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  1. Article: Editorial: GBM stem cells and the brain tumor microenvironment.

    Li, Yunqing / Abounader, Roger

    Frontiers in oncology

    2023  Volume 13, Page(s) 1153803

    Language English
    Publishing date 2023-02-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1153803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A new practical and versatile mouse model of proneural glioblastoma.

    Abounader, Roger

    Neuro-oncology

    2018  Volume 20, Issue 3, Page(s) 299–301

    MeSH term(s) Animals ; Brain Neoplasms ; Disease Models, Animal ; Glioblastoma ; Mice
    Language English
    Publishing date 2018-02-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/nox233
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    Zs.A 5307: Show issues Location:
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  3. Article ; Online: A new class of radiosensitizers for glioblastoma.

    Abounader, Roger / Schiff, David

    Oncotarget

    2021  Volume 12, Issue 13, Page(s) 1199–1200

    Language English
    Publishing date 2021-06-22
    Publishing country United States
    Document type News
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.27970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cryptic lncRNA-encoded ORFs: A hidden source of regulatory proteins.

    Dutta, Anindya / Li, Hui / Abounader, Roger

    The Journal of clinical investigation

    2023  Volume 133, Issue 5

    Abstract: A majority of the human genome is transcribed into noncoding RNAs, of which long noncoding RNAs (lncRNAs) form a large and heterogeneous fraction. While lncRNAs are mostly noncoding, recent evidence suggests that cryptic translation within some lncRNAs ... ...

    Abstract A majority of the human genome is transcribed into noncoding RNAs, of which long noncoding RNAs (lncRNAs) form a large and heterogeneous fraction. While lncRNAs are mostly noncoding, recent evidence suggests that cryptic translation within some lncRNAs may produce proteins with important regulatory functions. In this issue of the JCI, Zheng, Wei, and colleagues used an integrative functional genomic strategy to systematically identify cryptic lncRNA-encoded ORFs that play a role in estrogen receptor-positive (ER+) breast cancer (BC). They identified 758 cryptic lncRNA-encoded ORFs undergoing active translation, of which 28 had potential functional and clinical relevance in ER+ BC. The LINC00992-encoded polypeptide GT3-INCP was upregulated in ER+ BC and drove tumor growth. GT3-INCP was regulated by estrogen and the ER and acted via the transcription factor GATA3 to regulate BC susceptibility and risk genes. These findings discern a largely unexplored class of molecules and have implications for many pathologies, including cancer.
    MeSH term(s) Humans ; RNA, Long Noncoding/genetics ; Open Reading Frames ; Clinical Relevance ; Estrogens ; GATA3 Transcription Factor
    Chemical Substances RNA, Long Noncoding ; Estrogens ; GATA3 Transcription Factor
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI167271
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  5. Article ; Online: The blood-brain barrier limits the therapeutic efficacy of antibody-drug conjugates in glioblastoma.

    Abounader, Roger / Schiff, David

    Neuro-oncology

    2021  Volume 23, Issue 12, Page(s) 1993–1994

    MeSH term(s) Blood-Brain Barrier ; Brain Neoplasms/drug therapy ; Drug Delivery Systems ; Glioblastoma/drug therapy ; Humans ; Immunoconjugates/therapeutic use
    Chemical Substances Immunoconjugates
    Language English
    Publishing date 2021-09-06
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/noab223
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  6. Article ; Online: Cryptic lncRNA-encoded ORFs

    Anindya Dutta / Hui Li / Roger Abounader

    The Journal of Clinical Investigation, Vol 133, Iss

    A hidden source of regulatory proteins

    2023  Volume 5

    Abstract: A majority of the human genome is transcribed into noncoding RNAs, of which long noncoding RNAs (lncRNAs) form a large and heterogeneous fraction. While lncRNAs are mostly noncoding, recent evidence suggests that cryptic translation within some lncRNAs ... ...

