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Article: Vaccinia virus and peptide-receptor radiotherapy synergize to improve treatment of peritoneal carcinomatosis.

Ottolino-Perry, Kathryn / Mealiea, David / Sellers, Clara / Acuna, Sergio A / Angarita, Fernando A / Okamoto, Lili / Scollard, Deborah / Ginj, Mihaela / Reilly, Raymond / McCart, J Andrea

Molecular therapy oncolytics

2023 Volume 29, Page(s) 44–58

Abstract: Tumor-specific overexpression of receptors enables a variety of targeted cancer therapies, exemplified by peptide-receptor radiotherapy (PRRT) for somatostatin receptor (SSTR)-positive neuroendocrine tumors. While effective, PRRT is restricted to tumors ... ...

Abstract	Tumor-specific overexpression of receptors enables a variety of targeted cancer therapies, exemplified by peptide-receptor radiotherapy (PRRT) for somatostatin receptor (SSTR)-positive neuroendocrine tumors. While effective, PRRT is restricted to tumors with SSTR overexpression. To overcome this limitation, we propose using oncolytic vaccinia virus (vvDD)-mediated receptor gene transfer to permit molecular imaging and PRRT in tumors without endogenous SSTR overexpression, a strategy termed radiovirotherapy. We hypothesized that vvDD-SSTR combined with a radiolabeled somatostatin analog could be deployed as radiovirotherapy in a colorectal cancer peritoneal carcinomatosis model, producing tumor-specific radiopeptide accumulation. Following vvDD-SSTR and
Language	English
Publishing date	2023-04-10
Publishing country	United States
Document type	Journal Article
ISSN	2372-7705
ISSN	2372-7705
DOI	10.1016/j.omto.2023.04.001
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Article: Can Imaging Put the "

DaCosta, Ralph S / Ottolino-Perry, Kathryn / Banerjee, Jaideep

Advances in wound care

2016 Volume 5, Issue 8, Page(s) 329–331

Abstract: An effective, scientifically validated, diagnostic tool helps clinicians make better, timely, and more objective medical decisions in the care of their patients. Today, the need for such tools is especially urgent in the field of wound care where patient- ...

Abstract	An effective, scientifically validated, diagnostic tool helps clinicians make better, timely, and more objective medical decisions in the care of their patients. Today, the need for such tools is especially urgent in the field of wound care where patient-centric care is the goal, under ever tightening clinical budget constraints. In an era of countless "innovative" treatment options, that is, advanced dressings, negative pressure devices, and various debridement instruments available to the wound care clinical team, one area that has arguably languished in the past decade has been
Language	English
Publishing date	2016-08-01
Publishing country	United States
Document type	Editorial
ZDB-ID	2650541-1
ISSN	2162-1934 ; 2162-1918
ISSN (online)	2162-1934
ISSN	2162-1918
DOI	10.1089/wound.2016.0702
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Article ; Online: Mounting a strategic offense: fighting tumor vasculature with oncolytic viruses.

Angarita, Fernando A / Acuna, Sergio A / Ottolino-Perry, Kathryn / Zerhouni, Siham / McCart, J Andrea

Trends in molecular medicine

2013 Volume 19, Issue 6, Page(s) 378–392

Abstract: Blood supply within a tumor drives progression and ultimately allows for metastasis. Many anticancer therapies target tumor vasculature, but their individual effectiveness is limited because they induce indirect cell death. Agents that disrupt nascent ... ...

Abstract	Blood supply within a tumor drives progression and ultimately allows for metastasis. Many anticancer therapies target tumor vasculature, but their individual effectiveness is limited because they induce indirect cell death. Agents that disrupt nascent and/or established tumor vasculature while simultaneously killing cancer cells would certainly have a greater impact. Oncolytic virotherapy utilizes attenuated viruses that replicate specifically within a tumor. They induce cytotoxicity through a combination of direct cell lysis, antitumor immune stimulation, and recently identified antitumor vascular effects. This review summarizes the novel preclinical and clinical evidence regarding the antitumor vascular effects of oncolytic viruses, which include infection and lysis of tumor endothelial cells, natural or genetically engineered antiangiogenic properties, and combination therapy with clinically approved antivascular agents.
MeSH term(s)	Animals ; Humans ; Neoplasms/blood supply ; Neoplasms/pathology ; Neoplasms/therapy ; Neoplasms/virology ; Neovascularization, Pathologic ; Oncolytic Virotherapy ; Oncolytic Viruses/genetics ; Oncolytic Viruses/physiology ; Virus Replication
Language	English
Publishing date	2013-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2036490-8
ISSN	1471-499X ; 1471-4914
ISSN (online)	1471-499X
ISSN	1471-4914
DOI	10.1016/j.molmed.2013.02.008
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Zs.A 4345: Show issues

