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Article ; Online: Effectiveness of Insole Colour on Impact Loading and Lower-Limb Kinematics When Running at Preferred and Nonpreferred Speeds.

Wang, Yi / Lam, Wing-Kai / Pak, Lok-Yee / Wong, Charis K-W / Tan, Mohammad F / Leung, Aaron K-L

2021 Volume 2021, Page(s) 8947433

Abstract: While colour of red can play a significant role in altering human perception and performances, little is known about its perceptual-motor effect on running mechanics. This study examined the effects of variations in insole colours on impact forces, ankle ...

Abstract	While colour of red can play a significant role in altering human perception and performances, little is known about its perceptual-motor effect on running mechanics. This study examined the effects of variations in insole colours on impact forces, ankle kinematics, and trial-to-trial reliability at various running speeds. Sixteen male recreational runners ran on instrumented treadmill at slow (90%), preferred (100%), and fast (110%) running speeds when wearing insoles in red, blue, and white colours. We used synchronized force platform and motion capturing system to measure ground reaction force, ankle sagittal and frontal kinematics, and movement variability. A two-way (colour x speed) ANOVA with repeated measures was performed with Bonferroni adjusted post hoc comparisons, with alpha set at 0.05. Data analyses indicated that participants demonstrated higher impact and maximum loading rate of ground reaction force, longer stride length, shorter contact time, and smaller touchdown ankle inversion as well as larger ankle sagittal range of motion (RoM), but smaller frontal RoM in fast speed as compared with preferred (
MeSH term(s)	Biomechanical Phenomena ; Color ; Humans ; Male ; Reproducibility of Results ; Running ; Shoes
Language	English
Publishing date	2021-12-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2545054-2
ISSN	2040-2309 ; 2040-2295
ISSN (online)	2040-2309
ISSN	2040-2295
DOI	10.1155/2021/8947433
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effectiveness of Insole Colour on Impact Loading and Lower-Limb Kinematics When Running at Preferred and Nonpreferred Speeds

Yi Wang / Wing-Kai Lam / Lok-Yee Pak / Charis K.-W. Wong / Mohammad F. Tan / Aaron K.-L. Leung

Journal of Healthcare Engineering, Vol

2021 Volume 2021

Abstract	While colour of red can play a significant role in altering human perception and performances, little is known about its perceptual-motor effect on running mechanics. This study examined the effects of variations in insole colours on impact forces, ankle kinematics, and trial-to-trial reliability at various running speeds. Sixteen male recreational runners ran on instrumented treadmill at slow (90%), preferred (100%), and fast (110%) running speeds when wearing insoles in red, blue, and white colours. We used synchronized force platform and motion capturing system to measure ground reaction force, ankle sagittal and frontal kinematics, and movement variability. A two-way (colour x speed) ANOVA with repeated measures was performed with Bonferroni adjusted post hoc comparisons, with alpha set at 0.05. Data analyses indicated that participants demonstrated higher impact and maximum loading rate of ground reaction force, longer stride length, shorter contact time, and smaller touchdown ankle inversion as well as larger ankle sagittal range of motion (RoM), but smaller frontal RoM in fast speed as compared with preferred P<0.05 and slow speeds P<0.001. Although insole colour had minimal effect on mean values of any tested variables P>0.05, participants wearing red-coloured orthoses showed higher coefficient of variation values for maximum loading rate than wearing blue insoles P=0.009. These results suggest that running at faster speed would lead to higher impact loading and altered lower-limb mechanics and that colour used on the tops of insoles influences the wearers’ movement repeatability, with implications for use of foot insole in running.
Keywords	Medicine (General) ; R5-920 ; Medical technology ; R855-855.5
Subject code	796
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effectiveness and Reliability of Foot Orthoses on Impact Loading and Lower Limb Kinematics When Running at Preferred and Nonpreferred Speeds.

Wang, Yi / Lam, Wing K / Wong, Charis K / Park, Lok Y / Tan, Mohammad F / Leung, Aaron K L

Journal of applied biomechanics

2020 Volume 37, Issue 1, Page(s) 66–73

Abstract: This study examined the effect of foot orthoses used on ground reaction forces, ankle, and knee kinematics when running at preferred and nonpreferred speeds. Sixteen runners ran on instrumented treadmills at various speeds (90%, 100%, and 110% of ... ...

