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  1. Article ; Online: Effectiveness of a negative-pressure patient isolation hood shown using particle count.

    Lang, Angela L / Shaw, Kendrick M / Lozano, Rodrigo / Wang, Jingping

    British journal of anaesthesia

    2020  Volume 125, Issue 3, Page(s) e295–e296

    MeSH term(s) Aerosols ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/prevention & control ; Humans ; Pandemics/prevention & control ; Patient Isolation/methods ; Pneumonia, Viral/prevention & control ; SARS-CoV-2
    Chemical Substances Aerosols
    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country England
    Document type Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2020.05.002
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    Uk I Zs.80: Show issues Location:
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  2. Article ; Online: Low rate of severe-end-stage kidney disease after SABR for localised primary kidney cancer.

    Ali, Muhammad / Koo, Kendrick / Chang, David / Chan, Phil / Oon, Sheng F / Moon, Daniel / Murphy, Declan G / Eapen, Renu / Goad, Jeremy / Lawrentschuk, Nathan / Azad, Arun A / Chander, Sarat / Shaw, Mark / Hardcastle, Nicholas / Siva, Shankar

    Radiation oncology (London, England)

    2024  Volume 19, Issue 1, Page(s) 23

    Abstract: ... disease, baseline estimated glomerular filtration rate (eGFR) of ≥ 30 ml/min/1.73 m: Results: Seventy ...

    Abstract Background: Stereotactic ablative body radiotherapy (SABR) is an emerging treatment for patients with primary renal cell carcinoma (RCC). However, its impact on renal function is unclear. This study aimed to evaluate incidence and clinical factors predictive of severe to end-stage chronic kidney disease (CKD) after SABR for RCC.
    Methods and materials: This was a Single institutional retrospective analysis of patients with diagnosed primary RCC receiving SABR between 2012-2020. Adult patients with no metastatic disease, baseline estimated glomerular filtration rate (eGFR) of ≥ 30 ml/min/1.73 m
    Results: Seventy-eight consecutive patients were included, with median age of 77.8 years (IQR 70-83), tumor size of 4.5 cm (IQR 3.9-5.8) and follow-up of 42.2 months (IQR 23-60). Baseline median eGFR was 58 mls/min; 55% (n = 43) of patients had baseline CKD stage 3 and the remainder stage 1-2. By last follow-up, 1/35 (2.8%) of baseline CKD 1-2, 7/27 (25.9%) CKD 3a and 11/16 (68.8%) CKD 3b had developed CKD stage 4-5. The estimated probability of freedom from CKD stage 4-5 at 1 and 5 years was 89.6% (CI 83.0-97.6) and 65% (CI 51.4-81.7) respectively. On univariable analysis, worse baseline CKD (p < 0.0001) and multi-fraction SABR (p = 0.005) were predictive for development of stage 4-5 CKD though only the former remained significant in multivariable model.
    Conclusion: In this elderly cohort with pre-existing renal dysfunction, SABR achieved satisfactory nephron sparing with acceptable rates of severe to end-stage CKD. It can be an attractive option in patients who are medically inoperable.
    MeSH term(s) Adult ; Humans ; Aged ; Aged, 80 and over ; Carcinoma, Renal Cell/surgery ; Carcinoma, Renal Cell/radiotherapy ; Kidney Neoplasms/surgery ; Kidney Neoplasms/pathology ; Retrospective Studies ; Carcinoma, Transitional Cell ; Urinary Bladder Neoplasms ; Radiosurgery/adverse effects ; Radiosurgery/methods ; Kidney Failure, Chronic/etiology ; Renal Insufficiency, Chronic/etiology
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2224965-5
    ISSN 1748-717X ; 1748-717X
    ISSN (online) 1748-717X
    ISSN 1748-717X
    DOI 10.1186/s13014-024-02413-w
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  3. Article ; Online: Intensive care unit isolation hood decreases risk of aerosolization during noninvasive ventilation with COVID-19.

