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  1. Article: Electrochemical C-H oxygenation and alcohol dehydrogenation involving Fe-oxo species using water as the oxygen source.

    Das, Amit / Nutting, Jordan E / Stahl, Shannon S

    Chemical science

    2019  Volume 10, Issue 32, Page(s) 7542–7548

    Abstract: High-valent iron-oxo complexes are key intermediates in C-H functionalization reactions. Herein ...

    Abstract High-valent iron-oxo complexes are key intermediates in C-H functionalization reactions. Herein, we report the generation of a (TAML)Fe-oxo species (TAML = tetraamido macrocyclic ligand)
    Language English
    Publishing date 2019-06-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/c9sc02609f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The experiences of parents of children diagnosed with cerebral adrenoleukodystrophy.

    Piercy, Hilary / Nutting, Charlotte

    Child: care, health and development

    2023  Volume 50, Issue 1, Page(s) e13184

    Abstract: Background: Adrenoleukodystrophy (ALD) is a rare X-linked neurodegenerative disease, affecting the brain, spinal cord and adrenal cortex. Childhood cerebral ALD (CCALD) is the most severe form of disease, involving rapidly progressive neurological ... ...

    Abstract Background: Adrenoleukodystrophy (ALD) is a rare X-linked neurodegenerative disease, affecting the brain, spinal cord and adrenal cortex. Childhood cerebral ALD (CCALD) is the most severe form of disease, involving rapidly progressive neurological deterioration. The treatment option for CCALD is allogenic haemopoietic stem cell transplant, which is only successful for early-stage disease. Parents' experiences of CCALD can inform healthcare delivery.
    Study aim: To detail the experiences of parents of children diagnosed with cerebral ALD.
    Methods: A descriptive qualitative study. Parents were recruited via a UK-based community support organisation. Data collection involved single semi-structured interviews structured around a topic guide and conducted remotely. Data were analysed using the thematic analysis approach.
    Findings: Twelve parents from 11 families with a total of 16 children with ALD contributed to the study. Their 16 children with ALD followed one of three disease pathways, determined by the extent of neurological damage at diagnosis. Three themes, and their respective sub themes, describe the pathways and what they meant for parents. 'No possibility of treatment' concerns situations when CCALD was diagnosed at an advanced stage, the landslide of deterioration parents witnessed and their efforts to maintain normality. 'Close to the treatment threshold' describes situations where a small treatment window required parents to make agonising treatment decisions. 'Watching and waiting' explains the challenges for parents when disease was detected early enabling children to benefit from timely treatment.
    Discussion: Parents' experiences were largely defined by the extent of cerebral damage at diagnosis, which determined the availability and success of treatment. There were specific challenges related to the three situations, indicating areas where support from health and care services may help parents deal with this devastating diagnosis.
    Conclusion: This study indicates support needs of parents across the spectrum of CCALD diagnoses and highlights the critical importance of early diagnosis.
    MeSH term(s) Child ; Humans ; Adrenoleukodystrophy/diagnosis ; Adrenoleukodystrophy/metabolism ; Adrenoleukodystrophy/therapy ; Neurodegenerative Diseases ; Parents ; Brain Injuries
    Language English
    Publishing date 2023-10-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 223039-2
    ISSN 1365-2214 ; 0305-1862
    ISSN (online) 1365-2214
    ISSN 0305-1862
    DOI 10.1111/cch.13184
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  3. Article ; Online: Radiotherapy in head and neck cancer management: United Kingdom National Multidisciplinary Guidelines.

    Nutting, C

    The Journal of laryngology and otology

    2016  Volume 130, Issue S2, Page(s) S66–S67

    Abstract: This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. Radiotherapy is one of the key treatment modalities used in head and neck cancer management. This paper summarises the ... ...

    Abstract This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. Radiotherapy is one of the key treatment modalities used in head and neck cancer management. This paper summarises the current role and some of the recent advances in radiotherapy in head and neck cancer management.
    MeSH term(s) Head and Neck Neoplasms/radiotherapy ; Humans ; Interdisciplinary Communication ; Radiation Dosage ; United Kingdom
    Language English
    Publishing date 2016-05
    Publishing country England
    Document type Journal Article ; Practice Guideline
    ZDB-ID 218299-3
    ISSN 1748-5460 ; 0022-2151
    ISSN (online) 1748-5460
    ISSN 0022-2151
    DOI 10.1017/S0022215116000463
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  4. Article ; Online: The clozapine conundrum: Navigating neutropenia and the pursuit of effective care in treatment-resistant schizophrenia.

