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Book ; Online: Intentions of healthcare workers in France and Belgium to get vaccinated against monkeypox correlates with attitudes towards COVID-19 vaccination

Gagneux-Brunon, Amandine / Cornely, Oliver Andreas

2022

Abstract: ... of the exhaustion due to the COVID-19 pandemic, the team around Amandine Gagneux-Brunon aimed to evaluate intentions ...

Title variant	VACCELERATE WEBINAR DEC 07 2022: Intentions of healthcare workers to get vaccinated against mpox
Institution	VACCELERATE
Author's details	presenter: Dr Amandine Gagneux-Brunon ; moderator: Prof. Oliver A. Cornely ; organizor: VACCELERATE (coordinator: Prof. Oliver A. Cornely)
Abstract	Frontline healthcare workers (HCWs) could be at risk for monkeypox infections. Vaccine hesitancy can be found among HCWs and has an impact on their own attitudes towards vaccination. In the context of the exhaustion due to the COVID-19 pandemic, the team around Amandine Gagneux-Brunon aimed to evaluate intentions of HCWs in France and Belgium to get vaccinated against monkeypox. They performed a cross-sectional study using a self-administered online questionnaire evaluate intentions of HCWs to get vaccinated against monkeypox, in case a recommendation for HCW vaccination was given. 397 persons responded. The researchers then compared demographics characteristic, vaccination readiness, eagerness to receive a COVID-19 vaccine, and confidence in HCW with Chi-square tests, student-t and performed a binary regression.
Keywords	COVID-19
Subject	Coronavirus-Krankheit-2019 ; Corona virus disease 2019 ; Coronavirus disease 2019 ; 2019-nCoV acute respiratory disease ; Wuhan pneumonia ; COVID-19-Infektion ; Coronavirus-SARS-CoV-2-Infektion ; SARS-CoV-2-Infektion
Subject code	610
Language	English
Size	1 Online-Ressource (1 Videodatei, Lauflänge: 00:40:41)
Publisher	VACCELERATE_EU
Publishing place	Cologe
Publishing country	Germany
Document type	Book ; Online
HBZ-ID	HT021659086
DOI	10.4126/FRL01-006438672
Database	Repository for Life Sciences

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Article ; Online: Users' Reactions to Announced Vaccines Against COVID-19 Before Marketing in France: Analysis of Twitter Posts.

Dupuy-Zini, Alexandre / Audeh, Bissan / Gérardin, Christel / Duclos, Catherine / Gagneux-Brunon, Amandine / Bousquet, Cedric

Journal of medical Internet research

2023 Volume 25, Page(s) e37237

Abstract: Background: Within a few months, the COVID-19 pandemic had spread to many countries and had been a real challenge for health systems all around the world. This unprecedented crisis has led to a surge of online discussions about potential cures for the ... ...

Abstract	Background: Within a few months, the COVID-19 pandemic had spread to many countries and had been a real challenge for health systems all around the world. This unprecedented crisis has led to a surge of online discussions about potential cures for the disease. Among them, vaccines have been at the heart of the debates and have faced lack of confidence before marketing in France. Objective: This study aims to identify and investigate the opinions of French Twitter users on the announced vaccines against COVID-19 through sentiment analysis. Methods: This study was conducted in 2 phases. First, we filtered a collection of tweets related to COVID-19 available on Twitter from February 2020 to August 2020 with a set of keywords associated with vaccine mistrust using word embeddings. Second, we performed sentiment analysis using deep learning to identify the characteristics of vaccine mistrust. The model was trained on a hand-labeled subset of 4548 tweets. Results: A set of 69 relevant keywords were identified as the semantic concept of the word "vaccin" (vaccine in French) and focused mainly on conspiracies, pharmaceutical companies, and alternative treatments. Those keywords enabled us to extract nearly 350,000 tweets in French. The sentiment analysis model achieved 0.75 accuracy. The model then predicted 16% of positive tweets, 41% of negative tweets, and 43% of neutral tweets. This allowed us to explore the semantic concepts of positive and negative tweets and to plot the trends of each sentiment. The main negative rhetoric identified from users' tweets was that vaccines are perceived as having a political purpose and that COVID-19 is a commercial argument for the pharmaceutical companies. Conclusions: Twitter might be a useful tool to investigate the arguments for vaccine mistrust because it unveils political criticism contrasting with the usual concerns on adverse drug reactions. As the opposition rhetoric is more consistent and more widely spread than the positive rhetoric, we believe that this research provides effective tools to help health authorities better characterize the risk of vaccine mistrust.
MeSH term(s)	Humans ; COVID-19 ; COVID-19 Vaccines ; Social Media ; Pandemics ; Marketing ; Pharmaceutical Preparations
Chemical Substances	COVID-19 Vaccines ; Pharmaceutical Preparations
Language	English
Publishing date	2023-04-24
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1438-8871
ISSN (online)	1438-8871
ISSN	1438-8871
DOI	10.2196/37237
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Attitudes towards monkeypox vaccination among healthcare workers in France and Belgium: an element of complacency?

