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Article ; Online: The long and short of microRNAs in the kidney.

Ho, Jacqueline / Kreidberg, Jordan A

Journal of the American Society of Nephrology : JASN

2012 Volume 23, Issue 3, Page(s) 400–404

Abstract: MicroRNAs (miRNAs) are a group of small, noncoding RNAs that act as novel regulators of gene expression through the post-transcriptional repression of their target mRNAs. miRNAs have been implicated in diverse biologic processes, and it is estimated that ...

Abstract	MicroRNAs (miRNAs) are a group of small, noncoding RNAs that act as novel regulators of gene expression through the post-transcriptional repression of their target mRNAs. miRNAs have been implicated in diverse biologic processes, and it is estimated that up to half of all transcripts are regulated by miRNAs. Recent studies also demonstrate a critical role for miRNAs in renal development, physiology, and pathophysiology. Understanding the function of miRNAs in the kidney may lead to innovative approaches to renal disease.
MeSH term(s)	Animals ; Disease Models, Animal ; Gene Expression Regulation/physiology ; Humans ; Kidney/embryology ; Kidney/physiology ; Kidney/physiopathology ; Kidney Diseases/physiopathology ; MicroRNAs/physiology ; Transcription, Genetic/physiology
Chemical Substances	MicroRNAs
Language	English
Publishing date	2012-02-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.2011080797
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Article ; Online: MicroRNAs in renal development.

Ho, Jacqueline / Kreidberg, Jordan A

Pediatric nephrology (Berlin, Germany)

2012 Volume 28, Issue 2, Page(s) 219–225

Abstract: The discovery of microRNAs (miRNAs) as novel regulators of gene expression has led to a marked change in how gene regulation is viewed, with important implications for development and disease. MiRNAs are endogenous, small, noncoding RNAs that largely ... ...

Abstract	The discovery of microRNAs (miRNAs) as novel regulators of gene expression has led to a marked change in how gene regulation is viewed, with important implications for development and disease. MiRNAs are endogenous, small, noncoding RNAs that largely repress their target mRNAs post-transcriptionally. The regulation of gene expression by miRNAs represents an evolutionarily conserved mechanism that is broadly applicable to most biological processes. Recent studies have begun to define the role of miRNAs in different cell lineages during kidney development, and to implicate specific miRNAs in developmental and pathophysiological processes in the kidney. This review will focus on novel insights into the role(s) of miRNAs in kidney development, and discuss the implications for pediatric renal disease.
MeSH term(s)	Gene Expression Regulation ; Humans ; Kidney/embryology ; Kidney/metabolism ; Kidney Diseases/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism
Chemical Substances	MicroRNAs
Language	English
Publishing date	2012-06-02
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-012-2204-y
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Article: Functions of alpha3beta1 integrin.

Kreidberg, J A

Current opinion in cell biology

2000 Volume 12, Issue 5, Page(s) 548–553

Abstract: alpha3beta1 integrin is a laminin receptor with apparently diverse functions. In epithelial cells it acts as a receptor for the basement membrane, whereas in neuronal and possibly tumor cells it mediates migration. Interactions of alpha3beta1 integrin ... ...

Abstract	alpha3beta1 integrin is a laminin receptor with apparently diverse functions. In epithelial cells it acts as a receptor for the basement membrane, whereas in neuronal and possibly tumor cells it mediates migration. Interactions of alpha3beta1 integrin with tetraspanin proteins may provide clues to how it transduces signals that affect cell behavior.
MeSH term(s)	Animals ; Cell Adhesion/physiology ; Cell Movement/physiology ; Humans ; Integrin alpha3beta1 ; Integrins/physiology ; Signal Transduction
Chemical Substances	Integrin alpha3beta1 ; Integrins
Language	English
Publishing date	2000-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1026381-0
ISSN	1879-0410 ; 0955-0674
ISSN (online)	1879-0410
ISSN	0955-0674
DOI	10.1016/s0955-0674(00)00130-7
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Article ; Online: Epigenetic transcriptional reprogramming by WT1 mediates a repair response during podocyte injury.