Abstract	This study examined the effect of foot orthoses used on ground reaction forces, ankle, and knee kinematics when running at preferred and nonpreferred speeds. Sixteen runners ran on instrumented treadmills at various speeds (90%, 100%, and 110% of preferred speed) when wearing arch-support and flat-control orthoses. Two-way repeated analysis of variance (ANOVA) was performed on the mean and coefficient of variation of all variables. Results indicated that arch-support orthoses experienced larger maximum loading rates than flat-control orthoses (P = .017, 95% CI, 2.22 to 19.53). Slower speed was related to smaller loading rates (preferred: P = .002, 95% CI, -17.02 to -4.20; faster: P = .003, 95% CI, -29.78 to -6.17), shorter stride length (preferred: P < .001, 95% CI, -0.204 to -0.090; faster: P < .001, 95% CI, -0.382 to -0.237), and longer contact time (preferred: P < .001, 95% CI, 0.006-0.021; faster: 95% CI, 0.012-0.042). In arch-support condition, preferred speed induced higher stride length coefficient of variation (P = .046, 95% CI, 0.035-1.117) than faster speed, while displaying no differences in flat-control condition. These findings suggest that the use of arch-support orthoses would influence impact loading, but not spatial-temporal and joint kinematics in recreational runners.
MeSH term(s)	Adult ; Ankle/physiology ; Biomechanical Phenomena ; Foot Orthoses ; Humans ; Knee/physiology ; Male ; Running/physiology ; Weight-Bearing ; Young Adult
Language	English
Publishing date	2020-11-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1145288-2
ISSN	1543-2688 ; 1065-8483
ISSN (online)	1543-2688
ISSN	1065-8483
DOI	10.1123/jab.2019-0281
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Article ; Online: Amino acid homeostasis is a target of metformin therapy.

Molecular metabolism

2023 Volume 74, Page(s) 101750

Abstract: Objective: Unexplained changes in regulation of branched chain amino acids (BCAA) during diabetes therapy with metformin have been known for years. Here we have investigated mechanisms underlying this effect.: Methods: We used cellular approaches, ... ...

Abstract	Objective: Unexplained changes in regulation of branched chain amino acids (BCAA) during diabetes therapy with metformin have been known for years. Here we have investigated mechanisms underlying this effect. Methods: We used cellular approaches, including single gene/protein measurements, as well as systems-level proteomics. Findings were then cross-validated with electronic health records and other data from human material. Results: In cell studies, we observed diminished uptake/incorporation of amino acids following metformin treatment of liver cells and cardiac myocytes. Supplementation of media with amino acids attenuated known effects of the drug, including on glucose production, providing a possible explanation for discrepancies between effective doses in vivo and in vitro observed in most studies. Data-Independent Acquisition proteomics identified that SNAT2, which mediates tertiary control of BCAA uptake, was the most strongly suppressed amino acid transporter in liver cells following metformin treatment. Other transporters were affected to a lesser extent. In humans, metformin attenuated increased risk of left ventricular hypertrophy due to the AA allele of KLF15, which is an inducer of BCAA catabolism. In plasma from a double-blind placebo-controlled trial in nondiabetic heart failure (trial registration: NCT00473876), metformin caused selective accumulation of plasma BCAA and glutamine, consistent with the effects in cells. Conclusions: Metformin restricts tertiary control of BCAA cellular uptake. We conclude that modulation of amino acid homeostasis contributes to therapeutic actions of the drug.
MeSH term(s)	Humans ; Metformin/pharmacology ; Metformin/therapeutic use ; Amino Acids, Branched-Chain/metabolism ; Amino Acids/metabolism ; Glucose ; Homeostasis
Chemical Substances	Metformin (9100L32L2N) ; Amino Acids, Branched-Chain ; Amino Acids ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-06-09
Publishing country	Germany
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2708735-9
ISSN	2212-8778 ; 2212-8778
ISSN (online)	2212-8778
ISSN	2212-8778
DOI	10.1016/j.molmet.2023.101750
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Article ; Online: Travel-associated extensively drug-resistant typhoid fever: a case series to inform management in non-endemic regions.

Posen, H Joshua / Wong, Waison / Farrar, Daniel S / Campigotto, Aaron / Chan, Tiffany / Barker, Kevin R / Hagmann, Stefan H F / Ryan, Edward T / LaRocque, Regina C / Earl, Ashlee M / Worby, Colin J / Castelli, Francesco / Fumadó, Victoria Pérez / Britton, Philip N / Libman, Michael / Hamer, Davidson H / Morris, Shaun K

Journal of travel medicine

2022 Volume 30, Issue 1

Abstract: Background: Extensively drug-resistant (XDR) typhoid fever is a threat to travelers to Pakistan. We describe a multicontinental case series of travel-acquired XDR typhoid fever to demonstrate the global spread of the problem and encourage preventive ... ...