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Article ; Online: Oncolytic vaccinia virus synergizes with irinotecan in colorectal cancer.

Ottolino-Perry, Kathryn / Acuna, Sergio A / Angarita, Fernando A / Sellers, Clara / Zerhouni, Siham / Tang, Nan / McCart, J Andrea

Molecular oncology

2015 Volume 9, Issue 8, Page(s) 1539–1552

Abstract: Metastatic colorectal cancer (CRC) is complex clinical challenge for which there are limited treatment options. Chemotherapy with or without surgery provides moderate improvements in overall survival and quality of life; nevertheless the 5-year survival ... ...

Abstract	Metastatic colorectal cancer (CRC) is complex clinical challenge for which there are limited treatment options. Chemotherapy with or without surgery provides moderate improvements in overall survival and quality of life; nevertheless the 5-year survival remains below 30%. Oncolytic vaccinia virus (VV) shows strong anti-tumour activity in models of CRC, however transient delays in disease progression are insufficient to lead to long-term survival. Here we examined the efficacy of VV with oxaliplatin or SN-38 (active metabolite of irinotecan) in CRC cell lines in vitro and VV with irinotecan in an orthotopic model of metastatic CRC. Synergistic improvements in in vitro cell killing were observed in multiple cell lines. Combination therapy was well tolerated in tumour-bearing mice and the median survival was significantly increased relative to monotherapy despite a drug-dependent decrease in the mean tumour titer. Increased apoptosis following in vitro and in vivo combination therapy was observed. In vitro cell cycle analysis showed increases in S-phase cells following infection occurred in both infected and uninfected cell populations. This corresponded to a 4-fold greater increase in apoptosis in the uninfected compared to infected cells following combination therapy. Combination treatment strategies are among the best options for patients with advanced cancers. VV is currently under clinical investigation in patients with CRC and the data presented here suggest that its combination with irinotecan may provide benefit to a subset of CRC patients. Further, investigation of this combination is necessary to determine the tumour characteristics responsible for mediating synergy.
MeSH term(s)	Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Camptothecin/administration & dosage ; Camptothecin/analogs & derivatives ; Camptothecin/therapeutic use ; Cells, Cultured ; Chlorocebus aethiops ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/therapy ; Combined Modality Therapy ; Drug Synergism ; Female ; HT29 Cells ; Humans ; Irinotecan ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Oncolytic Virotherapy ; Oncolytic Viruses ; Organoplatinum Compounds/administration & dosage ; Oxaliplatin ; Vaccinia virus
Chemical Substances	Organoplatinum Compounds ; Oxaliplatin (04ZR38536J) ; Irinotecan (7673326042) ; Camptothecin (XT3Z54Z28A)
Language	English
Publishing date	2015-05-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2415106-3
ISSN	1878-0261 ; 1574-7891
ISSN (online)	1878-0261
ISSN	1574-7891
DOI	10.1016/j.molonc.2015.04.009
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Zs.A 6637: Show issues

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Article ; Online: Improved detection of clinically relevant wound bacteria using autofluorescence image-guided sampling in diabetic foot ulcers.

Ottolino-Perry, Kathryn / Chamma, Emilie / Blackmore, Kristina M / Lindvere-Teene, Liis / Starr, Danielle / Tapang, Kim / Rosen, Cheryl F / Pitcher, Bethany / Panzarella, Tony / Linden, Ron / DaCosta, Ralph S

International wound journal

2017 Volume 14, Issue 5, Page(s) 833–841

Abstract: Clinical wound assessment involves microbiological swabbing of wounds to identify and quantify bacterial species, and to determine microbial susceptibility to antibiotics. The Levine swabbing technique may be suboptimal because it samples only the wound ... ...

