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Article ; Online: The relation between proteinuria and the severity of COVID-19.

Fukui, Akira / Takeshita, Kohei / Nakashima, Akio / Maruyama, Yukio / Tsuboi, Nobuo / Hoshina, Tokio / Yokoo, Takashi

2023 Volume 28, Issue 3, Page(s) 235–244

Abstract: Background: The association between proteinuria, which is also an indicator of chronic kidney disease (CKD), and coronavirus disease 2019 (COVID-19) severity is unclear.: Methods: We selected 342 hospitalized patients with COVID-19 diagnosed via ... ...

Abstract	Background: The association between proteinuria, which is also an indicator of chronic kidney disease (CKD), and coronavirus disease 2019 (COVID-19) severity is unclear. Methods: We selected 342 hospitalized patients with COVID-19 diagnosed via polymerase chain reaction testing between February 2020 and October 2022 and who had at least one urinalysis 14-365 days before admission. Results: Proteinuria before admission was associated neither with oxygen administration nor developing pneumonia in multivariate analysis (odds ratio [OR] 1.03; 95% confidence interval (CI) 0.44-2.40, p = 0.95 and OR 1.01; 95% CI 0.47-2.17, p = 0.98, respectively). Proteinuria on admission was associated both with oxygen administration and developing pneumonia in multivariate analysis (OR 3.29; 95% CI 1.37-7.88, p < 0.01 and OR 3.81; 95% CI 1.68-8.62, p < 0.01, respectively). The percentage of patients with proteinuria on admission was significantly higher than those before admission (37.4% vs. 17.8%; p < 0.01). In the subgroup analysis, proteinuria on admission among patients with eGFR ≥ 60 mL/min/1.73 m Conclusions: Although underlying proteinuria before admission was not associated with COVID-19 severity, proteinuria on admission was associated with oxygen demand and developing pneumonia.
MeSH term(s)	Humans ; COVID-19/complications ; Proteinuria/complications ; Pneumonia/complications ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Oxygen ; Risk Factors
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2023-11-14
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1338768-6
ISSN	1437-7799 ; 1342-1751
ISSN (online)	1437-7799
ISSN	1342-1751
DOI	10.1007/s10157-023-02428-9
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Article ; Online: Factors associated with IgG titers against SARS-CoV-2 spike protein after second vaccination in people living with HIV controlled with anti-retroviral therapy.

Lee, Kwangyeol / Horino, Tetsuya / Hoshina, Tokio / Sawaki, Kenji / Sakamoto, Yohei / Miyajima, Makiko / Nakaharai, Kazuhiko / Nakazawa, Yasushi / Yoshida, Masaki

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2023 Volume 30, Issue 1, Page(s) 53–57

Abstract: Objective: This study aimed to identify factors associated with the response to the SARS-CoV-2 vaccine in people living with HIV (PLWH).: Methods: This study was conducted at the Jikei University School of Medicine, Tokyo, Japan. IgG antibodies ... ...

Abstract	Objective: This study aimed to identify factors associated with the response to the SARS-CoV-2 vaccine in people living with HIV (PLWH). Methods: This study was conducted at the Jikei University School of Medicine, Tokyo, Japan. IgG antibodies against spike and nucleocapsid proteins were detected using Abbott SARS-CoV-2 IgG II Quant assays. Results: During the investigation period, 371 PLWH were enrolled in this study. PLWH with previous COVID-19 infection, untreated or poorly controlled HIV infection, and those whose blood samples were obtained within less than seven days after the second vaccination were excluded. A total of 310 PLWH controlled with anti-retroviral therapy were included in the final analysis. Multivariate analysis demonstrated that chronic kidney disease (CKD) (β = -0.353, p = 0.049) and the duration between the second vaccination and blood sampling (β = -0.005, p < 0.001) were associated with low spike protein IgG titers. Conclusion: Even without hemodialysis or kidney transplant, CKD was associated with vaccine response in PLWH.
MeSH term(s)	Humans ; Spike Glycoprotein, Coronavirus ; HIV Infections/complications ; HIV Infections/drug therapy ; COVID-19 ; COVID-19 Vaccines ; SARS-CoV-2 ; Immunoglobulin G ; Renal Insufficiency, Chronic ; Vaccination
Chemical Substances	spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; COVID-19 Vaccines ; Immunoglobulin G
Language	English
Publishing date	2023-09-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2023.09.012
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Article ; Online: Cases of coronavirus disease-2019 in HIV-infected transgender women.