Gagneux-Brunon, A / Dauby, N / Launay, O / Botelho-Nevers, E

The Journal of hospital infection

2022 Volume 130, Page(s) 144–145

MeSH term(s)	Humans ; Smallpox Vaccine ; Belgium ; Vaccination ; Health Personnel ; France ; Attitude ; Health Knowledge, Attitudes, Practice ; Influenza Vaccines ; Influenza, Human
Chemical Substances	Smallpox Vaccine ; Influenza Vaccines
Language	English
Publishing date	2022-09-26
Publishing country	England
Document type	Letter
ZDB-ID	779366-2
ISSN	1532-2939 ; 0195-6701
ISSN (online)	1532-2939
ISSN	0195-6701
DOI	10.1016/j.jhin.2022.09.010
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Article ; Online: Evaluation of intentions to get vaccinated against influenza, COVID 19, pertussis and to get a future vaccine against respiratory syncytial virus in pregnant women.

Cubizolles, Charlotte / Barjat, Tiphaine / Chauleur, Céline / Bruel, Sébastien / Botelho-Nevers, Elisabeth / Gagneux-Brunon, Amandine

Vaccine

2023 Volume 41, Issue 49, Page(s) 7342–7347

Abstract: Introduction: Pregnant women (PW) are at increased risk of complications due to seasonal influenza and Covid-19. Immunization during pregnancy against pertussis and respiratory syncytial virus (RSV) protects newborns from severe diseases. Our aim was to ...

Abstract	Introduction: Pregnant women (PW) are at increased risk of complications due to seasonal influenza and Covid-19. Immunization during pregnancy against pertussis and respiratory syncytial virus (RSV) protects newborns from severe diseases. Our aim was to assess intentions to get vaccinated against seasonal influenza, COVID-19, pertussis and RSV in PW and to identify factors associated with intentions. Methods: Cross-sectional survey in PW followed at a University Hospital in France assessing their knowledge, and attitudes toward vaccination against influenza, Covid-19, and RSV during pregnancy. Primary outcome was intention to receive each vaccine or potential vaccine. Univariable and multivariable analysis were carried out to identify factors associated with intentions to get vaccinated for each vaccine. Results: Among the 1199 PW followed during the study period, 310 completed the questionnaire. Intentions to get vaccinated were respectively 43.9 %, 36.8 %, 36.1 % and 39.4 % against influenza, Covid-19, pertussis and RSV. Overall confidence in vaccines using 5C-model, recommendation by a healthcare professional (HCP), good knowledge about diseases and vaccines and previous influenza vaccination were associated with flu vaccine acceptance with respective adjusted odds ratios and 95 % Confidence Intervals (aOR) 1.69 (1.09-2.61) by one-point increase in confidence score, 4.89 (2.24-10.7), 1.56 by one-point increase in knowledge score (1.26-1.93), 13.5 and (5.3-34.3). Confidence was also associated with Covid-19 and RSV vaccine acceptance with respective aOR and 95 % CI 2.63 (1.7-4.07) and 1.92 (1.3-2.84). For pertussis, previous flu vaccination or pertussis vaccination in the last 5 years were predictors of pertussis vaccine acceptance during the pregnancy with respective aOR and 95 % CI 1.97 (1.1-3.84) and 2.9 (1.6-5.18). Conclusion: Confidence is associated with seasonal influenza, COVID-19 and RSV vaccines acceptance in pregnant women. Receiving a recommendation from a HCP was strongly associated with acceptance of influenza vaccine. Recent vaccination against pertussis was not a barrier to pertussis vaccine acceptance during pregnancy.
MeSH term(s)	Infant, Newborn ; Female ; Pregnancy ; Humans ; Pregnant Women ; Influenza Vaccines ; Influenza, Human/prevention & control ; Whooping Cough/prevention & control ; Intention ; Cross-Sectional Studies ; Health Knowledge, Attitudes, Practice ; COVID-19/prevention & control ; Pertussis Vaccine/therapeutic use ; Vaccination ; Respiratory Syncytial Virus, Human ; Surveys and Questionnaires
Chemical Substances	Influenza Vaccines ; Pertussis Vaccine
Language	English
Publishing date	2023-11-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.10.067
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Maternal immunization in women living with HIV.