Abstract	Background: Extensively drug-resistant (XDR) typhoid fever is a threat to travelers to Pakistan. We describe a multicontinental case series of travel-acquired XDR typhoid fever to demonstrate the global spread of the problem and encourage preventive interventions as well as appropriate empiric antimicrobial use. Methods: Cases were extracted from the GeoSentinel database, microbiologic laboratory records of two large hospitals in Toronto, Canada, and by invitation to TropNet sites. All isolates were confirmed XDR Salmonella enterica serovar Typhi (Salmonella typhi), with resistance to ampicillin, ceftriaxone, ciprofloxacin and trimethoprim-sulfamethoxazole. Results: Seventeen cases were identified in Canada (10), USA (2), Spain (2), Italy (1), Australia (1) and Norway (1). Patients under 18 years represented 71% (12/17) of cases, and all patients travelled to Pakistan to visit friends or relatives. Only one patient is known to have been vaccinated. Predominant symptoms were fever, abdominal pain, vomiting and diarrhoea. Antimicrobial therapy was started on Day 1 of presentation in 75% (12/16) of patients, and transition to a carbapenem or azithromycin occurred a median of 2 days after blood culture was drawn. Antimicrobial susceptibilities were consistent with the XDR S. typhi phenotype, and whole genome sequencing on three isolates confirmed their belonging to the XDR variant of the H58 clade. Conclusions: XDR typhoid fever is a particular risk for travelers to Pakistan, and empiric use of a carbapenem or azithromycin should be considered. Pre-travel typhoid vaccination and counseling are necessary and urgent interventions, especially for visiting friends and relatives travelers. Ongoing sentinel surveillance of XDR typhoid fever is needed to understand changing epidemiology.
MeSH term(s)	Humans ; Typhoid Fever/epidemiology ; Travel ; Azithromycin ; Anti-Bacterial Agents ; Salmonella typhi ; Anti-Infective Agents ; Carbapenems ; Pakistan/epidemiology
Chemical Substances	Azithromycin (83905-01-5) ; Anti-Bacterial Agents ; Anti-Infective Agents ; Carbapenems
Language	English
Publishing date	2022-07-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1212504-0
ISSN	1708-8305 ; 1195-1982
ISSN (online)	1708-8305
ISSN	1195-1982
DOI	10.1093/jtm/taac086
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Article ; Online: Amino acid homeostasis is a target of metformin therapy

Molecular Metabolism, Vol 74, Iss , Pp 101750- (2023)

2023

Abstract	Objective: Unexplained changes in regulation of branched chain amino acids (BCAA) during diabetes therapy with metformin have been known for years. Here we have investigated mechanisms underlying this effect. Methods: We used cellular approaches, including single gene/protein measurements, as well as systems-level proteomics. Findings were then cross-validated with electronic health records and other data from human material. Results: In cell studies, we observed diminished uptake/incorporation of amino acids following metformin treatment of liver cells and cardiac myocytes. Supplementation of media with amino acids attenuated known effects of the drug, including on glucose production, providing a possible explanation for discrepancies between effective doses in vivo and in vitro observed in most studies. Data-Independent Acquisition proteomics identified that SNAT2, which mediates tertiary control of BCAA uptake, was the most strongly suppressed amino acid transporter in liver cells following metformin treatment. Other transporters were affected to a lesser extent. In humans, metformin attenuated increased risk of left ventricular hypertrophy due to the AA allele of KLF15, which is an inducer of BCAA catabolism. In plasma from a double-blind placebo-controlled trial in nondiabetic heart failure (trial registration: NCT00473876), metformin caused selective accumulation of plasma BCAA and glutamine, consistent with the effects in cells. Conclusions: Metformin restricts tertiary control of BCAA cellular uptake. We conclude that modulation of amino acid homeostasis contributes to therapeutic actions of the drug.
Keywords	Metformin ; Branched chain amino acids ; mTOR ; SNAT2 ; Glutamine ; Rapamycin ; Internal medicine ; RC31-1245
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Post-ST-Segment Elevation Myocardial Infarction Follow-Up Care During the COVID-19 Pandemic and the Possible Benefit of Telemedicine: An Observational Study.

Frontiers in cardiovascular medicine

2021 Volume 8, Page(s) 755822

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-10-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2021.755822
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood.

