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  1. Article ; Online: Nanopore sensitization based on a double loop hybridization chain reaction and G-quadruplex.

    Li, Yanru / Yu, Chunmiao / Wang, Yesheng / Yu, Jin / Wang, Huaning / Li, Bingling

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 33, Page(s) 4487–4490

    Abstract: The widespread implementation of solid-state nanopores faces challenges such as lower resolution and increased electrical noise when compared to biological nanopores. Incorporating specific nucleic acid reactions can enhance resolution. In this study, we' ...

    Abstract The widespread implementation of solid-state nanopores faces challenges such as lower resolution and increased electrical noise when compared to biological nanopores. Incorporating specific nucleic acid reactions can enhance resolution. In this study, we've developed a nucleic acid amplifier to enhance the sensitivity of solid-state nanopores, utilizing a G-rich sequence and hybridization chain reaction. This amplifier improves target concentration and volume amplification, showing promise in nanopore sensitivity tests.
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d4cc00125g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Dexterous Manipulation for Multi-Fingered Robotic Hands With Reinforcement Learning: A Review.

    Yu, Chunmiao / Wang, Peng

    Frontiers in neurorobotics

    2022  Volume 16, Page(s) 861825

    Abstract: With the increasing demand for the dexterity of robotic operation, dexterous manipulation of multi-fingered robotic hands with reinforcement learning is an interesting subject in the field of robotics research. Our purpose is to present a comprehensive ... ...

    Abstract With the increasing demand for the dexterity of robotic operation, dexterous manipulation of multi-fingered robotic hands with reinforcement learning is an interesting subject in the field of robotics research. Our purpose is to present a comprehensive review of the techniques for dexterous manipulation with multi-fingered robotic hands, such as the model-based approach without learning in early years, and the latest research and methodologies focused on the method based on reinforcement learning and its variations. This work attempts to summarize the evolution and the state of the art in this field and provide a summary of the current challenges and future directions in a way that allows future researchers to understand this field.
    Language English
    Publishing date 2022-04-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2453002-5
    ISSN 1662-5218
    ISSN 1662-5218
    DOI 10.3389/fnbot.2022.861825
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  3. Article ; Online: The single strand template shortening strategy improves the sensitivity and specificity of solid-state nanopore detection.

    Yu, Jin / Yu, Chunxu / Li, Yanru / Yu, Chunmiao / Wang, Yesheng / Wu, Ruiping / Li, Bingling

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 35, Page(s) 4723–4726

    Abstract: Through controlling the ssDNA product length of rolling circle amplification with AcyNTP, here we develop a nanopore signal enhancement strategy (STSS), which can successfully transfer the short oligonucleotide targets into long ssDNAs with appropriate ... ...

    Abstract Through controlling the ssDNA product length of rolling circle amplification with AcyNTP, here we develop a nanopore signal enhancement strategy (STSS), which can successfully transfer the short oligonucleotide targets into long ssDNAs with appropriate lengths that can generate significant translocation currents. By labelling the RCA product with tags such as tetrahedral structures and isothermal amplicons, the resolution, signal specificity, and target range of the STSS can be further extended.
    MeSH term(s) Nanopores ; DNA, Single-Stranded/chemistry ; Nucleic Acid Amplification Techniques
    Chemical Substances DNA, Single-Stranded
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d4cc00961d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Experimental Research on Combustion, Pyrolysis Characteristics, and Kinetics of Three Different Coal Samples in China.

    Li, Chang / Liu, Zhengdong / Yuan, Chunmiao / Yu, Zhongjie

    ACS omega

    2023  Volume 8, Issue 38, Page(s) 34388–34396

    Abstract: Coal thermal and kinetic parameters are important for the design of combustion reactors and risk assessment. Two methods were employed to investigate such key parameters of lignite, bituminous, and anthracite coal samples from China. With ... ...

    Abstract Coal thermal and kinetic parameters are important for the design of combustion reactors and risk assessment. Two methods were employed to investigate such key parameters of lignite, bituminous, and anthracite coal samples from China. With thermogravimetry (TG) and differential scanning calorimetry (DSC) methods, two distinct transitional stages were found in all coal samples combustion, but reaction intervals shifted to higher temperatures from lignite to anthracite and varied between 317 and 665 °C depending on the sample nature. Compared to the other two coal types, the pyrolysis of anthracite was less sensitive to increasing temperature, and its combustion process occurred at a much higher temperature. The results indicated that anthracite is difficult to ignite but has a considerable heat of reaction of 22.6 kJ/kg if ignited, which is close to that of bituminous. The basket heating method was used to obtain the kinetic data. Sample activation energies varied in the ranges of 38-51 kJ/mol from TG analysis and 49-67 kJ/mol from basket heating tests. Both results were comparable and consistent with the reference data. Due to its higher activation energy, anthracite poses a lower risk of thermal runaway than other coal types. This conclusion was validated by performing a minimum ignition temperature determination of a dust layer (MITL). In contrast, lignite and bituminous should be handled with greater safety precautions in coal-related process industries. The data presented will be used for hazard analysis and for designing more efficient combustion reactors in power plants. The data collected led to an extension of the current data for coal dust, as found in the literature.
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c02151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Single Molecular Nanopores as a Label-Free Method for Homogeneous Conformation Investigation and Anti-Interference Molecular Analysis.

