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  1. Book: SURFACES OF NORMAL AND MALIGNANT CELLS. EDITED BY RICHARD O. HYNES

    Hynes, Richard O.

    1979  

    Title variant SURFACES OF NORMAL AND MALIGNANT CELLS
    Keywords CELL MEMBRANE ; CELL TRANSFORMATION, NEOPLASTIC ; NEOPLASMS ; SURFACE PROPERTIES ; Krebszelle ; Oberfläche ; Zelloberfläche ; Maligne Transformation
    Subject Krebs ; Zelltransformation ; Neoplastische Transformation ; Onkogene Transformation
    Size VIII,471 S.
    Publisher WILEY
    Publishing place CHICHESTER ETC
    Document type Book
    Note 'A WILEY-INTERSCIENCE PUBLICATION'
    HBZ-ID HT000395490
    ISBN 0-471-99712-9 ; 978-0-471-99712-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1979 A 1862 order for loan Magazin

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  2. Book: Extracellular matrix biology

    Hynes, Richard O. / Yamada, Kenneth M.

    a subject collection from Cold Spring Harbor Perspectives in Biology

    (Cold Spring Harbor perspectives in biology)

    2012  

    Author's details ed. by Richard O. Hynes ; Kenneth M. Yamada
    Series title Cold Spring Harbor perspectives in biology
    Keywords Extrazelluläre Matrix
    Subject ECM
    Language English
    Size VIII, 397 S. : Ill., graph. Darst.
    Publisher Cold Spring Harbor Laboratory Press
    Publishing place Cold Spring Harbor, NY
    Publishing country United States
    Document type Book
    Note Includes index
    HBZ-ID HT017217181
    ISBN 978-1-936113-38-5 ; 1-936113-38-4
    Database Catalogue ZB MED Medicine, Health

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  3. Article: Identification of a Gene Signature That Predicts Dependence upon YAP/TAZ-TEAD.

    Kanai, Ryan / Norton, Emily / Stern, Patrick / Hynes, Richard O / Lamar, John M

    Cancers

    2024  Volume 16, Issue 5

    Abstract: Targeted therapies are effective cancer treatments when accompanied by accurate diagnostic tests that can help identify patients that will respond to those therapies. The YAP/TAZ-TEAD axis is activated and plays a causal role in several cancer types, and ...

    Abstract Targeted therapies are effective cancer treatments when accompanied by accurate diagnostic tests that can help identify patients that will respond to those therapies. The YAP/TAZ-TEAD axis is activated and plays a causal role in several cancer types, and TEAD inhibitors are currently in early-phase clinical trials in cancer patients. However, a lack of a reliable way to identify tumors with YAP/TAZ-TEAD activation for most cancer types makes it difficult to determine which tumors will be susceptible to TEAD inhibitors. Here, we used a combination of RNA-seq and bioinformatic analysis of metastatic melanoma cells to develop a YAP/TAZ gene signature. We found that the genes in this signature are TEAD-dependent in several melanoma cell lines, and that their expression strongly correlates with YAP/TAZ activation in human melanomas. Using DepMap dependency data, we found that this YAP/TAZ signature was predictive of melanoma cell dependence upon YAP/TAZ or TEADs. Importantly, this was not limited to melanoma because this signature was also predictive when tested on a panel of over 1000 cancer cell lines representing numerous distinct cancer types. Our results suggest that YAP/TAZ gene signatures like ours may be effective tools to predict tumor cell dependence upon YAP/TAZ-TEAD, and thus potentially provide a means to identify patients likely to benefit from TEAD inhibitors.
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16050852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reflections on Integrins-Past, Present, and Future: The Albert Lasker Basic Medical Research Award.

    Hynes, Richard O / Ruoslahti, Erkki / Springer, Timothy A

    JAMA

    2022  Volume 328, Issue 13, Page(s) 1291–1292

    MeSH term(s) Awards and Prizes ; Biomedical Research ; Cell Biology/history ; Cell Biology/trends ; History, 21st Century ; Integrins/physiology ; United States
    Chemical Substances Integrins
    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.17005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Fibronectins

    Hynes, Richard O.

