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Artikel ; Online: The added value of (1,3)-β-D-glucan for the diagnosis of Invasive Candidiasis in ICU patients: a prospective cohort study.

Christner, Martin / Abdennadher, Beya / Wichmann, Dominic / Kluge, Stefan / Pepić, Amra / Aepfelbacher, Martin / Rohde, Holger / Olearo, Flaminia

Infection

2023 Band 52, Heft 1, Seite(n) 73–81

Abstract: Purpose: Beta-D-Glucan (BDG) testing has been suggested to support the diagnosis of candidemia and ...

Abstract	Purpose: Beta-D-Glucan (BDG) testing has been suggested to support the diagnosis of candidemia and invasive candidiasis. The actual benefit in critically ill high-risk patients in intensive care units (ICU) has not been verified so far. Methods: In ICU patients receiving empirical echinocandin treatment for suspected invasive candidiasis (IC), serial BDG testing using the Fujifilm Wako Beta-Glucan Test was performed, starting on the first day of echinocandin administration and every 24-48 h afterwards. Diagnostic accuracy was determined for single testing and serial testing strategies using a range of cut-off values. In addition, we compared the added value of these testing strategies when their results were introduced as additional predictors into a multivariable logistic regression model controlling for established risk factors of IC. Results: A total of 174 ICU patients, forty-six of which (25.7%) classified as cases of IC, were included in our study. Initial BDG testing showed moderate sensitivity (74%, 95%CI 59-86%) and poor specificity (45%, 95% CI 36-54%) for IC which could hardly be improved by follow-up testing. While raw BDG values or test results obtained with very high thresholds improved the predictive performance of our multivariable logistic regression model for IC, neither single nor serial testing with the manufacturer-proposed low-level cut-off showed substantial benefit. Conclusions: In our study of critically ill intensive care patients at high risk for candidemia or invasive candidiasis, diagnostic accuracy of BDG testing was insufficient to inform treatment decisions. Improved classification was only achieved for cases with very high BDG values.
Mesh-Begriff(e)	Humans ; Candidemia/diagnosis ; Glucans ; Prospective Studies ; Critical Illness ; Sensitivity and Specificity ; Candidiasis, Invasive/diagnosis ; Candidiasis, Invasive/drug therapy ; Critical Care ; Echinocandins/therapeutic use ; Intensive Care Units ; beta-Glucans ; Candidiasis ; Proteoglycans
Chemische Substanzen	polysaccharide-K (3X48A86C8K) ; Glucans ; Echinocandins ; beta-Glucans ; Proteoglycans
Sprache	Englisch
Erscheinungsdatum	2023-06-15
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-023-02053-4
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Measurement of the Dependence of the Hadron Production Fraction Ratios f_{s}/f_{u} and f_{d}/f_{u} on B Meson Kinematic Variables in Proton-Proton Collisions at sqrt[s]=13 TeV.

Tumasyan, A / Adam, W / Andrejkovic, J W / Bergauer, T / Chatterjee, S / Damanakis, K / Dragicevic, M / Escalante Del Valle, A / Hussain, P S / Jeitler, M / Krammer, N / Lechner, L / Liko, D / Mikulec, I / Paulitsch, P / Schieck, J / Schöfbeck, R / Schwarz, D / Sonawane, M /

