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  1. Article ; Online: Rapid syndromic multiplex PCR panels for the management of ventilator-associated lower respiratory tract infections: pondering important limitations. Author's reply.

    Kreitmann, Louis / Nseir, Saad

    Intensive care medicine

    2024  Volume 50, Issue 5, Page(s) 787–788

    MeSH term(s) Humans ; Multiplex Polymerase Chain Reaction/methods ; Pneumonia, Ventilator-Associated/diagnosis ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/therapy
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Letter
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-024-07402-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1089: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Ventilator associated tracheobronchitis and pneumonia: one infection with two faces.

    Martin-Loeches, Ignacio / Povoa, Pedro / Nseir, Saad

    Intensive care medicine

    2023  Volume 49, Issue 8, Page(s) 996–999

    MeSH term(s) Humans ; Bronchitis/complications ; Pneumonia ; Ventilators, Mechanical
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07086-9
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    Zs.A 1089: Show issues Location:
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  3. Article ; Online: Severe community-acquired pneumonia: in search of the guiding star.

    Póvoa, Pedro / Nseir, Saad / Salluh, Jorge

    Intensive care medicine

    2023  Volume 49, Issue 6, Page(s) 656–658

    MeSH term(s) Humans ; Pneumonia/drug therapy ; Community-Acquired Infections/drug therapy ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07063-2
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    Zs.A 1089: Show issues Location:
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  4. Article ; Online: Antifungal stewardship in critically ill patients.

    De Pascale, Gennaro / Martin-Loeches, Ignacio / Nseir, Saad

    Intensive care medicine

    2023  Volume 49, Issue 6, Page(s) 681–684

    MeSH term(s) Humans ; Antifungal Agents/therapeutic use ; Critical Illness/therapy ; Fluconazole ; Immunocompromised Host
    Chemical Substances Antifungal Agents ; Fluconazole (8VZV102JFY)
    Language English
    Publishing date 2023-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07034-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1089: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Dichotomy between ventilator associated-pneumonia/tracheobronchitis: did you ask the lung its opinion? Author's reply.

    Martin-Loeches, Ignacio / Povoa, Pedro / Nseir, Saad

    Intensive care medicine

    2023  Volume 49, Issue 8, Page(s) 1034–1035

    MeSH term(s) Humans ; Bronchitis ; Pneumonia, Ventilator-Associated/diagnosis ; Thorax ; Lung ; Ventilators, Mechanical
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07118-4
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    Zs.A 1089: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Relationship of multidrug-resistant bacterial colonization and immune status of patients in the ICU. Author's reply.

    Kreitmann, Louis / Vasseur, Margot / Labreuche, Julien / Nseir, Saad

    Intensive care medicine

    2023  Volume 49, Issue 4, Page(s) 481–482

    MeSH term(s) Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Multiple, Bacterial ; Intensive Care Units ; Cross Infection/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07016-9
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    Zs.A 1089: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Hospital-Acquired Pneumonia/Ventilator-Associated Pneumonia and Ventilator-Associated Tracheobronchitis in COVID-19.

    Rouzé, Anahita / Nseir, Saad

    Seminars in respiratory and critical care medicine

    2022  Volume 43, Issue 2, Page(s) 243–247

    Abstract: Although few studies evaluated the incidence of hospital-acquired pneumonia (HAP) or ventilator-associated tracheobronchitis in COVID-19 patients, several studies evaluated the incidence of ventilator-associated pneumonia (VAP) in these patients. Based ... ...

    Abstract Although few studies evaluated the incidence of hospital-acquired pneumonia (HAP) or ventilator-associated tracheobronchitis in COVID-19 patients, several studies evaluated the incidence of ventilator-associated pneumonia (VAP) in these patients. Based on the results of a large multicenter European study, VAP incidence is higher in patients with SARS-CoV-2 pneumonia (36.1%), as compared with those with influenza pneumonia (22.2%), or no viral infection at intensive care unit (ICU) admission (16.5%). Potential explanation for the high incidence of VAP in COVID-19 patients includes long duration of invasive mechanical ventilation, high incidence of acute respiratory distress syndrome, and immune-suppressive treatment. Specific risk factors for VAP, including SARS-CoV-2-related pulmonary lesions, and bacteria-virus interaction in lung microbiota might also play a role in VAP pathogenesis. VAP is associated with increased mortality, duration of mechanical ventilation, and ICU length of stay in COVID-19 patients. Further studies should focus on the incidence of HAP especially in ICU non-ventilated patients, better determine the pathophysiology of these infections, and evaluate the accuracy of currently available treatment guidelines in COVID-19 patients.
    MeSH term(s) Bronchitis/epidemiology ; Bronchitis/etiology ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/therapy ; Hospitals ; Humans ; Intensive Care Units ; Pneumonia, Ventilator-Associated/epidemiology ; Respiration, Artificial/adverse effects ; SARS-CoV-2 ; Tracheitis/epidemiology ; Tracheitis/etiology ; Ventilators, Mechanical
    Language English
    Publishing date 2022-01-18
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0041-1740334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1555: Show issues Location:
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  8. Article ; Online: Continuous Control of Tracheal Cuff Pressure and Ventilator-Associated Pneumonia: Beyond Agate and Feng Shui.

