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  1. Article ; Online: The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.

    Alexander, Stephen P H / Christopoulos, Arthur / Davenport, Anthony P / Kelly, Eamonn / Mathie, Alistair A / Peters, John A / Veale, Emma L / Armstrong, Jane F / Faccenda, Elena / Harding, Simon D / Davies, Jamie A / Abbracchio, Maria Pia / Abraham, George / Agoulnik, Alexander / Alexander, Wayne / Al-Hosaini, Khaled / Bäck, Magnus / Baker, Jillian G / Barnes, Nicholas M /
    Bathgate, Ross / Beaulieu, Jean-Martin / Beck-Sickinger, Annette G / Behrens, Maik / Bernstein, Kenneth E / Bettler, Bernhard / Birdsall, Nigel J M / Blaho, Victoria / Boulay, Francois / Bousquet, Corinne / Bräuner-Osborne, Hans / Burnstock, Geoffrey / Caló, Girolamo / Castaño, Justo P / Catt, Kevin J / Ceruti, Stefania / Chazot, Paul / Chiang, Nan / Chini, Bice / Chun, Jerold / Cianciulli, Antonia / Civelli, Olivier / Clapp, Lucie H / Couture, Réjean / Cox, Helen M / Csaba, Zsolt / Dahlgren, Claes / Dent, Gordon / Douglas, Steven D / Dournaud, Pascal / Eguchi, Satoru / Escher, Emanuel / Filardo, Edward J / Fong, Tung / Fumagalli, Marta / Gainetdinov, Raul R / Garelja, Michael L / de Gasparo, Marc / Gerard, Craig / Gershengorn, Marvin / Gobeil, Fernand / Goodfriend, Theodore L / Goudet, Cyril / Grätz, Lukas / Gregory, Karen J / Gundlach, Andrew L / Hamann, Jörg / Hanson, Julien / Hauger, Richard L / Hay, Debbie L / Heinemann, Akos / Herr, Deron / Hollenberg, Morley D / Holliday, Nicholas D / Horiuchi, Mastgugu / Hoyer, Daniel / Hunyady, László / Husain, Ahsan / IJzerman, Adriaan P / Inagami, Tadashi / Jacobson, Kenneth A / Jensen, Robert T / Jockers, Ralf / Jonnalagadda, Deepa / Karnik, Sadashiva / Kaupmann, Klemens / Kemp, Jacqueline / Kennedy, Charles / Kihara, Yasuyuki / Kitazawa, Takio / Kozielewicz, Pawel / Kreienkamp, Hans-Jürgen / Kukkonen, Jyrki P / Langenhan, Tobias / Larhammar, Dan / Leach, Katie / Lecca, Davide / Lee, John D / Leeman, Susan E / Leprince, Jérôme / Li, Xaria X / Lolait, Stephen J / Lupp, Amelie / Macrae, Robyn / Maguire, Janet / Malfacini, Davide / Mazella, Jean / McArdle, Craig A / Melmed, Shlomo / Michel, Martin C / Miller, Laurence J / Mitolo, Vincenzo / Mouillac, Bernard / Müller, Christa E / Murphy, Philip M / Nahon, Jean-Louis / Ngo, Tony / Norel, Xavier / Nyimanu, Duuamene / O'Carroll, Anne-Marie / Offermanns, Stefan / Panaro, Maria Antonietta / Parmentier, Marc / Pertwee, Roger G / Pin, Jean-Philippe / Prossnitz, Eric R / Quinn, Mark / Ramachandran, Rithwik / Ray, Manisha / Reinscheid, Rainer K / Rondard, Philippe / Rovati, G Enrico / Ruzza, Chiara / Sanger, Gareth J / Schöneberg, Torsten / Schulte, Gunnar / Schulz, Stefan / Segaloff, Deborah L / Serhan, Charles N / Singh, Khuraijam Dhanachandra / Smith, Craig M / Stoddart, Leigh A / Sugimoto, Yukihiko / Summers, Roger / Tan, Valerie P / Thal, David / Thomas, Walter Wally / Timmermans, Pieter B M W M / Tirupula, Kalyan / Toll, Lawrence / Tulipano, Giovanni / Unal, Hamiyet / Unger, Thomas / Valant, Celine / Vanderheyden, Patrick / Vaudry, David / Vaudry, Hubert / Vilardaga, Jean-Pierre / Walker, Christopher S / Wang, Ji Ming / Ward, Donald T / Wester, Hans-Jürgen / Willars, Gary B / Williams, Tom Lloyd / Woodruff, Trent M / Yao, Chengcan / Ye, Richard D

    British journal of pharmacology

    2023  Volume 180 Suppl 2, Page(s) S23–S144

    Abstract: ... of this section can be found at http://onlinelibrary.wiley.com/doi/bph.16177. G protein-coupled receptors are one ...