Templ, S / Waltenberger, W / Wulz, C-E / Darwish, M R / Janssen, T / Kello, T / Rejeb Sfar, H / Van Mechelen, P / Bols, E S / D'Hondt, J / De Moor, A / Delcourt, M / El Faham, H / Lowette, S / Morton, A / Müller, D / Sahasransu, A R / Tavernier, S / Van Doninck, W / Van Putte, S / Vannerom, D / Clerbaux, B / De Lentdecker, G / Favart, L / Hohov, D / Jaramillo, J / Lee, K / Mahdavikhorrami, M / Makarenko, I / Malara, A / Paredes, S / Pétré, L / Postiau, N / Thomas, L / Vanden Bemden, M / Vander Velde, C / Vanlaer, P / Dobur, D / Knolle, J / Lambrecht, L / Mestdach, G / Rendón, C / Samalan, A / Skovpen, K / Tytgat, M / Van Den Bossche, N / Vermassen, B / Wezenbeek, L / Benecke, A / Bruno, G / Bury, F / Caputo, C / David, P / Delaere, C / Donertas, I S / Giammanco, A / Jaffel, K / Jain, Sa / Lemaitre, V / Mondal, K / Taliercio, A / Tran, T T / Vischia, P / Wertz, S / Alves, G A / Coelho, E / Hensel, C / Moraes, A / Rebello Teles, P / Aldá Júnior, W L / Alves Gallo Pereira, M / Barroso Ferreira Filho, M / Brandao Malbouisson, H / Carvalho, W / Chinellato, J / Da Costa, E M / Da Silveira, G G / De Jesus Damiao, D / Dos Santos Sousa, V / Fonseca De Souza, S / Martins, J / Mora Herrera, C / Mota Amarilo, K / Mundim, L / Nogima, H / Santoro, A / Silva Do Amaral, S M / Sznajder, A / Thiel, M / Vilela Pereira, A / Bernardes, C A / Calligaris, L / Tomei, T R Fernandez Perez / Gregores, E M / Mercadante, P G / Novaes, S F / Padula, Sandra S / Aleksandrov, A / Antchev, G / Hadjiiska, R / Iaydjiev, P / Misheva, M / Rodozov, M / Shopova, M / Sultanov, G / Dimitrov, A / Ivanov, T / Litov, L / Pavlov, B / Petkov, P / Petrov, A / Shumka, E / Thakur, S / Cheng, T / Javaid, T / Mittal, M / Yuan, L / Ahmad, M / Bauer, G / Hu, Z / Lezki, S / Yi, K / Chen, G M / Chen, H S / Chen, M / Iemmi, F / Jiang, C H / Kapoor, A / Liao, H / Liu, Z-A / Milosevic, V / Monti, F / Sharma, R / Tao, J / Thomas-Wilsker, J / Wang, J / Zhang, H / Zhao, J / Agapitos, A / An, Y / Ban, Y / Levin, A / Li, C / Li, Q / Lyu, X / Mao, Y / Qian, S J / Sun, X / Wang, D / Xiao, J / Yang, H / Lu, M / You, Z / Lu, N / Gao, X / Leggat, D / Okawa, H / Zhang, Y / Lin, Z / Lu, C / Xiao, M / Avila, C / Barbosa Trujillo, D A / Cabrera, A / Florez, C / Fraga, J / Mejia Guisao, J / Ramirez, F / Rodriguez, M / Ruiz Alvarez, J D / Giljanovic, D / Godinovic, N / Lelas, D / Puljak, I / Antunovic, Z / Kovac, M / Sculac, T / Brigljevic, V / Chitroda, B K / Ferencek, D / Mishra, S / Roguljic, M / Starodumov, A / Susa, T / Attikis, A / Christoforou, K / Konstantinou, S / Mousa, J / Nicolaou, C / Ptochos, F / Razis, P A / Rykaczewski, H / Saka, H / Stepennov, A / Finger, M / Kveton, A / Ayala, E / Carrera Jarrin, E / Abdelalim, A A / Salama, E / Abdullah Al-Mashad, M / Mahmoud, M A / Bhowmik, S / Dewanjee, R K / Ehataht, K / Kadastik, M / Lange, T / Nandan, S / Nielsen, C / Pata, J / Raidal, M / Tani, L / Veelken, C / Eerola, P / Kirschenmann, H / Osterberg, K / Voutilainen, M / Bharthuar, S / Brücken, E / Garcia, F / Havukainen, J / Kim, M S / Kinnunen, R / Lampén, T / Lassila-Perini, K / Lehti, S / Lindén, T / Lotti, M / Martikainen, L / Myllymäki, M / Rantanen, M M / Siikonen, H / Tuominen, E / Tuominiemi, J / Luukka, P / Petrow, H / Tuuva, T / Amendola, C / Besancon, M / Couderc, F / Dejardin, M / Denegri, D / Faure, J L / Ferri, F / Ganjour, S / Gras, P / Hamel de Monchenault, G / Lohezic, V / Malcles, J / Rander, J / Rosowsky, A / Sahin, M Ö / Savoy-Navarro, A / Simkina, P / Titov, M / Baldenegro Barrera, C / Beaudette, F / Buchot Perraguin, A / Busson, P / Cappati, A / Charlot, C / Damas, F / Davignon, O / Diab, B / Falmagne, G / Fontana Santos Alves, B A / Ghosh, S / Granier de Cassagnac, R / Hakimi, A / Harikrishnan, B / Liu, G / Motta, J / Nguyen, M / Ochando, C / Portales, L / Salerno, R / Sarkar, U / Sauvan, J B / Sirois, Y / Tarabini, A / Vernazza, E / Zabi, A / Zghiche, A / Agram, J-L / Andrea, J / Apparu, D / Bloch, D / Bourgatte, G / Brom, J-M / Chabert, E C / Collard, C / Darej, D / Goerlach, U / Grimault, C / Le Bihan, A-C / Van Hove, P / Beauceron, S / Blancon, B / Boudoul, G / Carle, A / Chanon, N / Choi, J / Contardo, D / Depasse, P / Dozen, C / El Mamouni, H / Fay, J / Gascon, S / Gouzevitch, M / Grenier, G / Ille, B / Laktineh, I B / Lethuillier, M / Mirabito, L / Perries, S / Torterotot, L / Vander Donckt, M / Verdier, P / Viret, S / Lomidze, I / Toriashvili, T / Tsamalaidze, Z / Botta, V / Feld, L / Klein, K / Lipinski, M / Meuser, D / Pauls, A / Röwert, N / Teroerde, M / Diekmann, S / Dodonova, A / Eich, N / Eliseev, D / Erdmann, M / Fackeldey, P / Fasanella, D / Fischer, B / Hebbeker, T / Hoepfner, K / Ivone, F / Lee, M Y / Mastrolorenzo, L / Merschmeyer, M / Meyer, A / Mondal, S / Mukherjee, S / Noll, D / Novak, A / Nowotny, F / Pozdnyakov, A / Rath, Y / Redjeb, W / Rehm, F / Reithler, H / Schmidt, A / Schuler, S C / Sharma, A / Stein, A / Torres Da Silva De Araujo, F / Vigilante, L / Wiedenbeck, S / Zaleski, S / Dziwok, C / Flügge, G / Haj Ahmad, W / 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Physical review letters