Dauby, Nicolas / Gagneux-Brunon, Amandine / Martin, Charlotte / Mussi-Pinhata, Marisa Márcia / Goetghebuer, Tessa

AIDS (London, England)

2023 Volume 38, Issue 2, Page(s) 137–144

Abstract: Thanks to widespread use of antiretroviral therapy worldwide, women living with HIV (WLWH) are becoming pregnant and giving birth to HIV-exposed but uninfected (HEU) newborns. Both pregnancy and HIV infection-related factors such as low CD4+ T-cell count ...

Abstract	Thanks to widespread use of antiretroviral therapy worldwide, women living with HIV (WLWH) are becoming pregnant and giving birth to HIV-exposed but uninfected (HEU) newborns. Both pregnancy and HIV infection-related factors such as low CD4+ T-cell count or uncontrolled viral load increase the risk of severe infections such as influenza, COVID-19, and others, making maternal immunization a valuable tool to decrease maternal morbidity among WLWH. Vaccines administered during pregnancy may also benefit the health of HEU infants. Indeed, HEU infants suffer from higher risk of morbidity of infectious origin, including respiratory syncytial virus (RSV), group B streptococcus (GBS), pneumococcus and pertussis infections. Maternal pertussis immunization is recommended in various high-income countries but not in many low-middle income countries where HIV prevalence is higher. GBS and RSV vaccines to be administered during pregnancy are currently in late-phase clinical trials in HIV-uninfected women and could represent a valuable tool to decrease morbidity during infancy. Decreased transfer of vaccine-specific IgG, accelerated waning of vaccine-induced antibody responses, linked to persistent maternal immune activation, and blunting of infant immune response to vaccines could hamper vaccine effectiveness among WLWH and HEU infants. Vaccine hesitancy could limit benefits of maternal immunization and strategies to tackle vaccine hesitancy should be part of HIV routine care. The aim of this review is to summarize the current knowledge regarding the immunogenicity and efficacy of available and upcoming vaccines recommended during pregnancy of WLWH.
MeSH term(s)	Female ; Humans ; Infant ; Infant, Newborn ; Pregnancy ; HIV Infections/epidemiology ; Immunization ; Influenza Vaccines ; Vaccination ; Whooping Cough ; Mothers
Chemical Substances	Influenza Vaccines
Language	English
Publishing date	2023-12-20
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/QAD.0000000000003758
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Zs.A 2228: Show issues

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Article ; Online: Are the conditions met to make COVID-19 vaccination mandatory for healthcare professionals?