    Abstract The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.16177. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
    MeSH term(s) Humans ; Databases, Pharmaceutical ; Receptors, G-Protein-Coupled ; Ligands ; Ion Channels/chemistry ; Receptors, Cytoplasmic and Nuclear
    Chemical Substances Receptors, G-Protein-Coupled ; Ligands ; Ion Channels ; Receptors, Cytoplasmic and Nuclear
    Language English
    Publishing date 2023-12-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.16177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors.

    Alexander, Stephen Ph / Christopoulos, Arthur / Davenport, Anthony P / Kelly, Eamonn / Mathie, Alistair / Peters, John A / Veale, Emma L / Armstrong, Jane F / Faccenda, Elena / Harding, Simon D / Pawson, Adam J / Southan, Christopher / Davies, Jamie A / Abbracchio, Maria Pia / Alexander, Wayne / Al-Hosaini, Khaled / Bäck, Magnus / Barnes, Nicholas M / Bathgate, Ross /
    Beaulieu, Jean-Martin / Bernstein, Kenneth E / Bettler, Bernhard / Birdsall, Nigel J M / Blaho, Victoria / Boulay, Francois / Bousquet, Corinne / Bräuner-Osborne, Hans / Burnstock, Geoffrey / Caló, Girolamo / Castaño, Justo P / Catt, Kevin J / Ceruti, Stefania / Chazot, Paul / Chiang, Nan / Chini, Bice / Chun, Jerold / Cianciulli, Antonia / Civelli, Olivier / Clapp, Lucie H / Couture, Réjean / Csaba, Zsolt / Dahlgren, Claes / Dent, Gordon / Singh, Khuraijam Dhanachandra / Douglas, Steven D / Dournaud, Pascal / Eguchi, Satoru / Escher, Emanuel / Filardo, Edward J / Fong, Tung / Fumagalli, Marta / Gainetdinov, Raul R / Gasparo, Marc de / Gerard, Craig / Gershengorn, Marvin / Gobeil, Fernand / Goodfriend, Theodore L / Goudet, Cyril / Gregory, Karen J / Gundlach, Andrew L / Hamann, Jörg / Hanson, Julien / Hauger, Richard L / Hay, Debbie L / Heinemann, Akos / Hollenberg, Morley D / Holliday, Nicholas D / Horiuchi, Mastgugu / Hoyer, Daniel / Hunyady, László / Husain, Ahsan / IJzerman, Adriaan P / Inagami, Tadashi / Jacobson, Kenneth A / Jensen, Robert T / Jockers, Ralf / Jonnalagadda, Deepa / Karnik, Sadashiva / Kaupmann, Klemens / Kemp, Jacqueline / Kennedy, Charles / Kihara, Yasuyuki / Kitazawa, Takio / Kozielewicz, Pawel / Kreienkamp, Hans-Jürgen / Kukkonen, Jyrki P / Langenhan, Tobias / Leach, Katie / Lecca, Davide / Lee, John D / Leeman, Susan E / Leprince, Jérôme / Li, Xaria X / Williams, Tom Lloyd / Lolait, Stephen J / Lupp, Amelie / Macrae, Robyn / Maguire, Janet / Mazella, Jean / McArdle, Craig A / Melmed, Shlomo / Michel, Martin C / Miller, Laurence J / Mitolo, Vincenzo / Mouillac, Bernard / Müller, Christa E / Murphy, Philip / Nahon, Jean-Louis / Ngo, Tony / Norel, Xavier / Nyimanu, Duuamene / O'Carroll, Anne-Marie / Offermanns, Stefan / Panaro, Maria Antonietta / Parmentier, Marc / Pertwee, Roger G / Pin, Jean-Philippe / Prossnitz, Eric R / Quinn, Mark / Ramachandran, Rithwik / Ray, Manisha / Reinscheid, Rainer K / Rondard, Philippe / Rovati, G Enrico / Ruzza, Chiara / Sanger, Gareth J / Schöneberg, Torsten / Schulte, Gunnar / Schulz, Stefan / Segaloff, Deborah L / Serhan, Charles N / Stoddart, Leigh A / Sugimoto, Yukihiko / Summers, Roger / Tan, Valerie P / Thal, David / Thomas, Walter Wally / Timmermans, Pieter B M W M / Tirupula, Kalyan / Tulipano, Giovanni / Unal, Hamiyet / Unger, Thomas / Valant, Celine / Vanderheyden, Patrick / Vaudry, David / Vaudry, Hubert / Vilardaga, Jean-Pierre / Walker, Christopher S / Wang, Ji Ming / Ward, Donald T / Wester, Hans-Jürgen / Willars, Gary B / Woodruff, Trent M / Yao, Chengcan / Ye, Richard D

