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  1. Article ; Online: "Closed" Supraglottic Airway-Guided Intubation During the COVID-19 Pandemic: A Glo Germ Follow-up.

    Chua, Henry / Lim, Wan Yen / Mok, May / Wong, Patrick

    Anesthesia and analgesia

    2020  Volume 131, Issue 3, Page(s) e168–e169

    MeSH term(s) Airway Management ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Follow-Up Studies ; Humans ; Laryngeal Masks ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000005032
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  2. Article ; Online: Prospective Evaluation of Prostate and Organs at Risk Segmentation Software for MRI-based Prostate Radiation Therapy.

    Sanders, Jeremiah W / Kudchadker, Rajat J / Tang, Chad / Mok, Henry / Venkatesan, Aradhana M / Thames, Howard D / Frank, Steven J

    Radiology. Artificial intelligence

    2022  Volume 4, Issue 2, Page(s) e210151

    Abstract: The segmentation of the prostate and surrounding organs at risk (OARs) is a necessary workflow step for performing dose-volume histogram analyses of prostate radiation therapy procedures. Low-dose-rate prostate brachytherapy (LDRPBT) is a curative ... ...

    Abstract The segmentation of the prostate and surrounding organs at risk (OARs) is a necessary workflow step for performing dose-volume histogram analyses of prostate radiation therapy procedures. Low-dose-rate prostate brachytherapy (LDRPBT) is a curative prostate radiation therapy treatment that delivers a single fraction of radiation over a period of days. Prior studies have demonstrated the feasibility of fully convolutional networks to segment the prostate and surrounding OARs for LDRPBT dose-volume histogram analyses. However, performance evaluations have been limited to measures of global similarity between algorithm predictions and a reference. To date, the clinical use of automatic segmentation algorithms for LDRPBT has not been evaluated, to the authors' knowledge. The purpose of this work was to assess the performance of fully convolutional networks for prostate and OAR delineation on a prospectively identified cohort of patients who underwent LDRPBT by using clinically relevant metrics. Thirty patients underwent LDRPBT and were imaged with fully balanced steady-state free precession MRI after implantation. Custom automatic segmentation software was used to segment the prostate and four OARs. Dose-volume histogram analyses were performed by using both the original automatically generated contours and the physician-refined contours. Dosimetry parameters of the prostate, external urinary sphincter, and rectum were compared without and with the physician refinements. This study observed that physician refinements to the automatic contours did not significantly affect dosimetry parameters.
    Language English
    Publishing date 2022-01-26
    Publishing country United States
    Document type Journal Article
    ISSN 2638-6100
    ISSN (online) 2638-6100
    DOI 10.1148/ryai.210151
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  3. Article ; Online: Uncertainty in magnetic resonance imaging-based prostate postimplant dosimetry: Results of a 10-person human observer study, and comparisons with automatic postimplant dosimetry.

    Sanders, Jeremiah W / Tang, Chad / Kudchadker, Rajat J / Venkatesan, Aradhana M / Mok, Henry / Hanania, Alexander N / Thames, Howard D / Bruno, Teresa L / Starks, Christine / Santiago, Edwin / Cunningham, Mandy / Frank, Steven J

    Brachytherapy

    2023  Volume 22, Issue 6, Page(s) 822–832

    Abstract: Purpose: Uncertainties in postimplant quality assessment (QA) for low-dose-rate prostate brachytherapy (LDRPBT) are introduced at two steps: seed localization and contouring. We quantified how interobserver variability (IoV) introduced in both steps ... ...

    Abstract Purpose: Uncertainties in postimplant quality assessment (QA) for low-dose-rate prostate brachytherapy (LDRPBT) are introduced at two steps: seed localization and contouring. We quantified how interobserver variability (IoV) introduced in both steps impacts dose-volume-histogram (DVH) parameters for MRI-based LDRPBT, and compared it with automatically derived DVH parameters.
    Methods and materials: Twenty-five patients received MRI-based LDRPBT. Seven clinical observers contoured the prostate and four organs at risk, and 4 dosimetrists performed seed localization, on each MRI. Twenty-eight unique manual postimplant QAs were created for each patient from unique observer pairs. Reference QA and automatic QA were also performed for each patient. IoV of prostate, rectum, and external urinary sphincter (EUS) DVH parameters owing to seed localization and contouring was quantified with coefficients of variation. Automatically derived DVH parameters were compared with those of the reference plans.
    Results: Coefficients of variation (CoVs) owing to contouring variability (CoV
    Conclusions: Seed localization introduces substantially less variability in postimplant QA than does contouring for MRI-based LDRPBT. While automatic seed localization may potentially help improve workflow efficiency, it has limited potential for improving the consistency and quality of postimplant dosimetry.
    MeSH term(s) Male ; Humans ; Prostate/diagnostic imaging ; Prostate/pathology ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/pathology ; Uncertainty ; Brachytherapy/methods ; Radiotherapy Dosage ; Tomography, X-Ray Computed/methods ; Magnetic Resonance Imaging/methods
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2098608-7
    ISSN 1873-1449 ; 1538-4721
    ISSN (online) 1873-1449
    ISSN 1538-4721
    DOI 10.1016/j.brachy.2023.08.001
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  4. Article ; Online: Deep Parasternal Intercostal Plane Block for Intraoperative Pain Control in Cardiac Surgical Patients for Sternotomy: A Prospective Randomized Controlled Trial.

