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Book: Autophagy and signaling

Wong, Esther

(Methods in signal transduction series)

2018

Author's details	[edited by] Esther Wong
Series title	Methods in signal transduction series
MeSH term(s)	Autophagy/physiology ; Signal Transduction/physiology
Language	English
Size	p. ;, cm.
Document type	Book
ISBN	9781498731898 ; 1498731899
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Psychological distress and social support among community paediatric palliative care programme caregivers: longitudinal analysis.

Wong, Esther Chui Yan / Au-Doung, Phillip Lung Wai / Chu, Yvonne Yuen Ling / Wong, Sandy Sin Yuet / Li, Chi Kong / Cheung, Yin Ting

BMJ supportive & palliative care

2024 Volume 13, Issue e3, Page(s) e767–e769

MeSH term(s)	Humans ; Child ; Caregivers/psychology ; Palliative Care/psychology ; Home Care Services ; Social Support ; Psychological Distress ; Stress, Psychological/psychology
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Letter
ISSN	2045-4368
ISSN (online)	2045-4368
DOI	10.1136/spcare-2023-004301
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Children's Lived Experiences in Poverty in Hong Kong as a High-Income Asian Society.

Cho, Esther Yin-Nei / Wong, Victor C W

International journal of environmental research and public health

2022 Volume 19, Issue 10

Abstract: Child poverty situated in different socioeconomic and environmental contexts has long been a central concern for practitioners, researchers, and policy makers. However, concerned research studies are predominantly adult-centric, confined to specific ... ...

Abstract	Child poverty situated in different socioeconomic and environmental contexts has long been a central concern for practitioners, researchers, and policy makers. However, concerned research studies are predominantly adult-centric, confined to specific areas, or seldom found in Asian developed economies. Against the backdrop of this research gap, this study examines children's experiences of poverty in relation to economic and material aspects, social relationships and participation, and psychological and emotional wellbeing, and their ways of coping with the effects of poverty. Using a purposive sampling method, a total of 40 children participants aged 8-14 living in or near poverty were recruited for an individual interview. The study showed that children experienced a range of deprivations in relation to falling short of the resources, opportunities, and activities that are commanded by average young persons. Limited living space also stands out as a more severe problem that is difficult to cope with. The various coping strategies include small spending savvy tactics, parental buffering, compensation, and mental coping. Proximity to schools and NGOs can help children in poverty to cope with problems caused by deprivations in different aspects. Implications for research studies and practice for working with children in or near poverty are discussed accordingly.
MeSH term(s)	Adaptation, Psychological ; Adult ; Child ; Hong Kong ; Humans ; Income ; Poverty/psychology ; Societies
Language	English
Publishing date	2022-05-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19106190
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Article ; Online: Mid-term survivorship of fixed bearing unicondylar knee arthroplasty with no exclusion of early PFJ arthritis or ACL deficiency: Analysis of clinical and radiological predictors.

Lee, Qunn Jid / Chang, Wai Yee Esther / Wong, Yiu Chung

Journal of orthopaedic surgery (Hong Kong)

2022 Volume 30, Issue 3, Page(s) 10225536221141782

Abstract: Purpose: Fixed bearing (FB) UKA constituted 63.7% of unicondylar knee arthroplasties in 2020 Australian Registry with the longest UKA survivorship. The significance of patellofemoral joint (PFJ) arthritis, ACL deficiency, post-operative anteromedial ... ...