Gagneux-Brunon, Amandine / Botelho-Nevers, Elisabeth / Launay, Odile

Infectious diseases now

2021 Volume 51, Issue 6, Page(s) 507–509

MeSH term(s)	COVID-19/prevention & control ; COVID-19 Vaccines/therapeutic use ; Cross Infection/prevention & control ; Delivery of Health Care ; Health Personnel ; Humans ; Mandatory Programs ; SARS-CoV-2 ; Vaccination/methods ; Vaccination Refusal
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2021-06-16
Publishing country	France
Document type	Editorial
ISSN	2666-9919
ISSN (online)	2666-9919
DOI	10.1016/j.idnow.2021.06.301
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Midwives’ attitudes toward participation of pregnant individuals in a preventive vaccine hypothetical clinical trial

Gagneux-Brunon, Amandine / Guyot, Emilie / Detoc, Maëlle / Botelho-Nevers, Elisabeth / Raia-Barjat, Tiphaïne

Vaccine. 2022 July 29,

2022

Abstract: Pregnant individuals are frequently excluded from clinical trials. Yet, inclusion of Pregnant individuals is of interest in vaccinology including during health crisis. Promotion of clinical trials by midwives may facilitate the decision making of ... ...

Abstract	Pregnant individuals are frequently excluded from clinical trials. Yet, inclusion of Pregnant individuals is of interest in vaccinology including during health crisis. Promotion of clinical trials by midwives may facilitate the decision making of Pregnant individuals. Attitudes of midwives about pregnant individuals participation in a vaccine clinical trial have been little explored. We conducted an anonymous survey from the 11th of September to the 11th of November 2020. Primary endpoint was the willingness to encourage Pregnant individuals to participate in a hypothetical respiratory syncytial virus (RSV) vaccine clinical trial. Among 398 midwives who answered the questionnaire, 113 (28.3 %) were likely to encourage Pregnant individuals to participate in the vaccine clinical trial, this proportion ranged from 25 % in senior midwives to 34.5 % among the students. After adjustment on age, parenthood, previous personal attitudes of vaccine hesitancy, and psychological antecedents of vaccinations (5C-model), the only predictor of the promotion of the clinical trial was the experience of vaccine education (evaluated by a 20-point score) with an adjusted odds ratio of 1.09 (1.01–1.18, p = 0.027) for a one-point increase. Vaccine hesitancy and psychological antecedents of vaccinations were not associated with a lower promotion of pregnant individuals trial participation by midwives. Few respondents were likely to encourage Pregnant individuals to participate in a vaccine clinical trial. Midwives who considered themselves to have a good training about vaccines were more prone to encourage Pregnant individuals to participate in a RSV vaccine clinical trial.
Keywords	Respiratory syncytial virus ; clinical trials ; education ; odds ratio ; parenting ; questionnaires ; surveys ; vaccine development ; vaccines
Language	English
Dates of publication	2022-0729
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2022.07.049
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Mandatory COVID-19 vaccination for healthcare personnel in the era of new SARS-CoV-2 variants.

Maltezou, Helena C / Ledda, Caterina / Gagneux-Brunon, Amandine / Botelho-Nevers, Elisabeth

Vaccine

2022 Volume 40, Issue 50, Page(s) 7167–7169

MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19 Vaccines ; COVID-19/prevention & control ; Vaccination ; Delivery of Health Care
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-10-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2022.10.053
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Midwives' attitudes toward participation of pregnant individuals in a preventive vaccine hypothetical clinical trial.

Gagneux-Brunon, Amandine / Guyot, Emilie / Detoc, Maëlle / Botelho-Nevers, Elisabeth / Raia-Barjat, Tiphaïne

Vaccine

2022 Volume 40, Issue 37, Page(s) 5459–5463

Abstract: Introduction: Pregnant individuals are frequently excluded from clinical trials. Yet, inclusion of Pregnant individuals is of interest in vaccinology including during health crisis. Promotion of clinical trials by midwives may facilitate the decision ... ...