    British journal of pharmacology

    2021  Volume 178 Suppl 1, Page(s) S27–S156

    Abstract: ... The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15538. G protein ...

    Abstract The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15538. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
    MeSH term(s) Databases, Pharmaceutical ; Humans ; Ion Channels ; Ligands ; Pharmacology ; Receptors, Cytoplasmic and Nuclear ; Receptors, G-Protein-Coupled
    Chemical Substances Ion Channels ; Ligands ; Receptors, Cytoplasmic and Nuclear ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2021-09-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.15538
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Inhibition of G protein-coupled P2Y2 receptor induced analgesia in a rat model of trigeminal neuropathic pain.

    Li, Na / Lu, Zhan-ying / Yu, Li-hua / Burnstock, Geoffrey / Deng, Xiao-ming / Ma, Bei

    Molecular pain

    2014  Volume 10, Page(s) 21

    Abstract: ... of trigeminal neuropathic pain, while the role of G protein-coupled P2Y₂ receptors and the underlying mechanisms are less ...

    Abstract Backgrounds: ATP and P2X receptors play important roles in the modulation of trigeminal neuropathic pain, while the role of G protein-coupled P2Y₂ receptors and the underlying mechanisms are less clear. The threshold and frequency of action potentials, fast inactivating transient K+ channels (IA) are important regulators of membrane excitability in sensory neurons because of its vital role in the control of the spike onset. In this study, pain behavior tests, QT-RT-PCR, immunohistochemical staining, and patch-clamp recording, were used to investigate the role of P2Y₂ receptors in pain behaviour.
    Results: In control rats: 1) UTP, an agonist of P2Y₂/P2Y₄ receptors, caused a significant decrease in the mean threshold intensities for evoking action potentials and a striking increase in the mean number of spikes evoked by TG neurons. 2) UTP significantly inhibited IA and the expression of Kv1.4, Kv3.4 and Kv4.2 subunits in TG neurons, which could be reversed by the P2 receptor antagonist suramin and the ERK antagonist U0126. In ION-CCI (chronic constriction injury of infraorbital nerve) rats: 1) mRNA levels of Kv1.4, Kv3.4 and Kv4.2 subunits were significantly decreased, while the protein level of phosphorylated ERK was significantly increased. 2) When blocking P2Y₂ receptors by suramin or injection of P2Y2R antisense oligodeoxynucleotides both led to a time- and dose-dependent reverse of allodynia in ION-CCI rats. 3) Injection of P2Y₂ receptor antisense oligodeoxynucleotides induced a pronounced decrease in phosphorylated ERK expression and a significant increase in Kv1.4, Kv3.4 and Kv4.2 subunit expression in trigeminal ganglia.
    Conclusions: Our data suggest that inhibition of P2Y₂ receptors leads to down-regulation of ERK-mediated phosphorylation and increase of the expression of I(A)-related Kv channels in trigeminal ganglion neurons, which might contribute to the clinical treatment of trigeminal neuropathic pain.
    MeSH term(s) Action Potentials/drug effects ; Action Potentials/physiology ; Animals ; Cells, Cultured ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/pharmacology ; Face/innervation ; Gene Expression Regulation/drug effects ; Hyperalgesia/chemically induced ; Male ; Pain/drug therapy ; Pain/etiology ; Potassium Channels/genetics ; Potassium Channels/metabolism ; Purinergic P2Y Receptor Antagonists/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Receptors, Purinergic P2Y2/genetics ; Receptors, Purinergic P2Y2/metabolism ; Sensory Receptor Cells/drug effects ; Sensory Receptor Cells/physiology ; Skin/innervation ; Suramin/therapeutic use ; Trigeminal Ganglion/cytology ; Trigeminal Nerve Diseases/complications ; Uridine Triphosphate/adverse effects
    Chemical Substances Enzyme Inhibitors ; Potassium Channels ; Purinergic P2Y Receptor Antagonists ; Receptors, Purinergic P2Y2 ; Suramin (6032D45BEM) ; Uridine Triphosphate (UT0S826Z60)
    Language English
    Publishing date 2014-03-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2174252-2
    ISSN 1744-8069 ; 1744-8069
    ISSN (online) 1744-8069
    ISSN 1744-8069
    DOI 10.1186/1744-8069-10-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Introduction to Purinergic Signalling in the Brain.

