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Article ; Online: Perspektiven der Rehabilitation. Ein Positionspapier des Arztlichen Sachverständigenrates der Bundesarbeitsgemeinschaft f ü r Rehabilitation (BAR) zur Weiterentwicklung der Rehabilitation.

Seger, W / Petri, B / Müller-Fahrnow, W / Lay, W / Grotkamp, S / Hüller, E / Seidel, E / Steinke, B / Deetjen, W / Gronemeyer, St / Lübke, N / von Mittelstaedt, G / Korsukéwitz, Ch / Aubke, W / Schian, H-M / Heipertz, W / Wallrabenstein, H / Zelfel, R C / Cibis, W /

Philgus, B

Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))

2008 Volume 70, Issue 5, Page(s) 267–280

Abstract: The Health Advisory Board of the German Federal Association for Rehabilitation (BAR) describes future trends and challenges in rehabilitation as deriving from the socio-demographic development in Germany and the structural characteristics of its Social ... ...

Title translation	Perspectives in rehabilitation. General position paper on future trends and challenges in rehabilitation by the Health Advisory Board of the German Federal Association for Rehabilitation.
Abstract	The Health Advisory Board of the German Federal Association for Rehabilitation (BAR) describes future trends and challenges in rehabilitation as deriving from the socio-demographic development in Germany and the structural characteristics of its Social and Health Care Insurance System. The focus is on elder employees to sustain and regenerate their capacity for employment, on people which are no longer employed to activate their autonomy and ability for self-support, and on rehabilitation as a holistic and integrative process extending through the social security and health insurances. There is an urgent need and a real chance to benefit from already existing scientific findings more frequently and to integrate them effectively into adequate further education and training programmes for professionals. Finally the conclusion summarises 8 theses to facilitate rehabilitation as an integral and essential part of the German social security and health sector. This paper was fully accredited by the members of the BAR Managing Board.
MeSH term(s)	Advisory Committees ; Forecasting ; Rehabilitation/trends
Language	German
Publishing date	2008-05
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	1101426-x
ISSN	1439-4421 ; 0941-3790 ; 0949-7013
ISSN (online)	1439-4421
ISSN	0941-3790 ; 0949-7013
DOI	10.1055/s-2008-1077060
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Article ; Online: PENGARUH EMPLOYER BRANDING DAN REPUTASI PERUSAHAAN TERHADAP ORGANIZATIONAL ATTRACTIVENESS DI PERUSAHAAN STARTUP PADA GENERASI Z

Shafara Arifah Phalevi / Seger Handoyo

Sibatik Journal, Vol 2, Iss 7, Pp 2119-

2023 Volume 2132

Abstract: ... of the coefficient of determination analysis test, it is known that R square in the summary model is 0.631 or 63.1 ...

Abstract	Global economic development, the phenomenon of layoffs, and the threat of a global recession accelerate market disruption significantly, making it difficult for startups to attract employees to gain a competitive advantage in the intensifying talent war. To overcome this, startups have the challenge of improving post-layoff strategies by conducting employer branding and improving the company's reputation so that potential employees are interested in working at startups, so this study aims to determine whether there is an effect of employer branding and company reputation on organizational attractiveness in startup companies in Generation Z. The method used in this study is a survey method and obtained 223 respondents who are generation Z who were born in the range of 1997 - 2005 or currently 18-26 years old. The results obtained from this study employer branding and company reputation affect organizational attractiveness based on the results of the coefficient of determination analysis test, it is known that R square in the summary model is 0.631 or 63.1% employer branding and company reputation affect organizational attractiveness, while 36.9% is influenced by other factors not examined in this study.
Keywords	employer branding ; corporate reputation ; organizational attractiveness ; startup ; generation z ; Social Sciences ; H ; Technology ; T
Subject code	650
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	PENERBIT LAFADZ JAYA
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Retention of ERK in the cytoplasm mediates the pluripotency of embryonic stem cells.

Hacohen Lev-Ran, Avital / Seger, Rony

Stem cell reports

2022 Volume 18, Issue 1, Page(s) 305–318

Abstract: The dynamic subcellular localization of ERK1/2 plays an important role in regulating cell fate. Differentiation of mouse embryonic stem cells (mESCs) involves inductive stimulation of ERK1/2, and therefore, inhibitors of the ERK cascade are used to ... ...

