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  1. Article ; Online: Predictors for the development of thromboembolic events in cancer patients treated with bevacizumab, ramucirumab, and aflibercept: a single-institution retrospective analysis.

    Kanbayashi, Yuko / Ishikawa, Takeshi / Otsuji, Eigo / Takayama, Koichi

    Oncology

    2024  

    Abstract: Introduction The risk of thromboembolic events developing limits the dose of anti-angiogenic agents, thereby reducing their efficacy. This retrospective study therefore sought to identify predictors for the development of anti-angiogenic agent-induced ... ...

    Abstract Introduction The risk of thromboembolic events developing limits the dose of anti-angiogenic agents, thereby reducing their efficacy. This retrospective study therefore sought to identify predictors for the development of anti-angiogenic agent-induced thromboembolic events and to elucidate whether differences in the likelihood of thromboembolic events exist between different anti-angiogenic agents or cancer types, to guide future strategies for optimizing safety, efficacy, and quality of life in patients receiving chemotherapy. Methods This study retrospectively investigated 468 cancer patients who received chemotherapy with bevacizumab, ramucirumab, or aflibercept at our outpatient chemotherapy center between December 2016 and April 2022. Variables related to the development of thromboembolic events were extracted from the medical records and multivariate logistic regression analysis was performed to identify predictors for the development of thromboembolic events. The Wilcoxon/Kruskal-Wallis test was used to detect significant differences between groups. Results Significant factors included serum albumin level (odds ratio [OR] = 0.363, 95% confidence interval [CI] = 0.193-0.685; P = 0.0017) and diabetes mellitus (OR = 5.356, 95%CI = 1.711-16.769; P = 0.0039). RAS inhibitors (OR = 0.307) had low OR, although it was not significant. No difference in the development of thromboembolic events was evident between cancer types (P = 0.0781), but differences were identified between the three anti-angiogenic agents (P = 0.0132). Ramucirumab was associated with a lower likelihood of thromboembolic events. Conclusion Serum albumin level and diabetes mellitus were identified as significant predictors for the development of anti-angiogenic agent-induced thromboembolic events. In addition, the likelihood of thromboembolic events did not differ between cancer types, but differed between antiangiogenic agents.
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 250101-6
    ISSN 1423-0232 ; 0030-2414
    ISSN (online) 1423-0232
    ISSN 0030-2414
    DOI 10.1159/000536187
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  2. Article ; Online: Reply to 'C-CAT's triumph in gastroenterology: the wisdom of cats is infinitely superior'.

    Sakakida, Tomoki / Ishikawa, Takeshi / Itoh, Yoshito

    Journal of gastroenterology

    2023  Volume 59, Issue 2, Page(s) 159

    MeSH term(s) Humans ; Gastroenterology ; Gastrointestinal Tract
    Language English
    Publishing date 2023-11-19
    Publishing country Japan
    Document type Letter ; Comment
    ZDB-ID 1186495-3
    ISSN 1435-5922 ; 0944-1174
    ISSN (online) 1435-5922
    ISSN 0944-1174
    DOI 10.1007/s00535-023-02062-y
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  3. Article ; Online: Implementation of the Time-Dependent Complete-Active-Space Self-Consistent-Field Method for Diatomic Molecules.

    Li, Yang / He, Feng / Sato, Takeshi / Ishikawa, Kenichi L

    The journal of physical chemistry. A

    2024  Volume 128, Issue 8, Page(s) 1523–1532

    Abstract: We present a computational approach that implements the time-dependent complete-active-space self-consistent-field method, as introduced in [Phys. Rev. A 88, 023402 (2013)]. Our implementation addresses the challenge of diatomic molecules subjected to an ...

    Abstract We present a computational approach that implements the time-dependent complete-active-space self-consistent-field method, as introduced in [Phys. Rev. A 88, 023402 (2013)]. Our implementation addresses the challenge of diatomic molecules subjected to an intense laser pulse by considering the full dimensionality of the problem using prolate spheroidal coordinates. The method incorporates the gauge-invariant frozen-core approximation, boosts the evaluation of the electron-electron interaction term using finite-element discrete-variable representation with Neumann expansion, and utilizes an exponential time differencing scheme tailored for the stable propagation of the stiff nonlinear orbital functions. We have successfully applied this methodology to study high-harmonic generation in diatomic molecules such as H
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.3c06799
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  4. Article ; Online: Real-Time Imaging of Single Retinal Cell Apoptosis in a Non-Human Primate Ocular Hypertension Model.

    Ishikawa, Takeshi / Kishi, Naoki / Shimizu, Yoshiko / Fujimura, Takao / Yamazaki, Takao

    Translational vision science & technology

    2024  Volume 13, Issue 1, Page(s) 20

    Abstract: Purpose: To evaluate the feasibility of using DARC (detection of apoptosing retinal cells) technology as a biomarker for preclinical assessment of glaucomatous damage in a non-human primate (NHP) model of ocular hypertension (OHT).: Methods: Elevated ...

