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  1. Article: Contribution of Inhibitory Metabolites and Competition for Nutrients to Colonization Resistance against

    Reed, Amber D / Theriot, Casey M

    Microorganisms

    2021  Volume 9, Issue 2

    Abstract: Clostridioides ... ...

    Abstract Clostridioides difficile
    Language English
    Publishing date 2021-02-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9020371
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Beyond Structure: Defining the Function of the Gut Using Omic Approaches for Rational Design of Personalized Therapeutics.

    Theriot, Casey M

    mSystems

    2018  Volume 3, Issue 2

    Abstract: Over the past 10 years, microbiome research has focused on defining the structures associated with different disease states in multiple systems, but has fallen short on showing causation. Prior omic studies have generated many new hypotheses, but moving ... ...

    Abstract Over the past 10 years, microbiome research has focused on defining the structures associated with different disease states in multiple systems, but has fallen short on showing causation. Prior omic studies have generated many new hypotheses, but moving forward we need to start dissecting the function of each bacterium alone and in concert with complex bacterial communities in well-characterized systems. Over the next 5 years, we need a merging of new omic technologies for exploratory studies with classical bacterial genetics, bacterial physiology, protein engineering, and biochemistry to further define the biochemical mechanisms of the gut microbiota. The future of the systems microbiology field will focus on targeted engineering and editing of the microbiome to alter function, which will be leveraged to prevent and/or treat human diseases. This perspective will focus on my contribution to the microbiome field, both past and present, and where I think research in the field is headed in the near future.
    Language English
    Publishing date 2018-03-06
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5077
    ISSN 2379-5077
    DOI 10.1128/mSystems.00173-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Inter-library loan at ZB MED

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  3. Article: Loss of

    McMillan, Arthur S / Foley, Matthew H / Perkins, Caroline E / Theriot, Casey M

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Bacteroides thetaiotaomicron: Importance: Recent work on BSHs in Gram-negative bacteria, such ... ...

    Abstract Bacteroides thetaiotaomicron
    Importance: Recent work on BSHs in Gram-negative bacteria, such as
    Language English
    Publishing date 2023-06-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.27.546749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Metagenomic, metabolomic, and lipidomic shifts associated with fecal microbiota transplantation for recurrent

    McMillan, Arthur S / Zhang, Guozhi / Dougherty, Michael K / McGill, Sarah K / Gulati, Ajay S / Baker, Erin S / Theriot, Casey M

    bioRxiv : the preprint server for biology

    2024  

    Abstract: ... ...

    Abstract Recurrent
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.07.579219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The microbial derived bile acid lithocholate and its epimers inhibit

    Kisthardt, Samantha C / Thanissery, Rajani / Pike, Colleen M / Foley, Matthew H / Theriot, Casey M

    bioRxiv : the preprint server for biology

    2023  

    Abstract: C. difficile: Importance: In the search for a novel therapeutic that ... ...

    Abstract C. difficile
    Importance: In the search for a novel therapeutic that targets
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.06.543867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Role of Microbiota-Derived Bile Acids in Enteric Infections.

    Theriot, Casey M / Petri, William A

    Cell

    2020  Volume 181, Issue 7, Page(s) 1452–1454

    Abstract: In this issue of Cell, Alavi et al. report that infection by Vibrio cholerae is blocked by gut microbiome-mediated hydrolysis of bile acids. Cholera therefore joins amebic dysentery and Clostridioides difficile colitis as enteric infections profoundly ... ...

    Abstract In this issue of Cell, Alavi et al. report that infection by Vibrio cholerae is blocked by gut microbiome-mediated hydrolysis of bile acids. Cholera therefore joins amebic dysentery and Clostridioides difficile colitis as enteric infections profoundly influenced by the microbiome's impact on bile acid metabolism.
    MeSH term(s) Bile Acids and Salts ; Cholera ; Gastrointestinal Microbiome ; Humans ; Microbiota ; Vibrio cholerae
    Chemical Substances Bile Acids and Salts
    Language English
    Publishing date 2020-06-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2020.05.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1167: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 58: Show issues

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  7. Article ; Online: Mechanisms of Colonization Resistance Against Clostridioides difficile.