Adachi, Eisuke / Saito, Makoto / Ikeuchi, Kazuhiko / Hoshina, Tokio / Yotsuyanagi, Hiroshi

AIDS (London, England)

2020 Volume 34, Issue 9, Page(s) 1435–1436

MeSH term(s)	Adenine/analogs & derivatives ; Adenine/therapeutic use ; Adult ; Anti-HIV Agents/therapeutic use ; Antiviral Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/physiopathology ; Dideoxynucleosides/therapeutic use ; Drug Combinations ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Heterocyclic Compounds, 4 or More Rings/therapeutic use ; Humans ; Lamivudine/therapeutic use ; Lopinavir/therapeutic use ; Male ; Middle Aged ; Oxazines ; Pandemics ; Piperazines ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/physiopathology ; Pyridones ; Ritonavir/therapeutic use ; SARS-CoV-2 ; Tenofovir/therapeutic use ; Transgender Persons
Chemical Substances	Anti-HIV Agents ; Antiviral Agents ; Dideoxynucleosides ; Drug Combinations ; Heterocyclic Compounds, 3-Ring ; Heterocyclic Compounds, 4 or More Rings ; Oxazines ; Piperazines ; Pyridones ; bictegravir, emtricitabine, tenofovir alafenamide, drug combination ; lopinavir-ritonavir drug combination ; Lopinavir (2494G1JF75) ; Lamivudine (2T8Q726O95) ; Tenofovir (99YXE507IL) ; dolutegravir (DKO1W9H7M1) ; Adenine (JAC85A2161) ; Ritonavir (O3J8G9O825) ; abacavir (WR2TIP26VS)
Keywords	covid19
Language	English
Publishing date	2020-06-25
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/QAD.0000000000002573
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Article ; Online: Perinatal management of a pregnant woman with COVID-19: A case report from Japan.

Takahashi, Ken / Sato, Taisuke / Kamide, Taizan / Hoshina, Tokio / Kanuka, Hirotaka / Kumazawa, Kensuke / Tanabe, Yukitoshi / Samura, Osamu / Okamoto, Aikou

Taiwanese journal of obstetrics & gynecology

2022 Volume 61, Issue 2, Page(s) 378–381

Abstract: Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the coronavirus disease 2019 (COVID-19) pandemic. Owing to limited information, the impact and clinical course of COVID-19 in pregnant women and newborns remain unclear. ... ...

Abstract	Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the coronavirus disease 2019 (COVID-19) pandemic. Owing to limited information, the impact and clinical course of COVID-19 in pregnant women and newborns remain unclear. Here, we report the clinical course of a full-term pregnant woman with COVID-19 and her newborn. Case report: A 27-year-old pregnant woman with a fever and sore throat was diagnosed with COVID-19. To prevent and control SARS-CoV-2 infection to the newborn and medical staff, delivery was performed via cesarean section. Reverse-transcription quantitative polymerase chain reaction results of the placenta, umbilical cord, cord blood, amniotic fluid, vaginal fluid, breastmilk, newborn anal wipes, and nasopharyngeal samples were negative for SARS-CoV-2. An acute increase in maternal blood pressure and HELLP syndrome-like blood data fluctuations were observed after delivery. Conclusion: Perinatal management of patients with COVID-19 could be safely performed for medical staff and newborns under adequate infection control measures.
MeSH term(s)	Adult ; Amniotic Fluid ; COVID-19 ; Cesarean Section ; Female ; Humans ; Infant, Newborn ; Japan ; Pregnancy ; Pregnant Women ; SARS-CoV-2
Language	English
Publishing date	2022-02-11
Publishing country	China (Republic : 1949- )
Document type	Case Reports
ZDB-ID	2202946-1
ISSN	1875-6263 ; 1875-6263
ISSN (online)	1875-6263
ISSN	1875-6263
DOI	10.1016/j.tjog.2022.02.033
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Article: Cases of coronavirus disease-2019 in HIV-infected transgender women