    Kar, Anindya / Nutting, Thomas / Ikram, Mohammad / Sullivan, Charles

    International journal of psychiatry in medicine

    2023  , Page(s) 912174231214647

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 220669-9
    ISSN 1541-3527 ; 0091-2174
    ISSN (online) 1541-3527
    ISSN 0091-2174
    DOI 10.1177/00912174231214647
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  5. Article ; Online: Developing a National Infrastructure for Proton Beam Therapy Trials.

    Rieu, R / Crellin, A / Thomson, D / Nutting, C

    Clinical oncology (Royal College of Radiologists (Great Britain))

    2022  Volume 35, Issue 5, Page(s) 279–282

    MeSH term(s) Humans ; Proton Therapy ; Clinical Trials as Topic/standards
    Language English
    Publishing date 2022-12-21
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1036844-9
    ISSN 1433-2981 ; 0936-6555
    ISSN (online) 1433-2981
    ISSN 0936-6555
    DOI 10.1016/j.clon.2022.11.017
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  6. Article: Catatonia and melancholia interface: exploring a new paradigm for evaluation and treatment. A case series and literature review.

    Mahgoub, Yassir / Pathare, Aum / Hamlin, Dallas / Gomaa, Hassaan / Nutting, Sean / Mormando, Charles / Francis, Andrew

    Frontiers in psychiatry

    2024  Volume 15, Page(s) 1372136

    Abstract: Background: Catatonia has been increasingly associated with mood disorders and is recognized as a specifier in the DSM-5 and DSM-5-TR. The DSM-5-TR recognizes melancholia as a specifier for depressive episodes in major depressive disorder and bipolar ... ...

    Abstract Background: Catatonia has been increasingly associated with mood disorders and is recognized as a specifier in the DSM-5 and DSM-5-TR. The DSM-5-TR recognizes melancholia as a specifier for depressive episodes in major depressive disorder and bipolar disorder. It is characterized by severe anhedonia, lack of reactivity, excessive or delusional guilt, and significant vegetative symptoms. As the conceptualization of melancholia expanded beyond its mood components to include psychomotor disturbances, its overlap with psychomotor symptoms or catatonia becomes evident. This overlap was also described in Kahlbaum's original literature, where he describes the transition between states of melancholia, mania, and catatonia.
    Method: Case summary of six patients with major depressive disorder or depressed phase of bipolar disorder who were admitted for severe depression, anhedonia, intense anxiety, psychomotor agitation or retardation, indecisiveness, perseveration, and vegetative symptoms such as poor sleep, appetite, and significant weight loss.
    Results: All patients demonstrated rapid and complete resolution of their mood and psychomotor symptoms, indecisiveness, perseveration, as well as psychosis shortly after administration of lorazepam, with recurrence of the above symptoms upon lorazepam discontinuation and resolution upon resumption, in an on-and-off manner.
    Conclusion: The present study argues for a closer relationship between melancholia and catatonia based on our case series, historical review, overlap in phenomenology, and response to treatment. We propose provisional [Mahgoub] criteria for patients with severe depression and melancholia. The role of GABA agonists, such as lorazepam, can be explored as an option for patients with treatment-resistant depression who meet these criteria for melancholia.
    Limitations: Absence of a standardized, systematic assessment tool and a small sample size.
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2024.1372136
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  7. Article ; Online: Nutrition impact symptoms in head and neck cancer during radiotherapy: a longitudinal study.

    Li, Minmin / Nutting, Chris / Zhang, Tao / Gou, Qitao / Liu, Ting

    Acta oto-laryngologica

    2023  Volume 143, Issue 6, Page(s) 499–506

    Abstract: Background: Patients with head and neck cancer (HNC) receiving radiotherapy (RT) are at a high risk of weight loss (WL) due to a variety of nutrition impact symptoms (NISs).: Objective: This prospective observational study aimed to investigate the ... ...

    Abstract Background: Patients with head and neck cancer (HNC) receiving radiotherapy (RT) are at a high risk of weight loss (WL) due to a variety of nutrition impact symptoms (NISs).
    Objective: This prospective observational study aimed to investigate the consecutive changes of NIS during RT and analyzed its impact on body weight.
    Materials and methods: The Head and Neck patient Symptom Checklist was adopted to evaluate NIS. NIS, body weight, hemoglobin and lymphocyte of 94 participants were assessed at four time points during RT and the treatment outcomes were assessed at the time of 12 months after the completion of RT. Generalised estimation equations (GEEs) and Kendall's tau-
    Results: Our study found that pain, taste changes and dry mouth were the most common NIS, reported by >90% of patients and had higher interference scores (more than 85% >2) at the end of RT. The average WL was 4.22 ± 3.59 kg after treatment, and more than two-thirds of patients (67.02%, 64/94) experienced significant WL of >5%. Lack of energy, vomiting and taste changes impacted WL significantly (
    Conclusions and significance: In patients with HNC, taste changes, pain, dry mouth and vomiting were seen. Nutritional intervention applied as early as the first 10 days of RT could help to change the nutrition status and improve the clinical outcomes.
    MeSH term(s) Humans ; Nutritional Status ; Longitudinal Studies ; Body Weight ; Head and Neck Neoplasms/radiotherapy ; Weight Loss ; Xerostomia
    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Observational Study ; Journal Article
    ISSN 1651-2251
    ISSN (online) 1651-2251
    DOI 10.1080/00016489.2023.2217844
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  8. Article ; Online: Recent advances in the oncological management of head and neck cancer and implications for oral toxicity.

