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Article: Prostaglandin E2 as transduction enhancer affects competitive engraftment of human hematopoietic stem and progenitor cells.

Poletti, Valentina / Montepeloso, Annita / Pellin, Danilo / Biffi, Alessandra

Molecular therapy. Methods & clinical development

2023 Volume 31, Page(s) 101131

Abstract: ... Ex ... ...

Abstract	Ex vivo
Language	English
Publishing date	2023-10-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2872938-9
ISSN	2329-0501 ; 2329-0501
ISSN (online)	2329-0501
ISSN	2329-0501
DOI	10.1016/j.omtm.2023.101131
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Zs.A 7107: Show issues

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Article ; Online: Living beyond loss: a qualitative investigation of caregivers' experiences after the death of their relatives with amyotrophic lateral sclerosis.

Volpato, Eleonora / Banfi, Paolo / Poletti, Valentina / Pagnini, Francesco

Amyotrophic lateral sclerosis & frontotemporal degeneration

2023 Volume 25, Issue 1-2, Page(s) 75–87

Abstract: Background: Caregivers of Amyotrophic Lateral Sclerosis (ALS) patients experience varying psychological responses following the patient's death, including sadness, loneliness, guilt, and a loss of purpose.: Objectives: This research aims to ... ...

Abstract	Background: Caregivers of Amyotrophic Lateral Sclerosis (ALS) patients experience varying psychological responses following the patient's death, including sadness, loneliness, guilt, and a loss of purpose. Objectives: This research aims to investigate the caregiver journey experienced from the time of diagnosis to the loss of a care recipient, with a specific focus on understanding the factors that contribute to improved coping with bereavement. Methods: The present study used the Interpretative Phenomenological Approach (IPA) to qualitatively explore the accounts of 41 Italian bereaved caregivers of people affected by ALS (Mean Age = 59.78; Female: 60.98%; Male: 39.02%). Results: Results revealed 5 overarching themes representing 5 macro areas that emerged from the analysis of the interviews (" Conclusions: Results emphasize the need to improve the psychological support offered to caregivers of person living with ALS after the patient's death, tailoring it to the specificity of the condition, to meet their emotional needs, reduce isolation and help them cope with practical challenges and plans.
MeSH term(s)	Humans ; Male ; Female ; Middle Aged ; Amyotrophic Lateral Sclerosis/psychology ; Caregivers/psychology ; Social Support ; Coping Skills ; Qualitative Research
Language	English
Publishing date	2023-09-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2705049-X
ISSN	2167-9223 ; 2167-8421
ISSN (online)	2167-9223
ISSN	2167-8421
DOI	10.1080/21678421.2023.2255628
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Zs.A 5874: Show issues

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Article: Illness Perceptions, Cognitions, and Beliefs on COPD Patients' Adherence to Treatment - A Systematic Review.

Poletti, Valentina / Pagnini, Francesco / Banfi, Paolo / Volpato, Eleonora

Patient preference and adherence

2023 Volume 17, Page(s) 1845–1866

Abstract: Background: Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory lung disease characterized by persistent respiratory symptoms and airflow limitation. Besides its irreversibility, COPD is a treatable condition, and patients would ... ...

Abstract	Background: Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory lung disease characterized by persistent respiratory symptoms and airflow limitation. Besides its irreversibility, COPD is a treatable condition, and patients would strongly benefit from being adherent to their treatments. However, almost half of them are non-adherent, and, according to several recent studies, the way the patient perceives the disease might influence this variable. Aim: This systematic review provided a synthesis of studies about the relationships between illness perceptions (IP), cognitions, beliefs, and adherence in COPD. Methods: English language publications were searched in PubMed, Medline, Scopus, ResearchGate, PsycINFO, and Cochrane Library databases from November 2022 to February 2023, following PRISMA guidelines. The reference lists of eligible studies were also searched. Data extraction and critical appraisal were undertaken by two reviewers working independently. Results: A total of 14 studies were included. Adherence to treatment in COPD is confirmed to be low, using both self-report questionnaires and objective assessment systems. Most studies concluded that COPD is perceived as a moderate threat destined to last forever, even if many participants referred to little disease knowledge. This perception did not change between adherent and non-adherent groups. Those who considered more necessary to take their medicines and had a caregiver were more adherent and less concerned about their future. On the other side, forgetfulness, lack of trust in medications, and difficulties in understanding how to take them were perceived as the main causes of non-adherence. Other predictors of non-adherence, like depression, low self-efficacy, and severity of disease were confirmed. Conclusion: The systematic review highlights the variability of the relationship between IP, cognitions and beliefs, and COPD treatment adherence. A new level of awareness of the relationship between patients' subjective point of view and treatment adherence may inform future treatment options and promote a more personalized intervention.
Language	English
Publishing date	2023-07-28
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2455848-5
ISSN	1177-889X
ISSN	1177-889X
DOI	10.2147/PPA.S412136
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Article ; Online: Designing Lentiviral Vectors for Gene Therapy of Genetic Diseases.

