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  1. Article ; Online: Editorial Comment.

    Miest, Tanner S / Matin, Surena F

    The Journal of urology

    2021  Volume 206, Issue 3, Page(s) 576

    Language English
    Publishing date 2021-06-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000001786.02
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  2. Article ; Online: Genomic Predictors of Good Outcome, Recurrence, or Progression in High-Grade T1 Non-Muscle-Invasive Bladder Cancer.

    Mitra, Anirban P / Miest, Tanner / Dinney, Colin P N

    European urology

    2020  Volume 79, Issue 3, Page(s) 428–429

    MeSH term(s) Disease-Free Survival ; Genomics ; Humans ; Kaplan-Meier Estimate ; Neoplasm Recurrence, Local/genetics ; Urinary Bladder Neoplasms/genetics
    Language English
    Publishing date 2020-11-04
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2020.10.020
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  3. Article ; Online: The Impact of Upper Tract Urothelial Carcinoma Diagnostic Modality on Intravesical Recurrence after Radical Nephroureterectomy: A Single Institution Series and Updated Meta-analysis. Reply.

    Sharma, Vidit / Miest, Tanner S / Chamie, Karim / Matin, Surena F / Boorjian, Stephen A / Potretzke, Aaron M

    The Journal of urology

    2021  Volume 206, Issue 4, Page(s) 1072

    MeSH term(s) Carcinoma, Transitional Cell/diagnosis ; Carcinoma, Transitional Cell/surgery ; Humans ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/epidemiology ; Nephroureterectomy ; Ureteral Neoplasms/diagnosis ; Ureteral Neoplasms/surgery ; Urinary Bladder Neoplasms/surgery
    Language English
    Publishing date 2021-07-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000001929
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  4. Article: Incidence and predictors of occult preoperative deep vein thrombosis at radical cystectomy for urothelial carcinoma.

    Miest, Tanner S / Sharma, Vidit / Karnes, R Jeffrey / Boorjian, Stephen A / Thompson, R Houston / Frank, Igor / Tollefson, Matthew K

    Canadian Urological Association journal = Journal de l'Association des urologues du Canada

    2021  Volume 15, Issue 9, Page(s) E471–E475

    Abstract: Introduction: Patients undergoing radical cystectomy are at high perioperative risk for deep vein thrombosis due to age, malignancy, recent transurethral resection, and neoadjuvant chemotherapy. We, therefore, evaluated the incidence and predictors of ... ...

    Abstract Introduction: Patients undergoing radical cystectomy are at high perioperative risk for deep vein thrombosis due to age, malignancy, recent transurethral resection, and neoadjuvant chemotherapy. We, therefore, evaluated the incidence and predictors of occult preoperative deep vein thrombosis prior to radical cystectomy for urothelial carcinoma.
    Methods: We prospectively screened 52 asymptomatic patients with urothelial carcinoma undergoing radical cystectomy at our institution with lower extremity ultrasound and D-dimer assay within two weeks prior to surgery. Patients with a prior history of deep vein thrombosis and those on systemic anticoagulation were excluded.
    Results: We identified 4/52 patients (7.7%) with preoperative asymptomatic deep vein thrombosis prior to radical cystectomy. Median D-dimer for patients with and without preoperative deep vein thrombosis was 787 ng/ml (interquartile range [IQR] 365-1257) and 260 ng/ml (IQR 158-498), respectively. A D-dimer threshold of >250 ng/ml had a sensitivity of 100% and specificity of 50%, resulting in a negative predictive value of 100% and positive predictive value of 14.8% for preoperative deep vein thrombosis. Increasing the D-dimer threshold to >1000 ng/ml created a sensitivity of 50% and specificity of 85%, resulting in a negative predictive value of 92% and positive predictive value of 33%. D-dimer values did not significantly vary with neoadjuvant chemotherapy or days since transurethral resection.
    Conclusions: Approximately 8% of patients had an occult deep vein thrombosis prior to radical cystectomy. D-dimer can provide sensitive diagnostic utility for deep vein thrombosis in the pre-radical cystectomy setting and could help guide use of preoperative lower extremity ultrasound in this high-risk patient population.
    Language English
    Publishing date 2021-02-16
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2431403-1
    ISSN 1911-6470
    ISSN 1911-6470
    DOI 10.5489/cuaj.6852
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  5. Article ; Online: New viruses for cancer therapy: meeting clinical needs.

    Miest, Tanner S / Cattaneo, Roberto

    Nature reviews. Microbiology

    2013  Volume 12, Issue 1, Page(s) 23–34

    Abstract: Early-stage clinical trials of oncolytic virotherapy have reported the safety of several virus platforms, and viruses from three families have progressed to advanced efficacy trials. In addition, preclinical studies have established proof-of-principle ... ...

