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  1. Article: [Liver Cirrhosis].

    Brenig, Robert / Bernsmeier, Christine

    Praxis

    2023  Volume 112, Issue 11, Page(s) 554–561

    Abstract: Introduction: Cirrhosis is a common disease with high morbidity and mortality. In industrialised countries, the most common causes of cirrhosis are the alcoholic liver disease, non-alcoholic fatty liver disease and chronic viral hepatitis. Cirrhosis is ... ...

    Abstract Introduction: Cirrhosis is a common disease with high morbidity and mortality. In industrialised countries, the most common causes of cirrhosis are the alcoholic liver disease, non-alcoholic fatty liver disease and chronic viral hepatitis. Cirrhosis is often diagnosed late, as it can be asymptomatic for a long time. Therefore, hepatopathy screening in high-risk patients and fibrosis surveillance using the ultrasound, in the presence of a chronic hepatopathy are essential. A liver biopsy is necessary to confirm the diagnosis. With optimal therapy, in some cases, cirrhosis is preventable and potentially reversible in others. In the stage of decompensation, typically characterised by ascites, patients often die from recurrent infections or hepatocellular carcinoma unless cured by liver transplantation. The prevention and treatment of complications as well as the evaluation of a transplant require cooperation with a centre hospital.
    MeSH term(s) Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/therapy ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/etiology ; Liver Transplantation/adverse effects ; Liver Neoplasms/diagnosis ; Liver Neoplasms/etiology ; Liver Neoplasms/therapy
    Language German
    Publishing date 2023-09-28
    Publishing country Switzerland
    Document type English Abstract ; Journal Article
    ZDB-ID 209026-0
    ISSN 1661-8165 ; 1661-8157 ; 0369-8394
    ISSN (online) 1661-8165
    ISSN 1661-8157 ; 0369-8394
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  2. Book ; Thesis: Regulation des Pankreaskarzinom-assoziierten Proteins ZAP82 durch Mitogen aktivierte Protein-Kinasen und den Tumorsuppressor p53

    Bernsmeier, Christine

    2002  

    Author's details vorgelegt von Christine Bernsmeier
    Language German
    Size [8], 94 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Kiel, Univ., Diss., 2002
    HBZ-ID HT013673705
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2003 D 781 order for loan Magazin

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  3. Article ; Online: Plasticity of monocytes and macrophages in cirrhosis of the liver.

    Geng, Anne / Flint, Emilio / Bernsmeier, Christine

    Frontiers in network physiology

    2022  Volume 2, Page(s) 937739

    Abstract: Cirrhosis of the liver is a systemic condition with raising prevalence worldwide. Patients with cirrhosis are highly susceptible to develop bacterial infections leading to acute decompensation and acute-on-chronic liver failure both associated with a ... ...

    Abstract Cirrhosis of the liver is a systemic condition with raising prevalence worldwide. Patients with cirrhosis are highly susceptible to develop bacterial infections leading to acute decompensation and acute-on-chronic liver failure both associated with a high morbidity and mortality and sparse therapeutic options other than transplantation. Mononuclear phagocytes play a central role in innate immune responses and represent a first line of defence against pathogens. Their function includes phagocytosis, killing of bacteria, antigen presentation, cytokine production as well as recruitment and activation of immune effector cells. Liver injury and development of cirrhosis induces activation of liver resident Kupffer cells and recruitment of monocytes to the liver. Damage- and pathogen-associated molecular patterns promote systemic inflammation which involves multiple compartments besides the liver, such as the circulation, gut, peritoneal cavity and others. The function of circulating monocytes and tissue macrophages is severely impaired and worsens along with cirrhosis progression. The underlying mechanisms are complex and incompletely understood. Recent 'omics' technologies help to transform our understanding of cellular diversity and function in health and disease. In this review we point out the current state of knowledge on phenotypical and functional changes of monocytes and macrophages during cirrhosis evolution in different compartments and their role in disease progression. We also discuss the value of potential prognostic markers for cirrhosis-associated immuneparesis, and future immunotherapeutic strategies that may reduce the need for transplantation and death.
    Language English
    Publishing date 2022-07-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2674-0109
    ISSN (online) 2674-0109
    DOI 10.3389/fnetp.2022.937739
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  4. Article ; Online: Prevention of Hepatitis B Reactivation in Patients Receiving Immunosuppressive Therapy: a Case Series and Appraisal of Society Guidelines.

