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  1. Article: Prevalence of Dyslipidemia in Ischemic Stroke Patients: A Single-Center Prospective Study From Pakistan.

    Khan, Raja Sheraz Ullah / Nawaz, Mehwish / Khan, Sarfaraz / Raza, Hassan Ali / Nazir, Talha / Anwar, Muhammad Saad / Nadeem, Hafiz Muhammad Faisal / Rehman, Zia Ur / Akram, Amina

    Cureus

    2022  Volume 14, Issue 6, Page(s) e25880

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2022-06-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.25880
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Development and Characterization of Drug Loaded PVA/PCL Fibres for Wound Dressing Applications.

    Afzal, Ali / Jalalah, Mohammed / Noor, Abid / Khaliq, Zubair / Qadir, Muhammad Bilal / Masood, Rashid / Nazir, Ahsan / Ahmad, Sheraz / Ahmad, Faheem / Irfan, Muhammad / Afzal, Munazza / Faisal, Mohd / Alsareii, Saeed A / Harraz, Farid A

    Polymers

    2023  Volume 15, Issue 6

    Abstract: Nowadays, synthetic polymers are used in medical applications due to their special biodegradable, biocompatible, hydrophilic, and non-toxic properties. The materials, which can be used for wound dressing fabrication with controlled drug release profile, ... ...

    Abstract Nowadays, synthetic polymers are used in medical applications due to their special biodegradable, biocompatible, hydrophilic, and non-toxic properties. The materials, which can be used for wound dressing fabrication with controlled drug release profile, are the need of the time. The main aim of this study was to develop and characterize polyvinyl alcohol/polycaprolactone (PVA/PCL) fibres containing a model drug. A dope solution comprising PVA/PCL with the drug was extruded into a coagulation bath and became solidified. The developed PVA/PCL fibres were then rinsed and dried. These fibres were tested for Fourier transform infrared spectroscopy, linear density, topographic analysis, tensile properties, liquid absorption, swelling behaviour, degradation, antimicrobial activity, and drug release profile for improved and better healing of the wound. From the results, it was concluded that PVA/PCL fibres containing a model drug can be produced by using the wet spinning technique and have respectable tensile properties; adequate liquid absorption, swelling %, and degradation %; and good antimicrobial activity with the controlled drug release profile of the model drug for wound dressing applications.
    Language English
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15061355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Biostial iatrogenic coronary artery stenosis: a rare complication of aortic valve surgery successfully treated with percutaneous coronary stenting.

    Nazir, Sheraz A / Sarfraz, Sanaa / Krishnamoorthy, Suresh / Tapp, Luke

    Interactive cardiovascular and thoracic surgery

    2019  Volume 28, Issue 6, Page(s) 996–998

    Abstract: A 66-year-old woman presented 4 months after conventional surgical aortic valve replacement with an acute coronary syndrome resulting from rare iatrogenic biostial left main and right coronary artery stenoses, which were successfully treated with ... ...

    Abstract A 66-year-old woman presented 4 months after conventional surgical aortic valve replacement with an acute coronary syndrome resulting from rare iatrogenic biostial left main and right coronary artery stenoses, which were successfully treated with percutaneous coronary stenting, optimized by intracoronary imaging.
    MeSH term(s) Aged ; Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Coronary Angiography ; Coronary Stenosis/diagnosis ; Coronary Stenosis/etiology ; Coronary Stenosis/surgery ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery ; Female ; Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Iatrogenic Disease ; Percutaneous Coronary Intervention/methods ; Postoperative Complications ; Rare Diseases ; Stents ; Ultrasonography, Interventional
    Language English
    Publishing date 2019-01-30
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2095298-3
    ISSN 1569-9285 ; 1569-9293
    ISSN (online) 1569-9285
    ISSN 1569-9293
    DOI 10.1093/icvts/ivy359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Development and Characterization of Drug Loaded PVA/PCL Fibres for Wound Dressing Applications

    Ali Afzal / Mohammed Jalalah / Abid Noor / Zubair Khaliq / Muhammad Bilal Qadir / Rashid Masood / Ahsan Nazir / Sheraz Ahmad / Faheem Ahmad / Muhammad Irfan / Munazza Afzal / Mohd Faisal / Saeed A. Alsareii / Farid A. Harraz

    Polymers, Vol 15, Iss 1355, p

    2023  Volume 1355

    Abstract: Nowadays, synthetic polymers are used in medical applications due to their special biodegradable, biocompatible, hydrophilic, and non-toxic properties. The materials, which can be used for wound dressing fabrication with controlled drug release profile, ... ...