Ettou, Sandrine / Jung, Youngsook L / Miyoshi, Tomoya / Jain, Dhawal / Hiratsuka, Ken / Schumacher, Valerie / Taglienti, Mary E / Morizane, Ryuji / Park, Peter J / Kreidberg, Jordan A

Science advances

2020 Volume 6, Issue 30, Page(s) eabb5460

Abstract: In the context of human disease, the mechanisms whereby transcription factors reprogram gene expression in reparative responses to injury are not well understood. We have studied the mechanisms of transcriptional reprogramming in disease using murine ... ...

Abstract	In the context of human disease, the mechanisms whereby transcription factors reprogram gene expression in reparative responses to injury are not well understood. We have studied the mechanisms of transcriptional reprogramming in disease using murine kidney podocytes as a model for tissue injury. Podocytes are a crucial component of glomeruli, the filtration units of each nephron. Podocyte injury is the initial event in many processes that lead to end-stage kidney disease. Wilms tumor-1 (WT1) is a master regulator of gene expression in podocytes, binding nearly all genes known to be crucial for maintenance of the glomerular filtration barrier. Using murine models and human kidney organoids, we investigated WT1-mediated transcriptional reprogramming during the course of podocyte injury. Reprogramming the transcriptome involved highly dynamic changes in the binding of WT1 to target genes during a reparative injury response, affecting chromatin state and expression levels of target genes.
MeSH term(s)	Animals ; Epigenesis, Genetic ; Humans ; Kidney/metabolism ; Mice ; Podocytes/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; WT1 Proteins/genetics ; WT1 Proteins/metabolism
Chemical Substances	Transcription Factors ; WT1 Proteins ; WT1 protein, human ; WT1 protein, mouse
Language	English
Publishing date	2020-07-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abb5460
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Article: Gene targeting in kidney development.

Kreidberg, J A

Medical and pediatric oncology

1996 Volume 27, Issue 5, Page(s) 445–452

Abstract: Cancer and development are conceptually related because tumor formation in many cases results from the aberrant expression of a developmental program. This is certainly true of Wilms' tumors, which display a range of phenotypes resembling various stages ... ...

Abstract	Cancer and development are conceptually related because tumor formation in many cases results from the aberrant expression of a developmental program. This is certainly true of Wilms' tumors, which display a range of phenotypes resembling various stages of kidney development. WT1 has been identified as a tumor suppressor gene involved in a subset of Wilms' tumors. Gene targeting of the WT1 gene demonstrated the requirement for this gene product during early urogenital development. Several other genes, including Wnt-4, c-ret, ld and lim 1, have been shown by gene targeting to also be involved in early kidney development. This review discusses gene targeting as an approach to the study of development and reviews the phenotypes of these and other genes involved in kidney organogenesis.
MeSH term(s)	Animals ; DNA-Binding Proteins/genetics ; Drosophila Proteins ; Gene Expression Regulation ; Gene Expression Regulation, Neoplastic ; Gene Targeting ; Genes, Wilms Tumor/genetics ; Homeodomain Proteins/genetics ; Kidney/embryology ; Kidney Neoplasms/genetics ; LIM-Homeodomain Proteins ; Mice ; Mice, Mutant Strains ; Mice, Transgenic ; Oncogenes/genetics ; Phenotype ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-ret ; Receptor Protein-Tyrosine Kinases/genetics ; Transcription Factors/genetics ; Urogenital System/embryology ; WT1 Proteins ; Wilms Tumor/genetics ; Wnt Proteins ; Wnt4 Protein
Chemical Substances	DNA-Binding Proteins ; Drosophila Proteins ; Homeodomain Proteins ; LIM-Homeodomain Proteins ; Lhx1 protein, mouse ; Proto-Oncogene Proteins ; Transcription Factors ; WT1 Proteins ; Wnt Proteins ; Wnt4 Protein ; Wnt4 protein, mouse ; Proto-Oncogene Proteins c-ret (EC 2.7.10.1) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Ret protein, Drosophila (EC 2.7.10.1) ; Ret protein, mouse (EC 2.7.10.1)
Language	English
Publishing date	1996-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	191189-2
ISSN	1096-911X ; 0098-1532
ISSN (online)	1096-911X
ISSN	0098-1532
DOI	10.1002/(SICI)1096-911X(199611)27:5<445::AID-MPO10>3.0.CO;2-9
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Article ; Online: Early Release Science of the exoplanet WASP-39b with JWST NIRSpec PRISM.