2023 Band 131, Heft 12, Seite(n) 121901

Abstract: ... to B^{+} meson production fractions, f_{d}/f_{u}, is also measured, for the first time in proton-proton ...

Abstract	The dependence of the ratio between the B_{s}^{0} and B^{+} hadron production fractions, f_{s}/f_{u}, on the transverse momentum (p_{T}) and rapidity of the B mesons is studied using the decay channels B_{s}^{0}→J/ψϕ and B^{+}→J/ψK^{+}. The analysis uses a data sample of proton-proton collisions at a center-of-mass energy of 13 TeV, collected by the CMS experiment in 2018 and corresponding to an integrated luminosity of 61.6 fb^{-1}. The f_{s}/f_{u} ratio is observed to depend on the B p_{T} and to be consistent with becoming asymptotically constant at large p_{T}. No rapidity dependence is observed. The ratio of the B^{0} to B^{+} meson production fractions, f_{d}/f_{u}, is also measured, for the first time in proton-proton collisions, using the B^{0}→J/ψK^{*0} decay channel. The result is found to be within 1 standard deviation of unity and independent of p_{T} and rapidity, as expected from isospin invariance.
Sprache	Englisch
Erscheinungsdatum	2023-10-06
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.121901
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Online ; Dissertation / Habilitation: Vergleich zweier Techniken zur Bestimmung der horizontalen Kieferrelation mittels optischer 3-D-Messverfahren