    Abstract Nowadays, synthetic polymers are used in medical applications due to their special biodegradable, biocompatible, hydrophilic, and non-toxic properties. The materials, which can be used for wound dressing fabrication with controlled drug release profile, are the need of the time. The main aim of this study was to develop and characterize polyvinyl alcohol/polycaprolactone (PVA/PCL) fibres containing a model drug. A dope solution comprising PVA/PCL with the drug was extruded into a coagulation bath and became solidified. The developed PVA/PCL fibres were then rinsed and dried. These fibres were tested for Fourier transform infrared spectroscopy, linear density, topographic analysis, tensile properties, liquid absorption, swelling behaviour, degradation, antimicrobial activity, and drug release profile for improved and better healing of the wound. From the results, it was concluded that PVA/PCL fibres containing a model drug can be produced by using the wet spinning technique and have respectable tensile properties; adequate liquid absorption, swelling %, and degradation %; and good antimicrobial activity with the controlled drug release profile of the model drug for wound dressing applications.
    Keywords antimicrobial ; drug release ; medical ; polycaprolactone ; wound dressing ; Organic chemistry ; QD241-441
    Subject code 660
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Inter-study repeatability of circumferential strain and diastolic strain rate by CMR tagging, feature tracking and tissue tracking in ST-segment elevation myocardial infarction.

    Nazir, Sheraz A / Shetye, Abhishek M / Khan, Jamal N / Singh, Anvesha / Arnold, Jayanth R / Squire, Iain / McCann, Gerry P

    The international journal of cardiovascular imaging

    2020  Volume 36, Issue 6, Page(s) 1133–1146

    Abstract: Strain assessment allows accurate evaluation of myocardial function and mechanics in ST-segment elevation myocardial infarction (STEMI). Strain using cardiovascular magnetic resonance (CMR) has traditionally been assessed with tagging but limitations of ... ...

    Abstract Strain assessment allows accurate evaluation of myocardial function and mechanics in ST-segment elevation myocardial infarction (STEMI). Strain using cardiovascular magnetic resonance (CMR) has traditionally been assessed with tagging but limitations of this technique have led to more widespread use of alternative methods, which may be more robust. We compared the inter-study repeatability of circumferential global peak-systolic strain (Ecc) and peak-early diastolic strain rate (PEDSR) derived by tagging with values obtained using novel cine-based software: Feature Tracking (FT) (TomTec, Germany) and Tissue Tracking (TT) (Circle cvi
    MeSH term(s) Female ; Heart/diagnostic imaging ; Heart/physiology ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Predictive Value of Tests ; Reproducibility of Results ; ST Elevation Myocardial Infarction/diagnostic imaging ; ST Elevation Myocardial Infarction/physiopathology ; Systole
    Language English
    Publishing date 2020-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2055311-0
    ISSN 1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
    ISSN (online) 1875-8312 ; 1573-0743
    ISSN 1569-5794 ; 0167-9899
    DOI 10.1007/s10554-020-01806-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Effects of late, repetitive remote ischaemic conditioning on myocardial strain in patients with acute myocardial infarction.

    Arnold, J Ranjit / P Vanezis, Andrew / Rodrigo, Glenn C / Lai, Florence Y / Kanagala, Prathap / Nazir, Sheraz / Khan, Jamal N / Ng, Leong / Chitkara, Kamal / Coghlan, J Gerry / Hetherington, Simon / Samani, Nilesh J / McCann, Gerald P

    Basic research in cardiology

    2022  Volume 117, Issue 1, Page(s) 23

    Abstract: Late, repetitive or chronic remote ischaemic conditioning (CRIC) is a potential cardioprotective strategy against adverse remodelling following ST-segment elevation myocardial infarction (STEMI). In the randomised Daily Remote Ischaemic Conditioning ... ...