    Nseir, Saad / Gaudet, Alexandre

    Chest

    2021  Volume 160, Issue 2, Page(s) 393–395

    MeSH term(s) Humans ; Intubation, Intratracheal ; Pneumonia, Ventilator-Associated/epidemiology ; Pneumonia, Ventilator-Associated/prevention & control ; Trachea
    Language English
    Publishing date 2021-08-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.04.005
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    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  9. Article: ICU-Acquired Colonization and Infection Related to Multidrug-Resistant Bacteria in COVID-19 Patients: A Narrative Review.

    Gaudet, Alexandre / Kreitmann, Louis / Nseir, Saad

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 9

    Abstract: A large proportion of ICU-acquired infections are related to multidrug-resistant bacteria (MDR). Infections caused by these bacteria are associated with increased mortality, and prolonged duration of mechanical ventilation and ICU stay. The aim of this ... ...

    Abstract A large proportion of ICU-acquired infections are related to multidrug-resistant bacteria (MDR). Infections caused by these bacteria are associated with increased mortality, and prolonged duration of mechanical ventilation and ICU stay. The aim of this narrative review is to report on the association between COVID-19 and ICU-acquired colonization or infection related to MDR bacteria. Although a huge amount of literature is available on COVID-19 and MDR bacteria, only a few clinical trials have properly evaluated the association between them using a non-COVID-19 control group and accurate design and statistical methods. The results of these studies suggest that COVID-19 patients are at a similar risk of ICU-acquired MDR colonization compared to non-COVID-19 controls. However, a higher risk of ICU-acquired infection related to MDR bacteria has been reported in several studies, mainly ventilator-associated pneumonia and bloodstream infection. Several potential explanations could be provided for the high incidence of ICU-acquired infections related to MDR. Immunomodulatory treatments, such as corticosteroids, JAK2 inhibitors, and IL-6 receptor antagonist, might play a role in the pathogenesis of these infections. Additionally, a longer stay in the ICU was reported in COVID-19 patients, resulting in higher exposure to well-known risk factors for ICU-acquired MDR infections, such as invasive procedures and antimicrobial treatment. Another possible explanation is the surge during successive COVID-19 waves, with excessive workload and low compliance with preventive measures. Further studies should evaluate the evolution of the incidence of ICU-acquired infections related to MDR bacteria, given the change in COVID-19 patient profiles. A better understanding of the immune status of critically ill COVID-19 patients is required to move to personalized treatment and reduce the risk of ICU-acquired infections. The role of specific preventive measures, such as targeted immunomodulation, should be investigated.
    Language English
    Publishing date 2023-09-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12091464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Ventilator-Associated Pneumonia in Immunosuppressed Patients.

    Kreitmann, Louis / Gaudet, Alexandre / Nseir, Saad

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: Immunocompromised patients-including patients with cancer, hematological malignancies, solid organ transplants and individuals receiving immunosuppressive therapies for autoimmune diseases-account for an increasing proportion of critically-ill patients. ... ...

    Abstract Immunocompromised patients-including patients with cancer, hematological malignancies, solid organ transplants and individuals receiving immunosuppressive therapies for autoimmune diseases-account for an increasing proportion of critically-ill patients. While their prognosis has improved markedly in the last decades, they remain at increased risk of healthcare- and intensive care unit (ICU)-acquired infections. The most frequent of these are ventilator-associated lower respiratory tract infections (VA-LTRI), which include ventilator-associated pneumonia (VAP) and tracheobronchitis (VAT). Recent studies have shed light on some of the specific features of VAP and VAT in immunocompromised patients, which is the subject of this narrative review. Contrary to previous belief, the incidence of VAP and VAT might actually be lower in immunocompromised than non-immunocompromised patients. Further, the relationship between immunosuppression and the incidence of VAP and VAT related to multidrug-resistant (MDR) bacteria has also been challenged recently. Etiological diagnosis is essential to select the most appropriate treatment, and the role of invasive sampling, specifically bronchoscopy with bronchoalveolar lavage, as well as new molecular syndromic diagnostic tools will be discussed. While bacteria-especially gram negative bacteria-are the most commonly isolated pathogens in VAP and VAT, several opportunistic pathogens are a special concern among immunocompromised patients, and must be included in the diagnostic workup. Finally, the impact of immunosuppression on VAP and VAT outcomes will be examined in view of recent papers using improved statistical methodologies and treatment options-more specifically empirical antibiotic regimens-will be discussed in light of recent findings on the epidemiology of MDR bacteria in this population.
    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12020413
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