    (Springer series in molecular biology)

    1990  

    Author's details Richard O. Hynes
    Series title Springer series in molecular biology
    Keywords Fibronectins ; Fibronectin
    Subject Fibronektin
    Language English
    Size XV, 546 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003503402
    ISBN 0-387-97050-9 ; 3-540-97050-9 ; 978-0-387-97050-9 ; 978-3-540-97050-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 2807 order for loan Magazin

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  6. Article ; Online: Antibodies and methods for immunohistochemistry of extracellular matrix proteins.

    Rickelt, Steffen / Hynes, Richard O

    Matrix biology : journal of the International Society for Matrix Biology

    2018  Volume 71-72, Page(s) 10–27

    Abstract: The diversity of extracellular matrix (ECM) proteins encoded in mammalian genomes and detected by proteomic analyses generates a need for well validated antibodies against these proteins. We present characterization of a large number of antibodies ... ...

    Abstract The diversity of extracellular matrix (ECM) proteins encoded in mammalian genomes and detected by proteomic analyses generates a need for well validated antibodies against these proteins. We present characterization of a large number of antibodies against ECM proteins, from both commercial and academic sources, together with discussion of methods and strategies for their effective use in immunohistochemistry and illustrations of their efficacy. These data should be of value to investigators seeking well validated antibodies to ECM proteins of interest and save significant time and money tracking down effective reagents.
    MeSH term(s) Animals ; Antibodies/metabolism ; Drug Industry ; Extracellular Matrix/metabolism ; Extracellular Matrix Proteins/immunology ; Humans ; Immunohistochemistry
    Chemical Substances Antibodies ; Extracellular Matrix Proteins
    Language English
    Publishing date 2018-05-03
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1183793-7
    ISSN 1569-1802 ; 0945-053X
    ISSN (online) 1569-1802
    ISSN 0945-053X
    DOI 10.1016/j.matbio.2018.04.011
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  7. Article ; Online: Stretching the boundaries of extracellular matrix research.

    Hynes, Richard O

    Nature reviews. Molecular cell biology

    2014  Volume 15, Issue 12, Page(s) 761–763

    Abstract: Extracellular matrix (ECM) proteins constitute >1% of the proteome and interact with many modifiers and growth factors to affect most aspects of cellular behaviour during development and normal physiology, as well as in diseases such as fibroses, cancer ... ...

    Abstract Extracellular matrix (ECM) proteins constitute >1% of the proteome and interact with many modifiers and growth factors to affect most aspects of cellular behaviour during development and normal physiology, as well as in diseases such as fibroses, cancer and many genetic disorders. In addition to biochemical signals provided to cells by ECM proteins, important cell–ECM interactions involve bidirectional mechanotransduction influences, which are dependent on the physical structure and organization of the ECM. These are beginning to be understood using twenty-first-century approaches, including biophysics, nanotechnology, biological engineering and modern microscopy. Articles in this issue of Nature Reviews Molecular Cell Biology review progress in our understanding of the ECM.
    MeSH term(s) Animals ; Cell Biology ; Extracellular Matrix/chemistry ; Extracellular Matrix/metabolism ; Extracellular Matrix Proteins/chemistry ; Extracellular Matrix Proteins/metabolism ; Mechanotransduction, Cellular ; Pathology
    Chemical Substances Extracellular Matrix Proteins
    Language English
    Publishing date 2014
    Publishing country England
    Document type Research Support, Non-U.S. Gov't ; Introductory Journal Article
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
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    Zs.A 5446: Show issues Location:
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    Zs.MG 26: Show issues

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  8. Article ; Online: Evolving policy with science.

    Charo, R Alta / Hynes, Richard O

    Science (New York, N.Y.)

    2017  Volume 355, Issue 6328, Page(s) 889

    MeSH term(s) Bioethical Issues ; Cell Line ; Gene Editing/ethics ; Genome, Human ; Germ Cells ; Humans ; Policy
    Language English
    Publishing date 2017--03
    Publishing country United States
    Document type Editorial
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aan0509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 27: Show issues Location:
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    Zs.MG 77: Show issues

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  9. Article ; Online: Intravital imaging of metastasis in adult Zebrafish.