    Yu, Chunmiao / Wang, Yesheng / Wu, Ruiping / Li, Bingling

    ACS applied materials & interfaces

    2023  Volume 15, Issue 19, Page(s) 23602–23612

    Abstract: In this paper, we propose a "reciprocal strategy" that, on the one hand, explores the ability of solid-state nanopores in a homogeneous high-fidelity characterization of nucleic acid assembly and, on the other hand, the formed nucleic acid assembly with ... ...

    Abstract In this paper, we propose a "reciprocal strategy" that, on the one hand, explores the ability of solid-state nanopores in a homogeneous high-fidelity characterization of nucleic acid assembly and, on the other hand, the formed nucleic acid assembly with a large size serves as an amplifier to provide a highly distinguished and anti-interference signal for molecular sensing. Four-hairpin hybridization chain reaction (HCR) with G-rich tail tags is taken as the proof-of-concept demonstration. G-rich tail tags are commonly used to form G-quadruplex signal probes on the side chain of HCR duplex concatemers. When such G-tailed HCR concatemers translocate the nanopore, abnormal, much higher nanopore signals over normal duplexes can be observed. Combined with atomic force microscopy, we reveal the G-rich tail may easily induce the "intermolecular interaction" between HCR concatemers to form "branched assembly structure (BAS)". To the best of our knowledge, this is the first evidence for the formation BAS of the G tailed HCR concatemers in a homogeneous solution. Systematic nanopore measurements further suggest the formation of these BASs is closely related to the types of salt ions, the amount of G, the concentration of substrate hairpins, the reaction time, and so forth. Under optimized conditions, these BASs can be grown to just the right size without being too large to block the pores, while producing a current 14 times that of conventional double-stranded chains. Here, these very abnormal large current blockages have, in turn, been taken as an anti-interference signal indicator for small targets in order to defend the high noises resulting from co-existing big species (e.g., enzymes or other long double-stranded DNA).
    MeSH term(s) Nanopores ; DNA/chemistry ; Nucleic Acid Hybridization/methods ; Nucleic Acids ; Biosensing Techniques/methods
    Chemical Substances DNA (9007-49-2) ; Nucleic Acids
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c01884
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Foldaxane-Based Switchable [c2]Daisy Chains.

    Liao, Sibei / Tang, Jie / Ma, Chunmiao / Yu, Lu / Tan, Ying / Li, Xuanzhu / Gan, Quan

    Angewandte Chemie (International ed. in English)

    2024  Volume 63, Issue 14, Page(s) e202315668

    Abstract: Artificial molecular muscles are highly attractive in the field of molecular machinery due to their unique properties of contraction and stretching motion. However, the synthesis of molecular muscles poses formidable challenges as it is hindered by ... ...

    Abstract Artificial molecular muscles are highly attractive in the field of molecular machinery due to their unique properties of contraction and stretching motion. However, the synthesis of molecular muscles poses formidable challenges as it is hindered by undesirable yields and poor selectivity. Herein, we present a procedure for the dynamic assembly of foldaxane-based [c2]daisy chains, wherein the hermaphroditic sequences consisting of aromatic helices and peptide rods are interlocked through inter-strand hydrogen-bonding interactions. The binding complementarity facilitates a selective and efficient assembly of [c2]daisy chain structures, inhibiting the creation of by-products. Introducing multiple recognition sites confers the system with contraction and stretching motion actuated by chemical stimuli. The rate of this muscle-like motion is calculated to be 0.8 s
    Language English
    Publishing date 2024-02-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202315668
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  7. Article ; Online: Optimization of an Asymmetric Reaction.

    Ma, Chunmiao / Tang, Jie / Yu, Lu / Wen, Kehan / Gan, Quan

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2022  Volume 28, Issue 28, Page(s) e202201118

    Abstract: Invited for the cover of this issue are Quan Gan and co-workers at the Huazhong University of Science and Technology. The image depicts aromatic oligoamide sequences winding around a substrate with conformational control. Read the full text of the ... ...