    Etienne, Samuel / Vosbeck, Jürg / Bernsmeier, Christine / Osthoff, Michael

    Journal of general internal medicine

    2022  Volume 38, Issue 2, Page(s) 490–501

    Abstract: Hepatitis B (HBV) reactivation (HBVr) is a potentially fatal complication in patients with past HBV exposure receiving immunosuppressive therapy. HBVr can occur in patients with chronic HBV infection as well as in patients with resolved HBV infection. In ...

    Abstract Hepatitis B (HBV) reactivation (HBVr) is a potentially fatal complication in patients with past HBV exposure receiving immunosuppressive therapy. HBVr can occur in patients with chronic HBV infection as well as in patients with resolved HBV infection. In this article, we present the cases of four patients with resolved hepatitis B who presented with HBVr during or after immunosuppressive treatment, of whom two died as a consequence of HBVr. We then reflect on and summarize the recommendations of four major societies for the screening and management of previously HBV-exposed patients planned to receive immunosuppressive treatment. Current guidelines recommend screening for HBV in all patients planned to receive immunosuppressive therapy. Risk of HBVr is assessed based on the serological status of the patient and the planned immunosuppressive drug regimen. For patients considered to be at low risk of HBVr, management consists of serological monitoring for HBVr and immediate preemptive antiviral therapy in the case of HBVr. For patients considered to be at intermediate or high risk for HBVr, antiviral prophylaxis should be initiated concordantly with the immunosuppressive therapy and continued for up to 18 months after cessation of the immunosuppressive regimen. Areas of uncertainty include the risk of novel and emerging immunosuppressive and immune modulatory drugs and the exact duration of antiviral prophylaxis. Greater awareness is needed among clinicians regarding the risk of HBVr in patients receiving immunosuppressive therapy, especially in low-endemicity settings. Implementation of screening and management programs and decision support tools based on the presented guidelines may improve the management of these patients.
    MeSH term(s) Humans ; Antiviral Agents/therapeutic use ; Hepatitis B/chemically induced ; Hepatitis B/drug therapy ; Hepatitis B/prevention & control ; Hepatitis B virus/physiology ; Immunosuppression Therapy ; Immunosuppressive Agents/adverse effects ; Virus Activation
    Chemical Substances Antiviral Agents ; Immunosuppressive Agents
    Language English
    Publishing date 2022-09-22
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-022-07806-9
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  5. Article: Morbus Wilson oder hepatolentikuläre Degeneration

    Bernsmeier, Christine

    Therapeutische Umschau

    2018  Volume 76, Issue 4, Page(s) 241–248

    Abstract: Der Morbus Wilson, auch progressive hepatolentikuläre Degeneration genannt, ist eine seltene autosomal rezessive Kupferspeicherkrankheit, die sich als Hepatopathie und / oder neurologische bzw. psychiatrische Erkrankung manifestiert. ...

    Abstract Der Morbus Wilson, auch progressive hepatolentikuläre Degeneration genannt, ist eine seltene autosomal rezessive Kupferspeicherkrankheit, die sich als Hepatopathie und / oder neurologische bzw. psychiatrische Erkrankung manifestiert.
    Keywords Morbus Wilson ; Stoffwechselkrankheit
    Language German
    Document type Article
    ZDB-ID 82044-1
    ISSN 1664-2864 ; 0040-5930
    ISSN (online) 1664-2864
    ISSN 0040-5930
    Database bibnet.org

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  6. Article: Erhöhte Leberwerte – Zufallsbefund in der Hausarztpraxis.

    Keerl, Claudia / Bernsmeier, Christine

    Therapeutische Umschau. Revue therapeutique

    2020  Volume 77, Issue 8, Page(s) 371–378

    Abstract: Elevated liver function tests - as incidental finding in general ... ...

    Title translation Elevated liver function tests - as incidental finding in general practice.
    Abstract Elevated liver function tests - as incidental finding in general practice
    MeSH term(s) Family Practice ; Humans ; Incidental Findings ; Liver Function Tests ; Magnetic Resonance Imaging ; Ultrasonography
    Language German
    Publishing date 2020-10-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 82044-1
    ISSN 1664-2864 ; 0040-5930
    ISSN (online) 1664-2864
    ISSN 0040-5930
    DOI 10.1024/0040-5930/a001206
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  7. Article ; Online: Exacerbation of familial intrahepatic cholestasis in conjunction with COVID-19 vaccination.