Adachi, Eisuke / Saito, Makoto / Ikeuchi, Kazuhiko / Hoshina, Tokio / Yotsuyanagi, Hiroshi

AIDS

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32590441
Database	COVID19

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Article ; Online: Safety and tolerability of medicinal parasite ova (Trichuris suis) in healthy Japanese volunteers: A randomized, double-blind, placebo-controlled trial.

Hoshina, Tokio / Sakurai, Tatsuya / Ichimura, Hidetoshi / Ishiwata, Kenji / En, Shitan / Yamada, Takahiro / Kwangyole, Lee / Shimizu, Akihiro / Hase, Koji / Kanuka, Hirotaka

Parasitology international

2021 Volume 85, Page(s) 102441

Abstract: Background: Trichuris suis ova (TSO), with the potential to modulate the human immune system, have been tested for therapeutic application in autoimmune and allergic diseases such as inflammatory bowel disease (IBD). Previous clinical studies were ... ...

Abstract	Background: Trichuris suis ova (TSO), with the potential to modulate the human immune system, have been tested for therapeutic application in autoimmune and allergic diseases such as inflammatory bowel disease (IBD). Previous clinical studies were limited to European and American participants, whereas Asian populations have not been well documented. In this study, a clinical trial was conducted to examine the safety and tolerability of TSO administration among a healthy Japanese population. Methods: The study was a randomized, double-blind, placebo-controlled trial held at Jikei University Hospital, Tokyo. Twelve volunteers were stratified into three groups receiving different doses of TSO (TSO 1000, 2500, and 7500) and another into the control group. These cases were limited to healthy Japanese men aged over 20 years old. Single doses of medicinal TSO or placebo were given to three participants of each group. All participants were followed up to 56 days after ingestion. During the follow-up period, clinical practitioners checked each participant at the clinic at 7, 14, 28, and 56 days post-ingestion (dpi). Clinical symptoms were evaluated using questionnaire-based self-reporting, which participants filled at every visit. Blood samples were drawn at 7, 14, 28, and 56 dpi. Fecal samples were collected at 28 and 56 dpi. Results: During the study period, twelve healthy Japanese male volunteers were enrolled. All participants completed the follow-up period. No severe adverse events were observed during the study period in all groups. Three participants in the TSO 1000, 2500, and 7500 groups had mild to moderate abdominal symptoms, diarrhea, bloating, and appetite loss during the observation period. One participant in the placebo group presented with mild diarrhea. Microscopic examination identified no parasite ova in any fecal samples. Blood sample examination indicated elevated eosinophil count in several cases, especially in the groups with the higher dose of TSO. No extra-abdominal symptoms were present in all cases. Conclusions: Healthy Japanese people tolerated all doses of TSO without any severe adverse events. On the other hand, mild to moderate abdominal symptoms were observed in several participants. This study suggested that the medicinal use of TSO in Japan is relatively safe, and close follow-up is recommended for sustainable usage.
MeSH term(s)	Adult ; Animals ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy ; Double-Blind Method ; Humans ; Hypersensitivity/immunology ; Hypersensitivity/therapy ; Inflammatory Bowel Diseases/immunology ; Inflammatory Bowel Diseases/therapy ; Japan ; Male ; Therapy with Helminths/adverse effects ; Trichuris
Language	English
Publishing date	2021-08-21
Publishing country	Netherlands
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1363151-2
ISSN	1873-0329 ; 1383-5769
ISSN (online)	1873-0329
ISSN	1383-5769
DOI	10.1016/j.parint.2021.102441
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Article: Seroprevalence of Toxoplasma gondii in wild sika deer in Japan

Hoshina, Tokio / Aonuma, Hiroka / Fukumoto, Shinya / Hori, Seiji / Kanuka, Hirotaka / Saiki, Erisha

Parasitology international. 2019 Aug., v. 71

2019

Abstract: Toxoplasmosis is a food-borne infection that is widespread around the world, causing congenital disorders and opportunistic infections. Ingestion of undercooked meat is one of the risk factors for infection with the causative agent, Toxoplasma gondii. ... ...

