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  1. Book: Topics in prevalent diseases

    Chavez-Tapia, Norberto C.

    a minority's perspective

    (Nova biomedical)

    2009  

    Author's details Norberto C. Chavez-Tapia, ed
    Series title Nova biomedical
    Keywords Minority Health ; Healthcare Disparities
    Language English
    Size VI, 367 S. : Ill., graph. Darst.
    Publisher Nova Biomed. Books
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT015937429
    ISBN 978-1-60456-959-9 ; 1-60456-959-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 3173 order for loan Magazin

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  2. Article: Occult liver disease: A multinational perspective.

    Vidal-Cevallos, Paulina / Flores-García, Nayelli / Chávez-Tapia, Norberto C / Chalasani, Naga P

    Annals of hepatology

    2024  , Page(s) 101480

    Abstract: ... increasing over the last years. Viral hepatitis B and C accounted for 1.3 million deaths in 2020 ...

    Abstract Occult liver disease refers to the presence of unrecognized chronic liver disease and cirrhosis. Liver disease is currently the eleventh cause of death globally, representing 4% of all deaths in the world. Alcohol consumption is the leading cause of cirrhosis globally, accounting for approximately 60% of cases. The estimated global prevalence of non-alcoholic fatty liver disease (NAFLD) is 32.4% and has been steadily increasing over the last years. Viral hepatitis B and C accounted for 1.3 million deaths in 2020. Several studies in populations at high risk of chronic liver disease (elevated liver enzymes, type 2 diabetes, excessive alcohol consumption) have found an elevated prevalence of occult liver disease. Attempts should be made to assess the prevalence of occult liver disease in Latin America, a region with one of the highest rates of metabolic diseases and excessive alcohol consumption. Screening for NAFLD in high-risk subjects and screening for excessive drinking and alcohol use disorders at every level of medical care is relevant. Efforts should also focus on the early treatment of occult liver disease to try to reduce liver disease burden and, in the case of occult viral hepatitis infection, prevent further spreading.
    Language English
    Publishing date 2024-02-12
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 2188733-0
    ISSN 1665-2681
    ISSN 1665-2681
    DOI 10.1016/j.aohep.2024.101480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Relationship between Pathogenesis and Possible Treatments for the MASLD-Cirrhosis Spectrum.

    Vidal-Cevallos, Paulina / Sorroza-Martínez, Adriana P / Chávez-Tapia, Norberto C / Uribe, Misael / Montalvo-Javé, Eduardo E / Nuño-Lámbarri, Natalia

    International journal of molecular sciences

    2024  Volume 25, Issue 8

    Abstract: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a term that entails a broad spectrum of conditions that vary in severity. Its development is influenced by multiple factors such as environment, microbiome, comorbidities, and genetic ... ...

    Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is a term that entails a broad spectrum of conditions that vary in severity. Its development is influenced by multiple factors such as environment, microbiome, comorbidities, and genetic factors. MASLD is closely related to metabolic syndrome as it is caused by an alteration in the metabolism of fatty acids due to the accumulation of lipids because of an imbalance between its absorption and elimination in the liver. Its progression to fibrosis is due to a constant flow of fatty acids through the mitochondria and the inability of the liver to slow down this metabolic load, which generates oxidative stress and lipid peroxidation, triggering cell death. The development and progression of MASLD are closely related to unhealthy lifestyle habits, and nutritional epigenetic and genetic mechanisms have also been implicated. Currently, lifestyle modification is the first-line treatment for MASLD and nonalcoholic steatohepatitis; weight loss of ≥10% produces resolution of steatohepatitis and fibrosis regression. In many patients, body weight reduction cannot be achieved; therefore, pharmacological treatment should be offered in particular populations.
    MeSH term(s) Humans ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Liver Cirrhosis/etiology ; Fatty Liver/metabolism ; Fatty Liver/etiology ; Fatty Liver/therapy ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/therapy ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/pathology ; Oxidative Stress ; Life Style ; Animals ; Metabolic Syndrome/metabolism ; Metabolic Syndrome/therapy ; Metabolic Syndrome/etiology ; Liver/metabolism ; Liver/pathology
    Language English
    Publishing date 2024-04-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Understanding the Relationship between Nonalcoholic Fatty Liver Disease and Thyroid Disease.

    Vidal-Cevallos, Paulina / Murúa-Beltrán Gall, Sofía / Uribe, Misael / Chávez-Tapia, Norberto C

    International journal of molecular sciences

    2023  Volume 24, Issue 19

    Abstract: The prevalence of hypothyroidism in patients with nonalcoholic fatty liver disease (NAFLD) is high (22.4%). Thyroid hormones (THs) regulate many metabolic activities in the liver by promoting the export and oxidation of lipids, as well as de novo ... ...