    Abstract Early-stage clinical trials of oncolytic virotherapy have reported the safety of several virus platforms, and viruses from three families have progressed to advanced efficacy trials. In addition, preclinical studies have established proof-of-principle for many new genetic engineering strategies. Thus, the virotherapy field now has available a diverse collection of viruses that are equipped to address unmet clinical needs owing to improved systemic administration, greater tumour specificity and enhanced oncolytic efficacy. The current key challenge for the field is to develop viruses that replicate with greater efficiency within tumours while achieving therapeutic synergy with currently available treatments.
    MeSH term(s) Animals ; Disease Models, Animal ; Genetic Engineering ; Humans ; Neoplasms/therapy ; Oncolytic Virotherapy/methods ; Viruses/classification ; Viruses/genetics
    Language English
    Publishing date 2013-12-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2139054-X
    ISSN 1740-1534 ; 1740-1526
    ISSN (online) 1740-1534
    ISSN 1740-1526
    DOI 10.1038/nrmicro3140
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  6. Article ; Online: Reply by Authors.

    Sharma, Vidit / Miest, Tanner S / Juvet, Tristan S / Toussi, Amir / Packiam, Vignesh / Chamie, Karim / Matin, Surena F / Boorjian, Stephen A / Thompson, R Houston / Frank, Igor / Tollefson, Matthew K / Potretzke, Aaron M

    The Journal of urology

    2021  Volume 206, Issue 3, Page(s) 567

    Language English
    Publishing date 2021-06-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000001834.02
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  7. Article ; Online: Reply by Authors.

    Hensley, Patrick J / Bree, Kelly K / Campbell, Matthew T / Alhalabi, Omar / Kokorovic, Andrea / Miest, Tanner / Nogueras-Gonzalez, Graciela M / Gao, Jianjun / Siefker-Radtke, Arlene O / Guo, Charles C / Navai, Neema / Dinney, Colin P / Kamat, Ashish M

    The Journal of urology

    2021  Volume 206, Issue 5, Page(s) 1267

    Language English
    Publishing date 2021-08-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000001943.02
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  8. Article ; Online: Pediatric Robotic Prostatectomy and Pelvic Lymphadenectomy for Embryonal Rhabdomyosarcoma.

    Agarwal, Deepak K / Miest, Tanner S / Granberg, Candace F / Frank, Igor / Gargollo, Patricio C

    Urology

    2018  Volume 119, Page(s) 143–145

    Abstract: We present the first published case of a pediatric robot-assisted prostatectomy and pelvic lymphadenectomy for refractory prostatic embryonal rhabdomyosarcoma. The patient is a 7-year-old male who had been treated with 3 cycles of chemotherapy and ... ...

    Abstract We present the first published case of a pediatric robot-assisted prostatectomy and pelvic lymphadenectomy for refractory prostatic embryonal rhabdomyosarcoma. The patient is a 7-year-old male who had been treated with 3 cycles of chemotherapy and radiation, who underwent prostatectomy and lymphadenectomy for a recurrent mass. Surgery was uncomplicated and yielded negative surgical margins. We highlight the surgical technique and feasibility of utilizing robotic surgery for pediatric prostatectomy.
    MeSH term(s) Child ; Humans ; Lymph Node Excision/methods ; Male ; Pelvis ; Prostatectomy/methods ; Prostatic Neoplasms/surgery ; Rhabdomyosarcoma, Embryonal/surgery ; Robotic Surgical Procedures
    Language English
    Publishing date 2018-04-24
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2018.03.027
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  9. Article ; Online: Does Ureteral Stent Drainage Prior to Cystectomy Increase the Risk of Subsequent Upper Tract Urothelial Carcinoma and Ureteral Complications?

    Miest, Tanner S / Sharma, Vidit / Boeri, Luca / Tollefson, Matthew K / Thompson, R Houston / Boorjian, Stephen A / Frank, Igor / Karnes, R Jeffrey

    Urology

    2020  Volume 153, Page(s) 215–220

    Abstract: Objective: To guide management of preoperative hydronephrosis prior to radical cystectomy (RC), we compared post-RC risks of upper tract urothelial carcinoma (UTUC) and ureteroenteric anastomotic complications between ureteral stent and percutaneous ... ...