Abstract	Toxoplasmosis is a food-borne infection that is widespread around the world, causing congenital disorders and opportunistic infections. Ingestion of undercooked meat is one of the risk factors for infection with the causative agent, Toxoplasma gondii. Japanese people occasionally eat rare meat as a traditional cuisine style called “Sashimi”. A rapid increase in venison consumption in Japan has occurred mainly due to enhanced population control of wild Japanese deer (Cervus nippon) in recent decades. In particular, Yezo-sika deer (C. n. yesoensis) in Hokkaido (the northernmost and largest prefecture in Japan) is frequently supplied to markets as branded game/bushmeat. To study the possible burden of Toxoplasma gondii among wild Yezo-sika deer, plasma samples of Yezo-sika deer hunted during two seasons, 2010–2012, in Eastern Hokkaido were investigated. A total 80 samples were examined using the Sabin–Feldman dye test, which is highly specific and sensitive for identifying the development and persistence of antibodies after primary Toxoplasma infection, demonstrating that 38 cases (47.5%) were seropositive (cut-off titer <1:16). Antibody prevalence of T. gondii in female deer was higher than in males. Adult deer aged 3 years or over showed higher seroprevalence compared with younger animals. The overall seroprevalence fluctuated significantly according to the season when the deer were hunted. These results indicated widespread infection of T. gondii among Japanese wild Yezo-sika deer, suggesting that both appropriate handling and treatment of bushmeat are required to prevent food-borne toxoplasmosis in Japan.
Keywords	adults ; antibodies ; bushmeat ; Cervus nippon ; congenital abnormalities ; cuisine ; deer ; dyes ; females ; foodborne illness ; ingestion ; Japanese people ; males ; markets ; risk factors ; secondary infection ; seroprevalence ; Toxoplasma gondii ; toxoplasmosis ; venison ; Japan
Language	English
Dates of publication	2019-08
Size	p. 76-79.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1363151-2
ISSN	1383-5769
ISSN	1383-5769
DOI	10.1016/j.parint.2019.03.016
Database	NAL-Catalogue (AGRICOLA)

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Article: [Spondylitis and Iliopsoas Abscess Associated with Salmonella enterica ssp. arizonae in a 78-year-old Japanese Woman].

Amano, Hoichi / Kobayashi, Seiji / Hoshina, Tokio / Okada, Hideo / Hasegawa, Toshio / Kawaguchi, Yoshindo / Yokoo, Takashi

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

2018 Volume 106, Issue 1, Page(s) 84–89

MeSH term(s)	Aged ; Female ; Humans ; Psoas Abscess/microbiology ; Salmonella Infections/complications ; Salmonella arizonae/isolation & purification
Language	Japanese
Publishing date	2018-09-03
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	952816-7
ISSN	1883-2083 ; 0021-5384
ISSN (online)	1883-2083
ISSN	0021-5384
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Article ; Online: Seroprevalence of Toxoplasma gondii in wild sika deer in Japan.

Hoshina, Tokio / Fukumoto, Shinya / Aonuma, Hiroka / Saiki, Erisha / Hori, Seiji / Kanuka, Hirotaka