Behrens, Gabriela [Verfasser] / Matta, Ragai [Akademischer Betreuer] / Wichmann, Manfred [Gutachter]

2022

Verfasserangabe	Gabriela Behrens ; Gutachter: Manfred Wichmann ; Betreuer: Ragai Matta
Schlagwörter	Medizin, Gesundheit ; Medicine, Health
Thema/Rubrik (Code)	sg610
Sprache	Deutsch
Verlag	Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Erscheinungsort	Erlangen
Dokumenttyp	Buch ; Online ; Dissertation / Habilitation
Datenquelle	Digitale Dissertationen im Internet

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Artikel ; Online: Measurement of Prompt D^{0} Meson Azimuthal Anisotropy in Pb-Pb Collisions at sqrt[s_{NN}]=5.02 TeV.

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Physical review letters

2018 Band 120, Heft 20, Seite(n) 202301

Abstract: The prompt D^{0} meson azimuthal anisotropy coefficients, v_{2} and v_{3}, are measured ... throughout the p_{T} range studied. The first measurement of the prompt D^{0} meson v_{3} coefficient is performed ... particles, a similar p_{T} dependence, but smaller magnitude for p_{T}<6 GeV/c, is found for prompt D^{0 ...

Abstract	The prompt D^{0} meson azimuthal anisotropy coefficients, v_{2} and v_{3}, are measured at midrapidity (\|y\|<1.0) in Pb-Pb collisions at a center-of-mass energy sqrt[s_{NN}]=5.02 TeV per nucleon pair with data collected by the CMS experiment. The measurement is performed in the transverse momentum (p_{T}) range of 1 to 40 GeV/c, for central and midcentral collisions. The v_{2} coefficient is found to be positive throughout the p_{T} range studied. The first measurement of the prompt D^{0} meson v_{3} coefficient is performed, and values up to 0.07 are observed for p_{T} around 4 GeV/c. Compared to measurements of charged particles, a similar p_{T} dependence, but smaller magnitude for p_{T}<6 GeV/c, is found for prompt D^{0} meson v_{2} and v_{3} coefficients. The results are consistent with the presence of collective motion of charm quarks at low p_{T} and a path length dependence of charm quark energy loss at high p_{T}, thereby providing new constraints on the theoretical description of the interactions between charm quarks and the quark-gluon plasma.
Sprache	Englisch
Erscheinungsdatum	2018-05-18
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.120.202301
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Studies of Beauty Suppression via Nonprompt D^{0} Mesons in Pb-Pb Collisions at sqrt[s_{NN}]=5.02 TeV.

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Ledovskoy, A / Li, H / Neu, C / Sinthuprasith, T / Wolfe, E / Xia, F / Harr, R / Karchin, P E / Poudyal, N / Sturdy, J / Thapa, P / Zaleski, S / Brodski, M / Buchanan, J / Caillol, C / Carlsmith, D / Dasu, S / Dodd, L / Gomber, B / Grothe, M / Herndon, M / Hervé, A / Hussain, U / Klabbers, P / Lanaro, A / Long, K / Loveless, R / Ruggles, T / Savin, A / Smith, N / Smith, W H / Woods, N

Physical review letters

2019 Band 123, Heft 2, Seite(n) 22001

Abstract: The transverse momentum spectra of D^{0} mesons from b hadron decays are measured at midrapidity ... detector at the LHC. The D^{0} mesons from b hadron decays are distinguished from prompt D^{0} mesons ... D^{0} mesons and charged hadrons for p_{T} around 10 GeV/c. While theoretical calculations ...

Abstract	The transverse momentum spectra of D^{0} mesons from b hadron decays are measured at midrapidity (\|y\|<1) in pp and Pb-Pb collisions at a nucleon-nucleon center of mass energy of 5.02 TeV with the CMS detector at the LHC. The D^{0} mesons from b hadron decays are distinguished from prompt D^{0} mesons by their decay topologies. In Pb-Pb collisions, the B→D^{0} yield is found to be suppressed in the measured p_{T} range from 2 to 100 GeV/c as compared to pp collisions. The suppression is weaker than that of prompt D^{0} mesons and charged hadrons for p_{T} around 10 GeV/c. While theoretical calculations incorporating partonic energy loss in the quark-gluon plasma can successfully describe the measured B→D^{0} suppression at higher p_{T}, the data show an indication of larger suppression than the model predictions in the range of 2<p_{T}<5 GeV/c.<br />
Sprache	Englisch
Erscheinungsdatum	2019-08-03
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.123.022001
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Engineering a functional 1-deoxy-D-xylulose 5-phosphate (DXP) pathway in Saccharomyces cerevisiae.