Jakubek, Yasminka A / Ma, Xiaolong / Stilp, Adrienne M / Yu, Fulong / Bacon, Jason / Wong, Justin W / Aguet, Francois / Ardlie, Kristin / Arnett, Donna / Barnes, Kathleen / Bis, Joshua C / Blackwell, Tom / Becker, Lewis C / Boerwinkle, Eric / Bowler, Russell P / Budoff, Matthew J / Carson, April P / Chen, Jiawen / Cho, Michael H /

Coresh, Josef / Cox, Nancy / de Vries, Paul S / DeMeo, Dawn L / Fardo, David W / Fornage, Myriam / Guo, Xiuqing / Hall, Michael E / Heard-Costa, Nancy / Hidalgo, Bertha / Irvin, Marguerite Ryan / Johnson, Andrew D / Kenny, Eimear E / Levy, Dan / Li, Yun / Lima, Joao Ac / Liu, Yongmei / Loos, Ruth J F / Machiela, Mitchell J / Mathias, Rasika A / Mitchell, Braxton D / Murabito, Joanne / Mychaleckyj, Josyf C / North, Kari / Orchard, Peter / Parker, Stephen Cj / Pershad, Yash / Peyser, Patricia A / Pratte, Katherine A / Psaty, Bruce M / Raffield, Laura M / Redline, Susan / Rich, Stephen S / Rotter, Jerome I / Shah, Sanjiv J / Smith, Jennifer A / Smith, Aaron P / Smith, Albert / Taub, Margaret / Tiwari, Hemant K / Tracy, Russell / Tuftin, Bjoernar / Bick, Alexander G / Sankaran, Vijay G / Reiner, Alexander P / Scheet, Paul / Auer, Paul L

medRxiv : the preprint server for health sciences

2024

Abstract: Mosaic loss of Y (mLOY) is the most common somatic chromosomal alteration detected in human blood. The presence of mLOY is associated with altered blood cell counts and increased risk of Alzheimer's disease, solid tumors, and other age-related diseases. ... ...

Abstract	Mosaic loss of Y (mLOY) is the most common somatic chromosomal alteration detected in human blood. The presence of mLOY is associated with altered blood cell counts and increased risk of Alzheimer's disease, solid tumors, and other age-related diseases. We sought to gain a better understanding of genetic drivers and associated phenotypes of mLOY through analyses of whole genome sequencing of a large set of genetically diverse males from the Trans-Omics for Precision Medicine (TOPMed) program. This approach enabled us to identify differences in mLOY frequencies across populations defined by genetic similarity, revealing a higher frequency of mLOY in the European American (EA) ancestry group compared to those of Hispanic American (HA), African American (AA), and East Asian (EAS) ancestry. Further, we identified two genes (
Language	English
Publishing date	2024-04-19
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.04.16.24305851
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Article ; Online: Reply: Meta-Analysis of the Index of Microvascular Resistance in Acute STEMI Using Incomplete Data.

Bulluck, Heerajnarain / Foin, Nicolas / Cabrera-Fuentes, Hector A / Yeo, Khung K / Wong, Aaron S / Fam, Jiang M / Wong, Philip E / Tan, Jack W / Low, Adrian F / Hausenloy, Derek J

JACC. Cardiovascular interventions

2017 Volume 10, Issue 4, Page(s) 422

MeSH term(s)	Coronary Circulation ; Humans ; Percutaneous Coronary Intervention ; ST Elevation Myocardial Infarction
Language	English
Publishing date	2017-02-23
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2017.01.003
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Article: Multi-MHz laser-scanning single-cell fluorescence microscopy by spatiotemporally encoded virtual source array.

Wu, Jianglai / Tang, Anson H L / Mok, Aaron T Y / Yan, Wenwei / Chan, Godfrey C F / Wong, Kenneth K Y / Tsia, Kevin K

Biomedical optics express

2017 Volume 8, Issue 9, Page(s) 4160–4171

Abstract: Apart from the spatial resolution enhancement, scaling of temporal resolution, equivalently the imaging throughput, of fluorescence microscopy is of equal importance in advancing cell biology and clinical diagnostics. Yet, this attribute has mostly been ... ...

Abstract	Apart from the spatial resolution enhancement, scaling of temporal resolution, equivalently the imaging throughput, of fluorescence microscopy is of equal importance in advancing cell biology and clinical diagnostics. Yet, this attribute has mostly been overlooked because of the inherent speed limitation of existing imaging strategies. To address the challenge, we employ an all-optical laser-scanning mechanism, enabled by an array of reconfigurable spatiotemporally-encoded virtual sources, to demonstrate ultrafast fluorescence microscopy at line-scan rate as high as 8 MHz. We show that this technique enables high-throughput single-cell microfluidic fluorescence imaging at 75,000 cells/second and high-speed cellular 2D dynamical imaging at 3,000 frames per second, outperforming the state-of-the-art high-speed cameras and the gold-standard laser scanning strategies. Together with its wide compatibility to the existing imaging modalities, this technology could empower new forms of high-throughput and high-speed biological fluorescence microscopy that was once challenged.
Language	English
Publishing date	2017-08-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2572216-5
ISSN	2156-7085
ISSN	2156-7085
DOI	10.1364/BOE.8.004160
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