Abstract	The dynamic subcellular localization of ERK1/2 plays an important role in regulating cell fate. Differentiation of mouse embryonic stem cells (mESCs) involves inductive stimulation of ERK1/2, and therefore, inhibitors of the ERK cascade are used to maintain pluripotency. Interestingly, we found that in pluripotent mESCs, ERK1/2 do not translocate to the nucleus either before or after stimulation. This inhibition of nuclear translocation may be dependent on a lack of stimulated ERK1/2 interaction with importin7 rather than a lack of ERK1/2 phosphorylation activating translocation. At late stages of naive-to-primed transition, the action of the translocating machinery is restored, leading to elevation in ERK1/2-importin7 interaction and their nuclear translocation. Importantly, forcing ERK2 into the naive cells' nuclei accelerates their early differentiation, while prevention of the translocation restores stem cells' pluripotency. These results indicate that prevention of nuclear ERK1/2 translocation serves as a safety mechanism for keeping pluripotency of mESCs.
MeSH term(s)	Animals ; Mice ; Embryonic Stem Cells ; Cell Differentiation ; Phosphorylation ; Mouse Embryonic Stem Cells ; Cell Nucleus/metabolism
Language	English
Publishing date	2022-12-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2720528-9
ISSN	2213-6711 ; 2213-6711
ISSN (online)	2213-6711
ISSN	2213-6711
DOI	10.1016/j.stemcr.2022.11.017
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Article: Evidence for serial founder events during the colonization of North America by the yellow fever mosquito,

Pless, Evlyn / Powell, Jeffrey R / Seger, Krystal R / Ellis, Brett / Gloria-Soria, Andrea

Ecology and evolution

2022 Volume 12, Issue 5, Page(s) e8896

Abstract: ... ...

Abstract	The
Language	English
Publishing date	2022-05-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.8896
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Article ; Online: Intranasal oxytocin attenuates the effects of monetary feedback on procedural learning.

Doppler, Christopher E J / Meyer, Linda / Seger, Aline / Karges, Wolfram / Weiss, Peter H / Fink, Gereon R

Psychoneuroendocrinology

2022 Volume 143, Page(s) 105823

Abstract: Procedural learning is a vital brain function that allows us to acquire motor skills during development or re-learn them after lesions affecting the motor system. Procedural learning can be improved by feedback of different valence, e.g., monetary or ... ...

Abstract	Procedural learning is a vital brain function that allows us to acquire motor skills during development or re-learn them after lesions affecting the motor system. Procedural learning can be improved by feedback of different valence, e.g., monetary or social, mediated by dopaminergic circuits. While processing motivationally relevant stimuli, dopamine interacts closely with oxytocin, whose effects on procedural learning, particularly feedback-based approaches, remain poorly understood. In a randomized, double-blind, placebo-controlled trial, we investigated whether oxytocin modulates the differential effects of monetary and social feedback on procedural learning. Sixty-one healthy male participants were randomized to receive a placebo or oxytocin intranasally. The participants then performed a modified serial reaction time task. Oxytocin plasma concentrations were measured before and after applying the placebo or verum. Groups did not differ regarding general reaction times or measures of procedural learning. For the placebo group, monetary feedback improved procedural learning compared to a neutral control condition. In contrast, the oxytocin group did not show a differential effect of monetary or social feedback despite a significant increase in oxytocin plasma levels after intranasal application. The data suggest that oxytocin does not influence procedural learning per se. Instead, oxytocin seems to attenuate the effects of monetary feedback on procedural learning specifically.
MeSH term(s)	Administration, Intranasal ; Central Nervous System Agents/administration & dosage ; Central Nervous System Agents/pharmacology ; Double-Blind Method ; Feedback, Psychological/drug effects ; Feedback, Psychological/physiology ; Humans ; Learning/drug effects ; Learning/physiology ; Male ; Oxytocin/administration & dosage ; Oxytocin/pharmacology ; Psychomotor Performance/drug effects ; Psychomotor Performance/physiology ; Reaction Time ; Reward ; Social Behavior
Chemical Substances	Central Nervous System Agents ; Oxytocin (50-56-6)
Language	English
Publishing date	2022-06-03
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	197636-9
ISSN	1873-3360 ; 0306-4530
ISSN (online)	1873-3360
ISSN	0306-4530
DOI	10.1016/j.psyneuen.2022.105823
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Article: Clinical subtypes in patients with isolated REM sleep behaviour disorder.

Seger, Aline / Ophey, Anja / Doppler, Christopher E J / Kickartz, Johanna / Lindner, Marie-Sophie / Hommelsen, Maximilian / Fink, Gereon R / Sommerauer, Michael

NPJ Parkinson's disease

2023 Volume 9, Issue 1, Page(s) 155

Abstract: Patients with Parkinson's disease (PD) show a broad heterogeneity in clinical presentation, and subtypes may already arise in prodromal disease stages. Isolated REM sleep behaviour disorder (iRBD) is the most specific marker of prodromal PD, but data on ... ...