Kirby, James / Dietzel, Kevin L / Wichmann, Gale / Chan, Rossana / Antipov, Eugene / Moss, Nathan / Baidoo, Edward E K / Jackson, Peter / Gaucher, Sara P / Gottlieb, Shayin / LaBarge, Jeremy / Mahatdejkul, Tina / Hawkins, Kristy M / Muley, Sheela / Newman, Jack D / Liu, Pinghua / Keasling, Jay D / Zhao, Lishan

Metabolic engineering

2016 Band 38, Seite(n) 494–503

Abstract: ... pathway or from pyruvate and glyceraldehyde 3-phosphate via the 1-deoxy-D-xylulose 5-phosphate (DXP ...

Abstract	Isoprenoids are used in many commercial applications and much work has gone into engineering microbial hosts for their production. Isoprenoids are produced either from acetyl-CoA via the mevalonate pathway or from pyruvate and glyceraldehyde 3-phosphate via the 1-deoxy-D-xylulose 5-phosphate (DXP) pathway. Saccharomyces cerevisiae exclusively utilizes the mevalonate pathway to synthesize native isoprenoids and in fact the alternative DXP pathway has never been found or successfully reconstructed in the eukaryotic cytosol. There are, however, several advantages to isoprenoid synthesis via the DXP pathway, such as a higher theoretical yield, and it has long been a goal to transplant the pathway into yeast. In this work, we investigate and address barriers to DXP pathway functionality in S. cerevisiae using a combination of synthetic biology, biochemistry and metabolomics. We report, for the first time, functional expression of the DXP pathway in S. cerevisiae. Under low aeration conditions, an engineered strain relying solely on the DXP pathway for isoprenoid biosynthesis achieved an endpoint biomass 80% of that of the same strain using the mevalonate pathway.
Mesh-Begriff(e)	Metabolic Engineering ; Pentosephosphates/genetics ; Pentosephosphates/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Terpenes/metabolism
Chemische Substanzen	1-deoxylulose 5-phosphate ; Pentosephosphates ; Terpenes
Sprache	Englisch
Erscheinungsdatum	2016-10-27
Erscheinungsland	Belgium
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	1470383-x
ISSN	1096-7184 ; 1096-7176
ISSN (online)	1096-7184
ISSN	1096-7176
DOI	10.1016/j.ymben.2016.10.017
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Engineering a functional 1-deoxy-D-xylulose 5-phosphate (DXP) pathway in Saccharomyces cerevisiae

Kirby, James / Edward E.K. Baidoo / Eugene Antipov / Gale Wichmann / Jack D. Newman / Jay D. Keasling / Jeremy LaBarge / Kevin L. Dietzel / Kristy M. Hawkins / Lishan Zhao / Nathan Moss / Peter Jackson / Pinghua Liu / Rossana Chan / Sara P. Gaucher / Shayin Gottlieb / Sheela Muley / Tina Mahatdejkul

International Metabolic Engineering Society Metabolic engineering. 2016 Nov., v. 38

2016

Abstract: ... pathway or from pyruvate and glyceraldehyde 3-phosphate via the 1-deoxy-D-xylulose 5-phosphate (DXP ...