Rustamkulov, Z / Sing, D K / Mukherjee, S / May, E M / Kirk, J / Schlawin, E / Line, M R / Piaulet, C / Carter, A L / Batalha, N E / Goyal, J M / López-Morales, M / Lothringer, J D / MacDonald, R J / Moran, S E / Stevenson, K B / Wakeford, H R / Espinoza, N / Bean, J L /

Batalha, N M / Benneke, B / Berta-Thompson, Z K / Crossfield, I J M / Gao, P / Kreidberg, L / Powell, D K / Cubillos, P E / Gibson, N P / Leconte, J / Molaverdikhani, K / Nikolov, N K / Parmentier, V / Roy, P / Taylor, J / Turner, J D / Wheatley, P J / Aggarwal, K / Ahrer, E / Alam, M K / Alderson, L / Allen, N H / Banerjee, A / Barat, S / Barrado, D / Barstow, J K / Bell, T J / Blecic, J / Brande, J / Casewell, S / Changeat, Q / Chubb, K L / Crouzet, N / Daylan, T / Decin, L / Désert, J / Mikal-Evans, T / Feinstein, A D / Flagg, L / Fortney, J J / Harrington, J / Heng, K / Hong, Y / Hu, R / Iro, N / Kataria, T / Kempton, E M-R / Krick, J / Lendl, M / Lillo-Box, J / Louca, A / Lustig-Yaeger, J / Mancini, L / Mansfield, M / Mayne, N J / Miguel, Y / Morello, G / Ohno, K / Palle, E / Petit Dit de la Roche, D J M / Rackham, B V / Radica, M / Ramos-Rosado, L / Redfield, S / Rogers, L K / Shkolnik, E L / Southworth, J / Teske, J / Tremblin, P / Tucker, G S / Venot, O / Waalkes, W C / Welbanks, L / Zhang, X / Zieba, S

Nature

2023 Volume 614, Issue 7949, Page(s) 659–663

Abstract: Transmission ... ...

Abstract	Transmission spectroscopy
Language	English
Publishing date	2023-01-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-022-05677-y
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Article ; Online: EED, a member of the polycomb group, is required for nephron differentiation and the maintenance of nephron progenitor cells.

Zhang, Le / Ettou, Sandrine / Khalid, Myda / Taglienti, Mary / Jain, Dhawal / Jung, Youngsook L / Seager, Catherine / Liu, Yongqing / Ng, Kar-Hui / Park, Peter J / Kreidberg, Jordan A

Development (Cambridge, England)

2018 Volume 145, Issue 14

Abstract: Epigenetic regulation of gene expression has a crucial role allowing for the self-renewal and differentiation of stem and progenitor populations during organogenesis. The mammalian kidney maintains a population of self-renewing stem cells that ... ...

Abstract	Epigenetic regulation of gene expression has a crucial role allowing for the self-renewal and differentiation of stem and progenitor populations during organogenesis. The mammalian kidney maintains a population of self-renewing stem cells that differentiate to give rise to thousands of nephrons, which are the functional units that carry out filtration to maintain physiological homeostasis. The polycomb repressive complex 2 (PRC2) epigenetically represses gene expression during development by placing the H3K27me3 mark on histone H3 at promoter and enhancer sites, resulting in gene silencing. To understand the role of PRC2 in nephron differentiation, we conditionally inactivated the
MeSH term(s)	Animals ; Cell Differentiation/physiology ; Epigenesis, Genetic/physiology ; Gene Expression Regulation, Developmental/physiology ; LIM-Homeodomain Proteins/biosynthesis ; LIM-Homeodomain Proteins/genetics ; Mice ; Mice, Transgenic ; Mutation ; Nephrons/cytology ; Nephrons/embryology ; Polycomb Repressive Complex 2/biosynthesis ; Polycomb Repressive Complex 2/genetics ; Stem Cells/cytology ; Stem Cells/metabolism ; Transcription Factors/biosynthesis ; Transcription Factors/genetics
Chemical Substances	Eed protein, mouse ; LIM-Homeodomain Proteins ; Lhx1 protein, mouse ; Transcription Factors ; Polycomb Repressive Complex 2 (EC 2.1.1.43)
Language	English
Publishing date	2018-07-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.157149
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Article ; Online: Sulfur dioxide in the mid-infrared transmission spectrum of WASP-39b.

