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  1. Book ; Online ; E-Book: The retina illustrated

    Ehlers, Justis P. / Le, Thuy K.

    2020  

    Author's details Justis P. Ehlers ; assistant editor Thuy K. Le
    Keywords Retinal Diseases / diagnostic imaging ; Retinal Diseases / surgery
    Language English
    Size 1 Online-Ressource (xxvi, 422 Seiten), 407 Illustrationen
    Publisher Thieme
    Publishing place New York
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020360158
    ISBN 978-1-626-23833-6 ; 9781626238312 ; 1-626-23833-2 ; 1626238316
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: OCT and OCTA in retinal disorders

    Ehlers, Justis P. / Modi, Yasha / Srivastava, Sunil K. / Kaiser, Peter K.

    2021  

    Author's details editors-in-chief, Justis P. Ehlers, Yasha Modi, Sunil K. Srivastava, Peter K. Kaiser ; assistant editors, Nitish Mehta, Joseph Abraham, Thuy K. Le
    Keywords Retinal Diseases / diagnostic imaging ; Tomography, Optical Coherence / methods ; Retinal Vessels / diagnostic imaging ; Angiography / methods ; Diagnostic Techniques, Ophthalmological
    Language English
    Size xviii, 468 Seiten, Illustrationen
    Publisher Wolters Kluwer
    Publishing place Philadelphia
    Publishing country United States
    Document type Book
    Note Zugang zur Online-Ausgabe über Code
    HBZ-ID HT020700150
    ISBN 978-1-975144-22-7 ; 1-975144-22-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 A 115 available for loan (reading room) Lesesaal EG
    Zugang zur Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  3. Article ; Online: Use of physician extenders in ophthalmology: pros.

    Ehlers, Justis P / Baraona, Julianne

    Current opinion in ophthalmology

    2023  Volume 34, Issue 5, Page(s) 382–385

    Abstract: Purpose of review: The goal of this review is to provide a description of the potential role of physician extenders within ophthalmology with a specific focus on the retina field.: Recent findings: In this editorial, the evolving role of physician ... ...

    Abstract Purpose of review: The goal of this review is to provide a description of the potential role of physician extenders within ophthalmology with a specific focus on the retina field.
    Recent findings: In this editorial, the evolving role of physician extenders (e.g. physician assistants, nurse practitioners) in medicine and ophthalmology is discussed. Within ophthalmology, an experiential discussion is provided regarding the opportunities to utilize physician extenders to expand the bandwidth of subspecialists and increase access for patient care.
    Summary: Physician extenders, such as physician assistants, provide a unique opportunity for ophthalmology to innovate next-generation care delivery models. The roles for physician extenders throughout highly specialized fields in medicine have become a critical component for team-based patient care. Within retina and other ophthalmic subspecialties, physician extenders can enable top-of-license practice for physicians, while directly expanding the umbrella of care the specialist can provide through the physician extender's role in chronic disease medical management. The deployment of a physician assistants within the retina care team provided greater access for patients requiring ongoing medical monitoring and triage for acute issues, while expanding the retina specialist's ability to see a higher volume of higher acuity patients and those patients requiring procedural/surgical interventions. Importantly, the physician assistant's role is focused exclusively on medical management of retinal diseases with all procedures being performed by the retina specialist.
    MeSH term(s) Humans ; Ophthalmology ; Delivery of Health Care ; Physician Assistants
    Language English
    Publishing date 2023-05-03
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1049383-9
    ISSN 1531-7021 ; 1040-8738
    ISSN (online) 1531-7021
    ISSN 1040-8738
    DOI 10.1097/ICU.0000000000000972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3047: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: PARACENTRAL ACUTE MIDDLE MACULOPATHY ASSOCIATED WITH COCAINE USE.

    Arepalli, Sruthi / Ehlers, Justis P

    Retinal cases & brief reports

    2023  Volume 17, Issue 3, Page(s) 294–296

    Abstract: Background/purpose: To report a case of paracentral acute middle maculopathy in association with cocaine use.: Methods: This is a case report of a 26-year-old man presented with acute vision loss in the left eye following cocaine use.: Results: ... ...