    Abstract Late, repetitive or chronic remote ischaemic conditioning (CRIC) is a potential cardioprotective strategy against adverse remodelling following ST-segment elevation myocardial infarction (STEMI). In the randomised Daily Remote Ischaemic Conditioning Following Acute Myocardial Infarction (DREAM) trial, CRIC following primary percutaneous coronary intervention (P-PCI) did not improve global left ventricular (LV) systolic function. A post-hoc analysis was performed to determine whether CRIC improved regional strain. All 73 patients completing the original trial were studied (38 receiving 4 weeks' daily CRIC, 35 controls receiving sham conditioning). Patients underwent cardiovascular magnetic resonance at baseline (5-7 days post-STEMI) and after 4 months, with assessment of LV systolic function, infarct size and strain (longitudinal/circumferential, in infarct-related and remote territories). At both timepoints, there were no significant between-group differences in global indices (LV ejection fraction, infarct size, longitudinal/circumferential strain). However, regional analysis revealed a significant improvement in longitudinal strain in the infarcted segments of the CRIC group (from - 16.2 ± 5.2 at baseline to - 18.7 ± 6.3 at follow up, p = 0.0006) but not in corresponding segments of the control group (from - 15.5 ± 4.0 to - 15.2 ± 4.7, p = 0.81; for change: - 2.5 ± 3.6 versus + 0.3 ± 5.6, respectively, p = 0.027). In remote territories, there was a lower increment in subendocardial circumferential strain in the CRIC group than in controls (- 1.2 ± 4.4 versus - 2.5 ± 4.0, p = 0.038). In summary, CRIC following P-PCI for STEMI is associated with improved longitudinal strain in infarct-related segments, and an attenuated increase in circumferential strain in remote segments. Further work is needed to establish whether these changes may translate into a reduced incidence of adverse remodelling and clinical events. Clinical Trial Registration: http://clinicaltrials.gov/show/NCT01664611 .
    MeSH term(s) Humans ; Percutaneous Coronary Intervention/adverse effects ; ST Elevation Myocardial Infarction/therapy ; Stroke Volume ; Treatment Outcome ; Ventricular Function, Left
    Language English
    Publishing date 2022-04-23
    Publishing country Germany
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 189755-x
    ISSN 1435-1803 ; 0300-8428 ; 0175-9418
    ISSN (online) 1435-1803
    ISSN 0300-8428 ; 0175-9418
    DOI 10.1007/s00395-022-00926-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Implementation of more sensitive cardiac troponin T assay in a state-wide health service.

    Khan, Ehsan / Lambrakis, Kristina / Nazir, Sheraz A / Chuang, Anthony / Halabi, Amera / Tiver, Kathryn / Briffa, Tom / Cullen, Louise A / Horsfall, Matthew / French, John K / Sun, Benjamin C / Chew, Derek P

    International journal of cardiology

    2021  Volume 347, Page(s) 66–72

    Abstract: Aims: Explore the impact of deploying high-sensitivity (hs) cardiac troponin T (cTnT) assay across a state-wide health service.: Methods and results: Presentations to emergency departments of six tertiary hospitals between January 2008 and August ... ...