Abstract	Purpose: Fixed bearing (FB) UKA constituted 63.7% of unicondylar knee arthroplasties in 2020 Australian Registry with the longest UKA survivorship. The significance of patellofemoral joint (PFJ) arthritis, ACL deficiency, post-operative anteromedial pain, radiosclerosis or radiolucency on survivorship of FB UKA is not established. The aim of this study was to analyze the medium-term survivorship of fixed-bearing UKA with no exclusion of PFJ OA and ACL deficiency. Predictors for failure were analyzed. Methods: FB UKA performed in 2011-17 were reviewed. Cases with PFJ OA or ACL deficiency were not excluded. The effect on survivorship by ACL deficiency, PFJ arthritis, post-operative anteromedial pain and radiological abnormalities were analyzed. Results: There were 96 UKA with follow-up time of 66 ± 18 months (27-98). The mean age was 70 ± 9 years, BMI 25.8 ± 2.6 kg/m Conclusion: FB UKA with no exclusion of early PFJ arthritis and ACL deficiency has satisfactory medium-term survivorship. BMI ≥30 could have higher risk of all-cause revision. Tibial tray overhang, non-progressive radiolucency or radiosclerosis do not seem to be associated with anteromedial knee pain or poorer medium term survivorship.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Arthroplasty, Replacement, Knee ; Patellofemoral Joint/surgery ; Knee Prosthesis ; Osteoarthritis, Knee/diagnostic imaging ; Osteoarthritis, Knee/surgery ; Survivorship ; Prosthesis Failure ; Reoperation ; Australia ; Pain/surgery
Language	English
Publishing date	2022-11-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1493368-8
ISSN	2309-4990 ; 1022-5536
ISSN (online)	2309-4990
ISSN	1022-5536
DOI	10.1177/10225536221141782
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Article: The AMPK-like protein kinases Sik2 and Sik3 interact with Hipk and induce synergistic tumorigenesis in a

Yu, Kewei / Ramkumar, Niveditha / Wong, Kenneth Kin Lam / Tettweiler, Gritta / Verheyen, Esther M

Frontiers in cell and developmental biology

2023 Volume 11, Page(s) 1214539

Abstract: Homeodomain-interacting protein kinases (Hipks) regulate cell proliferation, apoptosis, and tissue development. Overexpression of Hipk ... ...

Abstract	Homeodomain-interacting protein kinases (Hipks) regulate cell proliferation, apoptosis, and tissue development. Overexpression of Hipk in
Language	English
Publishing date	2023-10-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2023.1214539
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: The role of consumer expectations in food choice

Newsholme, H. C. / Wong, Esther

a literature review

(Review / Campden & Chorleywood Food Research Association Group ; 24)

2001

Author's details	H. C. Newsholme ; E. Wong
Series title	Review / Campden & Chorleywood Food Research Association Group ; 24 Review / CCFRA, Campden & Chorleywood Food Research Association Group
Collection	Review / CCFRA, Campden & Chorleywood Food Research Association Group
Keywords	Food preferences
Subject code	641.3
Language	English
Size	74 S., graph. Darst., 30cm
Publisher	Campden & Chorleywood Food Research Assoc
Publishing place	Chipping Campden
Publishing country	Great Britain
Document type	Book
Note	Includes bibliographical references. - Project no. 35465
HBZ-ID	HT015341901
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

Shelf mark	Loan status	Location
064/1226	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: Children’s Lived Experiences in Poverty in Hong Kong as a High-Income Asian Society

Esther Yin-Nei Cho / Victor C. W. Wong

International Journal of Environmental Research and Public Health, Vol 19, Iss 6190, p

2022 Volume 6190

Abstract	Child poverty situated in different socioeconomic and environmental contexts has long been a central concern for practitioners, researchers, and policy makers. However, concerned research studies are predominantly adult-centric, confined to specific areas, or seldom found in Asian developed economies. Against the backdrop of this research gap, this study examines children’s experiences of poverty in relation to economic and material aspects, social relationships and participation, and psychological and emotional wellbeing, and their ways of coping with the effects of poverty. Using a purposive sampling method, a total of 40 children participants aged 8–14 living in or near poverty were recruited for an individual interview. The study showed that children experienced a range of deprivations in relation to falling short of the resources, opportunities, and activities that are commanded by average young persons. Limited living space also stands out as a more severe problem that is difficult to cope with. The various coping strategies include small spending savvy tactics, parental buffering, compensation, and mental coping. Proximity to schools and NGOs can help children in poverty to cope with problems caused by deprivations in different aspects. Implications for research studies and practice for working with children in or near poverty are discussed accordingly.
Keywords	child poverty ; lived experiences ; deprivation ; social participation ; coping strategies ; Medicine ; R
Subject code	360
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluating different low-density lipoprotein cholesterol thresholds to initiate statin for prevention of cardiovascular diseases in patients with type 2 diabetes mellitus: A target trial emulation study.