    Abstract Background/purpose: To report a case of paracentral acute middle maculopathy in association with cocaine use.
    Methods: This is a case report of a 26-year-old man presented with acute vision loss in the left eye following cocaine use.
    Results: Fundus examination demonstrated faint retinal, whereas optical coherence tomography displayed hyperreflectivity predominantly in the middle retinal layers. Because of associated loss-of-consciousness and vision loss, a stroke work-up was initiated and ruled-out embolic and neurologic causes. The vision loss was attributed to paracentral acute middle maculopathy secondary to cocaine. The vision and retinal alterations on optical coherence tomography improved with observation.
    Conclusion: This case demonstrates a potential unique etiology of paracentral acute middle maculopathy following exposure to cocaine. Paracentral acute middle maculopathy may occur in the setting of cocaine use. Optical coherence tomography evaluation with close surveillance can be helpful to identify the often subtle findings of paracentral acute middle maculopathy in cases of vision loss associated with illicit drug use.
    MeSH term(s) Male ; Humans ; Adult ; Retinal Diseases/diagnosis ; Fluorescein Angiography/methods ; Tomography, Optical Coherence/methods ; Fundus Oculi ; Macular Degeneration/complications ; Cocaine ; Acute Disease
    Chemical Substances Cocaine (I5Y540LHVR)
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 1937-1578
    ISSN (online) 1937-1578
    DOI 10.1097/ICB.0000000000001173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reply.

    Ehlers, Justis P

    Retina (Philadelphia, Pa.)

    2019  Volume 39, Issue 6, Page(s) e26

    MeSH term(s) Humans ; Retina ; Stargardt Disease
    Language English
    Publishing date 2019-04-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000002540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1724: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Erdafitinib-associated retinal alterations and rapid onset bilateral white cataracts.

    Sassine, Antoine G / Cakir, Yavuz / Della Vecchia, Lyndsey / Ehlers, Justis P

    American journal of ophthalmology case reports

    2024  Volume 34, Page(s) 102028

    Abstract: Purpose: This report aims to highlight the wide spectrum of ophthalmic adverse events associated with erdafitinib, a fibroblast growth factor inhibitor that blocks activation of the mitogen-activated protein kinase kinase (MAPK/MEK) cascade. The purpose ...

    Abstract Purpose: This report aims to highlight the wide spectrum of ophthalmic adverse events associated with erdafitinib, a fibroblast growth factor inhibitor that blocks activation of the mitogen-activated protein kinase kinase (MAPK/MEK) cascade. The purpose of this report is to describe a case of erdafitinib-associated bilateral outer retinal alterations in the MEK-associated retinopathy spectrum and rapid onset bilateral total cataracts following a 20-month course of erdafitinib therapy.
    Observations: A 69 year old male with metastatic bladder cancer presented 47 days following treatment initiation with daily erdafitinib (8-mg) with mild new subretinal fluid and minimal associated subretinal debris in the left eye and accentuation/thickening of the interdigitation zone in the right eye. Over the course of treatment, improvements were noted, particularly with erdafitinib dose reduction. At 20 months, both eyes developed rapidly progressive mature cataracts with significant visual changes, necessitating bilateral cataract extraction.
    Conclusions and importance: The potential stability of moderate outer retinal changes (i.e., ellipsoid zone/interdigitation zone, subretinal fluid) while continuing erdafitinib therapy is highlighted in this report. In addition, the importance of continued ophthalmic surveillance is emphasized given the possible association of anterior segment adverse events with long-term erdafitinib use.
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Case Reports
    ISSN 2451-9936
    ISSN (online) 2451-9936
    DOI 10.1016/j.ajoc.2024.102028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The OCT Angiography Revolution: Five Emerging Themes.

    Ehlers, Justis P

    Ophthalmology. Retina

    2018  Volume 1, Issue 6, Page(s) 457–460

    Language English
    Publishing date 2018-01-25
    Publishing country United States
    Document type Journal Article
    ISSN 2468-7219
    ISSN 2468-7219
    DOI 10.1016/j.oret.2017.09.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Clinical Signal-to-Noise Ratio of OCT Angiography: Key Applications for Routine Clinical Use.