Abstract	Clinical wound assessment involves microbiological swabbing of wounds to identify and quantify bacterial species, and to determine microbial susceptibility to antibiotics. The Levine swabbing technique may be suboptimal because it samples only the wound bed, missing other diagnostically relevant areas of the wound, which may contain clinically significant bacteria. Thus, there is a clinical need to improve the reliability of microbiological wound sampling. To address this, a handheld portable autofluorescence (AF) imaging device that detects bacteria in real time, without contrast agents, was developed. Here, we report the results of a clinical study evaluating the use of real-time AF imaging to visualise bacteria in and around the wound bed and to guide swabbing during the clinical assessment of diabetic foot ulcers, compared with the Levine technique. We investigated 33 diabetic foot ulcers (n = 31 patients) and found that AF imaging more accurately identified the presence of moderate and/or heavy bacterial load compared with the Levine technique (accuracy 78% versus 52%, P = 0·048; adjusted diagnostic odds ratio 7·67, P < 0·00022 versus 3·07, P = 0·066) and maximised the effectiveness of bacterial load sampling, with no significant impact on clinical workflow. AF imaging may help clinicians better identify the wound areas with clinically significant bacteria, and maximise sampling of treatment-relevant pathogens.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Bacteria/isolation & purification ; Bacterial Load/instrumentation ; Diabetic Foot/microbiology ; Female ; Humans ; Male ; Middle Aged ; Optical Imaging ; Reproducibility of Results ; Specimen Handling/methods ; Wound Infection/diagnosis ; Wound Infection/microbiology ; Young Adult
Language	English
Publishing date	2017-02-28
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	2170920-8
ISSN	1742-481X ; 1742-4801
ISSN (online)	1742-481X
ISSN	1742-4801
DOI	10.1111/iwj.12717
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Zs.A 6006: Show issues

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Article ; Online: Oncolytic vaccinia virus as an adjuvant treatment to cytoreductive surgery for malignant peritoneal mesothelioma.

Acuna, Sergio A / Ottolino-Perry, Kathryn / Çako, Besmira / Tang, Nan / Angarita, Fernando A / McCart, J Andrea

Annals of surgical oncology

2014 Volume 21, Issue 7, Page(s) 2259–2266

Abstract: Background: Malignant peritoneal mesothelioma (MPM) is an aggressive cancer with a dismal prognosis. Oncolytic viruses are a promising new therapy for cancer because of their ability to kill tumor cells with minimal toxicity to normal tissues. This ... ...

Abstract	Background: Malignant peritoneal mesothelioma (MPM) is an aggressive cancer with a dismal prognosis. Oncolytic viruses are a promising new therapy for cancer because of their ability to kill tumor cells with minimal toxicity to normal tissues. This experimental study aimed to examine the potential of modified vaccinia virus (VV) to treat MPM when administered alone or as an adjuvant treatment to surgery. Methods: Two aggressive murine mesothelioma cell lines (AC29, AB12), were used. Cell viability and viral cytopathic effects were assessed using MTS and crystal violet assays. Immunocompetent mice were injected intraperitoneally with MPM cells and treated with intraperitoneal VV. Tumor-bearing mice also underwent cytoreductive surgery (CRS) followed by VV (or control) therapy. Results: The cytotoxic effects of VV on MPM cell lines was significantly increased compared with the control non-cancer cell line. In both orthotopic models, VV induced tumor regression, prolonging median and long-term survival. VV treatment after incomplete CRS was not superior to VV alone; however, when mice with microscopic disease were treated with VV, further prolongation of median and long-term survivals was observed. Conclusions: VV selectively kills MPM cells in vitro and leads to improved survival and cures in immunocompetent murine models. Higher efficacy of the virus in the microscopic disease context suggests the use of the virus as an adjuvant treatment to complete surgical resection. These promising results justify further studies of VV in humans as a novel treatment for MPM.
MeSH term(s)	Adjuvants, Immunologic ; Animals ; Apoptosis ; Cell Proliferation ; Combined Modality Therapy ; Cytoreduction Surgical Procedures ; Female ; Humans ; Immunoenzyme Techniques ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Lung Neoplasms/therapy ; Mesothelioma/mortality ; Mesothelioma/pathology ; Mesothelioma/therapy ; Mesothelioma, Malignant ; Mice ; Mice, Inbred BALB C ; Mice, Inbred CBA ; Mice, SCID ; Oncolytic Virotherapy ; Peritoneal Neoplasms/mortality ; Peritoneal Neoplasms/pathology ; Peritoneal Neoplasms/therapy ; Survival Rate ; Tumor Cells, Cultured ; Vaccinia virus/physiology ; Virus Replication
Chemical Substances	Adjuvants, Immunologic
Language	English
Publishing date	2014-04-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-014-3651-4
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Zs.A 4042: Show issues