    Burnstock, Geoffrey

    Advances in experimental medicine and biology

    2020  Volume 1202, Page(s) 1–12

    Abstract: ... ionotropic receptors are involved in fast synaptic transmission and synaptic plasticity. P2Y G protein ...

    Abstract ATP is a cotransmitter with glutamate, noradrenaline, GABA, acetylcholine and dopamine in the brain. There is a widespread presence of both adenosine (P1) and P2 nucleotide receptors in the brain on both neurons and glial cells. Adenosine receptors play a major role in presynaptic neuromodulation, while P2X ionotropic receptors are involved in fast synaptic transmission and synaptic plasticity. P2Y G protein-coupled receptors are largely involved in presynaptic activities, as well as mediating long-term (trophic) signalling in cell proliferation, differentiation and death during development and regeneration. Both P1 and P2 receptors participate in neuron-glial interactions. Purinergic signalling is involved in control of cerebral vascular tone and remodelling and has been implicated in learning and memory, locomotor and feeding behaviour and sleep. There is increasing interest in the involvement of purinergic signalling in the pathophysiology of the CNS, including trauma, ischaemia, epilepsy, neurodegenerative diseases, neuropsychiatric and mood disorders, and cancer, including gliomas.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Animals ; Brain/metabolism ; Humans ; Receptors, Purinergic/metabolism ; Signal Transduction ; Synaptic Transmission
    Chemical Substances Receptors, Purinergic ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2020-02-07
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-30651-9_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy.

    Abbracchio, Maria P / Burnstock, Geoffrey / Boeynaems, Jean-Marie / Barnard, Eric A / Boyer, José L / Kennedy, Charles / Knight, Gillian E / Fumagalli, Marta / Gachet, Christian / Jacobson, Kenneth A / Weisman, Gary A

    Pharmacological reviews

    2006  Volume 58, Issue 3, Page(s) 281–341

    Abstract: There have been many advances in our knowledge about different aspects of P2Y receptor signaling since the last review published by our International Union of Pharmacology subcommittee. More receptor subtypes have been cloned and characterized and most ... ...

    Abstract There have been many advances in our knowledge about different aspects of P2Y receptor signaling since the last review published by our International Union of Pharmacology subcommittee. More receptor subtypes have been cloned and characterized and most orphan receptors de-orphanized, so that it is now possible to provide a basis for a future subdivision of P2Y receptor subtypes. More is known about the functional elements of the P2Y receptor molecules and the signaling pathways involved, including interactions with ion channels. There have been substantial developments in the design of selective agonists and antagonists to some of the P2Y receptor subtypes. There are new findings about the mechanisms underlying nucleotide release and ectoenzymatic nucleotide breakdown. Interactions between P2Y receptors and receptors to other signaling molecules have been explored as well as P2Y-mediated control of gene transcription. The distribution and roles of P2Y receptor subtypes in many different cell types are better understood and P2Y receptor-related compounds are being explored for therapeutic purposes. These and other advances are discussed in the present review.
    MeSH term(s) Animals ; Atherosclerosis/drug therapy ; Atherosclerosis/prevention & control ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Gene Expression Regulation ; Humans ; Ion Channels/physiology ; Models, Biological ; Models, Molecular ; Phylogeny ; Protein Isoforms/physiology ; Purinergic P2 Receptor Agonists ; Purinergic P2 Receptor Antagonists ; Receptors, Purinergic P2/classification ; Receptors, Purinergic P2/physiology ; Receptors, Purinergic P2/therapeutic use ; Second Messenger Systems/physiology ; Tissue Distribution
    Chemical Substances Ion Channels ; Protein Isoforms ; Purinergic P2 Receptor Agonists ; Purinergic P2 Receptor Antagonists ; Receptors, Purinergic P2
    Language English
    Publishing date 2006-09-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 209898-2
    ISSN 1521-0081 ; 0031-6997
    ISSN (online) 1521-0081
    ISSN 0031-6997
    DOI 10.1124/pr.58.3.3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Abundant and dynamic expression of G protein-coupled P2Y receptors in mammalian development.

