LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 37

Search options

  1. Book ; Online: Molecular Docking

    Salih Istifli, Erman

    Recent Advances

    (Biomedical Engineering ; 15)

    2023  

    Series title Biomedical Engineering ; 15
    Keywords Molecular biology ; Biology, life sciences
    Language English
    Size 1 electronic resource (182 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030383293
    ISBN 9781803564692 ; 1803564695
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Book ; Online: Lymphocytes

    Salih Istifli, Erman / Basri İla, Hasan

    2019  

    Keywords Haematology ; inflammation, immunity, asbestos, silica, malignancy, bone marrow
    Language English
    Size 1 electronic resource (124 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030645677
    ISBN 9781838817497 ; 1838817492
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Book ; Online: Cytotoxicity

    Salih Istifli, Erman / Basri Ila, Hasan

    Definition, Identification, and Cytotoxic Compounds

    2019  

    Keywords Medical toxicology ; breast cancer, nanoparticles, essential oils, flavonoids, natural products, dna damage
    Language English
    Size 1 electronic resource (118 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030645279
    ISBN 9781839622861 ; 1839622865
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Chemical Composition, Antioxidant and Enzyme Inhibitory Activities of

    Istifli, Erman Salih

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 10

    Abstract: The aim of this study was to investigate the chemical composition, antioxidant and enzyme inhibitory activities of methanol (MeOH) extracts ... ...

    Abstract The aim of this study was to investigate the chemical composition, antioxidant and enzyme inhibitory activities of methanol (MeOH) extracts from
    MeSH term(s) Antioxidants/pharmacology ; Boraginaceae/chemistry ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Free Radical Scavengers/pharmacology ; Molecular Docking Simulation ; Phytochemicals/pharmacology ; Plant Extracts/pharmacology ; Thermodynamics
    Chemical Substances Antioxidants ; Enzyme Inhibitors ; Free Radical Scavengers ; Phytochemicals ; Plant Extracts
    Language English
    Publishing date 2021-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26102981
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Chemical Composition, Antioxidant and Enzyme Inhibitory Activities of Onosma bourgaei and Onosma trachytricha and in Silico Molecular Docking Analysis of Dominant Compounds

    Erman Salih Istifli

    Molecules, Vol 26, Iss 2981, p

    2021  Volume 2981

    Abstract: The aim of this study was to investigate the chemical composition, antioxidant and enzyme inhibitory activities of methanol (MeOH) extracts from Onosma bourgaei (Boiss.) and O. trachytricha (Boiss.). In addition, the interactions between phytochemicals ... ...

    Abstract The aim of this study was to investigate the chemical composition, antioxidant and enzyme inhibitory activities of methanol (MeOH) extracts from Onosma bourgaei (Boiss.) and O. trachytricha (Boiss.). In addition, the interactions between phytochemicals found in extracts in high amounts and the target enzymes in question were revealed at the molecular scale by performing in silico molecular docking simulations. While the total amount of flavonoid compounds was higher in O. bourgaei , O. trachytricha was richer in phenolics. Chromatographic analysis showed that the major compounds of the extracts were luteolin 7-glucoside, apigenin 7-glucoside and rosmarinic acid. With the exception of the ferrous ion chelating assay, O. trachytricha exhibited higher antioxidant activity than O. bourgaei . O. bourgaei exhibited also slightly higher activity on digestive enzymes. The inhibitory activities of the Onosma species on tyrosinase were almost equal. In addition, the inhibitory activities of the extracts on acetylcholinesterase (AChE) were stronger than the activity on butyrylcholinesterase (BChE). Molecular docking simulations revealed that luteolin 7-glucoside and apigenin 7-glucoside have particularly strong binding affinities against ChEs, tyrosinase, α-amylase and α-glucosidase when compared with co-crystallized inhibitors. Therefore, it was concluded that the compounds in question could act as effective inhibitors on cholinesterases, tyrosinase and digestive enzymes.
    Keywords Onosma bourgaei ; Onosma trachytricha ; LC-MS/MS ; antioxidant ; enzyme inhibition ; molecular docking ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Correction to: Genotoxic and cytotoxic effects of pethoxamid herbicide on Allium cepa cells and its molecular docking studies to unravel genotoxicity mechanism.

    Liman, Recep / Muddassir Ali, Muhammad / Salih Istifli, Erman / Hakkı Ciğerci, İbrahim / Bonciu, Elena

    Environmental science and pollution research international

    2022  Volume 29, Issue 42, Page(s) 63141

    Language English
    Publishing date 2022-06-08
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-20946-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Comparative docking and molecular dynamics studies of molnupiravir (EIDD-2801): implications for novel mechanisms of action on influenza and SARS-CoV-2 protein targets.

    Istifli, Erman Salih / Okumus, Nurullah / Sarikurkcu, Cengiz / Kuhn, Eduardo Ramires / Netz, Paulo A / Tepe, Arzuhan Sihoglu

    Journal of biomolecular structure & dynamics

    2023  , Page(s) 1–13

    Abstract: Molnupiravir (EIDD-2801) (MLN) is an oral antiviral drug for COVID-19 treatment, being integrated into viral RNA through RNA-dependent RNA polymerase (RdRp). Upon ingestion, MLN is transformed into two active metabolites: β-d- ... ...