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Article ; Online: Intraoperative fluorescence imaging with aminolevulinic acid detects grossly occult breast cancer: a phase II randomized controlled trial.

Ottolino-Perry, Kathryn / Shahid, Anam / DeLuca, Stephanie / Son, Viktor / Sukhram, Mayleen / Meng, Fannong / Liu, Zhihui Amy / Rapic, Sara / Anantha, Nayana Thalanki / Wang, Shirley C / Chamma, Emilie / Gibson, Christopher / Medeiros, Philip J / Majeed, Safa / Chu, Ashley / Wignall, Olivia / Pizzolato, Alessandra / Rosen, Cheryl F / Teene, Liis Lindvere /

Starr-Dunham, Danielle / Kulbatski, Iris / Panzarella, Tony / Done, Susan J / Easson, Alexandra M / Leong, Wey L / DaCosta, Ralph S

Breast cancer research : BCR

2021 Volume 23, Issue 1, Page(s) 72

Abstract: Background: Re-excision due to positive margins following breast-conserving surgery (BCS) negatively affects patient outcomes and healthcare costs. The inability to visualize margin involvement is a significant challenge in BCS. 5-Aminolevulinic acid ... ...

Abstract	Background: Re-excision due to positive margins following breast-conserving surgery (BCS) negatively affects patient outcomes and healthcare costs. The inability to visualize margin involvement is a significant challenge in BCS. 5-Aminolevulinic acid hydrochloride (5-ALA HCl), a non-fluorescent oral prodrug, causes intracellular accumulation of fluorescent porphyrins in cancer cells. This single-center Phase II randomized controlled trial evaluated the safety, feasibility, and diagnostic accuracy of a prototype handheld fluorescence imaging device plus 5-ALA for intraoperative visualization of invasive breast carcinomas during BCS. Methods: Fifty-four patients were enrolled and randomized to receive no 5-ALA or oral 5-ALA HCl (15 or 30 mg/kg). Forty-five patients (n = 15/group) were included in the analysis. Fluorescence imaging of the excised surgical specimen was performed, and biopsies were collected from within and outside the clinically demarcated tumor border of the gross specimen for blinded histopathology. Results: In the absence of 5-ALA, tissue autofluorescence imaging lacked tumor-specific fluorescent contrast. Both 5-ALA doses caused bright red tumor fluorescence, with improved visualization of tumor contrasted against normal tissue autofluorescence. In the 15 mg/kg 5-ALA group, the positive predictive value (PPV) for detecting breast cancer inside and outside the grossly demarcated tumor border was 100.0% and 55.6%, respectively. In the 30 mg/kg 5-ALA group, the PPV was 100.0% and 50.0% inside and outside the demarcated tumor border, respectively. No adverse events were observed, and clinical feasibility of this imaging device-5-ALA combination approach was confirmed. Conclusions: This is the first known clinical report of visualization of 5-ALA-induced fluorescence in invasive breast carcinoma using a real-time handheld intraoperative fluorescence imaging device. Trial registration: Clinicaltrials.gov identifier NCT01837225 . Registered 23 April 2013.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Aminolevulinic Acid/therapeutic use ; Biopsy ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Contrast Media/therapeutic use ; Female ; Fluorescence ; Humans ; Intraoperative Care ; Margins of Excision ; Mastectomy, Segmental ; Middle Aged ; Optical Imaging/instrumentation ; Optical Imaging/methods ; Predictive Value of Tests ; Surgery, Computer-Assisted
Chemical Substances	Contrast Media ; Aminolevulinic Acid (88755TAZ87)
Language	English
Publishing date	2021-07-12
Publishing country	England
Document type	Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2015059-3
ISSN	1465-542X ; 1465-5411
ISSN (online)	1465-542X
ISSN	1465-5411
DOI	10.1186/s13058-021-01442-7
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Zs.A 5494: Show issues