    Cheung, Kwok-Kuen / Ryten, Mina / Burnstock, Geoffrey

    Developmental dynamics : an official publication of the American Association of Anatomists

    2003  Volume 228, Issue 2, Page(s) 254–266

    Abstract: ... the P2X and P2Y receptors. There is growing evidence to show that activation of G protein-coupled P2Y ...

    Abstract Extracellular ATP mediates diverse biological effects by activating two families of receptors, the P2X and P2Y receptors. There is growing evidence to show that activation of G protein-coupled P2Y receptors can produce trophic effects in many cell types. Yet the expression and function of the P2Y receptors in development has rarely been studied and has never been investigated in mammalian development. This study used the reverse transcription-polymerase chain reaction and immunohistochemistry to demonstrate the abundant and dynamic expression of P2Y receptors in rat development. These receptors were expressed in a wide range of embryonic structures, notably somites, skeletal muscle, the central and peripheral nervous system, the heart, lung, and liver. All the P2Y receptors studied were expressed as early as embryonic day 11, when most embryonic organs were far from being functional and still in the process of being formed. P2Y receptor proteins were strongly expressed in temporary, developmental structures that do not have a correlate in the adult animal, including the somites (P2Y1, P2Y2, and P2Y4) and the floor plate of the neural tube (P2Y1). P2Y receptors were also dynamically expressed, with receptor mRNA and protein being both up- and down-regulated at different developmental stages. The down-regulation of the P2Y1, 2, and 4 receptor proteins in skeletal muscle and heart, and the disappearance of the P2Y4 receptor from the brainstem and ventral white matter of the spinal cord postnatally, demonstrated that many P2Y receptors were likely to be involved in functions specific to embryonic life. Thus, these findings strongly suggest that P2Y receptors play an important role in the development of many tissues, and pioneer further studies into the role of purinergic signalling in development.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Animals ; GTP-Binding Proteins/metabolism ; Gene Expression Regulation, Developmental ; Immunohistochemistry ; Mammals/embryology ; RNA, Messenger/metabolism ; Rats/embryology ; Receptors, Purinergic P2/analysis ; Receptors, Purinergic P2/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Time Factors ; Tissue Distribution
    Chemical Substances RNA, Messenger ; Receptors, Purinergic P2 ; Adenosine Triphosphate (8L70Q75FXE) ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 2003-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1102541-4
    ISSN 1097-0177 ; 1058-8388
    ISSN (online) 1097-0177
    ISSN 1058-8388
    DOI 10.1002/dvdy.10378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Purinergic signalling and the nervous system

    Burnstock, Geoffrey / Verchrackij, Aleksej Nestorovič

    2012  

    Author's details Geoffrey Burnstock ; Alexej Verkhratsky
    Keywords Synaptische Transmission ; Purinozeptor
    Subject Purinerger Rezeptor ; Purinrezeptor ; ATP-Rezeptor ; Purinozeptoren ; Purinrezeptoren ; ATP-Rezeptoren ; Neurotransmission ; Synaptische Übertragung
    Language English
    Size XVIII, 715 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT017368238
    ISBN 978-3-642-28862-3 ; 3-642-28862-6 ; 9783642288630 ; 3642288634
    Database Catalogue ZB MED Medicine, Health

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  8. Article: G protein-coupled receptors for ATP and other nucleotides: a new receptor family.

    Barnard, E A / Burnstock, G / Webb, T E

    Trends in pharmacological sciences

    1994  Volume 15, Issue 3, Page(s) 67–70

    MeSH term(s) Adenosine Triphosphate/metabolism ; Animals ; Cell Membrane/metabolism ; GTP-Binding Proteins/metabolism ; Nucleotides/metabolism ; Receptors, Purinergic/classification ; Receptors, Purinergic/metabolism
    Chemical Substances Nucleotides ; Receptors, Purinergic ; Adenosine Triphosphate (8L70Q75FXE) ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 1994-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/0165-6147(94)90280-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Introduction to Purinergic Signaling.