Poletti, Valentina / Mavilio, Fulvio

Viruses

2021 Volume 13, Issue 8

Abstract: Lentiviral vectors are the most frequently used tool to stably transfer and express genes in the context of gene therapy for monogenic diseases. The vast majority of clinical applications involves an ex vivo modality whereby lentiviral vectors are used ... ...

Abstract	Lentiviral vectors are the most frequently used tool to stably transfer and express genes in the context of gene therapy for monogenic diseases. The vast majority of clinical applications involves an ex vivo modality whereby lentiviral vectors are used to transduce autologous somatic cells, obtained from patients and re-delivered to patients after transduction. Examples are hematopoietic stem cells used in gene therapy for hematological or neurometabolic diseases or T cells for immunotherapy of cancer. We review the design and use of lentiviral vectors in gene therapy of monogenic diseases, with a focus on controlling gene expression by transcriptional or post-transcriptional mechanisms in the context of vectors that have already entered a clinical development phase.
MeSH term(s)	Animals ; Clinical Trials as Topic ; Gene Expression ; Genetic Therapy/methods ; Genetic Vectors ; Green Fluorescent Proteins ; Humans ; Lentivirus/genetics ; Mice ; Transduction, Genetic/methods
Chemical Substances	Green Fluorescent Proteins (147336-22-9)
Language	English
Publishing date	2021-08-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13081526
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Article: Designing Lentiviral Vectors for Gene Therapy of Genetic Diseases

Poletti, Valentina / Mavilio, Fulvio

Viruses. 2021 Aug. 02, v. 13, no. 8

2021

Abstract	Lentiviral vectors are the most frequently used tool to stably transfer and express genes in the context of gene therapy for monogenic diseases. The vast majority of clinical applications involves an ex vivo modality whereby lentiviral vectors are used to transduce autologous somatic cells, obtained from patients and re-delivered to patients after transduction. Examples are hematopoietic stem cells used in gene therapy for hematological or neurometabolic diseases or T cells for immunotherapy of cancer. We review the design and use of lentiviral vectors in gene therapy of monogenic diseases, with a focus on controlling gene expression by transcriptional or post-transcriptional mechanisms in the context of vectors that have already entered a clinical development phase.
Keywords	gene expression ; gene therapy ; immunotherapy ; transcription (genetics)
Language	English
Dates of publication	2021-0802
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v13081526
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effects of the presence of fibrin strands on complete blood count parameters.

Rosetti, Marco / Olivieri, Melania / Polli, Valentina / Massari, Evita / Monti, Marta / Clementoni, Alice / Libri, Virginia / Poletti, Giovanni / Fasano, Tommaso

Scandinavian journal of clinical and laboratory investigation

2024 Volume 83, Issue 8, Page(s) 620–621

MeSH term(s)	Humans ; Fibrin ; Blood Cell Count
Chemical Substances	Fibrin (9001-31-4)
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	3150-1
ISSN	1502-7686 ; 0036-5513
ISSN (online)	1502-7686
ISSN	0036-5513
DOI	10.1080/00365513.2023.2292601
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Article ; Online: The Role of Depression on Treatment Adherence in Patients with Heart Failure-a Systematic Review of the Literature.