    Abstract Molnupiravir (EIDD-2801) (MLN) is an oral antiviral drug for COVID-19 treatment, being integrated into viral RNA through RNA-dependent RNA polymerase (RdRp). Upon ingestion, MLN is transformed into two active metabolites: β-d-N
    Language English
    Publishing date 2023-10-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2267696
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Investigation of the genotoxic effects of patent blue V (E131) in human peripheral lymphocytes and

    Husunet, Mehmet Tahir / Mısırlı, Rima Çelik / Istıflı, Erman Salih / Ila, Hasan Basri

    Drug and chemical toxicology

    2021  Volume 45, Issue 4, Page(s) 1780–1786

    Abstract: Patent Blue V (PBV) is a water-soluble synthetic dyestuff that is used as a coloring agent in the food industry and for medical imaging in health monitoring. The aim of this study was to investigate the in vitro clastogenic, aneugenic and cytotoxic ... ...

    Abstract Patent Blue V (PBV) is a water-soluble synthetic dyestuff that is used as a coloring agent in the food industry and for medical imaging in health monitoring. The aim of this study was to investigate the in vitro clastogenic, aneugenic and cytotoxic effects of PBV in human peripheral lymphocytes using micronucleus assay, comet assay, as well as plasmid DNA interaction and bacterial AMES tests. In addition to
    MeSH term(s) Comet Assay ; DNA Damage ; Humans ; Hydrogen Peroxide/pharmacology ; Lymphocytes ; Micronucleus Tests/methods ; Molecular Docking Simulation ; Mutagens/toxicity ; Rosaniline Dyes
    Chemical Substances Mutagens ; Rosaniline Dyes ; Hydrogen Peroxide (BBX060AN9V) ; sulfan blue (FH1929ICIT)
    Language English
    Publishing date 2021-01-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 548368-2
    ISSN 1525-6014 ; 0148-0545
    ISSN (online) 1525-6014
    ISSN 0148-0545
    DOI 10.1080/01480545.2021.1878208
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1380: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Cyto-Genotoxic and Behavioral Effects of Flubendiamide in

    Ciğerci, İbrahim Hakkı / Liman, Recep / İstifli, Erman Salih / Akyıl, Dilek / Özkara, Arzu / Bonciu, Elena / Colă, Florica

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: Flubendiamide (FLB) is an insecticide that is commonly employed to control pests on a variety of vegetables and fruits, with low toxicity for non-target organisms. However, due to its widespread use, the environmental risks and food safety have become ... ...

    Abstract Flubendiamide (FLB) is an insecticide that is commonly employed to control pests on a variety of vegetables and fruits, with low toxicity for non-target organisms. However, due to its widespread use, the environmental risks and food safety have become major concerns. In this study, the toxicity potential of FLB was studied in the model organisms,
    MeSH term(s) Animals ; Drosophila melanogaster/genetics ; Onions/genetics ; Molecular Docking Simulation ; Plant Roots/genetics ; DNA Damage ; Meristem/genetics ; Chromosome Aberrations ; Allium
    Chemical Substances flubendiamide (GEV84ZI4K6)
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021565
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Genotoxic and cytotoxic effects of pethoxamid herbicide on Allium cepa cells and its molecular docking studies to unravel genotoxicity mechanism.

    Liman, Recep / Ali, Muhammad Muddassir / Istifli, Erman Salih / Ciğerci, İbrahim Hakkı / Bonciu, Elena

    Environmental science and pollution research international

    2022  Volume 29, Issue 42, Page(s) 63127–63140

    Abstract: Pethoxamid is chloroacetamide herbicide. Pethoxamid is commonly used to kill different weeds in various crops. Pethoxamid can leach in the water and soil and can cause toxic effects to other non-target species. Current study is therefore aimed to perform ...

    Abstract Pethoxamid is chloroacetamide herbicide. Pethoxamid is commonly used to kill different weeds in various crops. Pethoxamid can leach in the water and soil and can cause toxic effects to other non-target species. Current study is therefore aimed to perform the investigation of the cytotoxic and genotoxic effects of pethoxamid on Allium cepa cells.The root growth, mitotic index (MI), chromosomal aberrations (CAs), and DNA damage were assessed through root growth inhibition, A. cepa ana-telophase, and alkaline comet assays, respectively. Furthermore, molecular docking was performed to evaluate binding affinity of pethoxamid on DNA and very-long-chain fatty acid (VLCFA) synthases. In root growth inhibition test, onion root length was statistically significantly decreased in a concentration dependent manner. Concentration- and time-dependent decreases in MI were observed, whereas increase in CAs such as disturbed ana-telophase, chromosome laggards, stickiness, anaphase bridges, and DNA damage was caused by the pethoxamid on A. cepa root cells. Molecular docking revealed that pethoxamid binds selectively to GC-rich regions in the minor groove of the DNA structure and showed remarkable binding affinity against all synthases taking part in the sequential biosynthesis of VLCFAs. It was concluded that the pethoxamid-induced genotoxicity and cytotoxicity may be through multiple binding ability of this herbicide with DNA and VLCFA synthases.
    MeSH term(s) Acetamides ; Chromosome Aberrations/chemically induced ; DNA Damage ; Fatty Acids/pharmacology ; Herbicides/toxicity ; Meristem ; Mitotic Index ; Molecular Docking Simulation ; Onions ; Plant Roots ; Soil ; Water
    Chemical Substances Acetamides ; Fatty Acids ; Herbicides ; Soil ; pethoxamid ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-04-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-20166-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top