    Burnstock, Geoffrey

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 2041, Page(s) 1–15

    Abstract: Purinergic signaling was proposed in 1972, after it was demonstrated that adenosine 5'-triphosphate (ATP) was a transmitter in nonadrenergic, noncholinergic inhibitory nerves supplying the guinea-pig taenia coli. Later, ATP was identified as an ... ...

    Abstract Purinergic signaling was proposed in 1972, after it was demonstrated that adenosine 5'-triphosphate (ATP) was a transmitter in nonadrenergic, noncholinergic inhibitory nerves supplying the guinea-pig taenia coli. Later, ATP was identified as an excitatory cotransmitter in sympathetic and parasympathetic nerves, and it is now apparent that ATP acts as a cotransmitter in most, if not all, nerves in both the peripheral nervous system and central nervous system (CNS). ATP acts as a short-term signaling molecule in neurotransmission, neuromodulation, and neurosecretion. It also has potent, long-term (trophic) roles in cell proliferation, differentiation, and death in development and regeneration. Receptors to purines and pyrimidines have been cloned and characterized: P1 adenosine receptors (with four subtypes), P2X ionotropic nucleotide receptors (seven subtypes) and P2Y metabotropic nucleotide receptors (eight subtypes). ATP is released from different cell types by mechanical deformation, and after release, it is rapidly broken down by ectonucleotidases. Purinergic receptors were expressed early in evolution and are widely distributed on many different nonneuronal cell types as well as neurons. Purinergic signaling is involved in embryonic development and in the activities of stem cells. There is a growing understanding about the pathophysiology of purinergic signaling and there are therapeutic developments for a variety of diseases, including stroke and thrombosis, osteoporosis, pain, chronic cough, kidney failure, bladder incontinence, cystic fibrosis, dry eye, cancer, and disorders of the CNS, including Alzheimer's, Parkinson's. and Huntington's disease, multiple sclerosis, epilepsy, migraine, and neuropsychiatric and mood disorders.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Animals ; Central Nervous System Diseases/physiopathology ; Humans ; Nervous System Physiological Phenomena ; Purines/metabolism ; Receptors, Purinergic/metabolism ; Signal Transduction ; Synaptic Transmission
    Chemical Substances Purines ; Receptors, Purinergic ; Adenosine Triphosphate (8L70Q75FXE) ; purine (W60KTZ3IZY)
    Language English
    Publishing date 2019-10-23
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9717-6_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Cloning and functional expression of a brain G-protein-coupled ATP receptor.

    Webb, T E / Simon, J / Krishek, B J / Bateson, A N / Smart, T G / King, B F / Burnstock, G / Barnard, E A

    FEBS letters

    1993  Volume 324, Issue 2, Page(s) 219–225

    Abstract: A cDNA encoding a novel member of the G-protein-coupled receptor (GCR) superfamily, an ATP receptor ...

    Abstract A cDNA encoding a novel member of the G-protein-coupled receptor (GCR) superfamily, an ATP receptor, has been isolated from an embryonic chick whole brain cDNA library by hybridization screening. The encoded protein has a sequence of 362 amino acids (41 kDa) and shares no more than 27% amino acid identity with any known GCR. When expressed as a complementary RNA (cRNA) in Xenopus oocytes a slowly-developing inward current was observed in response to application of ATP. The pharmacology of this expressed protein defines it as a P2Y purinoceptor.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Amino Acid Sequence ; Animals ; Base Sequence ; Brain Chemistry ; Chick Embryo ; Cloning, Molecular ; Electric Conductivity ; GTP-Binding Proteins/metabolism ; Molecular Sequence Data ; Oocytes ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Receptors, Purinergic/biosynthesis ; Receptors, Purinergic/classification ; Receptors, Purinergic/genetics ; Recombinant Proteins/biosynthesis ; Sequence Homology, Amino Acid ; Tissue Distribution ; Transcription, Genetic ; Xenopus
    Chemical Substances RNA, Messenger ; Receptors, Purinergic ; Recombinant Proteins ; Adenosine Triphosphate (8L70Q75FXE) ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 1993-06-14
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1016/0014-5793(93)81397-i
    Database MEDical Literature Analysis and Retrieval System OnLINE

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