    Shaw, Kendrick M / Lang, Angela L / Lozano, Rodrigo / Szabo, Michele / Smith, Samuel / Wang, Jingping

    Canadian journal of anaesthesia = Journal canadien d'anesthesie

    2020  Volume 67, Issue 10, Page(s) 1481–1483

    MeSH term(s) Aerosols ; COVID-19 ; Coronavirus Infections/therapy ; Coronavirus Infections/virology ; Equipment Design ; Humans ; Intensive Care Units ; Noninvasive Ventilation/methods ; Pandemics ; Patient Isolators ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology
    Chemical Substances Aerosols
    Keywords covid19
    Language English
    Publishing date 2020-05-26
    Publishing country United States
    Document type Letter
    ZDB-ID 91002-8
    ISSN 1496-8975 ; 0832-610X
    ISSN (online) 1496-8975
    ISSN 0832-610X
    DOI 10.1007/s12630-020-01721-5
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    Zs.A 109: Show issues Location:
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  5. Article ; Online: The other side of the story - maternal perceptions of safety advice and information: a qualitative approach.

    Ablewhite, J / Kendrick, D / Watson, M / Shaw, I

    Child: care, health and development

    2015  Volume 41, Issue 6, Page(s) 1106–1113

    Abstract: Background: A qualitative study of maternal perceptions of home safety advice. The aim was to gain an understanding of maternal perceptions of and possible barriers to the implementation of home safety advice.: Methods: Semi-structured interviews ... ...

    Abstract Background: A qualitative study of maternal perceptions of home safety advice. The aim was to gain an understanding of maternal perceptions of and possible barriers to the implementation of home safety advice.
    Methods: Semi-structured interviews with 37 mothers with a child aged less than 5 years of age; 16 were mothers living in an area of socio-economic disadvantage (with a high rate of childhood unintentional injury), 21 were mothers living in an area of relative affluence (with a low rate of childhood unintentional injury). Thematic analysis was used to analyse the data.
    Results: Although some mothers living in both areas found talking to a health professional about child home safety was helpful, mothers in both areas tended to find talking to other mothers as being more helpful and they preferred this to talking to a professional. Barriers to obtaining safety advice from professionals exist for mothers living in both areas. Mothers living in the advantaged area describe 'feeling silly' and that they should 'know it already' when talking to professionals. Mothers living in the disadvantaged area are less likely to access home safety advice due to fear of being perceived as an incompetent mother and the fear of social service involvement.
    Conclusions: Mothers find home safety advice from other parents more useful and prefer this to advice from professionals. This suggests greater use could be made of appropriately trained parents to deliver safety advice and education. Fear and mistrust can limit access to child safety advice in parents living in disadvantaged areas and this may be a potential explanation for differential unintentional injury rates as those who need the advice and support most may be least likely to access it. Further research should explore how professionals can build trust, gain parents' confidence and provide child safety advice and education that is targeted appropriately to parents living circumstances and their child safety needs.
    MeSH term(s) Accidents, Home/prevention & control ; Adult ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Interviews as Topic ; Middle Aged ; Mothers/psychology ; Perception ; Qualitative Research ; Safety Management
    Language English
    Publishing date 2015-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 223039-2
    ISSN 1365-2214 ; 0305-1862
    ISSN (online) 1365-2214
    ISSN 0305-1862
    DOI 10.1111/cch.12224
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  6. Article: Intensive care unit isolation hood decreases risk of aerosolization during noninvasive ventilation with COVID-19

    Shaw, Kendrick M / Lang, Angela L / Lozano, Rodrigo / Szabo, Michele / Smith, Samuel / Wang, Jingping

    Can J Anaesth

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #378125
    Database COVID19

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  7. Article ; Online: Intensive care unit isolation hood decreases risk of aerosolization during noninvasive ventilation with COVID-19

    Shaw, Kendrick M. / Lang, Angela L. / Lozano, Rodrigo / Szabo, Michele / Smith, Samuel / Wang, Jingping

    Canadian Journal of Anesthesia/Journal canadien d'anesthésie

    2020  Volume 67, Issue 10, Page(s) 1481–1483

    Keywords Anesthesiology and Pain Medicine ; General Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 91002-8
    ISSN 1496-8975 ; 0832-610X
    ISSN (online) 1496-8975
    ISSN 0832-610X
    DOI 10.1007/s12630-020-01721-5
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    Zs.A 109: Show issues Location:
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  8. Article ; Online: Robustness, flexibility, and sensitivity in a multifunctional motor control model.

    Lyttle, David N / Gill, Jeffrey P / Shaw, Kendrick M / Thomas, Peter J / Chiel, Hillel J

    Biological cybernetics

    2016  Volume 111, Issue 1, Page(s) 25–47

    Abstract: Motor systems must adapt to perturbations and changing conditions both within and outside the body. We refer to the ability of a system to maintain performance despite perturbations as "robustness," and the ability of a system to deploy alternative ... ...

