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  1. Article ; Online: Advancing pharmacogenetics research in Africa: the "Project Africa GRADIENT" initiative.

    Ndong Sima, Carene Anne Alene / Othman, Houcemeddine / Möller, Marlo

    Drug discovery today

    2024  Volume 29, Issue 5, Page(s) 103939

    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Editorial
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2024.103939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4725: Show issues Location:
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  2. Article ; Online: Characterizing the combined effects of cytochrome P450 missense variation within star allele definitions.

    Khoza, Nhlamulo / Twesigomwe, David / Othman, Houcemeddine

    Pharmacogenomics

    2023  Volume 24, Issue 10, Page(s) 561–578

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Cytochrome P-450 CYP2D6/genetics ; Cytochrome P-450 CYP2D6/metabolism ; Alleles ; Cytochrome P-450 Enzyme System/genetics ; Haplotypes/genetics ; Mutation, Missense/genetics
    Chemical Substances Cytochrome P-450 CYP2D6 (EC 1.14.14.1) ; Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2023-07-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/pgs-2023-0068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Internationalization of the Moroccan Journal of Chemistry: A bibliometric study.

    Lrhoul, Hanae / Turki, Houcemeddine / Hammouti, Belkheir / Benammar, Othman

    Heliyon

    2023  Volume 9, Issue 5, Page(s) e15857

    Abstract: In this research paper, we analyzed the bibliographic data of the research publications issued by the Moroccan Journal of Chemistry between 2013 and 2021. As an open-access country-based research journal with a narrow area of interest and international ... ...

    Abstract In this research paper, we analyzed the bibliographic data of the research publications issued by the Moroccan Journal of Chemistry between 2013 and 2021. As an open-access country-based research journal with a narrow area of interest and international online exposure, it will be interesting to see how it affects the local chemical research community through the comparison of the characteristics of the research outputs of the journal as retrieved from the
    Language English
    Publishing date 2023-05-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15857
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  4. Article ; Online: Internationalization of the Moroccan Journal of Chemistry

    Hanae Lrhoul / Houcemeddine Turki / Belkheir Hammouti / Othman Benammar

    Heliyon, Vol 9, Iss 5, Pp e15857- (2023)

    A bibliometric study

    2023  

    Abstract: In this research paper, we analyzed the bibliographic data of the research publications issued by the Moroccan Journal of Chemistry between 2013 and 2021. As an open-access country-based research journal with a narrow area of interest and international ... ...

    Abstract In this research paper, we analyzed the bibliographic data of the research publications issued by the Moroccan Journal of Chemistry between 2013 and 2021. As an open-access country-based research journal with a narrow area of interest and international online exposure, it will be interesting to see how it affects the local chemical research community through the comparison of the characteristics of the research outputs of the journal as retrieved from the Directory of Open Access Journals (DOAJ) with the features of Moroccan chemical research from 2014 to 2021 in the Web of Science Core Collection (WoS). In this context, we generated scientometric networks using Gephi, a tool for large-scale data visualization, to reveal the patterns of the publications in the Moroccan Journal of Chemistry. When performing our analysis, we found a significant alignment between the research topics featured in the Moroccan Journal of Chemistry and the main research areas of the Moroccan chemical scholarly outputs, particularly Multidisciplinary Chemistry, Physical Chemistry, and Analytical Chemistry. We also identified that the Moroccan Journal of Chemistry functions as an incubator for establishing new traditions of research collaboration between Moroccan institutions and target nations such as Asian and African countries. As well, it is clear that the Moroccan Journal of Chemistry is an interesting venue for the most productive chemical researchers in Morocco for sharing preliminary research findings and discussing trendy topics.
    Keywords Bibliometrics ; Internationalization ; Scholarly journals ; Research community ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 001
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Molecular dynamics of G6PD variants from sub-Saharan Africa.

    Batista da Rocha, Jorge / Othman, Houcemeddine / Hazelhurst, Scott

    Biochemistry and biophysics reports

    2022  Volume 30, Page(s) 101236

    Abstract: Precision medicine uses genomic guidance to improve drug treatment safety and efficacy. Prior knowledge of genetic variant impact can enable such strategies, but current knowledge of African variants remains scarce. ...

