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  1. Article ; Online: Sifting for Gold in Terabytes of Data: Illuminating Cardiovascular Biology in the 'Omics Age.

    Shah, Svati H / Gerszten, Robert E

    Circulation

    2024  Volume 149, Issue 17, Page(s) 1323–1325

    MeSH term(s) Humans ; Cardiovascular Diseases ; Genomics
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.123.066988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Exercise, exerkines, and cardiometabolic health: from individual players to a team sport.

    Robbins, Jeremy M / Gerszten, Robert E

    The Journal of clinical investigation

    2023  Volume 133, Issue 13

    MeSH term(s) Humans ; Team Sports ; Exercise ; Cardiovascular Diseases
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI172916
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exercise, exerkines, and cardiometabolic health: from individual players to a team sport.

    Robbins, Jeremy M / Gerszten, Robert E

    The Journal of clinical investigation

    2023  Volume 133, Issue 11

    Abstract: Exercise confers numerous salutary effects that extend beyond individual organ systems to provide systemic health benefits. Here, we discuss the role of exercise in cardiovascular health. We summarize major findings from human exercise studies in ... ...

    Abstract Exercise confers numerous salutary effects that extend beyond individual organ systems to provide systemic health benefits. Here, we discuss the role of exercise in cardiovascular health. We summarize major findings from human exercise studies in cardiometabolic disease. We next describe our current understanding of cardiac-specific substrate metabolism that occurs with acute exercise and in response to exercise training. We subsequently focus on exercise-stimulated circulating biochemicals ("exerkines") as a paradigm for understanding the global health circuitry of exercise, and discuss important concepts in this emerging field before highlighting exerkines relevant in cardiovascular health and disease. Finally, this Review identifies gaps that remain in the field of exercise science and opportunities that exist to translate biologic insights into human health improvement.
    MeSH term(s) Humans ; Team Sports ; Exercise/physiology ; Cardiovascular System ; Heart ; Cardiovascular Diseases
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI168121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Molecular Biomarkers for Cardiometabolic Disease: Risk Assessment in Young Individuals.

    Tahir, Usman A / Gerszten, Robert E

    Circulation research

    2023  Volume 132, Issue 12, Page(s) 1663–1673

    Abstract: Cardiometabolic diseases, including cardiovascular disease and diabetes, are major causes of morbidity and mortality worldwide. Despite progress in prevention and treatment, recent trends show a stalling in the reduction of cardiovascular disease ... ...

    Abstract Cardiometabolic diseases, including cardiovascular disease and diabetes, are major causes of morbidity and mortality worldwide. Despite progress in prevention and treatment, recent trends show a stalling in the reduction of cardiovascular disease morbidity and mortality, paralleled by increasing rates of cardiometabolic disease risk factors in young adults, underscoring the importance of risk assessments in this population. This review highlights the evidence for molecular biomarkers for early risk assessment in young individuals. We examine the utility of traditional biomarkers in young individuals and discuss novel, nontraditional biomarkers specific to pathways contributing to early cardiometabolic disease risk. Additionally, we explore emerging omic technologies and analytical approaches that could enhance risk assessment for cardiometabolic disease.
    MeSH term(s) Young Adult ; Humans ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Risk Assessment ; Biomarkers ; Risk Factors
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.123.322000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Mitochondrial choline import regulates purine nucleotide pools via SLC25A48.

    Verkerke, Anthony R P / Shi, Xu / Abe, Ichitaro / Gerszten, Robert E / Kajimura, Shingo

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Choline is an essential nutrient for cellular metabolism, including the biosynthesis of phospholipids, neurotransmitters, and one-carbon metabolism. A critical step of choline catabolism is the mitochondrial import and synthesis of chorine-derived methyl ...

    Abstract Choline is an essential nutrient for cellular metabolism, including the biosynthesis of phospholipids, neurotransmitters, and one-carbon metabolism. A critical step of choline catabolism is the mitochondrial import and synthesis of chorine-derived methyl donors, such as betaine. However, the underlying mechanisms and the biological significance of mitochondrial choline catabolism remain insufficiently understood. Here, we report that a mitochondrial inner-membrane protein SLC25A48 controls mitochondrial choline transport and catabolism
    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.31.573776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Exercise, exerkines, and cardiometabolic health

    Jeremy M. Robbins / Robert E. Gerszten

    The Journal of Clinical Investigation, Vol 133, Iss

    from individual players to a team sport

    2023  Volume 13

    Keywords Medicine ; R
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Visualizing biomarkers and their association with clinical outcomes: A machine learning approach.

    Zheng, Hui / Gerszten, Robert E / Corey, Kathleen E

    Computers in biology and medicine

    2022  Volume 149, Page(s) 106005

    Abstract: Introduction: Clinical investigators often seek to identify biomarkers that are associated with clinical outcomes. The challenge is that biomarkers tend to be numerous, often inter-correlated, and with varying degrees of association with the clinical ... ...