Wan, Eric Yuk Fai / Xu, Wanchun / Mok, Anna Hoi Ying / Chin, Weng Yee / Yu, Esther Yee Tak / Chui, Celine Sze Ling / Chan, Esther Wai Yin / Wong, Ian Chi Kei / Lam, Cindy Lo Kuen / Danaei, Goodarz

Diabetes, obesity & metabolism

2024 Volume 26, Issue 5, Page(s) 1877–1887

Abstract: Aim: The present study aimed to evaluate the effect of statin therapy for primary prevention of cardiovascular diseases (CVDs) when initiating therapy at different baseline low-density lipoprotein cholesterol (LDL-C) levels in patients with type 2 ... ...

Abstract	Aim: The present study aimed to evaluate the effect of statin therapy for primary prevention of cardiovascular diseases (CVDs) when initiating therapy at different baseline low-density lipoprotein cholesterol (LDL-C) levels in patients with type 2 diabetes mellitus (T2DM). Materials and methods: Using territory-wide public electronic medical records in Hong Kong, we emulated a sequence of trials on patients with T2DM with elevated LDL-C levels in every calendar month from January 2008 to December 2014. Pooled logistic regression was applied to obtain the hazard ratios for the major CVDs (stroke, myocardial infarction, heart failure), all-cause mortality and major adverse events (myopathies and liver dysfunction) of statin therapy. Results: The estimated hazard ratios (95% confidence intervals) of CVD incidence for statin initiation were 0.78 (0.72, 0.84) in patients with baseline LDL-C of 1.8-2.5 mmol/L (i.e., 70-99 mg/dL) and 0.90 (0.88, 0.92) in patients with baseline LDL-C ≥2.6 mmol/L (i.e., ≥100 mg/dL) in intention-to-treat analysis, which was 0.59 (0.51, 0.68) and 0.77 (0.74, 0.81) in per-protocol analysis, respectively. No significant increased risks were observed for the major adverse events. The absolute 10-year risk difference of overall CVD in per-protocol analysis was -7.1% (-10.7%, -3.6%) and -3.9% (-5.1%, -2.7%) in patients with baseline LDL-C 1.8-2.5 and ≥2.6 mmol/L, respectively. The effectiveness and safety were consistently observed in patients aged >75 years initiating statin at both LDL-C thresholds. Conclusions: Compared with the threshold of 2.6 mmol/L, initiating statin in patients with a lower baseline LDL-C level at 1.8-2.5 mmol/L can further reduce the risks of CVD and all-cause mortality without significantly increasing the risk of major adverse events in patients with T2DM, including patients aged >75 years.
MeSH term(s)	Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Cholesterol, LDL ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Myocardial Infarction
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Cholesterol, LDL
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.15503
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5442: Show issues

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Article: Concomitant Obstructive Sleep Apnoea in Patients with Meniere's Disease: A Case Report and Literature Review.

Low, Wong Kein / Lim, Esther Jiayi

Case reports in otolaryngology

2021 Volume 2021, Page(s) 5592611

Abstract: Meniere's disease (MD) is a condition characterised by fluctuating and progressive hearing loss, aural fullness, tinnitus, and intermittent attacks of vertigo. The disabling vertigo symptoms can be controlled in most patients by lifestyle changes and ... ...