    Guri, Yakir / Vosbeck, Jürg / Dickenmann, Michael / Jetter, Alexander / Bernsmeier, Christine

    Journal of hepatology

    2022  Volume 77, Issue 3, Page(s) 872–874

    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Cholestasis ; Cholestasis, Intrahepatic/diagnosis ; Cholestasis, Intrahepatic/genetics ; Humans ; Mutation ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-05-16
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2022.05.003
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  8. Article ; Online: TAM Receptors in the Pathophysiology of Liver Disease

    Emilio Flint / Evangelos Triantafyllou / Christine Bernsmeier

    Livers, Vol 2, Iss 2, Pp 15-

    2022  Volume 29

    Abstract: TAM receptors (Tyro3, Axl and MerTK) are a family of tyrosine kinase receptors that are expressed in a variety of cell populations, including liver parenchymal and non-parenchymal cells. These receptors are vital for immune homeostasis, as they regulate ... ...

    Abstract TAM receptors (Tyro3, Axl and MerTK) are a family of tyrosine kinase receptors that are expressed in a variety of cell populations, including liver parenchymal and non-parenchymal cells. These receptors are vital for immune homeostasis, as they regulate the innate immune response by suppressing inflammation via toll-like receptor inhibition and by promoting tissue resolution through efferocytosis. However, there is increasing evidence indicating that aberrant TAM receptor signaling may play a role in pathophysiological processes in the context of liver disease. This review will explore the roles of TAM receptors and their ligands in liver homeostasis as well as a variety of disease settings, including acute liver injury, steatosis, fibrosis, cirrhosis-associated immune dysfunction and hepatocellular carcinoma. A better understanding of our current knowledge of TAM receptors in liver disease may identify new opportunities for disease monitoring as well as novel therapeutic targets. Nonetheless, this review also aims to highlight areas where further research on TAM receptor biology in liver disease is required.
    Keywords TAM receptors ; Axl ; MerTK ; liver inflammation ; cirrhosis ; Medicine (General) ; R5-920
    Subject code 610 ; 571
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Editorial: outcome prediction in patients with cirrhosis and acute-on-chronic liver failure-authors' reply.

    Bernsmeier, Christine / McPhail, Mark J W

    Alimentary pharmacology & therapeutics

    2020  Volume 52, Issue 7, Page(s) 1227–1228

    MeSH term(s) Acute-On-Chronic Liver Failure/diagnosis ; Biomarkers ; Humans ; Leukocytes ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Prognosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-09-11
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.16053
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  10. Article ; Online: Innate immune cells in cirrhosis.

    Bernsmeier, Christine / van der Merwe, Schalk / Périanin, Axel

    Journal of hepatology

    2020  Volume 73, Issue 1, Page(s) 186–201

    Abstract: Cirrhosis is a multisystemic disease wherein inflammatory responses originating from advanced liver disease and its sequelae affect distant compartments. Patients with cirrhosis are susceptible to bacterial infections, which may precipitate acute ... ...

    Abstract Cirrhosis is a multisystemic disease wherein inflammatory responses originating from advanced liver disease and its sequelae affect distant compartments. Patients with cirrhosis are susceptible to bacterial infections, which may precipitate acute decompensation and acute-on-chronic liver failure, both of which are associated with high short-term mortality. Innate immune cells are an essential first line of defence against pathogens. Activation of liver macrophages (Kupffer cells) and resident mastocytes generate proinflammatory and vaso-permeating mediators that induce accumulation of neutrophils, lymphocytes, eosinophils and monocytes in the liver, and promote tissue damage. During cirrhosis progression, damage- and pathogen-associated molecular patterns activate immune cells and promote development of systemic inflammatory responses which may involve different tissues and compartments. The antibacterial function of circulating neutrophils and monocytes is gradually and severely impaired as cirrhosis worsens, contributing to disease progression. The mechanisms underlying impaired antimicrobial responses are complex and incompletely understood. This review focuses on the continuous and distinct perturbations arising in innate immune cells during cirrhosis, including their impact on disease progression, as well as reviewing potential therapeutic targets.
    MeSH term(s) Acute-On-Chronic Liver Failure/etiology ; Acute-On-Chronic Liver Failure/immunology ; Disease Progression ; Humans ; Immunity, Innate/physiology ; Immunotherapy/methods ; Liver Cirrhosis/complications ; Liver Cirrhosis/immunology ; Liver Cirrhosis/therapy
    Language English
    Publishing date 2020-03-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2020.03.027
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