Abstract	Introduction: Pregnant individuals are frequently excluded from clinical trials. Yet, inclusion of Pregnant individuals is of interest in vaccinology including during health crisis. Promotion of clinical trials by midwives may facilitate the decision making of Pregnant individuals. Attitudes of midwives about pregnant individuals participation in a vaccine clinical trial have been little explored. Methods: We conducted an anonymous survey from the 11th of September to the 11th of November 2020. Primary endpoint was the willingness to encourage Pregnant individuals to participate in a hypothetical respiratory syncytial virus (RSV) vaccine clinical trial. Results: Among 398 midwives who answered the questionnaire, 113 (28.3 %) were likely to encourage Pregnant individuals to participate in the vaccine clinical trial, this proportion ranged from 25 % in senior midwives to 34.5 % among the students. After adjustment on age, parenthood, previous personal attitudes of vaccine hesitancy, and psychological antecedents of vaccinations (5C-model), the only predictor of the promotion of the clinical trial was the experience of vaccine education (evaluated by a 20-point score) with an adjusted odds ratio of 1.09 (1.01-1.18, p = 0.027) for a one-point increase. Vaccine hesitancy and psychological antecedents of vaccinations were not associated with a lower promotion of pregnant individuals trial participation by midwives. Conclusion: Few respondents were likely to encourage Pregnant individuals to participate in a vaccine clinical trial. Midwives who considered themselves to have a good training about vaccines were more prone to encourage Pregnant individuals to participate in a RSV vaccine clinical trial.
MeSH term(s)	Female ; Health Knowledge, Attitudes, Practice ; Humans ; Midwifery ; Pregnancy ; Respiratory Syncytial Virus Vaccines ; Surveys and Questionnaires ; Vaccination/psychology
Chemical Substances	Respiratory Syncytial Virus Vaccines
Language	English
Publishing date	2022-08-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2022.07.049
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Vaccination contre la grippe, le pneumocoque et le zona chez les sujets âgés Enquête menée autour des médecins prescripteurs : état des lieux des connaissances et identification des freins à la prescription de la vaccination.

Leman, Mélanie / Devun, Amandine / Botelho-Nevers, Elisabeth / Spiga, Radia / Lafaie, Ludovic / Gagneux-Brunon, Amandine / Celarier, Thomas

Geriatrie et psychologie neuropsychiatrie du vieillissement

2023 Volume 21, Issue 3, Page(s) 319–329

Abstract: Vaccination coverage is insufficient for influenza, pneumococcus, and herpes zoster in people over the age of 65 in France, even though these are common infectious diseases. Using a computerised questionnaire, the aim of our study was to assess the ... ...

Title translation	Vaccination against influenza, pneumococcus and herpes zoster in the elderly Survey of prescribing physicians: assessment of knowledge and identification of obstacles to the prescription of vaccination.
Abstract	Vaccination coverage is insufficient for influenza, pneumococcus, and herpes zoster in people over the age of 65 in France, even though these are common infectious diseases. Using a computerised questionnaire, the aim of our study was to assess the knowledge of general practitioners, geriatricians, infectious diseases specialists and interns in the Loire region about the vaccination against these three diseases in elderly subjects, to identify the obstacles to vaccination, and to evaluate whether the provision of knowledge modifies the prescriptions and vaccination recommendations made to patients. Of the 125 responses from doctors and interns, 90.2 % are correct for influenza, 69.2 % for pneumococcus, and 32.8 % for herpes zoster, with no significant difference between specialities. By providing information, practitioners are more willing to vaccinate their patients against influenza (99 %), pneumococcus (93 %), and herpes zoster (39 %). The main obstacles to vaccination are the patient's refusal (85 %), the doctor's lack of knowledge and time (70 % and 41 % respectively), doubts about the vaccine's effectiveness (28 %), and fear of side effects (21 %).
MeSH term(s)	Humans ; Aged ; Influenza, Human/prevention & control ; Streptococcus pneumoniae ; Influenza Vaccines ; Herpes Zoster/prevention & control ; Vaccination ; Surveys and Questionnaires ; General Practitioners ; Communicable Diseases ; Prescriptions ; Herpes Zoster Vaccine ; Pneumococcal Vaccines
Chemical Substances	Influenza Vaccines ; Herpes Zoster Vaccine ; Pneumococcal Vaccines
Language	French
Publishing date	2023-12-14
Publishing country	France
Document type	English Abstract ; Journal Article
ISSN	2115-7863
ISSN (online)	2115-7863
DOI	10.1684/pnv.2023.1111
Database	MEDical Literature Analysis and Retrieval System OnLINE

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