Poletti, Valentina / Pagnini, Francesco / Banfi, Paolo / Volpato, Eleonora

Current cardiology reports

2022

Abstract: Introduction: Although poor medication adherence is considered an impacting risk factor for worsening heart failure (HF) outcomes, adherence rates in HF patients continue to be considerably low. To improve this condition, several studies investigated ... ...

Abstract	Introduction: Although poor medication adherence is considered an impacting risk factor for worsening heart failure (HF) outcomes, adherence rates in HF patients continue to be considerably low. To improve this condition, several studies investigated the impact of many determinants on medication adherence; however, few authors explored the role of depression on it. Purpose of review: The purpose of this systematic review was to explore the association between depressive symptoms and medication adherence in HF patients. In particular, the research question was is depression a barrier to medication adherence in HF patients? Methods: A systematic review of quantitative analysis studies was undertaken. Six electronic databases were searched between the end of October and March 2022. Thirty-one trials were included, all of them assessed depression, adherence to medication, and their possible relationship. Results: As was intended, findings showed that the impact of a mild to moderate level of depression was significant on adherence to treatment in HF patients. However, many other risk factors emerged, like family support and health practices (es. low sodium diet). Conclusion: The detection of depression in the setting of HF should be crucial to HF patients' physical health and quality of life. Future research should take depression into account, exploring this area through self-report and qualitative interview as well.
Language	English
Publishing date	2022-11-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2055373-0
ISSN	1534-3170 ; 1523-3782
ISSN (online)	1534-3170
ISSN	1523-3782
DOI	10.1007/s11886-022-01815-0
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Zs.A 5524: Show issues

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Article ; Online: Feasibility and effectiveness of Dialectical-Behavior Therapy for patients with borderline personality disorder in Italian mental health services: a preliminary study.

Giordano, Chiara / Iannuzzi, Valentina / Danesi, Francesca / Poletti, Michele

Rivista di psichiatria

2021 Volume 56, Issue 1, Page(s) 43–45

Abstract: Dialectical-Behavior Therapy (DBT) is an evidence-based effective psychotherapeutic intervention for patients with Borderline Personality Disorder (BPD). There is a paucity of empirical evidences on the feasibility and the effectiveness of DBT in real- ... ...

Abstract	Dialectical-Behavior Therapy (DBT) is an evidence-based effective psychotherapeutic intervention for patients with Borderline Personality Disorder (BPD). There is a paucity of empirical evidences on the feasibility and the effectiveness of DBT in real-world Italian mental health services. This study aimed at reporting preliminary data on the implementation of DBT for adult patients with BPD attending an Italian mental health service. 28 BPD patients attending a mental health service underwent a 16-session DBT program. Effects of DBT were measured with the Difficulties in Emotion Regulation Scale (DERS) and the Barratt Impulsiveness Scale (BIS-11). 17 patients completed the DBT program, reporting reduced levels of emotion dysregulation and impulsiveness at follow up in comparison with baseline. Higher emotional dysregulation was a risk factor for dropout. In conclusion, this preliminary pilot study suggests that DBT is feasible and effective for BPD patients in Italian adult mental health services.
MeSH term(s)	Adult ; Behavior Therapy ; Borderline Personality Disorder/therapy ; Feasibility Studies ; Humans ; Italy ; Mental Health Services ; Pilot Projects ; Treatment Outcome
Language	English
Publishing date	2021-02-09
Publishing country	Italy
Document type	Journal Article
ZDB-ID	205570-3
ISSN	2038-2502 ; 0035-6484
ISSN (online)	2038-2502
ISSN	0035-6484
DOI	10.1708/3546.35219
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Article ; Online: Gene-Based Approaches to Inherited Neurometabolic Diseases.

Poletti, Valentina / Biffi, Alessandra

Human gene therapy

2019 Volume 30, Issue 10, Page(s) 1222–1235

Abstract: In the last decade, the gene therapy (GT) field experienced a renaissance, thanks to crucial understandings and innovations in vector design, stem cell manipulation, conditioning protocols, and cell/vector delivery. These efforts were successfully ... ...