Abstract	Meniere's disease (MD) is a condition characterised by fluctuating and progressive hearing loss, aural fullness, tinnitus, and intermittent attacks of vertigo. The disabling vertigo symptoms can be controlled in most patients by lifestyle changes and medications such as diuretics. Should standard medical therapy fail, the patient may require surgery in order to control the disease, but such surgical procedures can be functionally destructive. Obstructive sleep apnoea syndrome (OSAS) is common, especially in people who are grossly overweight. Up to 15% of patients with MD may have concomitant OSA. Unless the OSA is well controlled, such patients may continue to experience MD symptoms despite receiving adequate standard medical therapy for MD. Moreover, MD patients may experience insomnia as a result of vertigo and/or tinnitus where sedatives are indicated. The use of sedatives with muscle relaxant properties may inadvertently further aggravate OSA resulting in a vicious cycle of symptoms. Symptoms suggestive of concomitant OSA must be proactively sought as these patients do not necessarily exhibit the obvious phenotypic features of OSA. This is especially so in Asians where OSAS is commonly observed in people who are not overly obese. We report a case of a female patient who presented with recalcitrant MD disease and was later found to have concomitant OSA. The relevant literature will be reviewed, and learning points will be discussed from the perspective of the otologist/neurotologist. The clinician must always be mindful of the existence of concomitant "silent" OSAS as this impacts the management of patients with MD.
Language	English
Publishing date	2021-03-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	2648756-1
ISSN	2090-6773 ; 2090-6765
ISSN (online)	2090-6773
ISSN	2090-6765
DOI	10.1155/2021/5592611
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effectiveness and Safety of Endoanchors in Abdominal and Thoracic Endovascular Aneurysm Repair: A Systematic Review and Meta-analysis.

Tang, Esther Wai Chi / Lau, Arthur Chak Kai / Cheng, Joshua Cheuk Hei / Wong, Joseph Chi-Yeung / Chan, Yiu Che

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

2024 , Page(s) 15266028241245911

Abstract: Purpose: This systematic review aimed to summarize the effectiveness and safety of endoanchor, a stabilizing device for the proximal endograft designed to prevent endoleak and stent migration in endovascular aneurysm repair (EVAR) and thoracic ... ...

Abstract	Purpose: This systematic review aimed to summarize the effectiveness and safety of endoanchor, a stabilizing device for the proximal endograft designed to prevent endoleak and stent migration in endovascular aneurysm repair (EVAR) and thoracic endovascular aneurysm repair (TEVAR). Materials and methods: A systematic review and meta-analysis was conducted per the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline. Literature up to May 31, 2023 was searched and independently screened from 4 databases. Data were pooled for meta-analysis. Primary outcomes included intraoperative and follow-up endoleak, stent migration, and reintervention rates; sac regression; and 30-day all-cause mortality. Results: Sixteen EVAR (n=1145) and 6 TEVAR studies (n=163) using the Heli-Fx EndoAnchor system were included from 2225 retrieved records. For EVAR patients (mean follow-up=11.9 months), the endoleak, graft migration, and reintervention rates were 3.97% (95% confidence interval [CI]=0.36%-1.99%), 0.004% (95% CI=0.00%-0.76%), and 5.43% (95% CI=0.86%-12.54%), respectively. The endoleak rates for primary and revision EVAR were 0.16% (95% CI=0.00%-1.65%) and 3.60% (95% CI=0.14%-9.72%), respectively. Only 4 cases of 30-day mortality (n=4) were reported in the literature. For TEVAR patients, the endoleak, stent migration, and reintervention rates were 7.4% (95% CI=0.03%-0.13%), 0.2% (95% CI=0.00%-0.06%), and 17.1% (95% CI=0.01%-0.45%), respectively. The 30-day mortality was 0.9% (95% CI=0%-0.12%). Conclusions: Endoanchor fixation in EVAR and TEVAR is effective and safe in preventing and treating endoleak and stent migration. The mortality is minimal in EVAR but higher in TEVAR. Clinical impact: Endoleak, graft migration, and reintervention in EVAR and TEVAR with endoanchor use were rare. Mortality in EVAR was low. The adjunctive deployment of endoanchors is an effective and safe means to prevent and treat endoleak and stent migration in EVAR and TEVAR. Yet, long-term efficacy and safety data and randomized controlled trials would be required to definitively recommend endoanchor use in routine clinical practice.
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2006618-1
ISSN	1545-1550 ; 1526-6028
ISSN (online)	1545-1550
ISSN	1526-6028
DOI	10.1177/15266028241245911
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