    Abstract Precision medicine uses genomic guidance to improve drug treatment safety and efficacy. Prior knowledge of genetic variant impact can enable such strategies, but current knowledge of African variants remains scarce.
    Language English
    Publishing date 2022-03-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2831046-9
    ISSN 2405-5808 ; 2405-5808
    ISSN (online) 2405-5808
    ISSN 2405-5808
    DOI 10.1016/j.bbrep.2022.101236
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  6. Article ; Online: Overexpression of WT1 in all molecular subtypes of breast cancer and its impact on survival: exploring oncogenic and tumor suppressor roles of distinct WT1 isoforms.

    Ben Haj Othmen, Hind / Othman, Houcemeddine / Khamessi, Oussema / Bettaieb, Ilhem / Gara, Sonia / Kharrat, Maher

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 544

    Abstract: Background: Breast cancer is a highly heterogeneous solid tumor, posing challenges in developing targeted therapies effective for all mammary carcinoma subtypes. WT1 emerges as a promising target for breast cancer therapy due to its potential oncogenic ... ...

    Abstract Background: Breast cancer is a highly heterogeneous solid tumor, posing challenges in developing targeted therapies effective for all mammary carcinoma subtypes. WT1 emerges as a promising target for breast cancer therapy due to its potential oncogenic role in various cancer types. Previous works have yielded inconsistent results. Therefore, further studies are needed to clarify the behavior of this complex gene in breast cancer.
    Methods and results: In this study, we examined WT1 expression in both Formalin Fixed Paraffin Embedded breast tumors (n = 41) and healthy adjacent tissues (n = 41) samples from newly diagnosed cases of ductal invasive breast cancer. The fold change in gene expression between the tumor and healthy tissue was determined by calculating 2
    Conclusions: Interestingly, this overexpression was observed in all molecular subtypes of invasive breast cancer, underscoring the significance of WT1 as a potential target in all these subtypes. The observed WT1 down-expression in a few cases of invasive breast cancer, associated with better survival outcomes, may correspond to the down-regulation of a particular WT1-KTS (-) isoform: the WT1 A isoform (EX5-/KTS-). The co-expression of this WT1 oncogenic isoform with a regulated WT1- tumor suppressor isoform, such as the major WT1 F isoform (EX5-/KTS +), could also explain such survival outcomes. Due to its capacity to adopt dual roles, it becomes imperative to conduct individual molecular expression profiling of the WT1 gene. Such an approach holds great promise in the development of personalized treatment strategies for breast cancer.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; WT1 Proteins/genetics ; WT1 Proteins/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Genes, Tumor Suppressor
    Chemical Substances WT1 Proteins ; Protein Isoforms ; WT1 protein, human
    Language English
    Publishing date 2024-04-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-024-09450-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Internationalization of the Moroccan Journal of Chemistry: A bibliometric study

    Lrhoul, Hanae / Turki, Houcemeddine / Hammouti, Belkheir / Benammar, Othman

    Heliyon. 2023 May, v. 9, no. 5 p.e15857-

    2023  

    Abstract: In this research paper, we analyzed the bibliographic data of the research publications issued by the Moroccan Journal of Chemistry between 2013 and 2021. As an open-access country-based research journal with a narrow area of interest and international ... ...

    Abstract In this research paper, we analyzed the bibliographic data of the research publications issued by the Moroccan Journal of Chemistry between 2013 and 2021. As an open-access country-based research journal with a narrow area of interest and international online exposure, it will be interesting to see how it affects the local chemical research community through the comparison of the characteristics of the research outputs of the journal as retrieved from the Directory of Open Access Journals (DOAJ) with the features of Moroccan chemical research from 2014 to 2021 in the Web of Science Core Collection (WoS). In this context, we generated scientometric networks using Gephi, a tool for large-scale data visualization, to reveal the patterns of the publications in the Moroccan Journal of Chemistry. When performing our analysis, we found a significant alignment between the research topics featured in the Moroccan Journal of Chemistry and the main research areas of the Moroccan chemical scholarly outputs, particularly Multidisciplinary Chemistry, Physical Chemistry, and Analytical Chemistry. We also identified that the Moroccan Journal of Chemistry functions as an incubator for establishing new traditions of research collaboration between Moroccan institutions and target nations such as Asian and African countries. As well, it is clear that the Moroccan Journal of Chemistry is an interesting venue for the most productive chemical researchers in Morocco for sharing preliminary research findings and discussing trendy topics.
    Keywords analytical chemistry ; bibliometric analysis ; cooperative research ; data visualization ; physical chemistry ; Morocco ; Bibliometrics ; Internationalization ; Scholarly journals ; Research community
    Language English
    Dates of publication 2023-05
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15857
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Molecular dynamics of G6PD variants from sub-Saharan Africa

    Jorge Batista da Rocha / Houcemeddine Othman / Scott Hazelhurst

    Biochemistry and Biophysics Reports, Vol 30, Iss , Pp 101236- (2022)

    2022  

    Abstract: Precision medicine uses genomic guidance to improve drug treatment safety and efficacy. Prior knowledge of genetic variant impact can enable such strategies, but current knowledge of African variants remains scarce. G6PD variants are linked to haemolytic ...