    Abstract Purpose: To evaluate the feasibility of using DARC (detection of apoptosing retinal cells) technology as a biomarker for preclinical assessment of glaucomatous damage in a non-human primate (NHP) model of ocular hypertension (OHT).
    Methods: Elevated intraocular pressure (IOP) was induced by applying a laser to the trabecular meshwork in each eye of NHPs. Changes in DARC counts in the retina, identified as fluorescent-tagged annexin V (ANX776)-positive cells, were evaluated together with optic nerve damage, assessed using spectral domain-optical coherence tomography. The pharmacokinetic properties of ANX776 in both healthy and OHT model monkeys were also examined.
    Results: Sustained elevation of IOP and subsequent thinning of the retinal nerve fiber layer thickness (RNFLT) around the optic nerve head were confirmed in the OHT model. Increases in DARC counts were also detected after IOP elevation. We identified a statistically significant relationship between cumulative DARC counts and reductions in RNFLT both globally and in each peripapillary sector. Intravenous administration of ANX776 increased blood annexin V in a dose-dependent manner, which was subsequently eliminated.
    Conclusions: This study revealed that DARC technology can effectively assess glaucomatous damage in an NHP OHT model. We obtained the fundamental data that could serve as a reference for developing preclinical models to evaluate the pharmacodynamics of neuroprotective agents using DARC technology in NHP OHT models.
    Translational relevance: Our basic data in a monkey OHT model could be useful for future preclinical studies using DARC technology to estimate the pharmacodynamic response of neuroprotective agents.
    MeSH term(s) Animals ; Annexin A5 ; Neuroprotective Agents ; Glaucoma ; Ocular Hypertension ; Primates ; Apoptosis
    Chemical Substances Annexin A5 ; Neuroprotective Agents
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2674602-5
    ISSN 2164-2591 ; 2164-2591
    ISSN (online) 2164-2591
    ISSN 2164-2591
    DOI 10.1167/tvst.13.1.20
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  5. Article ; Online: Use of Erfgau Potential for Simulations of Multielectron Dynamics in Intense Laser Pulses.

    Orimo, Yuki / Sato, Takeshi / Ishikawa, Kenichi L

    The journal of physical chemistry. A

    2023  Volume 127, Issue 49, Page(s) 10499–10505

    Abstract: We propose the use of the erfgau potential as a smooth alternative to the pure Coulomb potential between nuclei and electrons in simulating the dynamics of electrons within atoms and molecules driven by high-intensity laser pulses. Even without the ... ...

    Abstract We propose the use of the erfgau potential as a smooth alternative to the pure Coulomb potential between nuclei and electrons in simulating the dynamics of electrons within atoms and molecules driven by high-intensity laser pulses. Even without the sophistication of pseudopotentials, by utilizing a well-designed simple approximate potential, it is possible to make the simulations computationally less demanding while keeping accuracy. By employing the erfgau potential designed for the stationary state of hydrogen-like atoms, we demonstrate that it is possible to simulate not only the high harmonic generation from a hydrogen atom but also that of multielectron systems, including molecules.
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.3c06530
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  6. Article ; Online: Visualization of the Interfacial Electrostatic Complementarity: A Method for Analysis of Protein-Protein Interaction Based on

    Ozono, Hiroki / Ishikawa, Takeshi

    Journal of chemical theory and computation

    2021  Volume 17, Issue 9, Page(s) 5600–5610

    Abstract: In this study, we report a method for analyzing the protein-protein interaction based ... ...

    Abstract In this study, we report a method for analyzing the protein-protein interaction based on
    MeSH term(s) Models, Molecular ; Protein Binding ; Proteins/chemistry ; Quantum Theory ; Static Electricity
    Chemical Substances Proteins
    Language English
    Publishing date 2021-08-25
    Publishing country United States
    Document type Journal Article
    ISSN 1549-9626
    ISSN (online) 1549-9626
    DOI 10.1021/acs.jctc.1c00475
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  7. Article: Smoothness of gait in healthy older females and patients with postoperative proximal femur fracture.

    Shimamura, Takeshi / Ishikawa, Hitoshi / Fujii, Hiromi / Katoh, Hiroshi

    Journal of physical therapy science

    2023  Volume 35, Issue 12, Page(s) 796–801

    Abstract: Purpose] This study aimed to investigate the usefulness of a quality index in gait for proximal femur fractures. [Participants and Methods] In this study, 20 females with postoperative proximal femur fracture in the preparation phase for discharge ( ... ...