Abstract	Patients with Parkinson's disease (PD) show a broad heterogeneity in clinical presentation, and subtypes may already arise in prodromal disease stages. Isolated REM sleep behaviour disorder (iRBD) is the most specific marker of prodromal PD, but data on clinical subtyping of patients with iRBD remain scarce. Therefore, this study aimed to identify iRBD subtypes. We conducted comprehensive clinical assessments in 66 patients with polysomnography-proven iRBD, including motor and non-motor evaluations, and applied a two-step cluster analysis. Besides, we compared iRBD clusters to matched healthy controls and related the resulting cluster solution to cortical and subcortical grey matter volumes by voxel-based morphometry analysis. We identified two distinct subtypes of patients based on olfactory function, dominant electroencephalography frequency, amount of REM sleep without atonia, depressive symptoms, disease duration, and motor functions. One iRBD cluster (Cluster I, late onset-aggressive) was characterised by higher non-motor symptom burden despite shorter disease duration than the more benign subtype (Cluster II, early onset-benign). Motor functions were comparable between the clusters. Patients from Cluster I were significantly older at iRBD onset and exhibited a widespread reduction of cortical grey matter volume compared to patients from Cluster II. In conclusion, our findings suggest the existence of clinical subtypes already in the prodromal stage of PD. Future longitudinal studies are warranted that replicate these findings and investigate the risk of the more aggressive phenotype for earlier phenoconversion and dementia development.
Language	English
Publishing date	2023-11-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2819218-7
ISSN	2373-8057
ISSN	2373-8057
DOI	10.1038/s41531-023-00598-7
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Article ; Online: Visuo-spatial processing is linked to cortical glutamate dynamics in Parkinson's disease - a 7-T functional magnetic resonance spectroscopy study.

Ophey, Anja / Farrher, Ezequiel / Pagel, Nora / Seger, Aline / Doppler, Christopher E J / Shah, N Jon / Kalbe, Elke / Fink, Gereon R / Sommerauer, Michael

European journal of neurology

2023 Volume 30, Issue 7, Page(s) 2106–2111

Abstract: Background and purpose: Cognitive decline is a frequent and debilitating non-motor symptom for patients with Parkinson's disease (PD). Metabolic alterations in the occipital cortex during visual processing may serve as a biomarker for cognitive decline ... ...

Abstract	Background and purpose: Cognitive decline is a frequent and debilitating non-motor symptom for patients with Parkinson's disease (PD). Metabolic alterations in the occipital cortex during visual processing may serve as a biomarker for cognitive decline in patients with PD. Methods: Sixteen patients with PD (Unified Parkinson's Disease Rating Scale Part 3, OFF, 38.69 ± 17.25) and 10 age- and sex-matched healthy controls (HC) underwent 7-T functional magnetic resonance spectroscopy (MRS) utilizing a visual checkerboard stimulation. Glutamate metabolite levels during rest versus stimulation were compared. Furthermore, correlates of the functional MRS response with performance in visuo-cognitive tests were investigated. Results: No differences in static MRS between patients with PD and HC were detected, but a dynamic glutamate response was observed in functional MRS in HC upon visual stimulation, which was blunted in patients with PD (F Conclusions: Our results indicate that functional MRS captures even subtle differences in neural processing linked to the behavioral performance, which would have been missed by conventional, static MRS. Functional MRS thus represents a promising tool for studying molecular alterations at high sensitivity. Its prognostic potential should be evaluated in longitudinal studies, prospectively contributing to earlier diagnosis and individual treatment decisions.
MeSH term(s)	Humans ; Parkinson Disease ; Glutamic Acid ; Spatial Processing ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Spectroscopy ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/metabolism
Chemical Substances	Glutamic Acid (3KX376GY7L)
Language	English
Publishing date	2023-04-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1280785-0
ISSN	1468-1331 ; 1351-5101 ; 1471-0552
ISSN (online)	1468-1331
ISSN	1351-5101 ; 1471-0552
DOI	10.1111/ene.15818
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Article ; Online: Ligand Binding Prolongs Androgen Receptor Protein Half-Life by Reducing its Degradation.

Astapova, Olga / Seger, Christina / Hammes, Stephen R

Journal of the Endocrine Society

2021 Volume 5, Issue 5, Page(s) bvab035

Abstract: Androgens are important in female reproduction, but the molecular actions of androgens in female reproductive tissues are not fully understood. We investigated the androgen-responsive transcriptome in human and mouse granulosa cells (GCs) and ... ...