    Abstract A majority of the human genome is transcribed into noncoding RNAs, of which long noncoding RNAs (lncRNAs) form a large and heterogeneous fraction. While lncRNAs are mostly noncoding, recent evidence suggests that cryptic translation within some lncRNAs may produce proteins with important regulatory functions. In this issue of the JCI, Zheng, Wei, and colleagues used an integrative functional genomic strategy to systematically identify cryptic lncRNA-encoded ORFs that play a role in estrogen receptor–positive (ER+) breast cancer (BC). They identified 758 cryptic lncRNA-encoded ORFs undergoing active translation, of which 28 had potential functional and clinical relevance in ER+ BC. The LINC00992-encoded polypeptide GT3-INCP was upregulated in ER+ BC and drove tumor growth. GT3-INCP was regulated by estrogen and the ER and acted via the transcription factor GATA3 to regulate BC susceptibility and risk genes. These findings discern a largely unexplored class of molecules and have implications for many pathologies, including cancer.
    Keywords Medicine ; R
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: HGF/MET Signaling in Malignant Brain Tumors.

    Mulcahy, Elizabeth Qian Xu / Colόn, Rossymar Rivera / Abounader, Roger

    International journal of molecular sciences

    2020  Volume 21, Issue 20

    Abstract: Hepatocyte growth factor (HGF) ligand and its receptor tyrosine kinase (RTK) mesenchymal-epithelial transition factor (MET) are important regulators of cellular processes such as proliferation, motility, angiogenesis, and tissue regeneration. In healthy ... ...

    Abstract Hepatocyte growth factor (HGF) ligand and its receptor tyrosine kinase (RTK) mesenchymal-epithelial transition factor (MET) are important regulators of cellular processes such as proliferation, motility, angiogenesis, and tissue regeneration. In healthy adult somatic cells, this ligand and receptor pair is expressed at low levels and has little activity except when tissue injuries arise. In cancer cells, HGF/MET are often overexpressed, and this overexpression is found to correlate with tumorigenesis, metastasis, and poorer overall prognosis. This review focuses on the signaling of these molecules in the context of malignant brain tumors. RTK signaling pathways are among the most common and universally dysregulated pathways in gliomas. We focus on the role of HGF/MET in the following primary malignant brain tumors: astrocytomas, glioblastomas, oligodendrogliomas, ependymomas, and embryonal central nervous system tumors (including medulloblastomas and others). Brain metastasis, as well as current advances in targeted therapies, are also discussed.
    MeSH term(s) Animals ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Glioma/metabolism ; Glioma/pathology ; Hepatocyte Growth Factor/metabolism ; Humans ; Neoplasm Metastasis ; Proto-Oncogene Proteins c-met/metabolism ; Signal Transduction
    Chemical Substances Hepatocyte Growth Factor (67256-21-7) ; Proto-Oncogene Proteins c-met (EC 2.7.10.1)
    Language English
    Publishing date 2020-10-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21207546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The tumor-suppressive long noncoding RNA DRAIC inhibits protein translation and induces autophagy by activating AMPK.

    Saha, Shekhar / Zhang, Ying / Wilson, Briana / Abounader, Roger / Dutta, Anindya

    Journal of cell science

    2021  Volume 134, Issue 24

    Abstract: Long noncoding RNAs (lncRNAs) are long RNA transcripts that do not code for proteins and have been shown to play a major role in cellular processes through diverse mechanisms. DRAIC, a lncRNA that is downregulated in castration-resistant advanced ... ...

    Abstract Long noncoding RNAs (lncRNAs) are long RNA transcripts that do not code for proteins and have been shown to play a major role in cellular processes through diverse mechanisms. DRAIC, a lncRNA that is downregulated in castration-resistant advanced prostate cancer, inhibits the NF-κB pathway by inhibiting the IκBα kinase. Decreased DRAIC expression predicted poor patient outcome in gliomas and seven other cancers. We now report that DRAIC suppresses invasion, migration, colony formation and xenograft growth of glioblastoma-derived cell lines. DRAIC activates AMP-activated protein kinase (AMPK) by downregulating the NF-κB target gene GLUT1, and thus represses mTOR, leading to downstream effects, such as a decrease in protein translation and increase in autophagy. DRAIC, therefore, has an effect on multiple signal transduction pathways that are important for oncogenesis, namely, the NF-κB pathway and AMPK-mTOR-S6K/ULK1 pathway. The regulation of NF-κB, protein translation and autophagy by the same lncRNA explains the tumor-suppressive role of DRAIC in different cancers and reinforces the importance of lncRNAs as emerging regulators of signal transduction pathways. This article has an associated First Person interview with the first author of the paper.
    MeSH term(s) AMP-Activated Protein Kinases/genetics ; Autophagy/genetics ; Cell Line, Tumor ; Humans ; Male ; Prostatic Neoplasms ; Protein Biosynthesis ; RNA, Long Noncoding/genetics
    Chemical Substances RNA, Long Noncoding ; AMP-Activated Protein Kinases (EC 2.7.11.31)
    Language English
    Publishing date 2021-12-20
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.259306
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  9. Article ; Online: The role of microRNAs in brain metastasis.