    Wong, Henry M K / Chen, P Y / Tang, Geoffrey C C / Chiu, Sandra L C / Mok, Louis Y H / Au, Sylvia S W / Wong, Randolph H L

    Journal of cardiothoracic and vascular anesthesia

    2023  Volume 38, Issue 3, Page(s) 683–690

    Abstract: Objectives: Sternotomy pain is common after cardiac surgery. The deep parasternal intercostal plane (DPIP) block is a novel technique that provides analgesia to the anterior chest wall. The aim of this study was to investigate the analgesic effect of ... ...

    Abstract Objectives: Sternotomy pain is common after cardiac surgery. The deep parasternal intercostal plane (DPIP) block is a novel technique that provides analgesia to the anterior chest wall. The aim of this study was to investigate the analgesic effect of bilateral DPIP blocks on intraoperative pain control in cardiac surgery.
    Design: This is a double-blinded, prospective randomized controlled trial (Oct 2020-Dec 2022).
    Settings: This study was conducted in a single institution, which is an academic university hospital.
    Participants: Eighty-six elective cardiac surgical patients with median sternotomy were recruited.
    Interventions: Patients were randomly divided into DPIP or control group. Either 20ml 0.25% levobupivacaine or 0.9% normal saline was injected for the DPIP under ultrasound guidance after induction of general anaesthesia.
    Measurements and main results: The primary outcome was intraoperative opioids consumption and hemodynamic changes at sternotomy. Secondary outcomes included postoperative morphine consumption, postoperative pain and time to tracheal extubation. Intraoperative opioids requirement was reduced from a median (IQR) intravenous morphine equivalence of 21.4mg (13.8-24.3mg) in control group to 9.5mg (7.3-11.2mg) in the DPIP group (P<0.001). Hemodynamic parameters were more stable in DPIP group at sternotomy, as evidenced by lower percentage increase in systolic, diastolic and mean arterial blood pressure from baseline. No difference was observed in time to tracheal extubation, postoperative morphine consumption, postoperative pain score and spirometry.
    Conclusions: Bilateral DPIP block provides effective intraoperative analgesia and opioid-sparing. It may be included as part of the multimodal analgesia for enhanced recovery in cardiac surgery.
    MeSH term(s) Humans ; Sternotomy/adverse effects ; Prospective Studies ; Nerve Block/methods ; Cardiac Surgical Procedures/methods ; Pain, Postoperative/diagnosis ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control ; Analgesics, Opioid ; Morphine ; Iopanoic Acid/analogs & derivatives
    Chemical Substances 1,3-dihydroxypropan-2-one 1,3-diiopanoate ; Analgesics, Opioid ; Morphine (76I7G6D29C) ; Iopanoic Acid (FE9794P71J)
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2023.11.038
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    Zs.A 2203: Show issues Location:
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  7. Article ; Online: The diversified defocus profile of the near-work environment and myopia development.

    Choi, Kai Yip / Mok, Angela Yuen-Ting / Do, Chi-Wai / Lee, Paul Hong / Chan, Henry Ho-Lung

    Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

    2020  Volume 40, Issue 4, Page(s) 463–471

    Abstract: Purpose: To quantify the defocus characteristics in the near-work environment at home and investigate the relationship with subsequent myopia progression.: Methods: Fifty subjects (aged 7-12 years) were recruited and followed for 1 year. The home ... ...

    Abstract Purpose: To quantify the defocus characteristics in the near-work environment at home and investigate the relationship with subsequent myopia progression.
    Methods: Fifty subjects (aged 7-12 years) were recruited and followed for 1 year. The home near-work environment (writing desk) was measured at a baseline home-visit using the Kinect-for-Windows to capture a 3-dimensional image. The depth values of the image were then converted into scene defocus with respect to the subject's viewpoint. The defocus characteristics were quantified as the dioptric volume (the total amount of net defocus, or DV) and standard deviation of the defocus values (SD
    Results: The baseline spherical equivalent refraction (M) and refraction change over 1 year (∆M) were - 1.51 ± 2.02 D and - 0.56 ± 0.45 D respectively. DV was not significantly correlated with ∆M (Spearman's ρ = -0.25, p = 0.08), while SD
    Conclusion: The defocus profile in the home environment within the para-central field of view is associated with childhood refractive error development.
    MeSH term(s) Child ; Eyeglasses ; Female ; Humans ; Male ; Myopia, Degenerative/etiology ; Myopia, Degenerative/physiopathology ; Myopia, Degenerative/therapy ; Refraction, Ocular/physiology ; Retrospective Studies ; Vision Tests
    Language English
    Publishing date 2020-06-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604564-9
    ISSN 1475-1313 ; 0275-5408
    ISSN (online) 1475-1313
    ISSN 0275-5408
    DOI 10.1111/opo.12698
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  8. Article ; Online: “Closed” Supraglottic Airway-Guided Intubation During the COVID-19 Pandemic