Abstract	Isoprenoids are used in many commercial applications and much work has gone into engineering microbial hosts for their production. Isoprenoids are produced either from acetyl-CoA via the mevalonate pathway or from pyruvate and glyceraldehyde 3-phosphate via the 1-deoxy-D-xylulose 5-phosphate (DXP) pathway. Saccharomyces cerevisiae exclusively utilizes the mevalonate pathway to synthesize native isoprenoids and in fact the alternative DXP pathway has never been found or successfully reconstructed in the eukaryotic cytosol. There are, however, several advantages to isoprenoid synthesis via the DXP pathway, such as a higher theoretical yield, and it has long been a goal to transplant the pathway into yeast. In this work, we investigate and address barriers to DXP pathway functionality in S. cerevisiae using a combination of synthetic biology, biochemistry and metabolomics. We report, for the first time, functional expression of the DXP pathway in S. cerevisiae. Under low aeration conditions, an engineered strain relying solely on the DXP pathway for isoprenoid biosynthesis achieved an endpoint biomass 80% of that of the same strain using the mevalonate pathway.
Schlagwörter	acetyl coenzyme A ; aeration ; biomass ; biosynthesis ; cytosol ; glyceraldehyde 3-phosphate ; isoprenoids ; metabolomics ; pyruvic acid ; Saccharomyces cerevisiae ; synthetic biology ; yeasts
Sprache	Englisch
Erscheinungsverlauf	2016-11
Umfang	p. 494-503.
Erscheinungsort	Elsevier Inc.
Dokumenttyp	Artikel
ZDB-ID	1470383-x
ISSN	1096-7184 ; 1096-7176
ISSN (online)	1096-7184
ISSN	1096-7176
DOI	10.1016/j.ymben.2016.10.017
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: 3-D-basiertes, minimalinvasives Bone-Splitting

Nickenig, Hans-Joachim / Bonsmann, Martin / Wichmann, Manfred / Eitner, Stephan / Zöller, Joachim / Kreppel, Matthias

Implantologie

2014 Band 22, Heft 3, Seite(n) 249

Sprache	Deutsch
Dokumenttyp	Artikel
ZDB-ID	1151752-9
ISSN	0943-9692
Datenquelle	Current Contents Medizin

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Artikel ; Online: Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion.

Diabetes

2011 Band 61, Heft 1, Seite(n) 187–196

Abstract: To clarify the physiological role of Na(+)-D-glucose cotransporter SGLT1 in small intestine and ... kidney, Sglt1(-/-) mice were generated and characterized phenotypically. After gavage of d-glucose ... but thrive normally when fed a glucose-galactose-free diet. In wild-type mice, passage of D-glucose across ...

Abstract	To clarify the physiological role of Na(+)-D-glucose cotransporter SGLT1 in small intestine and kidney, Sglt1(-/-) mice were generated and characterized phenotypically. After gavage of d-glucose, small intestinal glucose absorption across the brush-border membrane (BBM) via SGLT1 and GLUT2 were analyzed. Glucose-induced secretion of insulinotropic hormone (GIP) and glucagon-like peptide 1 (GLP-1) in wild-type and Sglt1(-/-) mice were compared. The impact of SGLT1 on renal glucose handling was investigated by micropuncture studies. It was observed that Sglt1(-/-) mice developed a glucose-galactose malabsorption syndrome but thrive normally when fed a glucose-galactose-free diet. In wild-type mice, passage of D-glucose across the intestinal BBM was predominantly mediated by SGLT1, independent the glucose load. High glucose concentrations increased the amounts of SGLT1 and GLUT2 in the BBM, and SGLT1 was required for upregulation of GLUT2. SGLT1 was located in luminal membranes of cells immunopositive for GIP and GLP-1, and Sglt1(-/-) mice exhibited reduced glucose-triggered GIP and GLP-1 levels. In the kidney, SGLT1 reabsorbed ∼3% of the filtered glucose under normoglycemic conditions. The data indicate that SGLT1 is 1) pivotal for intestinal mass absorption of d-glucose, 2) triggers the glucose-induced secretion of GIP and GLP-1, and 3) triggers the upregulation of GLUT2.
Mesh-Begriff(e)	Animals ; Female ; Glucose/pharmacokinetics ; Glucose/pharmacology ; Glycosuria/metabolism ; Incretins/metabolism ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; Intestinal Absorption/genetics ; Intestine, Small/metabolism ; Kidney Tubules, Proximal/drug effects ; Kidney Tubules, Proximal/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Oocytes/drug effects ; Oocytes/metabolism ; Sodium-Glucose Transporter 1/genetics ; Sodium-Glucose Transporter 1/metabolism ; Sodium-Glucose Transporter 1/physiology
Chemische Substanzen	Incretins ; Slc5a1 protein, mouse ; Sodium-Glucose Transporter 1 ; Glucose (IY9XDZ35W2)
Sprache	Englisch
Erscheinungsdatum	2011-11-28
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	80085-5
ISSN	1939-327X ; 0012-1797
ISSN (online)	1939-327X
ISSN	0012-1797
DOI	10.2337/db11-1029
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Respiratory health in children, and indoor exposure to (1,3)-β-D-glucan, EPS mould components and endotoxin.

