_25
    Format 152 x 226 x 20
    ISBN 9781433844072 ; 1433844079
    Database PDA

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  3. Article: Kinase signalling adaptation supports dysfunctional mitochondria in disease.

    Skalka, George L / Tsakovska, Mina / Murphy, Daniel J

    Frontiers in molecular biosciences

    2024  Volume 11, Page(s) 1354682

    Abstract: Mitochondria form a critical control nexus which are essential for maintaining correct tissue homeostasis. An increasing number of studies have identified dysregulation of mitochondria as a driver in cancer. However, which pathways support and promote ... ...

    Abstract Mitochondria form a critical control nexus which are essential for maintaining correct tissue homeostasis. An increasing number of studies have identified dysregulation of mitochondria as a driver in cancer. However, which pathways support and promote this adapted mitochondrial function? A key hallmark of cancer is perturbation of kinase signalling pathways. These pathways include mitogen activated protein kinases (MAPK), lipid secondary messenger networks, cyclic-AMP-activated (cAMP)/AMP-activated kinases (AMPK), and Ca
    Language English
    Publishing date 2024-01-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2024.1354682
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  4. Article ; Online: HTLV-1 and blood donation.

    Murphy, Edward L

    British journal of haematology

    2023  Volume 204, Issue 1, Page(s) 29–30

    Abstract: ... opportunities. Br J Haematol 2023;202:1220-1223. ...

    Abstract Human T-cell leukaemia virus type 1 (HTLV-1) is a human retrovirus that causes adult T-cell lymphoma and HTLV-associated myelopathy. In this issue, Rosadas et al. use data from a recent WHO report to describe how blood banks test for HTLV-1 and how this testing contributes to public health surveillance for the virus. Commentary on: Rosadas et al. HTLV-1 screening of blood donations: we are systematically missing opportunities. Br J Haematol 2023;202:1220-1223.
    MeSH term(s) Adult ; Humans ; Human T-lymphotropic virus 1 ; Blood Donation ; Leukemia-Lymphoma, Adult T-Cell ; HTLV-I Infections
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19051
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  5. Article ; Online: The immunobiology of SARS-CoV-2 infection and vaccine responses: potential influences of cross-reactive memory responses and aging on efficacy and off-target effects.

    Collins, Craig P / Longo, Dan L / Murphy, William J

    Frontiers in immunology

    2024  Volume 15, Page(s) 1345499

    Abstract: Immune responses to both SARS-CoV-2 infection and its associated vaccines have been highly variable within the general population. The increasing evidence of long-lasting symptoms after resolution of infection, called post-acute sequelae of COVID-19 ( ... ...

    Abstract Immune responses to both SARS-CoV-2 infection and its associated vaccines have been highly variable within the general population. The increasing evidence of long-lasting symptoms after resolution of infection, called post-acute sequelae of COVID-19 (PASC) or "Long COVID," suggests that immune-mediated mechanisms are at play. Closely related endemic common human coronaviruses (hCoV) can induce pre-existing and potentially cross-reactive immunity, which can then affect primary SARS-CoV-2 infection, as well as vaccination responses. The influence of pre-existing immunity from these hCoVs, as well as responses generated from original CoV2 strains or vaccines on the development of new high-affinity responses to CoV2 antigenic viral variants, needs to be better understood given the need for continuous vaccine adaptation and application in the population. Due in part to thymic involution, normal aging is associated with reduced naïve T cell compartments and impaired primary antigen responsiveness, resulting in a reliance on the pre-existing cross-reactive memory cell pool which may be of lower affinity, restricted in diversity, or of shorter duration. These effects can also be mediated by the presence of down-regulatory anti-idiotype responses which also increase in aging. Given the tremendous heterogeneity of clinical data, utilization of preclinical models offers the greatest ability to assess immune responses under a controlled setting. These models should now involve prior antigen/viral exposure combined with incorporation of modifying factors such as age on immune responses and effects. This will also allow for mechanistic dissection and understanding of the different immune pathways involved in both SARS-CoV-2 pathogen and potential vaccine responses over time and how pre-existing memory responses, including potential anti-idiotype responses, can affect efficacy as well as potential off-target effects in different tissues as well as modeling PASC.
    MeSH term(s) Humans ; COVID-19 ; Post-Acute COVID-19 Syndrome ; SARS-CoV-2 ; Vaccines ; Aging ; Immunoglobulin Idiotypes
    Chemical Substances Vaccines ; Immunoglobulin Idiotypes
    Language English
    Publishing date 2024-02-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1345499
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  6. Article ; Online: Correction to: Differing field methods and site conditions lead to varying bias in suspended sediment concentrations in the Lower Mississippi and Atchafalaya Rivers.