    Abstract Aims: Explore the impact of deploying high-sensitivity (hs) cardiac troponin T (cTnT) assay across a state-wide health service.
    Methods and results: Presentations to emergency departments of six tertiary hospitals between January 2008 and August 2019 were included; standard cTnT assay was superseded by hs-cTnT in June 2011 without changing the reference range (≥30 ng/L reported as elevated), despite cTnT level of 30 ng/L being equivalent to ∼44 ng/L with hs-cTnT. Clinical outcomes were captured using state-wide linked health records. Interrupted time series analyses were used adjusted for seasonality and multiple co-morbidities using propensity score matching allowing for correlation within hospitals. In total, 614,847 presentations had ≥1 troponin measurement. Clinical ordering of troponin decreased throughout the study with no increase in elevated measurements amongst those tested with hs-cTnT. Small but statistically significant changes in index myocardial infarction (MI) diagnosis (-0.36%/year, 95%CI [confidence interval]:-0.48, -0.24,p < 0.001) and invasive coronary angiography (0.12%/year,95%CI:0, 0.24,p = 0.02) were seen, with no impact on death/MI at 30 days or 3-year survival in episodes of care (EOCs) with elevated cTnT after hs-cTnT implementation. Length of stay (LOS) was shorter among those with an elevated hs-cTnT (-4.44 h/year, 95%CI:-5.27, -3.60, p < 0.001). Non-elevated cTnT EOCs demonstrated shorter total LOS and improved 3-year survival (adjusted hazard ratio:0.90, 95%CI:0.83, 0.97,p = 0.008) although death/MI at 30 days was unchanged using hs-cTnT.
    Conclusion: Widespread implementation of hs-cTnT without altering clinical thresholds reported to clinicians provided significantly shorter LOS without a clinically significant impact on clinical outcomes. A safer cohort with non-elevated cTnT was identified by hs-cTnT compared to the standard cTnT assay.
    MeSH term(s) Biomarkers ; Cohort Studies ; Coronary Angiography ; Emergency Service, Hospital ; Humans ; Myocardial Infarction/diagnosis ; Myocardial Infarction/epidemiology ; Troponin T
    Chemical Substances Biomarkers ; Troponin T
    Language English
    Publishing date 2021-11-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2021.11.013
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  8. Article ; Online: Response of Rice ( Oryza sativa L.) Cultivars to Variable Rate of Nitrogen under Wet Direct Seeding in Temperate Ecology

    Intikhab Aalum Jehangir / Ashaq Hussain / Shabir H. Wani / Syed Sheraz Mahdi / Mohammad Anwar Bhat / Manzoor A. Ganai / Najeeb R. Sofi / Nazir Ahmad Teeli / Waseem Raja / Walid Soufan / Akihiro Ueda / Milan Skalicky / Marian Brestic / Ayman EL Sabagh

    Sustainability, Vol 14, Iss 638, p

    2022  Volume 638

    Abstract: Transplanting rice appears to pose many problems, including depletion of freshwater reservoirs and competition for labor. Conversely, direct seeding allows us to overcome shortcomings associated with conventional transplanting. Nitrogen is a crucial ... ...

    Abstract Transplanting rice appears to pose many problems, including depletion of freshwater reservoirs and competition for labor. Conversely, direct seeding allows us to overcome shortcomings associated with conventional transplanting. Nitrogen is a crucial nutrient needed for plant growth and yield. Therefore, this study was executed to analyze the influence of nitrogen on the performance of rice genotypes grown by direct seeding in wet soil. The experiment comprised various rice cultivars, i.e., Shalimar Rice-1, Shalimar Rice-3, Shalimar Rice-4, and Jhelum, and nitrogen (N) levels, i.e., 0, 90, 120, and 150 kg/ha. Shalimar Rice-4 produced a maximum grain yield (6.39 t/ha), followed by Shalimar Rice-3 and Jhelum). The application of 150 kg N/ha showed maximum values for growth parameters, yield attributing traits, and grain yield (6.68 t/ha); however, it remained at par with 120 kg N/ha. Crop water productivity was highest in Shalimar Rice-4 (0.49 kg/m 3 ), and the same showed a consistent increase with increasing N levels from 0–150 kg/ha, with a comparable value of 0.49 to 0.51 recorded at 120 and 150 kg N/ha. Moreover, the Shalimar Rice-1 variety required the maximum in growing degree days (GDD) and helio-thermal units (HTU) to attain different phenological stages till physiological maturity (131 days). However, the cultivar Shalimar rice-4 (SR-4) performed better by registering significantly higher heat use efficiency (HUE) (4.44 kg/ha °C/day). Additionally, the highest net return and the benefit-cost ratio were registered by Shalimar Rice-4. B:C ratio of 1.75 was realized from application of 150 kg N/ha, which remained very close to that achieved with 120 kg N/ha. In conclusion, the rice cultivar Shalimar Rice-4 with the application of 120 kg N/ha could boost rice production under DSR in water-scarce regions of temperate northern India.
    Keywords direct seeded rice ; nitrogen ; rice ; water productivity ; temperate ecology ; yield ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 580
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Free breathing motion-corrected T1 mapping for robust assessment of myocardial injury post myocardial infarction.