    Hudson, Kadie / Mondia, Mark Willy / Zhang, Ying / Saha, Shekhar / Gibert, Myron K / Dube, Collin / Sun, Yunan / Marcinkiewicz, Pawel / Fadul, Camilo / Abounader, Roger

    Journal of neuro-oncology

    2024  Volume 166, Issue 2, Page(s) 231–241

    Abstract: Brain metastasis (BM) is the most common type of brain tumor and frequently foreshadows disease progression and poor overall survival with patients having a median survival of 6 months. 70,000 new cases of BM are diagnosed each year in the United States ( ...

    Abstract Brain metastasis (BM) is the most common type of brain tumor and frequently foreshadows disease progression and poor overall survival with patients having a median survival of 6 months. 70,000 new cases of BM are diagnosed each year in the United States (US) and the incidence rate for BM is increasing with improved detection. MicroRNAs (miRNAs) are small non-coding RNAs that serve as critical regulators of gene expression and can act as powerful oncogenes and tumor suppressors. MiRNAs have been heavily implicated in cancer and proposed as biomarkers or therapeutic targets or agents. In this review, we summarize an extensive body of scientific work investigating the role of microRNAs in BM. We discuss miRNA dysregulation, functions, targets, and mechanisms of action in BM and present the current standing of miRNAs as biomarkers and potential therapeutics for BM. We conclude with future directions of miRNA basic and clinical research in BM.
    MeSH term(s) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Brain Neoplasms/genetics ; Oncogenes ; Gene Expression Regulation, Neoplastic
    Chemical Substances MicroRNAs ; Biomarkers, Tumor
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604875-4
    ISSN 1573-7373 ; 0167-594X
    ISSN (online) 1573-7373
    ISSN 0167-594X
    DOI 10.1007/s11060-023-04541-x
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  10. Article ; Online: MicroRNAs: Key Regulators in Lung Cancer.

    El Founini, Younes / Chaoui, Imane / Dehbi, Hind / El Mzibri, Mohammed / Abounader, Roger / Guessous, Fadila

    MicroRNA (Shariqah, United Arab Emirates)

    2021  Volume 10, Issue 2, Page(s) 109–122

    Abstract: Noncoding RNAs have emerged as key regulators of the genome upon gene expression profiling and genome-wide sequencing. Among these noncoding RNAs, microRNAs are short noncoding RNAs that regulate a plethora of functions, biological processes and human ... ...

    Abstract Noncoding RNAs have emerged as key regulators of the genome upon gene expression profiling and genome-wide sequencing. Among these noncoding RNAs, microRNAs are short noncoding RNAs that regulate a plethora of functions, biological processes and human diseases by targeting the messenger RNA stability through 3'UTR binding, leading to either mRNA cleavage or translation repression, depending on microRNA-mRNA complementarity degree. Additionally, strong evidence has suggested that dysregulation of miRNAs contributes to the etiology and progression of human cancers, such as lung cancer, the most common and deadliest cancer worldwide. Indeed, by acting as oncogenes or tumor suppressors, microRNAs control all aspects of lung cancer malignancy, including cell proliferation, survival, migration, invasion, angiogenesis, cancer stem cells, immune-surveillance escape, and therapy resistance; and their expressions are often associated with clinical parameters. Moreover, several deregulated microRNAs in lung cancer are carried by exosomes and microvesicles and secreted in body fluids, mainly the circulation, where they conserve their stable forms. Subsequently, seminal efforts have been focused on extracellular microRNAs levels as noninvasive diagnostic and prognostic biomarkers in lung cancer. In this review, focusing on recent literature, we summarize the deregulation, mechanisms of action, functions and highlight clinical applications of miRNAs for better management and design of future lung cancer targeted therapies.
    MeSH term(s) Biomarkers, Tumor/genetics ; Exosomes/genetics ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/genetics ; MicroRNAs/genetics ; RNA, Messenger
    Chemical Substances Biomarkers, Tumor ; MicroRNAs ; RNA, Messenger
    Language English
    Publishing date 2021-08-10
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ISSN 2211-5374
    ISSN (online) 2211-5374
    DOI 10.2174/2211536610666210527102522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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