Tischer, C / Gehring, U / Chen, C-M / Kerkhof, M / Koppelman, G / Sausenthaler, S / Herbarth, O / Schaaf, B / Lehmann, I / Krämer, U / Berdel, D / von Berg, A / Bauer, C P / Koletzko, S / Wichmann, H-E / Brunekreef, B / Heinrich, J

The European respiratory journal

2010 Band 37, Heft 5, Seite(n) 1050–1059

Abstract: ... that early childhood exposure to mould components, such as (1,3)-β-D-glucan and extracellular polysaccharides (EPSs ... may protect children from developing allergy. We investigated the association of exposure to (1,3)-β-D-glucan ... in Germany (n = 358) and one in the Netherlands (n = 338) were selected. Levels of (1,3)-β-D-glucan, EPS and ...

Abstract	For a long time, exposure to mould and dampness-derived microbial components was considered a risk factor for the development of respiratory diseases and symptoms. Some recent studies suggested that early childhood exposure to mould components, such as (1,3)-β-D-glucan and extracellular polysaccharides (EPSs), may protect children from developing allergy. We investigated the association of exposure to (1,3)-β-D-glucan, EPS and endotoxin with asthma and allergies in 6-yr-old children. This investigation was the follow-up to a nested case-control study among three European birth cohorts. Children from two ongoing birth cohort studies performed in Germany (n = 358) and one in the Netherlands (n = 338) were selected. Levels of (1,3)-β-D-glucan, EPS and endotoxin were measured in settled house dust sampled from children's mattresses and living-room floors when the children were, on average, 5 yrs of age. At the age of 6 yrs, health outcome information was available for 678 children. In the two German subsets, domestic EPS and endotoxin exposure from children's mattresses were significantly negatively associated with physician-diagnosed asthma (OR per interquartile range increase 0.60 (95% CI 0.39-0.92) and 0.55 (95% CI 0.31-0.97), respectively). In addition, EPS exposure was inversely related to physician-diagnosed allergic rhinitis (OR 0.50, 95% CI 0.31-0.81). For the Dutch population, no associations were observed between exposure to microbial agents and respiratory health outcomes. We found inverse associations between domestic exposure to EPS and endotoxin from children's mattresses, and doctor-diagnosed asthma and rhinitis in German, but not in Dutch, school children. The reasons for the differences between countries are not clear.
Mesh-Begriff(e)	Asthma/epidemiology ; Asthma/microbiology ; Asthma/prevention & control ; Beds/microbiology ; Case-Control Studies ; Child ; Child, Preschool ; Cohort Studies ; Dust/immunology ; Female ; Floors and Floorcoverings ; Fungi/immunology ; Germany ; Humans ; Male ; Netherlands/epidemiology ; Rhinitis, Allergic, Perennial/epidemiology ; Rhinitis, Allergic, Perennial/microbiology ; Rhinitis, Allergic, Perennial/prevention & control ; Toxins, Biological/immunology ; beta-Glucans/immunology
Chemische Substanzen	Dust ; Toxins, Biological ; beta-Glucans ; polysaccharide-K (3X48A86C8K)
Sprache	Englisch
Erscheinungsdatum	2010-09-03
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/09031936.00091210
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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