Parasitology international

2019 Volume 71, Page(s) 76–79

Abstract	Toxoplasmosis is a food-borne infection that is widespread around the world, causing congenital disorders and opportunistic infections. Ingestion of undercooked meat is one of the risk factors for infection with the causative agent, Toxoplasma gondii. Japanese people occasionally eat rare meat as a traditional cuisine style called "Sashimi". A rapid increase in venison consumption in Japan has occurred mainly due to enhanced population control of wild Japanese deer (Cervus nippon) in recent decades. In particular, Yezo-sika deer (C. n. yesoensis) in Hokkaido (the northernmost and largest prefecture in Japan) is frequently supplied to markets as branded game/bushmeat. To study the possible burden of Toxoplasma gondii among wild Yezo-sika deer, plasma samples of Yezo-sika deer hunted during two seasons, 2010-2012, in Eastern Hokkaido were investigated. A total 80 samples were examined using the Sabin-Feldman dye test, which is highly specific and sensitive for identifying the development and persistence of antibodies after primary Toxoplasma infection, demonstrating that 38 cases (47.5%) were seropositive (cut-off titer <1:16). Antibody prevalence of T. gondii in female deer was higher than in males. Adult deer aged 3 years or over showed higher seroprevalence compared with younger animals. The overall seroprevalence fluctuated significantly according to the season when the deer were hunted. These results indicated widespread infection of T. gondii among Japanese wild Yezo-sika deer, suggesting that both appropriate handling and treatment of bushmeat are required to prevent food-borne toxoplasmosis in Japan.
MeSH term(s)	Age Factors ; Animals ; Antibodies, Protozoan/blood ; Deer/parasitology ; Female ; Japan/epidemiology ; Male ; Meat/parasitology ; Seroepidemiologic Studies ; Sex Factors ; Toxoplasma ; Toxoplasmosis, Animal/epidemiology
Chemical Substances	Antibodies, Protozoan
Language	English
Publishing date	2019-03-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1363151-2
ISSN	1873-0329 ; 1383-5769
ISSN (online)	1873-0329
ISSN	1383-5769
DOI	10.1016/j.parint.2019.03.016
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Article ; Online: Risk factors associated with hospitalization in patients with asymptomatic or mild COVID-19 in public accommodation facilities in Tokyo.

Sakamoto, Yohei / Satoh, Kenichi / Tanaka, Takuma / Yamaguchi, Takayuki / Miyamoto, Tomomi / Sawaki, Kenji / Miyajima, Makiko / Nakaharai, Kazuhiko / Hoshina, Tokio / Horino, Tetsuya / Nakazawa, Yasushi / Ikenoue, Tatsuyoshi / Yoshida, Masaki

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2022 Volume 28, Issue 10, Page(s) 1439–1444

Abstract: Introduction: In Japan, patients with coronavirus disease 2019 (COVID-19) who do not require medical intervention are provided care in recovery accommodation facilities (RAFs). However, some patients may require hospitalization if their symptoms become ... ...

Abstract	Introduction: In Japan, patients with coronavirus disease 2019 (COVID-19) who do not require medical intervention are provided care in recovery accommodation facilities (RAFs). However, some patients may require hospitalization if their symptoms become more severe during their stay. We conducted an observational study using epidemiological data of patients with COVID-19 admitted to RAFs in Tokyo. Methods: This was an observational cohort study using data from COVID-19 patients admitted to one of the RAFs in Tokyo from December 2020 to November 2021. Admissions to the facilities were limited to patients with asymptomatic or mild COVID-19 with no underlying disease or at least stable underlying disease at the time of admission. Patients were hospitalized when they required oxygen administration or when they had, or persistent fever, or severe respiratory symptoms. We evaluated the association between hospitalization and the risk factors for hospitalization using a Cox regression model. Results: The number of patients with COVID-19 admitted to the RAF was 6176. The number of hospitalized patients was 393 (6.4%), and the median length of stay was 5.50 days (IQR: 4.50, 6.50). In the Cox regression analysis, the hazard ratio increased with age and was significantly higher among patients aged >60 years (HR = 10.23, 95% CI: 6.72-15.57) than those in other age groups. This trend is similar to that observed in the sensitivity analysis. Conclusion: Patients with diabetes, the elderly, obesity, and medications for gout and psychiatric diseases may be at a high risk of hospitalization. In particular, an age over 60 years was strongly associated with hospitalization.
MeSH term(s)	Aged ; COVID-19/epidemiology ; COVID-19/therapy ; Hospitalization ; Humans ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 ; Tokyo/epidemiology
Language	English
Publishing date	2022-06-13
Publishing country	Netherlands
Document type	Journal Article ; Observational Study
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2022.06.002
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