    Ramakrishnan, Meera S / Ehlers, Justis P / Modi, Yasha S

    Ophthalmology. Retina

    2022  Volume 6, Issue 9, Page(s) 751–752

    MeSH term(s) Fluorescein Angiography ; Humans ; Signal-To-Noise Ratio ; Tomography, Optical Coherence
    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2468-6530
    ISSN (online) 2468-6530
    DOI 10.1016/j.oret.2022.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Posterior Vitreous Detachment: Methods for Detection.

    Abraham, Joseph R / Ehlers, Justis P

    Ophthalmology. Retina

    2020  Volume 4, Issue 2, Page(s) 119–121

    MeSH term(s) Data Collection ; Humans ; Macula Lutea ; Tomography, Optical Coherence ; Vitreous Body ; Vitreous Detachment
    Language English
    Publishing date 2020-02-04
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2468-7219
    ISSN (online) 2468-7219
    DOI 10.1016/j.oret.2019.12.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Texture-Based Radiomic SD-OCT Features Associated With Response to Anti-VEGF Therapy in a Phase III Neovascular AMD Clinical Trial.

    Sil Kar, Sudeshna / Cetin, Hasan / Srivastava, Sunil K / Madabhushi, Anant / Ehlers, Justis P

    Translational vision science & technology

    2024  Volume 13, Issue 1, Page(s) 29

    Abstract: Purpose: The goal of this study was to evaluate the role of texture-based baseline radiomic features (Fr) and dynamic radiomics alterations (delta, FΔr) within multiple targeted compartments on optical coherence tomography (OCT) scans to predict ... ...

    Abstract Purpose: The goal of this study was to evaluate the role of texture-based baseline radiomic features (Fr) and dynamic radiomics alterations (delta, FΔr) within multiple targeted compartments on optical coherence tomography (OCT) scans to predict response to anti-vascular endothelial growth factor (VEGF) therapy in neovascular age-related macular degeneration (nAMD).
    Methods: HAWK is a phase 3 clinical trial data set of active nAMD patients (N = 1082) comparing brolucizumab and aflibercept. This analysis included patients receiving 6 mg brolucizumab or 2 mg aflibercept and categorized as complete responders (n = 280) and incomplete responders (n = 239) based on whether or not the eyes achieved/maintained fluid resolution on OCT. A total of 481 Fr were extracted from each of the fluid, subretinal hyperreflective material (SHRM), retinal tissue, and sub-retinal pigment epithelium (RPE) compartments. Most discriminating eight baseline features, selected by the minimum redundancy, maximum relevance feature selection, were evaluated using a quadratic discriminant analysis (QDA) classifier on the training set (Str, n = 363) to differentiate between the two patient groups. Classifier performance was subsequently validated on independent test set (St, n = 156).
    Results: In total, 519 participants were included in this analysis from the HAWK phase 3 study. There were 280 complete responders and 219 incomplete responders. Compartmental analysis of radiomics featured identified the sub-RPE and SHRM compartments as the most distinguishing between the two response groups. The QDA classifier yielded areas under the curve of 0.78, 0.79, and 0.84, respectively, using Fr, FΔr, and combined Fr, FΔr, and Fc on St.
    Conclusions: Utilizing compartmental static and dynamic radiomics features, unique differences were identified between eyes that respond differently to anti-VEGF therapy in a large phase 3 trial that may provide important predictive value.
    Translational relevance: Imaging biomarkers, such as radiomics features identified in this analysis, for predicting treatment response are needed to enhanced precision medicine in the management of nAMD.
    MeSH term(s) Humans ; Angiogenesis Inhibitors/therapeutic use ; Radiomics ; Retinal Pigment Epithelium ; Tomography, Optical Coherence ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Visual Acuity ; Wet Macular Degeneration/diagnostic imaging ; Wet Macular Degeneration/drug therapy
    Chemical Substances Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Clinical Trial, Phase III ; Journal Article
    ZDB-ID 2674602-5
    ISSN 2164-2591 ; 2164-2591
    ISSN (online) 2164-2591
    ISSN 2164-2591
    DOI 10.1167/tvst.13.1.29
    Database MEDical Literature Analysis and Retrieval System OnLINE

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