    Abstract Invited for the cover of this issue are Quan Gan and co-workers at the Huazhong University of Science and Technology. The image depicts aromatic oligoamide sequences winding around a substrate with conformational control. Read the full text of the article at 10.1002/chem.202200834.
    Language English
    Publishing date 2022-04-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202201118
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  8. Article ; Online: How aromatic dissolved organic matter differs in competitiveness against organic micropollutant adsorption.

    Wang, Qi / Lechtenfeld, Oliver J / Rietveld, Luuk C / Schuster, Jonas / Ernst, Mathias / Hofman-Caris, Roberta / Kaesler, Jan / Wang, Chunmiao / Yang, Min / Yu, Jianwei / Zietzschmann, Frederik

    Environmental science and ecotechnology

    2024  Volume 21, Page(s) 100392

    Abstract: Activated carbon is employed for the adsorption of organic micropollutants (OMPs) from water, typically present in concentrations ranging from ng ... ...

    Abstract Activated carbon is employed for the adsorption of organic micropollutants (OMPs) from water, typically present in concentrations ranging from ng L
    Language English
    Publishing date 2024-01-27
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-4984
    ISSN (online) 2666-4984
    DOI 10.1016/j.ese.2024.100392
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  9. Article ; Online: Integrating Metabolomics and Network Pharmacology to Explore the Protective Effect of Ginsenoside Re against Radiotherapy Injury in Mice

    Chunmiao Yu / Jiaqi Fu / Lidong Guo / Miaomiao Yu / Donghua Yu

    Evidence-Based Complementary and Alternative Medicine, Vol

    2022  Volume 2022

    Abstract: Ionizing radiation (IR) can cause radiation damage, mutagenesis, or carcinogenesis in the irradiated subject. It is manifested as metabolic disorders of the body and damage to the immune system, nervous system, and endocrine system, which can lead to ... ...

    Abstract Ionizing radiation (IR) can cause radiation damage, mutagenesis, or carcinogenesis in the irradiated subject. It is manifested as metabolic disorders of the body and damage to the immune system, nervous system, and endocrine system, which can lead to physiological and pathological changes and endogenous metabolic disorders. Ginsenoside Re (G-Re), a single component of traditional Chinese medicine, has a certain ameliorating effect on radiation damage. However, its mechanism of action in the treatment of radiotherapy injury remains unclear. With this purpose, the hematopoietic function of mice damaged by X-ray radiation was studied, and the protective effect of G-Re on mice damaged by radiation was preliminarily evaluated. Network pharmacology and metabolomics analysis are used to further reveal the mechanism of G-Re to improve radiation damage through metabolomics research. Results of metabolomics analysis showed that 16 potential biomarkers were identified as participating in the therapeutic effect of G-Re on IR. Most of these metabolites are adjusted to recover after G-Re treatment. The pathways involved included glycerophospholipid metabolism, sphingolipid metabolism, and linoleic acid metabolism. According to network pharmacology analysis, we found 10 hub genes, which is partly consistent with the findings of metabolomics. Further comprehensive analysis focused on 4 key targets, including SRC, EGFR, AKT1, and MAPK8, and their related core metabolites and pathways. This study combines metabolomics and network pharmacology analysis to explore the key targets and mechanisms of G-Re in the treatment of IR, in order to provide new strategies for clinical treatment of radiotherapy injury.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 570
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Optimization of an Asymmetric Reaction in the Cavity of Chiral Aromatic Oligoamide Foldamers.

    Ma, Chunmiao / Tang, Jie / Yu, Lu / Wen, Kehan / Gan, Quan

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2022  Volume 28, Issue 28, Page(s) e202200834

    Abstract: An asymmetric reaction can be implemented and refined in the helical cavity of aromatic oligoamide sequences. These sequences, which bear a chiral inducer, can fold into helical structures with absolute control of the helical sense, whereby a ketone ... ...

    Abstract An asymmetric reaction can be implemented and refined in the helical cavity of aromatic oligoamide sequences. These sequences, which bear a chiral inducer, can fold into helical structures with absolute control of the helical sense, whereby a ketone substrate covalently linked in the cavity can be asymmetrically reduced to diastereomers. The diastereoselectivity of the reduction is highly dependent on the shielding efficiency of the helical cavity. Iterative modifications of the sequence, such as addition and replacement of monomers, can fine-tune the cavity to realize the asymmetric reaction, thereby progressively increasing the diastereomeric excess up to 90 %.
    MeSH term(s) Amides/chemistry
    Chemical Substances Amides
    Language English
    Publishing date 2022-04-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202200834
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