    Abstract The prevalence of hypothyroidism in patients with nonalcoholic fatty liver disease (NAFLD) is high (22.4%). Thyroid hormones (THs) regulate many metabolic activities in the liver by promoting the export and oxidation of lipids, as well as de novo lipogenesis. They also control hepatic insulin sensitivity and suppress hepatic gluconeogenesis. Because of its importance in lipid and carbohydrate metabolism, the involvement of thyroid dysfunction in the pathogenesis of NAFLD seems plausible. The mechanisms implicated in this relationship include high thyroid-stimulating hormone (TSH) levels, low TH levels, and chronic inflammation. The activity of the TH receptor (THR)-β in response to THs is essential in the pathogenesis of hypothyroidism-induced NAFLD. Therefore, an orally active selective liver THR-β agonist, Resmetirom (MGL-3196), was developed, and has been shown to reduce liver fat content, and as a secondary end point, to improve nonalcoholic steatohepatitis. The treatment of NAFLD with THR-β agonists seems quite promising, and other agonists are currently under development and investigation. This review aims to shine a light on the pathophysiological and epidemiological evidence regarding this relationship and the effect that treatment with THs and selective liver THR-β agonists have on hepatic lipid metabolism.
    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/metabolism ; Liver/metabolism ; Thyroid Diseases/pathology ; Thyroid Hormones/metabolism ; Hypothyroidism/complications ; Gluconeogenesis
    Chemical Substances Thyroid Hormones
    Language English
    Publishing date 2023-09-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241914605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Current approaches to hepatic encephalopathy.

    Vidal-Cevallos, Paulina / Chávez-Tapia, Norberto C / Uribe, Misael

    Annals of hepatology

    2022  Volume 27, Issue 6, Page(s) 100757

    Abstract: Hepatic encephalopathy (HE) is a brain dysfunction caused by liver insufficiency and/or portosystemic shunts. Between 30%-40% of patients with cirrhosis will present overt HE during their lifetime. While the pathophysiology of HE is not entirely ... ...

    Abstract Hepatic encephalopathy (HE) is a brain dysfunction caused by liver insufficiency and/or portosystemic shunts. Between 30%-40% of patients with cirrhosis will present overt HE during their lifetime. While the pathophysiology of HE is not entirely understood, three critical factors have been identified: hyperammonaemia, systemic inflammation and oxidative stress by glutaminase gene alterations. Minimal HE is defined by the presence of signs of cognitive abnormalities in a patient without asterixis or disorientation; it can only be diagnosed with neuropsychological or psychometric tests. The diagnosis of overt HE is based on clinical examination with clinical scales. Currently, only overt HE should be routinely treated. The aims of treatment in an acute episode should be to improve the mental status, identify and treat the precipitating factor, reduce duration and limit consequences. Treatment strategies are targeted at reducing ammonia production and/or increasing its elimination. Even though minimal HE has negative effects on the patient's quality of life and effects on prognosis, indications for treatment are still controversial. There are still many unanswered questions regarding the pathophysiology and management of HE. We should also endeavor to develop more accurate and objective diagnostic methods for overt HE that would permit early detection and help improve outcomes on quality of life and economic burden.
    MeSH term(s) Humans ; Hepatic Encephalopathy/diagnosis ; Hepatic Encephalopathy/etiology ; Hepatic Encephalopathy/therapy ; Quality of Life ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/therapy ; Hyperammonemia/diagnosis ; Hyperammonemia/etiology ; Hyperammonemia/therapy ; Psychometrics
    Language English
    Publishing date 2022-09-14
    Publishing country Mexico
    Document type Journal Article ; Review
    ZDB-ID 2188733-0
    ISSN 1665-2681
    ISSN 1665-2681
    DOI 10.1016/j.aohep.2022.100757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6221: Show issues Location:
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  6. Article ; Online: Current approaches to hepatic encephalopathy

    Paulina Vidal-Cevallos / Norberto C. Chávez-Tapia / Misael Uribe

    Annals of Hepatology, Vol 27, Iss 6, Pp 100757- (2022)

    2022  

    Abstract: Hepatic encephalopathy (HE) is a brain dysfunction caused by liver insufficiency and/or portosystemic shunts. Between 30%–40% of patients with cirrhosis will present overt HE during their lifetime. While the pathophysiology of HE is not entirely ... ...

    Abstract Hepatic encephalopathy (HE) is a brain dysfunction caused by liver insufficiency and/or portosystemic shunts. Between 30%–40% of patients with cirrhosis will present overt HE during their lifetime. While the pathophysiology of HE is not entirely understood, three critical factors have been identified: hyperammonaemia, systemic inflammation and oxidative stress by glutaminase gene alterations. Minimal HE is defined by the presence of signs of cognitive abnormalities in a patient without asterixis or disorientation; it can only be diagnosed with neuropsychological or psychometric tests. The diagnosis of overt HE is based on clinical examination with clinical scales. Currently, only overt HE should be routinely treated. The aims of treatment in an acute episode should be to improve the mental status, identify and treat the precipitating factor, reduce duration and limit consequences. Treatment strategies are targeted at reducing ammonia production and/or increasing its elimination. Even though minimal HE has negative effects on the patient's quality of life and effects on prognosis, indications for treatment are still controversial. There are still many unanswered questions regarding the pathophysiology and management of HE. We should also endeavor to develop more accurate and objective diagnostic methods for overt HE that would permit early detection and help improve outcomes on quality of life and economic burden.
    Keywords Liver cirrhosis ; Classification ; Physiopathology ; Therapeutics ; Diagnosis ; Specialties of internal medicine ; RC581-951
    Subject code 610
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Epidemiological and Genetic Aspects of NAFLD and NASH in Mexico.