    Murphy, J / Schafer, L / Mize, S

    Environmental monitoring and assessment

    2023  Volume 196, Issue 1, Page(s) 100

    Language English
    Publishing date 2023-12-29
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 782621-7
    ISSN 1573-2959 ; 0167-6369
    ISSN (online) 1573-2959
    ISSN 0167-6369
    DOI 10.1007/s10661-023-12263-w
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  7. Article ; Online: The impact of air pollution on asthma: clinical outcomes, current epidemiology, and health disparities.

    Fiter, Ryan J / Murphy, Lila J / Gong, Michelle N / Cleven, Krystal L

    Expert review of respiratory medicine

    2024  Volume 17, Issue 12, Page(s) 1237–1247

    Abstract: Introduction: Air pollution has been shown to have a significant impact on morbidity and mortality of respiratory illnesses including asthma.: Areas covered: Outdoor air pollution consists of a mixture of individual pollutants including vehicle ... ...

    Abstract Introduction: Air pollution has been shown to have a significant impact on morbidity and mortality of respiratory illnesses including asthma.
    Areas covered: Outdoor air pollution consists of a mixture of individual pollutants including vehicle traffic and industrial pollution. Studies have implicated an array of individual components of air pollution, with PM
    Expert opinion: Pollution has multiple deleterious effects on respiratory health but there is a lack of data on individualized pollution monitoring, making it difficult to establish a temporal relationship between exposure and symptoms, thereby limiting our understanding of safe exposure levels. Future research should focus on more personalized monitoring and treatment plans for mitigating exposure.
    MeSH term(s) Adult ; Humans ; Air Pollutants/adverse effects ; Air Pollutants/analysis ; Particulate Matter/analysis ; Air Pollution/adverse effects ; Asthma/epidemiology ; Health Inequities ; Environmental Exposure/adverse effects
    Chemical Substances Air Pollutants ; Particulate Matter
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2024.2307545
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  8. Article ; Online: Differing field methods and site conditions lead to varying bias in suspended sediment concentrations in the Lower Mississippi and Atchafalaya Rivers.

    Murphy, J / Schafer, L / Mize, S

    Environmental monitoring and assessment

    2023  Volume 195, Issue 11, Page(s) 1260

    Abstract: At sites that have been sampled for decades, changes in field and laboratory methods happen over time as instrumentation and protocols improve. Here, we compare the influence of depth- and point-integrated sampling on total, fine (< 0.0625 mm), and ... ...

    Abstract At sites that have been sampled for decades, changes in field and laboratory methods happen over time as instrumentation and protocols improve. Here, we compare the influence of depth- and point-integrated sampling on total, fine (< 0.0625 mm), and coarse (≥ 0.0625 mm) suspended sediment (SS) concentrations in the Lower Mississippi and Atchafalaya Rivers. Using historical field method information, we identified seven sites to test such differences. We found SS samples collected using point-integration tended to have higher concentrations than those collected using depth-integration. However, the presence and magnitude of the bias were inconsistent across sites. Bias was present at the site with less-than-ideal conditions (i.e., non-trapezoidal channel, non-uniform flow) and non-existent at the ideal site location, indicating the bias between sampling methods depends on site sampling conditions. When present, the bias is greater at higher concentrations and at moderate to high flows. At the less-than-ideal site, point-integrated samples can have 16% (total) and 34% (coarse) higher concentrations than depth-integrated samples. When flow effects are removed, this translates to a bias of 19, 9, and 8 mg per liter for total, fine, and coarse SS. When a change in field methods occurs, comparison samples and a rigorous evaluation of those samples are warranted to determine the proper course of action for a particular site. Often, the effect and solution will not be known until several years of comparison samples have been collected under a variety of hydrologic conditions.
    MeSH term(s) Environmental Monitoring/methods ; Mississippi ; Rivers ; Geologic Sediments
    Language English
    Publishing date 2023-10-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 782621-7
    ISSN 1573-2959 ; 0167-6369
    ISSN (online) 1573-2959
    ISSN 0167-6369
    DOI 10.1007/s10661-023-11836-z
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  9. Article ; Online: Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination. Reply.

    Murphy, William J / Longo, Dan L

    The New England journal of medicine

    2022  Volume 386, Issue 9, Page(s) 898–899

    MeSH term(s) Antibodies, Anti-Idiotypic ; Antibodies, Neutralizing/immunology ; COVID-19/prevention & control ; Humans ; SARS-CoV-2 ; Vaccination
    Chemical Substances Antibodies, Anti-Idiotypic ; Antibodies, Neutralizing
    Language English
    Publishing date 2022-02-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2119443
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  10. Article: Serendipity in Pediatrics.

    Quinn, N / Corley, L / Beirne, N / Murphy, J F A

    Irish medical journal

    2023  Volume 116, Issue 6, Page(s) 794

    Language English
    Publishing date 2023-06-29
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 193134-9
    ISSN 0332-3102 ; 0021-129X
    ISSN 0332-3102 ; 0021-129X
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