    O Leary, Ben / Young, Adam / Nutting, Christopher

    British dental journal

    2022  Volume 233, Issue 9, Page(s) 737–743

    Abstract: Radiotherapy is a key treatment modality for cancers of the head and neck, being used for curative intent either alone or in combination with surgery and chemotherapy. The treatment-related toxicities of these treatments can be significant in both the ... ...

    Abstract Radiotherapy is a key treatment modality for cancers of the head and neck, being used for curative intent either alone or in combination with surgery and chemotherapy. The treatment-related toxicities of these treatments can be significant in both the short and longer term. Many of these toxicities manifest orally, even in patients whose primary malignancy was outside the oral cavity, as radiotherapy often involves elective treatment of high-risk areas, such as locally draining lymph nodes in the neck. Reducing the burden of treatment is an area of intense focus in head and neck oncology. New technology and imaging techniques, such as proton therapy and magnetic resonance imaging, are being integrated into radiotherapy treatment to minimise radiation dose outside of the target areas. In parallel, tumour biology is being explored as a means of identifying patients who might be suitable for de-escalated therapy. This review will cover the latest advances in the oncology treatment available for patients with head and neck cancers, with a focus on how these might help reduce oral toxicity.
    MeSH term(s) Humans ; Head and Neck Neoplasms/therapy ; Neck
    Language English
    Publishing date 2022-11-11
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-022-5195-5
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  9. Article ; Online: Dysphagia-optimised intensity-modulated radiotherapy versus standard radiotherapy in patients with pharyngeal cancer - Authors' reply.

    Nutting, Christopher / Finneran, Laura / Roe, Justin / Petkar, Imran / Rooney, Keith / Hall, Emma

    The Lancet. Oncology

    2023  Volume 24, Issue 10, Page(s) e398

    MeSH term(s) Humans ; Radiotherapy, Intensity-Modulated/adverse effects ; Deglutition Disorders/etiology ; Pharyngeal Neoplasms/radiotherapy ; Carcinoma, Squamous Cell/radiotherapy ; Radiation Oncology ; Radiotherapy Dosage ; Head and Neck Neoplasms
    Language English
    Publishing date 2023-10-05
    Publishing country England
    Document type Letter
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(23)00457-6
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  10. Article ; Online: "It's Just Always Eating": The Experiences of Young People Growing up Medium Chain Acyl-coA Dehydrogenase Deficiency.

    Piercy, Hilary / Nutting, Charlotte / Yap, Sufin

    Global qualitative nursing research

    2021  Volume 8, Page(s) 23333936211032203

    Abstract: Medium chain acyl-CoA dehydrogenase deficiency (MCADD) is a rare metabolic disorder, and commonly now part of newborn screening programs. Those diagnosed at birth are now progressing from childhood to adulthood. The study aim was to explore young people' ... ...

    Abstract Medium chain acyl-CoA dehydrogenase deficiency (MCADD) is a rare metabolic disorder, and commonly now part of newborn screening programs. Those diagnosed at birth are now progressing from childhood to adulthood. The study aim was to explore young people's experiences of living with MCADD and managing their condition. A descriptive qualitative study design involving semi-structured interviews with 12 participants aged 10 to 15 years, recruited from one regional pediatric metabolic disorder service in England. Data were analyzed using thematic analysis. The two major themes were "Eating for energy" and "Growing into a self-management role." Self-monitoring and self-management skills had been nurtured from early childhood by parents and healthcare providers. Young people's anxieties concerned having to maintain adequate energy input to stay safe and the associated burden of responsibility. Growing up with MCADD presents specific challenges. Self-management and ongoing support are important for dealing with those challenges.
    Language English
    Publishing date 2021-08-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2777573-2
    ISSN 2333-3936 ; 2333-3936
    ISSN (online) 2333-3936
    ISSN 2333-3936
    DOI 10.1177/23333936211032203
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