    Abstract Precision medicine uses genomic guidance to improve drug treatment safety and efficacy. Prior knowledge of genetic variant impact can enable such strategies, but current knowledge of African variants remains scarce. G6PD variants are linked to haemolytic adverse effects for a number of drugs commonly used in African populations. We have investigated a set of G6PD variants with structural bioinformatics techniques to further characterise variants with known effect, and gain insights into variants with unknown impact. We observed wide variations in patterns of root-mean-square deviation between wild-type and variant structures. Variants with known, highly deleterious impact show structural effects which may likely result in the destabilisation of the G6PD homodimer. The V68M and N126D variants (which are both common across African populations, and together form the A- haplotype) induce large conformational shifts in the catalytic NADP+ binding domain. We observed a greater impact for the haplotype than for each of the individual variants in these cases. A novel African variant (M207T) shows the potential to disrupt interactions within the protein core, urging further investigation. We explore how characterising the molecular impact of African G6PD variants can enable advanced strategies for precision medicine, as well as impact the use of novel therapeutics aiming to treat G6PD deficiency. This knowledge can assist in bridging current knowledge gaps, and aid to facilitate precision medicine applications in African populations.
    Keywords G6PD ; Structural bioinformatics ; Variants ; Precision medicine ; Africa ; Molecular Dynamics ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
    Subject code 306
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: SWAAT Bioinformatics Workflow for Protein Structure-Based Annotation of ADME Gene Variants.

    Othman, Houcemeddine / Jemimah, Sherlyn / da Rocha, Jorge Emanuel Batista

    Journal of personalized medicine

    2022  Volume 12, Issue 2

    Abstract: Recent genomic studies have revealed the critical impact of genetic diversity within small population groups in determining the way individuals respond to drugs. One of the biggest challenges is to accurately predict the effect of single nucleotide ... ...

    Abstract Recent genomic studies have revealed the critical impact of genetic diversity within small population groups in determining the way individuals respond to drugs. One of the biggest challenges is to accurately predict the effect of single nucleotide variants and to get the relevant information that allows for a better functional interpretation of genetic data. Different conformational scenarios upon the changing in amino acid sequences of pharmacologically important proteins might impact their stability and plasticity, which in turn might alter the interaction with the drug. Current sequence-based annotation methods have limited power to access this type of information. Motivated by these calls, we have developed the Structural Workflow for Annotating ADME Targets (SWAAT) that allows for the prediction of the variant effect based on structural properties. SWAAT annotates a panel of 36 ADME genes including 22 out of the 23 clinically important members identified by the PharmVar consortium. The workflow consists of a set of Python codes of which the execution is managed within Nextflow to annotate coding variants based on 37 criteria. SWAAT also includes an auxiliary workflow allowing a versatile use for genes other than ADME members. Our tool also includes a machine learning random forest binary classifier that showed an accuracy of 73%. Moreover, SWAAT outperformed six commonly used sequence-based variant prediction tools (PROVEAN, SIFT, PolyPhen-2, CADD, MetaSVM, and FATHMM) in terms of sensitivity and has comparable specificity. SWAAT is available as an open-source tool.
    Language English
    Publishing date 2022-02-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12020263
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  10. Article ; Online: Promoting Pharmacogenomics in Africa: Perspectives From Variation in G6PD and Other Pharmacogenes.

    Sitabule, Blessing R / Othman, Houcemeddine / Choudhury, Ananyo / Twesigomwe, David / Hanchard, Neil A

    Clinical pharmacology and therapeutics

    2022  Volume 113, Issue 3, Page(s) 476–479

    MeSH term(s) Humans ; Pharmacogenetics ; Africa ; Genetic Variation ; Glucosephosphate Dehydrogenase Deficiency
    Language English
    Publishing date 2022-12-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Intramural
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.2816
    Database MEDical Literature Analysis and Retrieval System OnLINE

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