    Pike, Colleen M / Theriot, Casey M

    The Journal of infectious diseases

    2020  Volume 223, Issue 12 Suppl 2, Page(s) S194–S200

    Abstract: Clostridioides difficile is an urgent antimicrobial-resistant bacterium, causing mild to moderate and sometimes life-threatening disease. Commensal gut microbes are critical for providing colonization resistance against C difficile and can be leveraged ... ...

    Abstract Clostridioides difficile is an urgent antimicrobial-resistant bacterium, causing mild to moderate and sometimes life-threatening disease. Commensal gut microbes are critical for providing colonization resistance against C difficile and can be leveraged as non-antibiotic alternative therapeutics for the prevention and treatment of C difficile infection.
    MeSH term(s) Animals ; Anti-Bacterial Agents/immunology ; Anti-Bacterial Agents/metabolism ; Anti-Bacterial Agents/therapeutic use ; Antibiosis ; Bile Acids and Salts/immunology ; Bile Acids and Salts/metabolism ; Clostridioides difficile/drug effects ; Clostridioides difficile/growth & development ; Clostridioides difficile/metabolism ; Clostridium Infections/drug therapy ; Clostridium Infections/immunology ; Clostridium Infections/microbiology ; Fatty Acids, Volatile/immunology ; Fatty Acids, Volatile/metabolism ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Microbiome/physiology ; Humans ; Nutrients/immunology ; Nutrients/metabolism
    Chemical Substances Anti-Bacterial Agents ; Bile Acids and Salts ; Fatty Acids, Volatile
    Language English
    Publishing date 2020-12-16
    Publishing country United States
    Document type Introductory Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiaa408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.50: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 445: Show issues

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  8. Article ; Online: The microbial-derived bile acid lithocholate and its epimers inhibit

    Kisthardt, Samantha C / Thanissery, Rajani / Pike, Colleen M / Foley, Matthew H / Theriot, Casey M

    Journal of bacteriology

    2023  Volume 205, Issue 9, Page(s) e0018023

    Abstract: Clostridioides ... ...

    Abstract Clostridioides difficile
    MeSH term(s) Humans ; Virulence ; Gastrointestinal Microbiome ; Clostridioides difficile ; Caco-2 Cells ; Bile Acids and Salts/pharmacology ; Lithocholic Acid
    Chemical Substances Bile Acids and Salts ; Lithocholic Acid (5QU0I8393U)
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/jb.00180-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.50: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Intestinal bile acids provide a surmountable barrier against

    Icho, Simoun / Ward, Jennifer S / Tam, John / Kociolek, Larry K / Theriot, Casey M / Melnyk, Roman A

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 19, Page(s) e2301252120

    Abstract: Intestinal bile acids play an essential role in ... ...

    Abstract Intestinal bile acids play an essential role in the
    MeSH term(s) Humans ; Mice ; Animals ; Bacterial Toxins ; Clostridioides difficile ; Bile Acids and Salts ; Clostridium Infections/pathology ; Intestines/pathology ; Bacterial Proteins
    Chemical Substances Bacterial Toxins ; Bile Acids and Salts ; Bacterial Proteins
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2301252120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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  10. Article ; Online: Loss of

    McMillan, Arthur S / Foley, Matthew H / Perkins, Caroline E / Theriot, Casey M

    Microbiology spectrum

    2023  Volume 12, Issue 1, Page(s) e0357623

    Abstract: Importance: Recent work on bile salt hydrolases (BSHs) in Gram-negative bacteria, such as Bacteroides, has primarily focused on how they can impact host physiology. However, the benefits bile acid metabolism confers to the bacterium that performs it are ...

    Abstract Importance: Recent work on bile salt hydrolases (BSHs) in Gram-negative bacteria, such as Bacteroides, has primarily focused on how they can impact host physiology. However, the benefits bile acid metabolism confers to the bacterium that performs it are not well understood. In this study, we set out to define if and how
    MeSH term(s) Bacteroides thetaiotaomicron/genetics ; Transcriptome ; Bile Acids and Salts ; Bacteroides/genetics ; Bacteroides/metabolism ; Polysaccharides/metabolism ; Bacteria/genetics
    Chemical Substances Bile Acids and Salts ; Polysaccharides
    Language English
    Publishing date 2023-11-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.03576-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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