    Benjamin, David C / Hynes, Richard O

    BMC cancer

    2017  Volume 17, Issue 1, Page(s) 660

    Abstract: Background: Metastasis is a major clinical problem whose biology is not yet fully understood. This lack of understanding is especially true for the events at the metastatic site, which include arrest, extravasation, and growth into macrometastases. ... ...

    Abstract Background: Metastasis is a major clinical problem whose biology is not yet fully understood. This lack of understanding is especially true for the events at the metastatic site, which include arrest, extravasation, and growth into macrometastases. Intravital imaging is a powerful technique that has shown great promise in increasing our understanding of these events. To date, most intravital imaging studies have been performed in mice, which has limited its adoption. Zebrafish are also a common system for the intravital imaging of metastasis. However, as imaging in embryos is technically simpler, relatively few studies have used adult zebrafish to study metastasis and none have followed individual cells at the metastatic site over time. The aim of this study was to demonstrate that adult casper zebrafish offer a convenient model system for performing intravital imaging of the metastatic site over time with single-cell resolution.
    Methods: ZMEL1 zebrafish melanoma cells were injected into 6 to 10-week-old casper fish using an intravenous injection protocol. Because casper fish are transparent even as adults, they could be imaged without surgical intervention. Individual cells were followed over the course of 2 weeks as they arrested, extravasated, and formed macroscopic metastases.
    Results: Our injection method reliably delivered cells into circulation and led to the formation of tumors in multiple organs. Cells in the skin and sub-dermal muscle could be imaged at high resolution over 2 weeks using confocal microscopy. Arrest was visualized and determined to be primarily due to size restriction. Following arrest, extravasation was seen to occur between 1 and 6 days post-injection. Once outside of the vasculature, cells were observed migrating as well as forming protrusions.
    Conclusions: Casper fish are a useful model for studying the events at the metastatic site using intravital imaging. The protocols described in this study are relatively simple. Combined with the reasonably low cost of zebrafish, they offer to increase access to intravital imaging.
    MeSH term(s) Animals ; Cell Line, Tumor ; Disease Models, Animal ; Humans ; Intravital Microscopy/methods ; Melanoma/diagnostic imaging ; Melanoma/pathology ; Mice ; Microscopy, Confocal ; Neoplasm Metastasis ; Zebrafish
    Language English
    Publishing date 2017-09-25
    Publishing country England
    Document type Journal Article
    ISSN 1471-2407
    ISSN (online) 1471-2407
    DOI 10.1186/s12885-017-3647-0
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  10. Article ; Online: The evolution of metazoan extracellular matrix.

    Hynes, Richard O

    The Journal of cell biology

    2012  Volume 196, Issue 6, Page(s) 671–679

    Abstract: The modular domain structure of extracellular matrix (ECM) proteins and their genes has allowed extensive exon/domain shuffling during evolution to generate hundreds of ECM proteins. Many of these arose early during metazoan evolution and have been ... ...

    Abstract The modular domain structure of extracellular matrix (ECM) proteins and their genes has allowed extensive exon/domain shuffling during evolution to generate hundreds of ECM proteins. Many of these arose early during metazoan evolution and have been highly conserved ever since. Others have undergone duplication and divergence during evolution, and novel combinations of domains have evolved to generate new ECM proteins, particularly in the vertebrate lineage. The recent sequencing of several genomes has revealed many details of this conservation and evolution of ECM proteins to serve diverse functions in metazoa.
    MeSH term(s) Animals ; Evolution, Molecular ; Extracellular Matrix/genetics ; Extracellular Matrix/physiology ; Extracellular Matrix Proteins/genetics ; Extracellular Matrix Proteins/metabolism ; Genome ; Invertebrates/genetics ; Vertebrates/genetics
    Chemical Substances Extracellular Matrix Proteins
    Language English
    Publishing date 2012-03-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.201109041
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