    Vidal-Cevallos, Paulina / Torre, Aldo / Mendez-Sanchez, Nahum / Uribe, Misael / Chavez-Tapia, Norberto C

    Clinical liver disease

    2022  Volume 19, Issue 2, Page(s) 68–72

    Abstract: Content available: Author Interview and Audio Recording. ...

    Abstract Content available: Author Interview and Audio Recording.
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1002/cld.1167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Hepatitis C mortality trends in Mexico from 2001 to 2017.

    Martínez-Bohorquez, María Carolina / Carnalla, Martha / Chávez-Tapia, Norberto / Barrientos-Gutiérrez, Tonatiuh

    Annals of hepatology

    2023  Volume 28, Issue 3, Page(s) 101083

    Abstract: ... from hepatitis C virus (HCV) and to estimate the proportion of non-alcoholic liver disease deaths in Mexico attributable ...

    Abstract Introduction and objectives: We aimed to analyze the trends of total and sex-stratified mortality from hepatitis C virus (HCV) and to estimate the proportion of non-alcoholic liver disease deaths in Mexico attributable to HCV from 2001-2017.
    Materials and methods: Using the mortality multiple-cause dataset, we selected the codes for acute HCV and chronic HCV to analyze trends from 2001 to 2017. We then estimated the proportion of HCV-related deaths out of non-alcoholic chronic liver disease deaths, by including in the denominator: other acute and chronic viral hepatitis, malignant neoplasm of the liver, liver failure, chronic hepatitis, fibrosis, and cirrhosis of the liver, and other inflammatory diseases of the liver. Average percent change (APC) for trends, overall and by sex, were estimated using Joinpoint regression.
    Results: The trend in crude mortality rate significantly increased from 2001-2005 (APC 18.4%; 95%CI=12.5, 24.5; p value<0.001), and then significantly decreased from 2013-2017 (APC -6.5%; 95%CI=-10.1, -2.9; p value<0.001). Stratified by sex women experienced a more rapid decline in the 2014-2017 period than men.
    Conclusions: HCV mortality seems to have started to decrease, but much remains to be done in terms of prevention, diagnosis, and timely access to treatment.
    MeSH term(s) Male ; Humans ; Female ; Hepacivirus ; Mexico/epidemiology ; Hepatitis C/diagnosis ; Hepatitis C/epidemiology ; Liver Cirrhosis ; Hepatitis C, Chronic/diagnosis ; Hepatitis C, Chronic/epidemiology
    Language English
    Publishing date 2023-03-05
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 2188733-0
    ISSN 1665-2681
    ISSN 1665-2681
    DOI 10.1016/j.aohep.2023.101083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Clostridioides Difficile in Latin America: An Epidemiological Overview.

    Morales-Olvera, Claudia G / Lanz-Zubiría, Lorena / Aguilar-Zamora, Emmanuel / Camorlinga-Ponce, Margarita / Aparicio-Ozores, Gerardo / Aguilar-Zapata, Daniel / Chávez-Tapia, Norberto C / Uribe, M / Barbero-Becerra, Varenka J / Juárez-Hernández, Eva

    Current microbiology

    2023  Volume 80, Issue 11, Page(s) 357

    Abstract: Clostridioides difficile infection is one of the most significant causes of nosocomial diarrhea associated with antibiotic use worldwide. In recent years, the incidence of Clostridioides difficile infection in Latin American countries has increased due ... ...

    Abstract Clostridioides difficile infection is one of the most significant causes of nosocomial diarrhea associated with antibiotic use worldwide. In recent years, the incidence of Clostridioides difficile infection in Latin American countries has increased due to the emergence and spread of epidemic Clostridioides difficile strains, such as RT027/NAP1/ST1, RT078/ST11, and RT017/ST37; additionally, endemic multi-drug-resistant strains have recently appeared due to the lack of heterogeneous diagnostic algorithms and guidelines for antibiotic use in each country. The aim of this review is to present the latest information regarding Clostridioides difficile and emphasize the importance of epidemiological surveillance of this pathogen in Latin American countries.
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-023-03475-x
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  10. Article: A New Stage in Annals of Hepatology.

    Panduro, Arturo / Tiribelli, Claudio / Chávez-Tapia, Norberto C / Uribe, Misael

    Annals of hepatology

    2018  Volume 17, Issue 3, Page(s) 339–340

    MeSH term(s) Biomedical Research/methods ; Biomedical Research/trends ; Diffusion of Innovation ; Editorial Policies ; Forecasting ; Gastroenterology/methods ; Gastroenterology/trends ; Humans ; Liver Diseases/diagnosis ; Liver Diseases/physiopathology ; Liver Diseases/therapy ; Periodicals as Topic/trends
    Language English
    Publishing date 2018-04-09
    Publishing country Mexico
    Document type Editorial
    ZDB-ID 2188733-0
    ISSN 1665-2681
    ISSN 1665-2681
    DOI 10.5604/01.3001.0011.7377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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