    Abstract [Purpose] This study aimed to investigate the usefulness of a quality index in gait for proximal femur fractures. [Participants and Methods] In this study, 20 females with postoperative proximal femur fracture in the preparation phase for discharge (femur fracture group) aged ≥60 years (63.0 ± 3.0 years) and 20 healthy older females (healthy group) participated (75.7 ± 7.7 years) (n=40). Measurements were conducted at comfortable and maximal gait speeds. Power spectrum entropy (PSE), harmonic ratio (HR), and modified HR (mHR), which are smoothness indices, were calculated from the measured data in each of the three axial directions and compared. [Results] The healthy and femur fracture groups showed significant differences in the PSE, HR, and mHR for comfortable and maximal gait speed in the lateral and vertical directions. Furthermore, all directions between the HR and mHR in the femur fracture group had significant differences. [Conclusion] The usefulness of the PSE, HR, and mHR as quality evaluation indices of gait was demonstrated in patients with postoperative femur fractures after unilateral disability.
    Language English
    Publishing date 2023-12-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2038898-6
    ISSN 0915-5287
    ISSN 0915-5287
    DOI 10.1589/jpts.35.796
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  8. Article ; Online: Smoothness Evaluation Indices during Sit-to-Stand-to-Sit Motions in Healthy Older Females and after Hip Fracture Using an Accelerometer: A Pilot Study.

    Shimamura, Takeshi / Ishikawa, Hitoshi / Fujii, Hiromi / Katoh, Hiroshi

    Geriatrics (Basel, Switzerland)

    2023  Volume 8, Issue 5

    Abstract: Background: Studies that quantify the quality of sit-to-stand-to-sit (STS) motions, particularly in terms of smoothness, are limited. Thus, this study aimed to investigate the possibility and usefulness of quality evaluation during STS motions.: ... ...

    Abstract Background: Studies that quantify the quality of sit-to-stand-to-sit (STS) motions, particularly in terms of smoothness, are limited. Thus, this study aimed to investigate the possibility and usefulness of quality evaluation during STS motions.
    Methods: This cross-sectional study enrolled 36 females aged >60 years, including 18 females each in the healthy and hip fracture groups. Measurements were performed at two different speeds: five STS as fast as possible (STSF) and two seconds for each motion (STS2s). Indices of smoothness, including harmonic ratio (HR) and power spectrum entropy (PSE), were calculated and compared from the measured data in each of the three axial directions.
    Results: HR in the vertical direction was significantly higher in the healthy group (STSF: 3.65 ± 1.74, STS2s: 3.42 ± 1.54) than in the hip fracture group (STSF: 2.67 ± 1.01, STS2s: 2.58 ± 0.83) for STSF and STS2s. Furthermore, PSE for all directions and triaxial composites were significantly lower for STS2s (the healthy group (mediolateral (ML): 7.63 ± 0.31, vertical (VT): 7.46 ± 0.22, anterior-posterior (AP): 7.47 ± 0.15, triaxial: 7.45 ± 0.25), the hip fracture group (ML: 7.82 ± 0.16, VT: 7.63 ± 0.16, AP: 7.61 ± 0.17, triaxial: 7.66 ± 0.17)).
    Conclusions: This study suggests the usefulness of HR and PSE as quality evaluations for STS motions.
    Language English
    Publishing date 2023-10-01
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2308-3417
    ISSN (online) 2308-3417
    DOI 10.3390/geriatrics8050098
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  9. Article ; Online: Adult-onset leukoencephalopathy with axonal spheroids and pigmental glia with diffuse cerebral microbleeds: case report.

    Ishikawa, Ryo / Wada, Ken / Ikeuchi, Takeshi

    Acta neurologica Belgica

    2022  Volume 123, Issue 2, Page(s) 739–741

    MeSH term(s) Adult ; Humans ; Neuroglia ; Leukoencephalopathies/complications ; Leukoencephalopathies/diagnostic imaging ; Cerebral Hemorrhage/diagnostic imaging ; Mutation
    Language English
    Publishing date 2022-10-07
    Publishing country Italy
    Document type Case Reports ; Letter
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-022-02110-z
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  10. Article ; Online: A novel GABAergic population in the medial vestibular nucleus maintains wakefulness and gates rapid eye movement sleep.

    Nakatsuka, Daiki / Kanda, Takeshi / Sato, Makito / Ishikawa, Yukiko / Cherasse, Yoan / Yanagisawa, Masashi

    iScience

    2024  Volume 27, Issue 3, Page(s) 109289

    Abstract: Body rocking can either induce sleep or arousal. That is, the vestibular sense influences sleep-wake states. Neuronal interactions between sleep-wake systems and vestibular systems, however, remain unclear. In this study, we found that GABAergic neurons ... ...

    Abstract Body rocking can either induce sleep or arousal. That is, the vestibular sense influences sleep-wake states. Neuronal interactions between sleep-wake systems and vestibular systems, however, remain unclear. In this study, we found that GABAergic neurons in the lateral part of the medial vestibular nucleus (LMVN), a primary vestibular afferent projection site, control sleep-wake states. Specific inhibition of LMVN GABAergic neurons revealed that the firing of LMVN GABAergic neurons underlies stable wakefulness and smooth transitions from non-rapid-eye-movement (NREM) sleep to rapid eye movement (REM) sleep and that LMVN GABAergic neurons do not affect body balance control in freely moving conditions. Selective axonal tracing of LMVN GABAergic neurons indicated that LMVN GABAergic neurons send axons not only to areas involved in vestibular and oculomotor functions but also to areas regulating sleep-wake states. Our findings suggest that LMVN GABAergic neurons stabilize wakefulness and gate the entry into REM sleep through the use of vestibular information.
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109289
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