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  1. Article: Hallmarks of cancer: The insulin-like growth factors perspective.

    Werner, Haim / LeRoith, Derek

    Frontiers in oncology

    2022  Volume 12, Page(s) 1055589

    Abstract: The identification of a series of attributes ... ...

    Abstract The identification of a series of attributes or
    Language English
    Publishing date 2022-11-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1055589
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  2. Article: A MESSAGE FROM THE EDITOR-IN-CHIEF.

    LeRoith, Derek

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2020  Volume 26, Issue 1, Page(s) 5

    Language English
    Publishing date 2020-02-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.4158/1934-2403-26.1.5
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  3. Article: Management of Type 2 Diabetes Mellitus in the Very Elderly: One Practice's Experience.

    Grajower, Martin M / LeRoith, Derek

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2023  Volume 29, Issue 7, Page(s) 560–565

    Abstract: Objective: Type 2 diabetes mellitus (T2DM) affects 25% of adults over age 65. Nevertheless, few clinical trials include patients over age 75.: Methods: This case series reports retrospective data on a cohort of 85 patients aged 80 and over (mean 88.1, ...

    Abstract Objective: Type 2 diabetes mellitus (T2DM) affects 25% of adults over age 65. Nevertheless, few clinical trials include patients over age 75.
    Methods: This case series reports retrospective data on a cohort of 85 patients aged 80 and over (mean 88.1, range 80-104) with T2DM, managed by a single endocrinologist. The practice's computerized data base was searched for all patients 80 years of age and older with a diagnosis of T2DM.
    Results: The major observations were the significant decrease in the use of agents associated with hypoglycemia (sulfonylureas and insulin), and the beneficial and well-tolerated use of glucagon like peptide-1 receptor analogues (GLP-1 RA). The mean A1c in the entire cohort dropped from 7.6% to 6.6% over a mean of 9 months. Nearly one-half of the cohort were treated with GLP1-RA, reflecting studies demonstrating the safety and efficacy of this class of drugs in less elderly patients. At presentation, 75% were on sulfonylurea and/or insulin; this number was reduced to 27%. Furthermore, none of the patients required short-acting (bolus) insulin to achieve the individualized A1c target.
    Conclusion: Patients with T2DM aged 80 and over respond well to GLP1-RA drugs, drastically reducing the need for agents associated with hypoglycemia. The important question, which will require larger and prospective studies, is whether the lowering of A1c, as shown in this paper, and the use of GLP-1 RA specifically, are associated with improved morbidity and mortality in the very elderly.
    MeSH term(s) Adult ; Aged ; Humans ; Aged, 80 and over ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/complications ; Hypoglycemic Agents/therapeutic use ; Glycated Hemoglobin ; Retrospective Studies ; Prospective Studies ; Insulin/therapeutic use ; Hypoglycemia/chemically induced ; Hypoglycemia/epidemiology ; Hypoglycemia/prevention & control ; Sulfonylurea Compounds/therapeutic use ; Glucagon-Like Peptide-1 Receptor ; Insulin, Regular, Human/therapeutic use ; Glucagon-Like Peptide 1/therapeutic use
    Chemical Substances Hypoglycemic Agents ; Glycated Hemoglobin ; Insulin ; Sulfonylurea Compounds ; Glucagon-Like Peptide-1 Receptor ; Insulin, Regular, Human ; Glucagon-Like Peptide 1 (89750-14-1)
    Language English
    Publishing date 2023-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.1016/j.eprac.2023.03.271
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  4. Article: A Message from the Editor-in-Chief.

    LeRoith, Derek

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2019  Volume 25, Issue 1, Page(s) 5

    MeSH term(s) Periodicals as Topic
    Language English
    Publishing date 2019-01-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.4158/1934-2403-25.1.5
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  5. Article ; Online: Obesity and cancer.

    Gallagher, Emily J / LeRoith, Derek

    Cancer metastasis reviews

    2022  Volume 41, Issue 3, Page(s) 463–464

    MeSH term(s) Humans ; Neoplasms ; Obesity/complications
    Language English
    Publishing date 2022-07-08
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 604857-2
    ISSN 1573-7233 ; 0167-7659
    ISSN (online) 1573-7233
    ISSN 0167-7659
    DOI 10.1007/s10555-022-10049-z
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  6. Book ; Online: Controversies in Treating Diabetes

    LeRoith, Derek / Vinik, Aaron I.