    Nazir, Sheraz A / Khan, Jamal N / McCann, Gerry P

    The international journal of cardiovascular imaging

    2014  Volume 31, Issue 1, Page(s) 123–124

    MeSH term(s) Algorithms ; Contrast Media ; Edema, Cardiac/pathology ; Humans ; Image Interpretation, Computer-Assisted ; Inferior Wall Myocardial Infarction/pathology ; Inferior Wall Myocardial Infarction/therapy ; Magnetic Resonance Imaging ; Myocardial Reperfusion ; Myocardium/pathology ; Predictive Value of Tests ; Respiration ; Time Factors ; Treatment Outcome
    Chemical Substances Contrast Media
    Language English
    Publishing date 2014-07-19
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2055311-0
    ISSN 1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
    ISSN (online) 1875-8312 ; 1573-0743
    ISSN 1569-5794 ; 0167-9899
    DOI 10.1007/s10554-014-0500-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Association of life style and dietary habits with blood choline and cardiovascular outcome.

    Ali, Muhammad Asif / Nasir, Muhammad / Pasha, Talat Naseer / Javid, Imran / Ullah, Azmat / Iqbal, Muhammad Amir / Ahmed, Sheraz / Nazir, Muhammad Mudasser / Gondal, Tanweer Aslam / Imran, Muhammad / Sharifi-Rad, Javad / Mahomoodally, Mohamad Fawzi

    Cellular and molecular biology (Noisy-le-Grand, France)

    2020  Volume 66, Issue 4, Page(s) 178–183

    Abstract: Whole-blood choline, plasma choline and serum choline are emerging biomarkers in cardiovascular diseases (CVD). To examine the association of Whole-blood choline is an early predictor for cardiac events. In case control study, we enrolled 240 individuals ...

    Abstract Whole-blood choline, plasma choline and serum choline are emerging biomarkers in cardiovascular diseases (CVD). To examine the association of Whole-blood choline is an early predictor for cardiac events. In case control study, we enrolled 240 individuals including 120 normal (39 females and 82 males) and 120 cases (49 females and 71 males) where age limit was >40 years) Information through interviews, family disease history, 24 recall diet assessment and blood sampling. Odds ratios express the associated risks with CVD and without CVD patients. In healthy populations, good dietary habits and active lifestyle were observed. The number of participants with CVD were smokers than normal. In men, and women the risk was observed highly significant. (p=0.0049) Different blood parameters like Triglycerides, Uric Acid, Urea, Creatinine, CRP and ESR were non-significant observed. In females the low carbohydrates and high protein and frequent salad vegetable consumption observed. On the other hand, men consume more carbohydrates. Body mass index was significantly with p= 0.036 (OD 1.12 95% 1.00-1.26). The total fats (p=0.017) (OD 1.3301 95% 1.05-1.69) total carbohydrate (p=0.076) (OD 1.1536 95% 0.98-1.35) and total proteins (p=0.287) (OD 1.1456 95% 0.89-1.47) effecting respectively.  The Blood choline level was significant observed between cases (p=0.026) OD (0.944 95%0.89- 0.99).
    MeSH term(s) Adult ; Cardiovascular Diseases/blood ; Case-Control Studies ; Choline/blood ; Feeding Behavior ; Humans ; Life Style ; Risk Factors
    Chemical Substances Choline (N91BDP6H0X)
    Language English
    Publishing date 2020-06-25
    Publishing country France
    Document type Journal Article
    ZDB-ID 1161779-2
    ISSN 1165-158X ; 0145-5680
    ISSN (online) 1165-158X
    ISSN 0145-5680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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