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Article ; Online: Antiproliferative effects of 111In- or 177Lu-DOTATOC on cells exposed to low multiplicity-of-infection double-deleted vaccinia virus encoding somatostatin subtype-2 receptor.

Akinlolu, Olayinka / Ottolino-Perry, Kathryn / McCart, Judith Andrea / Reilly, Raymond M

Cancer biotherapy & radiopharmaceuticals

2010 Volume 25, Issue 3, Page(s) 325–333

Abstract: Oncolytic viruses may be limited in their ability to infect and lyse tumor cells because of penetration barriers and viral elimination by the immune system. Combining virotherapy with targeted radiotherapy that uses (111)In- or (177)Lu-DOTATOC may ... ...

Abstract	Oncolytic viruses may be limited in their ability to infect and lyse tumor cells because of penetration barriers and viral elimination by the immune system. Combining virotherapy with targeted radiotherapy that uses (111)In- or (177)Lu-DOTATOC may address such issues by spatially enhancing antitumor effects through bystander and/or cross-fire phenomena. In this study, a double-deleted vaccinia virus (vvDD) encoding the gene for somatostatin subtype-2 receptor (sstr-2) infected MC-38 murine colon adenocarcinoma cells and increased their sstr-2 expression by 2-fold. A low multiplicity-of-infection (MOI = 0.1) of vvDD and short exposure time (48 hours) preserved MC-38 viability (>80%-90%) for up to 3 days, permitting targeting of sstr-2 by (111)In- or (177)Lu-DOTATOC. (111)In-DOTATOC, alone or in combination with vvDD, was less effective than (177)Lu-DOTATOC at decreasing the growth of sstr-2-gene-transfected human embryonic kidney (HEK)-293 cells or MC-38 cells in monolayer. However, (111)In- or (177)Lu-DOTATOC combined with vvDD provided equivalent growth inhibition of HEK-293 or MC-38 cells as spheroids, suggesting a bystander effect from (111)In-DOTATOC. Growth of the cells was reduced 4-fold (from 20% to <5%) at 8 days in this case. Further evaluation of low-MOI vvDD in combination with (111)In- or (177)Lu-DOTATOC for the treatment of MC-38 tumors in mice is planned.
MeSH term(s)	Adenocarcinoma ; Animals ; Cell Line ; Cell Line, Tumor ; Cell Membrane/metabolism ; Cell Nucleus/metabolism ; Cell Proliferation/radiation effects ; Colonic Neoplasms ; Combined Modality Therapy/methods ; Cytoplasm/metabolism ; Gene Deletion ; Humans ; Mice ; Neoplasms/radiotherapy ; Neoplasms/therapy ; Octreotide/analogs & derivatives ; Octreotide/metabolism ; Octreotide/pharmacology ; Oncolytic Virotherapy/methods ; Radiation Dosage ; Radiopharmaceuticals/metabolism ; Radiopharmaceuticals/pharmacology ; Receptors, Somatostatin/genetics ; Receptors, Somatostatin/metabolism ; Transfection ; Vaccinia virus/genetics ; Vaccinia virus/physiology
Chemical Substances	111In-DOTA-TOC ; 177Lu-octreotide, DOTA(0)-Tyr(3)- ; Radiopharmaceuticals ; Receptors, Somatostatin ; somatostatin receptor 2 (D73QL0OMU2) ; Octreotide (RWM8CCW8GP)
Language	English
Publishing date	2010-06-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1315649-4
ISSN	1557-8852 ; 1084-9785
ISSN (online)	1557-8852
ISSN	1084-9785
DOI	10.1089/cbr.2009.0713
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Zs.A 1896: Show issues

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Article ; Online: Intelligent design: combination therapy with oncolytic viruses.