Abstract	Androgens are important in female reproduction, but the molecular actions of androgens in female reproductive tissues are not fully understood. We investigated the androgen-responsive transcriptome in human and mouse granulosa cells (GCs) and surprisingly found that the gene-regulation activity of androgen receptor (AR) in these cells is negligible. We then investigated extranuclear actions of AR and found that in human and mouse GCs, as well as in prostate cancer cells, dihydrotestosterone (DHT) dramatically increases the half-life of its own receptor protein. Using the human granulosa-like KGN cells, we show that this effect is not the result of increased
Language	English
Publishing date	2021-03-05
Publishing country	United States
Document type	Journal Article
ISSN	2472-1972
ISSN (online)	2472-1972
DOI	10.1210/jendso/bvab035
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Article ; Online: The impact of early diagnosis of fetal single-ventricle cardiac defects on reproductive choices.

Kegel, Samantha / Abi Habib, Paola / Seger, Lindsey / Turan, Ozhan M / Turan, Sifa

American journal of obstetrics & gynecology MFM

2023 Volume 5, Issue 9, Page(s) 101093

Abstract: ... gestational age at diagnosis was correlated with earlier gestational age at termination (r=0.92; P<.001 ...

Abstract	Background: Congenital heart defects are the most common fetal anomaly. Congenital heart defects with single-ventricle cardiac defects have high mortality rates, and in pregnancies diagnosed with this condition, patients are often offered termination of pregnancy as an option. Objective: This study aimed to investigate the relationship between gestational age at diagnosis and reproductive choices in fetuses diagnosed with single-ventricle cardiac defects. Study design: This was a retrospective single-center cohort study in which 158 patients with a fetal diagnosis of single-ventricle cardiac defects were reviewed. Cases were categorized as isolated or complex. Complex cases included fetuses with single-ventricle cardiac defects in addition to other fetal extracardiac anomalies or chromosomal abnormalities. Results: A total of 158 patients were diagnosed with single-ventricle cardiac defects during the study period. Of those patients, 37 (23.4%) underwent termination of pregnancy, 113 (71.5%) delivered, and 8 (5.1%) had an intrauterine fetal demise. Gestational age at diagnosis and race were significant predictors of the termination decision. The median gestational age at diagnosis was earlier in the termination of pregnancy group (20.4 vs 23.6 weeks; P<.001). Pregnancies complicated by single-ventricle cardiac defects diagnosed in early gestation (11 0/7 to 14 5/7 weeks of gestation) were more likely to be terminated than pregnancies complicated by single-ventricle cardiac defects diagnosed in middle gestation (15 0/7 to 27 5/7 weeks of gestation) and late gestation (≥28 weeks of gestation) (54.2% vs 23.2% and 2.9%; P<.001). Earlier gestational age at diagnosis was correlated with earlier gestational age at termination (r=0.92; P<.001). Conclusion: Termination of pregnancy was more common when the single-ventricle cardiac defect was diagnosed earlier in pregnancy. This could be explained by the fact that early diagnoses allow parents to make deliberate and informed decisions.
MeSH term(s)	Female ; Pregnancy ; Humans ; Infant ; Cohort Studies ; Retrospective Studies ; Ultrasonography, Prenatal ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/epidemiology ; Fetus ; Early Diagnosis
Language	English
Publishing date	2023-07-13
Publishing country	United States
Document type	Journal Article
ISSN	2589-9333
ISSN (online)	2589-9333
DOI	10.1016/j.ajogmf.2023.101093
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Article ; Online: From Pipettes to Science Policy.

Seger, Yvette R

Trends in immunology

2015 Volume 36, Issue 11, Page(s) 663–665

Abstract: Science policy provides PhD-trained scientists with unique and rewarding opportunities to support the research community. Careers in science policy require broad scientific knowledge coupled with keen problem-solving, data-analysis, and communication ... ...

Abstract	Science policy provides PhD-trained scientists with unique and rewarding opportunities to support the research community. Careers in science policy require broad scientific knowledge coupled with keen problem-solving, data-analysis, and communication skills. This article describes strategies for scientists to engage in policy discussions, both extramural and full-time.
MeSH term(s)	Career Mobility ; Humans ; Public Policy ; Research Personnel/education ; Science/manpower
Language	English
Publishing date	2015-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2036831-8
ISSN	1471-4981 ; 1471-4906
ISSN (online)	1471-4981
ISSN	1471-4906
DOI	10.1016/j.it.2015.09.002
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