    Abstract Introduction: Clinical investigators often seek to identify biomarkers that are associated with clinical outcomes. The challenge is that biomarkers tend to be numerous, often inter-correlated, and with varying degrees of association with the clinical outcome of interest. We developed a straightforward, effective visualization approach that allows investigators to see the inter-correlations of biomarkers and their association with clinical outcomes rendered in a 2-dimensional (2-D) plot.
    Method: We extracted pairwise differences between outcome groups. Next, a t-SNE machine learning method was applied to reduce dimensionality of the data into 2-dimensional data. This data was then rendered as 2-D plots allowing visualization of either the original biomarker values or their ranking in the sample. We apply this method to a dataset of 235 subjects with data of 114 metabolomic biomarkers and cardiovascular outcomes.
    Result: The 2-D plots demonstrated that the metabolite biomarkers with high degrees of association with the outcome tend to be positioned away from non-significant markers. Markers that are correlated with each other are positioned in clusters. An online demo version application of this visualization tool is available at http://52.9.140.88:3838/MarkersVu/.
    Conclusion: This is an effective approach to visualize biomarkers and their correlations, allowing rapid visual identification of biomarkers and marker clusters with potentially higher degree of association with the outcome.
    MeSH term(s) Biomarkers/metabolism ; Humans ; Machine Learning
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-08-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2022.106005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Exercise, exerkines, and cardiometabolic health

    Jeremy M. Robbins / Robert E. Gerszten

    The Journal of Clinical Investigation, Vol 133, Iss

    from individual players to a team sport

    2023  Volume 11

    Abstract: Exercise confers numerous salutary effects that extend beyond individual organ systems to provide systemic health benefits. Here, we discuss the role of exercise in cardiovascular health. We summarize major findings from human exercise studies in ... ...

    Abstract Exercise confers numerous salutary effects that extend beyond individual organ systems to provide systemic health benefits. Here, we discuss the role of exercise in cardiovascular health. We summarize major findings from human exercise studies in cardiometabolic disease. We next describe our current understanding of cardiac-specific substrate metabolism that occurs with acute exercise and in response to exercise training. We subsequently focus on exercise-stimulated circulating biochemicals (“exerkines”) as a paradigm for understanding the global health circuitry of exercise, and discuss important concepts in this emerging field before highlighting exerkines relevant in cardiovascular health and disease. Finally, this Review identifies gaps that remain in the field of exercise science and opportunities that exist to translate biologic insights into human health improvement.
    Keywords Medicine ; R
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article ; Online: Omics and Cardiometabolic Disease Risk Prediction.

    Tahir, Usman A / Gerszten, Robert E

    Annual review of medicine

    2020  Volume 71, Page(s) 163–175

    Abstract: Risk assessments are integral for the prevention and management of cardiometabolic disease (CMD). However, individuals may develop CMD without traditional risk factors, necessitating the development of novel biomarkers to aid risk prediction. The ... ...

    Abstract Risk assessments are integral for the prevention and management of cardiometabolic disease (CMD). However, individuals may develop CMD without traditional risk factors, necessitating the development of novel biomarkers to aid risk prediction. The emergence of omic technologies, including genomics, proteomics, and metabolomics, has allowed for assessment of orthogonal measures of cardiometabolic risk, potentially improving the ability for novel biomarkers to refine disease risk assessments. While omics has shed light on novel mechanisms for the development of CMD, its adoption in clinical practice faces significant challenges. We review select omic technologies and cardiometabolic investigations for risk prediction, while highlighting challenges and opportunities for translating findings to clinical practice.
    MeSH term(s) Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/metabolism ; Computational Biology ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Genomics ; Humans ; Metabolomics ; Proteomics ; Risk Assessment
    Language English
    Publishing date 2020-01-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207930-6
    ISSN 1545-326X ; 0066-4219
    ISSN (online) 1545-326X
    ISSN 0066-4219
    DOI 10.1146/annurev-med-042418-010924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Metabolomics and Proteomics in Type 2 Diabetes.

    Chen, Zsu-Zsu / Gerszten, Robert E

    Circulation research

    2020  Volume 126, Issue 11, Page(s) 1613–1627

    Abstract: The persistent increase in the worldwide burden of type 2 diabetes mellitus (T2D) and the accompanying rise of its complications, including cardiovascular disease, necessitates our understanding of the metabolic disturbances that cause diabetes mellitus. ...

    Abstract The persistent increase in the worldwide burden of type 2 diabetes mellitus (T2D) and the accompanying rise of its complications, including cardiovascular disease, necessitates our understanding of the metabolic disturbances that cause diabetes mellitus. Metabolomics and proteomics, facilitated by recent advances in high-throughput technologies, have given us unprecedented insight into circulating biomarkers of T2D even over a decade before overt disease. These markers may be effective tools for diabetes mellitus screening, diagnosis, and prognosis. As participants of metabolic pathways, metabolite and protein markers may also highlight pathways involved in T2D development. The integration of metabolomics and proteomics with genomics in multiomics strategies provides an analytical method that can begin to decipher causal associations. These methods are not without their limitations; however, with careful study design and sample handling, these methods represent powerful scientific tools that can be leveraged for the study of T2D. In this article, we aim to give a timely overview of circulating metabolomics and proteomics findings with T2D observed in large human population studies to provide the reader with a snapshot into these emerging fields of research.
    MeSH term(s) Animals ; Biomarkers/blood ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Genomics/methods ; Humans ; Metabolome ; Proteome/genetics ; Proteome/metabolism
    Chemical Substances Biomarkers ; Proteome
    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.120.315898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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