    Chua, Henry / Lim, Wan Yen / Mok, May / Wong, Patrick

    Anesthesia & Analgesia

    A Glo Germ Follow-up

    2020  Volume 131, Issue 3, Page(s) e168–e169

    Keywords Anesthesiology and Pain Medicine ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ane.0000000000005032
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  9. Article ; Online: Onsite versus offsite radiation treatment of malignant spinal cord compression: lessons from a safety net health system.

    Chen, Albert C / Bonnen, Mark D / Mok, Henry

    The British journal of radiology

    2017  Volume 90, Issue 1072, Page(s) 20160922

    Abstract: Objective: Metastatic spinal cord compression (MSCC) is an oncologic emergency that often warrants emergent treatment; but, it is unclear whether radiation treatment (RT) can be optimally managed from an offsite radiotherapy facility.: Methods: ... ...

    Abstract Objective: Metastatic spinal cord compression (MSCC) is an oncologic emergency that often warrants emergent treatment; but, it is unclear whether radiation treatment (RT) can be optimally managed from an offsite radiotherapy facility.
    Methods: Patient charts from consecutive patients with MSCC who were treated with radiotherapy alone at either an onsite hospital radiation department (from 2008 to 2012) or an offsite radiotherapy centre (2012-2015) were reviewed. Patient clinical parameters were compared across groups with either the χ
    Results: A total of 45 patients were identified, with 19 patients treated onsite in the hospital department and 26 patients treated at the offsite radiotherapy centre with median follow-up of 42 days vs 48.5 days, respectively. The ambulatory rate over time, overall survival and cancer-specific survival were not significantly different between the two eras. Patients treated in-hospital were more likely to start treatment the same day as the consult ("sim and treat") (79% vs 27%, p = 0.006) and were more likely to not complete treatment (26% vs 4%, p = 0.029) as compared with those treated in the offsite centre.
    Conclusion: Patients with MSCC can be feasibly treated at an offsite radiotherapy centre with outcomes similar to those treated in-hospital. Advances in knowledge: This is the first study in literature to compare outcomes between onsite and offsite RT of MSCC.
    MeSH term(s) Ambulatory Care/methods ; Ambulatory Care Facilities/statistics & numerical data ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Radiology Department, Hospital/statistics & numerical data ; Spinal Cord Compression/radiotherapy ; Spinal Neoplasms/radiotherapy ; Survival Analysis ; Treatment Outcome
    Language English
    Publishing date 2017-04
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20160922
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  10. Article: Baveno VII Criteria Is an Accurate Risk Stratification Tool to Predict High-Risk Varices Requiring Intervention and Hepatic Events in Patients with Advanced Hepatocellular Carcinoma.

    Wu, Claudia Wing-Kwan / Lui, Rashid Nok-Shun / Wong, Vincent Wai-Sun / Yam, Tsz-Fai / Yip, Terry Cheuk-Fung / Liu, Ken / Lai, Jimmy Che-To / Tse, Yee-Kit / Mok, Tony Shu-Kam / Chan, Henry Lik-Yuen / Ng, Kelvin Kwok-Chai / Wong, Grace Lai-Hung / Chan, Stephen Lam

    Cancers

    2023  Volume 15, Issue 9

    Abstract: The Baveno VII criteria are used in patients with liver cirrhosis to predict high-risk varices in patients with liver cirrhosis. Yet its use in patients with advanced hepatocellular carcinoma (HCC) has not been validated. HCC alone is accompanied with a ... ...

    Abstract The Baveno VII criteria are used in patients with liver cirrhosis to predict high-risk varices in patients with liver cirrhosis. Yet its use in patients with advanced hepatocellular carcinoma (HCC) has not been validated. HCC alone is accompanied with a higher variceal bleeding risk due to its association with liver cirrhosis and portal vein thrombosis. The use of systemic therapy in advanced HCC has been thought to further augment this risk. Upper endoscopy is commonly used to evaluate for the presence of varices before initiation of treatment with systemic therapy. Yet it is associated with procedural risks, waiting time and limited availability in some localities which may delay the commencement of systemic therapy. Our study successfully validated the Baveno VI criteria with a 3.5% varices needing treatment (VNT) missed rate, also with acceptable <5% VNT missed rates when considering alternative liver stiffness (LSM) and platelet cut-offs. The Baveno VII clinically significant portal hypertension rule-out criteria (LSM < 15 kPa and platelet >150 × 10
    Language English
    Publishing date 2023-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15092480
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