Ottolino-Perry, Kathryn / Diallo, Jean-Simon / Lichty, Brian D / Bell, John C / McCart, J Andrea

Molecular therapy : the journal of the American Society of Gene Therapy

2009 Volume 18, Issue 2, Page(s) 251–263

Abstract: Metastatic cancer remains an incurable disease in the majority of cases and thus novel treatment strategies such as oncolytic virotherapy are rapidly advancing toward clinical use. In order to be successful, it is likely that some type of combination ... ...

Abstract	Metastatic cancer remains an incurable disease in the majority of cases and thus novel treatment strategies such as oncolytic virotherapy are rapidly advancing toward clinical use. In order to be successful, it is likely that some type of combination therapy will be necessary to have a meaningful impact on this disease. Although it may be tempting to simply combine an oncolytic virus with the existing standard radiation or chemotherapeutics, the long-term goal of such treatments must be to have a rational, potentially synergistic combination strategy that can be safely and easily used in the clinical setting. The combination of oncolytic virotherapy with existing radiotherapy and chemotherapy modalities is reviewed along with novel biologic therapies including immunotherapies, in order to help investigators make intelligent decisions during the clinical development of these products.
MeSH term(s)	Combined Modality Therapy/methods ; Humans ; Neoplasms/drug therapy ; Neoplasms/radiotherapy ; Neoplasms/therapy ; Oncolytic Virotherapy/methods
Language	English
Publishing date	2009-12-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2010592-7
ISSN	1525-0024 ; 1525-0016
ISSN (online)	1525-0024
ISSN	1525-0016
DOI	10.1038/mt.2009.283
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Zs.A 5640: Show issues

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Article ; Online: Tumor vascularization is critical for oncolytic vaccinia virus treatment of peritoneal carcinomatosis.

Ottolino-Perry, Kathryn / Tang, Nan / Head, Renee / Ng, Calvin / Arulanandam, Rozanne / Angarita, Fernando A / Acuna, Sergio A / Chen, Yonghong / Bell, John / Dacosta, Ralph S / McCart, J Andrea

International journal of cancer

2014 Volume 134, Issue 3, Page(s) 717–730

Abstract: Peritoneal carcinomatosis (PC) represents a significant clinical challenge for which there are few treatment options. Oncolytic viruses are ideal candidates for PC treatment because of their high tumor specificity, excellent safety profile and ... ...

Abstract	Peritoneal carcinomatosis (PC) represents a significant clinical challenge for which there are few treatment options. Oncolytic viruses are ideal candidates for PC treatment because of their high tumor specificity, excellent safety profile and suitability for peritoneal delivery. Here, we described the use of vvDD-SR-RFP, a recombinant vaccinia virus, in xenograft and syngeneic models of colorectal PC. Colorectal cancer cell lines were highly susceptible to vvDD-SR-RFP replication and cytotoxicity. Intraperitoneal delivery of vvDD-SR-RFP on Day 12 to mice with colorectal carcinomatosis significantly improved survival whereas survival was not improved following virus treatment on Day 8, when tumors were smaller. Immunohistochemistry revealed early tumors had a poorly distributed network of blood vessels and lower proliferation index compared to later tumors. Virus infection was also restricted to tumor rims following Day 8 treatment, whereas it was disseminated in tumors treated on Day 12. Additionally, direct infection of tumor endothelium was observed and virus infection correlated with a loss of endothelial staining and induction of cell death. Our results demonstrate that tumor vasculature has a critical role in virus delivery and tumor response. This will have significant implications in the clinical setting, both in understanding timing of therapies and in designing combination treatment strategies.
MeSH term(s)	Animals ; Carcinoma/blood supply ; Carcinoma/pathology ; Carcinoma/therapy ; Cell Proliferation ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, SCID ; Oncolytic Virotherapy ; Peritoneal Neoplasms/blood supply ; Peritoneal Neoplasms/pathology ; Peritoneal Neoplasms/therapy ; Vaccinia virus/physiology ; Xenograft Model Antitumor Assays
Language	English
Publishing date	2014-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.28395
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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