Powell, Diana / Feinstein, Adina D / Lee, Elspeth K H / Zhang, Michael / Tsai, Shang-Min / Taylor, Jake / Kirk, James / Bell, Taylor / Barstow, Joanna K / Gao, Peter / Bean, Jacob L / Blecic, Jasmina / Chubb, Katy L / Crossfield, Ian J M / Jordan, Sean / Kitzmann, Daniel / Moran, Sarah E / Morello, Giuseppe / Moses, Julianne I /

Welbanks, Luis / Yang, Jeehyun / Zhang, Xi / Ahrer, Eva-Maria / Bello-Arufe, Aaron / Brande, Jonathan / Casewell, S L / Crouzet, Nicolas / Cubillos, Patricio E / Demory, Brice-Olivier / Dyrek, Achrène / Flagg, Laura / Hu, Renyu / Inglis, Julie / Jones, Kathryn D / Kreidberg, Laura / López-Morales, Mercedes / Lagage, Pierre-Olivier / Meier Valdés, Erik A / Miguel, Yamila / Parmentier, Vivien / Piette, Anjali A A / Rackham, Benjamin V / Radica, Michael / Redfield, Seth / Stevenson, Kevin B / Wakeford, Hannah R / Aggarwal, Keshav / Alam, Munazza K / Batalha, Natalie M / Batalha, Natasha E / Benneke, Björn / Berta-Thompson, Zach K / Brady, Ryan P / Caceres, Claudio / Carter, Aarynn L / Désert, Jean-Michel / Harrington, Joseph / Iro, Nicolas / Line, Michael R / Lothringer, Joshua D / MacDonald, Ryan J / Mancini, Luigi / Molaverdikhani, Karan / Mukherjee, Sagnick / Nixon, Matthew C / Oza, Apurva V / Palle, Enric / Rustamkulov, Zafar / Sing, David K / Steinrueck, Maria E / Venot, Olivia / Wheatley, Peter J / Yurchenko, Sergei N

Nature

2024 Volume 626, Issue 8001, Page(s) 979–983

Abstract: The recent inference of sulfur dioxide ( ... ...

Abstract	The recent inference of sulfur dioxide (SO
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-024-07040-9
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Article: Integrins in kidney development, function, and disease.

Kreidberg, J A / Symons, J M

American journal of physiology. Renal physiology

2000 Volume 279, Issue 2, Page(s) F233–42

Abstract: ... adult kidney (Korhonen M, Ylkanne J, Laitinen L, and Virtanen I. Development 122: 3537-3547, 1996 ... Rahilly MA and Fleming S. J Pathol 167: 327-334, 1992). This review will summarize present knowledge ...

Abstract	Integrins are heterodimeric cell surface receptors that mediate heterophilic cell-cell interactions and interactions between cells and the extracellular matrix (Hynes RO. Cell 69: 11-25, 1991). As such, they are involved in morphogenetic processes during development, as well as in the maintenance of normal tissue architecture in fully developed organs. Integrins are now recognized to be a large family of receptors, and several different integrins have been demonstrated as being expressed in the developing and adult kidney (Korhonen M, Ylkanne J, Laitinen L, and Virtanen I. Development 122: 3537-3547, 1996; Rahilly MA and Fleming S. J Pathol 167: 327-334, 1992). This review will summarize present knowledge about integrin expression in the developing, normal, and diseased kidney and attempt to provide a hypothetical framework for understanding integrin function in the urogenital system. Since the last time this area was reviewed (Hamerski DA and Santoro S. Curr Opin Nephrol Hypertens 8: 9-14, 1999), there have been significant publications on the roles of integrins in kidney development and disease. At present, there are many more questions than answers, and integrins present an area where many novel and exciting findings will emerge in the coming years.
MeSH term(s)	Aging/physiology ; Animals ; Embryo, Mammalian/physiology ; Embryonic and Fetal Development ; Humans ; Integrins/metabolism ; Integrins/physiology ; Kidney/embryology ; Kidney/growth & development ; Kidney Diseases/physiopathology
Chemical Substances	Integrins
Language	English
Publishing date	2000-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603837-2
ISSN	1522-1466 ; 1931-857X ; 0363-6127
ISSN (online)	1522-1466
ISSN	1931-857X ; 0363-6127
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Article ; Online: Dicer function is required in the metanephric mesenchyme for early kidney development.