    Clinical and Research Aspects

    2008  

    Author's details edited by Derek LeRoith, Aaron I. Vinik
    Keywords Diabetes ; Endocrinology ; Internal medicine
    Language English
    Publisher Humana Press
    Publishing place Totowa, NJ
    Document type Book ; Online
    HBZ-ID TT050387146
    ISBN 978-1-588-29708-2 ; 978-1-597-45572-5 ; 1-588-29708-X ; 1-597-45572-5
    DOI 10.1007/978-1-59745-572-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Article: A MESSAGE FROM THE EDITOR-IN-CHIEF.

    LeRoith, Derek

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2018  Volume 24, Issue 1, Page(s) 5

    MeSH term(s) Endocrinology ; Humans ; Periodicals as Topic
    Language English
    Publishing date 2018-01-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.4158/1934-2403-24.1.5
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  8. Article ; Online: Subjective social status, race, and metabolic syndrome in women with breast cancer.

    Greco, Giampaolo / Bickell, Nina A / Lin, Sylvia / Yagnik, Radhi / LeRoith, Derek / Gallagher, Emily J

    Breast cancer research and treatment

    2023  Volume 199, Issue 3, Page(s) 479–487

    Abstract: Purpose: To evaluate the association of subjective social status (SSS) with metabolic syndrome (MetS) severity and its potential contribution to racial health disparities in women with breast cancer.: Methods: Multicenter cross-sectional study (10 US ...

    Abstract Purpose: To evaluate the association of subjective social status (SSS) with metabolic syndrome (MetS) severity and its potential contribution to racial health disparities in women with breast cancer.
    Methods: Multicenter cross-sectional study (10 US hospitals) in women (n = 1206) with primary diagnosis of invasive breast cancer received during Mar/2013-Feb/2020. Participants, self-identified as non-Hispanic White or Black, underwent physical and laboratory examinations and survey questions assessing socioeconomic parameters, medical history, and behavioral risks. SSS was measured with the 10-rung MacArthur scale. MetS severity was measured with a validated Z-Score. Generalized linear mixed modeling was used to analyze the associations. Missing data were handled using multiple imputation.
    Results: Average age was 58 years. On average, the SSS of Black women, given equivalent level of income and education, was lower than the SSS of White women: 6.6 (6.1-7.0) vs 7.7 (7.54-7.79) among college graduates and 6.8 (6.4-7.2) vs 7.6 (7.5-7.8) among women in the high-income category (> $75,000). In multivariable analysis, after controlling for age, income, education, diet, and physical activity, increasing SSS was associated with a decrease in MetS-Z score, - 0.10 (- 0.16 to - 0.04) per every 2 rung increase in the MacArthur scale.
    Conclusion: Black women with breast cancer rank their SSS lower than White women with breast cancer do at each level of income and education. As SSS is strongly associated with MetS severity these results identify potentially modifiable factors that contribute to racial disparities.
    MeSH term(s) Humans ; Female ; Middle Aged ; Social Class ; Social Status ; Metabolic Syndrome/epidemiology ; Breast Neoplasms/complications ; Breast Neoplasms/epidemiology ; Breast Neoplasms/metabolism ; Cross-Sectional Studies
    Language English
    Publishing date 2023-04-23
    Publishing country Netherlands
    Document type Multicenter Study ; Journal Article
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-023-06949-5
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  9. Article: A Message from the Editor-in-Chief.

    LeRoith, Derek

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2017  Volume 23, Issue 1, Page(s) 4

    MeSH term(s) Happiness ; Humans ; Peer Review, Research ; Periodicals as Topic
    Language English
    Publishing date 2017-01-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.4158/1934-2403-23.1.4
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  10. Article ; Online: Editorial

    Le Roith D

    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society

    1999  Volume 9, Issue 5, Page(s) 279

    Language English
    Publishing date 1999-10
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 1436781-6
    ISSN 1532-2238 ; 1096-6374
    ISSN (online) 1532-2238
    ISSN 1096-6374
    DOI 10.1054/ghir.1999.0121
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