    Abstract Objective: To guide management of preoperative hydronephrosis prior to radical cystectomy (RC), we compared post-RC risks of upper tract urothelial carcinoma (UTUC) and ureteroenteric anastomotic complications between ureteral stent and percutaneous nephrostomy tube drainage.
    Methods: Patients who underwent RC for urothelial carcinoma without a prior diagnosis of UTUC at our institution between 2000 and 2015 were included and divided into 4 patient groups: (1) no hydronephrosis (75%, N = 787); (2) hydronephrosis without preoperative upper tract drainage (13%, N = 132); (3) hydronephrosis treated with nephrostomy tube (3%, N = 36); (4) hydronephrosis treated with ureteral stent (9%, N = 94). The incidence of post-RC UTUC and ureteral complications was compared using Kaplan-Meier analyses and multivariable Cox proportional hazard modeling.
    Results: We identified a total of 1049 patients who underwent RC (median postoperative follow-up 4.3 years). Five-year post-RC UTUC incidence was 6.6%, 10.2%, 17%, 18.7% for groups 1-4, respectively (P= .13). On multivariable analysis, nephrostomy tube drainage (hazard ratio [HR] 4.10, P = .02) and preoperative ureteral stenting (HR 2.35, P = .04) were both associated with UTUC after RC, but ureteral stenting did not have a significantly higher association with UTUC than nephrostomy tube drainage. Severe hydronephrosis was also associated with development of UTUC (HR 4.03, P = .02). The incidence of ureteroenteric anastomotic complications did not vary by drainage modality.
    Conclusion: Preoperative hydronephrosis was associated with UTUC after RC, but ureteral stent placement did not increase the risk of UTUC or ureteral complications relative to nephrostomy tube placement. The choice of hydronephrosis drainage pre-RC should not be guided by concern for UTUC risk.
    MeSH term(s) Aged ; Anastomosis, Surgical ; Carcinoma, Transitional Cell/complications ; Carcinoma, Transitional Cell/surgery ; Cystectomy ; Drainage/instrumentation ; Female ; Humans ; Hydronephrosis/etiology ; Hydronephrosis/surgery ; Incidence ; Kidney Neoplasms/complications ; Kidney Neoplasms/surgery ; Male ; Nephrostomy, Percutaneous ; Postoperative Complications/epidemiology ; Preoperative Period ; Retrospective Studies ; Risk Assessment ; Stents ; Ureter/surgery ; Ureteral Diseases/epidemiology ; Ureteral Neoplasms/complications ; Ureteral Neoplasms/surgery
    Language English
    Publishing date 2020-08-05
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2020.07.034
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  10. Article ; Online: Longitudinal GFR trends after neoadjuvant chemotherapy prior to nephroureterectomy for upper tract urothelial carcinoma.

    Labbate, Craig V / Hensley, Patrick J / Miest, Tanner S / Qiao, Wei / Adibi, Mehrad / Shah, Amishi Y / Chery, Lisly / Papadopoulos, John / Siefker-Radtke, Arlene O / Gao, Jianjun / Guo, Charles C / Czerniak, Bogdan A / Navai, Neema / Kamat, Ashish M / Dinney, Colin P / Campbell, Matthew T / Matin, Surena F

    Urologic oncology

    2022  Volume 40, Issue 10, Page(s) 454.e17–454.e23

    Abstract: Purpose: Renal function dictates sequencing and eligibility for definitive therapy in upper tract urothelial carcinoma. We investigated longitudinal glomerular filtration rate (GFR) changes after neoadjuvant chemotherapy (NAC) and nephroureterectomy ( ... ...

    Abstract Purpose: Renal function dictates sequencing and eligibility for definitive therapy in upper tract urothelial carcinoma. We investigated longitudinal glomerular filtration rate (GFR) changes after neoadjuvant chemotherapy (NAC) and nephroureterectomy (RNU).
    Materials and methods: Patients treated with ≥3 cycles of chemotherapy prior to RNU for UTUC from 2000 to 2019 were included. GFR was calculated by CKD-Epi before chemotherapy, before RNU, 1 to 3 months, and 12 months post-RNU. Pathologic stage and overall survival were compared in those with stable GFR (+/-10% of baseline) to the rest of the cohort.
    Results: One hundred and fifty-two patients received ≥3 cycles of NAC, with 121 (79%) receiving at least 1 cycle of cisplatin. Renal function dropped by mean of 22.3 ml/min/1.73 m
    Conclusions: In patients managed with NAC prior to RNU, renal function stabilizes at 1 to 3 months post-operatively and remains clinically similar for cisplatin or non-cisplatin-based therapy. Improvement in GFR during NAC was associated with higher pathologic stage and poorer survival, especially in those receiving non-cisplatin-based therapy, an observation that requires further investigation.
    MeSH term(s) Carcinoma, Transitional Cell/drug therapy ; Carcinoma, Transitional Cell/pathology ; Carcinoma, Transitional Cell/surgery ; Cisplatin/therapeutic use ; Glomerular Filtration Rate ; Humans ; Neoadjuvant Therapy ; Nephroureterectomy ; Retrospective Studies ; Ureteral Neoplasms/drug therapy ; Ureteral Neoplasms/pathology ; Ureteral Neoplasms/surgery ; Urinary Bladder Neoplasms/surgery
    Chemical Substances Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2022-08-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1336505-8
    ISSN 1873-2496 ; 1078-1439
    ISSN (online) 1873-2496
    ISSN 1078-1439
    DOI 10.1016/j.urolonc.2022.06.014
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