Chu, Jessica Y S / Sims-Lucas, Sunder / Bushnell, Daniel S / Bodnar, Andrew J / Kreidberg, Jordan A / Ho, Jacqueline

American journal of physiology. Renal physiology

2014 Volume 306, Issue 7, Page(s) F764–72

Abstract: ... Khalid M, Frank MH, Hartwig S, Kreidberg JA. J Am Soc Nephrol 22: 1053-1063, 2011). To interrogate roles ... roles for miRNAs in nephron progenitors at midgestation (Ho J, Pandey P, Schatton T, Sims-Lucas S ...

Abstract	MicroRNAs (miRNAs) are small, noncoding regulatory RNAs that act as posttranscriptional repressors by binding to the 3'-untranslated region (3'-UTR) of target genes. They require processing by Dicer, an RNase III enzyme, to become mature regulatory RNAs. Previous work from our laboratory revealed critical roles for miRNAs in nephron progenitors at midgestation (Ho J, Pandey P, Schatton T, Sims-Lucas S, Khalid M, Frank MH, Hartwig S, Kreidberg JA. J Am Soc Nephrol 22: 1053-1063, 2011). To interrogate roles for miRNAs in the early metanephric mesenchyme, which gives rise to nephron progenitors as well as the renal stroma during kidney development, we conditionally ablated Dicer function in this lineage. Despite normal ureteric bud outgrowth and condensation of the metanephric mesenchyme to form nephron progenitors, early loss of miRNAs in the metanephric mesenchyme resulted in severe renal dysgenesis. Nephron progenitors are initially correctly specified in the mutant kidneys, with normal expression of several transcription factors known to be critical in progenitors, including Six2, Pax2, Sall1, and Wt1. However, there is premature loss of the nephron progenitor marker Cited1, marked apoptosis, and increased expression of the proapoptotic protein Bim shortly after the initial inductive events in early kidney development. Subsequently, there is a failure in ureteric bud branching and nephron progenitor differentiation. Taken together, our data demonstrate a previously undetermined requirement for miRNAs during early kidney organogenesis and indicate a crucial role for miRNAs in regulating the survival of this lineage.
MeSH term(s)	Animals ; Apoptosis ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Bcl-2-Like Protein 11 ; DEAD-box RNA Helicases/deficiency ; DEAD-box RNA Helicases/genetics ; DEAD-box RNA Helicases/metabolism ; Embryonic Stem Cells/enzymology ; Gene Expression Regulation, Developmental ; Gene Expression Regulation, Enzymologic ; Gestational Age ; Kidney/abnormalities ; Kidney/enzymology ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mesoderm/abnormalities ; Mesoderm/enzymology ; Mice ; Mice, Knockout ; MicroRNAs/metabolism ; Nephrons/abnormalities ; Nephrons/enzymology ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Organogenesis ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Ribonuclease III/deficiency ; Ribonuclease III/genetics ; Ribonuclease III/metabolism ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Ureter/abnormalities ; Ureter/enzymology
Chemical Substances	Apoptosis Regulatory Proteins ; Bcl-2-Like Protein 11 ; Bcl2l11 protein, mouse ; Cited1 protein, mouse ; Membrane Proteins ; MicroRNAs ; Nuclear Proteins ; Proto-Oncogene Proteins ; Trans-Activators ; Dicer1 protein, mouse (EC 3.1.26.3) ; Ribonuclease III (EC 3.1.26.3) ; DEAD-box RNA Helicases (EC 3.6.4.13)
Language	English
Publishing date	2014-02-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	603837-2
ISSN	1522-1466 ; 0363-6127
ISSN (online)	1522-1466
ISSN	0363-6127
DOI	10.1152/ajprenal.00426.2013
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