    Abstract Motor systems must adapt to perturbations and changing conditions both within and outside the body. We refer to the ability of a system to maintain performance despite perturbations as "robustness," and the ability of a system to deploy alternative strategies that improve fitness as "flexibility." Different classes of pattern-generating circuits yield dynamics with differential sensitivities to perturbations and parameter variation. Depending on the task and the type of perturbation, high sensitivity can either facilitate or hinder robustness and flexibility. Here we explore the role of multiple coexisting oscillatory modes and sensory feedback in allowing multiphasic motor pattern generation to be both robust and flexible. As a concrete example, we focus on a nominal neuromechanical model of triphasic motor patterns in the feeding apparatus of the marine mollusk Aplysia californica. We find that the model can operate within two distinct oscillatory modes and that the system exhibits bistability between the two. In the "heteroclinic mode," higher sensitivity makes the system more robust to changing mechanical loads, but less robust to internal parameter variations. In the "limit cycle mode," lower sensitivity makes the system more robust to changes in internal parameter values, but less robust to changes in mechanical load. Finally, we show that overall performance on a variable feeding task is improved when the system can flexibly transition between oscillatory modes in response to the changing demands of the task. Thus, our results suggest that the interplay of sensory feedback and multiple oscillatory modes can allow motor systems to be both robust and flexible in a variable environment.
    MeSH term(s) Animals ; Aplysia ; Feedback, Sensory ; Motor Activity
    Language English
    Publishing date 2016-12-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 220699-7
    ISSN 1432-0770 ; 0340-1200
    ISSN (online) 1432-0770
    ISSN 0340-1200
    DOI 10.1007/s00422-016-0704-8
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    Zs.A 1279: Show issues Location:
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  9. Article ; Online: Motor neuronal activity varies least among individuals when it matters most for behavior.

    Cullins, Miranda J / Shaw, Kendrick M / Gill, Jeffrey P / Chiel, Hillel J

    Journal of neurophysiology

    2014  Volume 113, Issue 3, Page(s) 981–1000

    Abstract: How does motor neuronal variability affect behavior? To explore this question, we quantified activity of multiple individual identified motor neurons mediating biting and swallowing in intact, behaving Aplysia californica by recording from the protractor ...

    Abstract How does motor neuronal variability affect behavior? To explore this question, we quantified activity of multiple individual identified motor neurons mediating biting and swallowing in intact, behaving Aplysia californica by recording from the protractor muscle and the three nerves containing the majority of motor neurons controlling the feeding musculature. We measured multiple motor components: duration of the activity of identified motor neurons as well as their relative timing. At the same time, we measured behavioral efficacy: amplitude of grasping movement during biting and amplitude of net inward food movement during swallowing. We observed that the total duration of the behaviors varied: Within animals, biting duration shortened from the first to the second and third bites; between animals, biting and swallowing durations varied. To study other sources of variation, motor components were divided by behavior duration (i.e., normalized). Even after normalization, distributions of motor component durations could distinguish animals as unique individuals. However, the degree to which a motor component varied among individuals depended on the role of that motor component in a behavior. Motor neuronal activity that was essential for the expression of biting or swallowing was similar among animals, whereas motor neuronal activity that was not essential for that behavior varied more from individual to individual. These results suggest that motor neuronal activity that matters most for the expression of a particular behavior may vary least from individual to individual. Shaping individual variability to ensure behavioral efficacy may be a general principle for the operation of motor systems.
    MeSH term(s) Action Potentials ; Analysis of Variance ; Animals ; Aplysia ; Deglutition ; Eating ; Feeding Behavior ; Motor Neurons/physiology ; Muscle, Skeletal/innervation ; Muscle, Skeletal/physiology
    Language English
    Publishing date 2014-11-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 80161-6
    ISSN 1522-1598 ; 0022-3077
    ISSN (online) 1522-1598
    ISSN 0022-3077
    DOI 10.1152/jn.00729.2014
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  10. Article ; Online: IBI* series winner. Learning biology by recreating and extending mathematical models.

    Chiel, Hillel J / Gill, Jeffrey P / McManus, Jeffrey M / Shaw, Kendrick M

    Science (New York, N.Y.)

    2012  Volume 336, Issue 6084, Page(s) 993–994

    MeSH term(s) Awards and Prizes ; Biology/education ; Computer Simulation ; Models, Biological ; Nonlinear Dynamics ; Software ; Systems Theory ; Teaching/methods
    Language English
    Publishing date 2012-05-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1214192
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