Abstract	In the last decade, the gene therapy (GT) field experienced a renaissance, thanks to crucial understandings and innovations in vector design, stem cell manipulation, conditioning protocols, and cell/vector delivery. These efforts were successfully coupled with unprecedented clinical results of the trials employing the newly developed technology and with the novel establishment of academic-industrial partnerships. A renewed and strengthened interest is rising in the development of gene-based approaches for inherited neurometabolic disorders with severe neurological involvement. Inherited metabolic disorders are monogenetic diseases caused by enzymatic or structural deficiencies affecting the lysosomal or peroxisomal metabolic activity. The metabolic defect can primarily affect the central nervous system, leading to neuronal death, microglial activation, inflammatory demyelination, and axonal degeneration. This review provides an overview of the GT strategies currently under clinical investigation for neurometabolic lysosomal and peroxisomal storage diseases, such as adrenoleukodystrophy and metachromatic leukodystrophy, as well as novel emerging indications such as mucopolysaccharidoses, gangliosidoses, and neuronal ceroid lipofuscinoses, with a comprehensive elucidation of the main features and mechanisms at the basis of a successful GT approach for these devastating diseases.
MeSH term(s)	Adrenoleukodystrophy/enzymology ; Adrenoleukodystrophy/genetics ; Adrenoleukodystrophy/pathology ; Adrenoleukodystrophy/therapy ; Animals ; Central Nervous System/enzymology ; Central Nervous System/pathology ; Clinical Trials as Topic ; Dependovirus/genetics ; Dependovirus/metabolism ; Disease Models, Animal ; Gangliosidoses/enzymology ; Gangliosidoses/genetics ; Gangliosidoses/pathology ; Gangliosidoses/therapy ; Gene Editing/methods ; Gene Transfer Techniques ; Genetic Therapy/methods ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Humans ; Lentivirus/genetics ; Lentivirus/metabolism ; Leukodystrophy, Metachromatic/enzymology ; Leukodystrophy, Metachromatic/genetics ; Leukodystrophy, Metachromatic/pathology ; Leukodystrophy, Metachromatic/therapy ; Mucopolysaccharidoses/enzymology ; Mucopolysaccharidoses/genetics ; Mucopolysaccharidoses/pathology ; Mucopolysaccharidoses/therapy ; Neuronal Ceroid-Lipofuscinoses/enzymology ; Neuronal Ceroid-Lipofuscinoses/genetics ; Neuronal Ceroid-Lipofuscinoses/pathology ; Neuronal Ceroid-Lipofuscinoses/therapy
Language	English
Publishing date	2019-09-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1028152-6
ISSN	1557-7422 ; 1043-0342
ISSN (online)	1557-7422
ISSN	1043-0342
DOI	10.1089/hum.2019.190
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Article ; Online: Hippocampal and parahippocampal volume and function predict antidepressant response in patients with major depression: A multimodal neuroimaging study.

Paolini, Marco / Harrington, Yasmin / Colombo, Federica / Bettonagli, Valentina / Poletti, Sara / Carminati, Matteo / Colombo, Cristina / Benedetti, Francesco / Zanardi, Raffaella

Journal of psychopharmacology (Oxford, England)

2023 Volume 37, Issue 11, Page(s) 1070–1081

Abstract: Background: For many patients with major depressive disorder (MDD) adequate treatment remains elusive. Neuroimaging techniques received attention for their potential use in guiding and predicting response, but were rarely investigated in real-world ... ...

Abstract	Background: For many patients with major depressive disorder (MDD) adequate treatment remains elusive. Neuroimaging techniques received attention for their potential use in guiding and predicting response, but were rarely investigated in real-world psychiatric settings. Aims: To identify structural and functional Magnetic Resonance Imaging (MRI) biomarkers associated with antidepressant response in a real-world clinical sample. Methods: We studied 100 MDD inpatients admitted to our psychiatric ward, treated with various antidepressants upon clinical need. Hamilton Depression Rating Scale percentage decrease from admission to discharge was used as a measure of response. All patients underwent 3.0 T MRI scanning. Grey matter (GM) volumes were investigated both in a voxel-based morphometry (VBM), and in a regions of interest (ROI) analysis. In a subsample of patients, functional resting-state connectivity patterns were also explored. Results: In the VBM analysis, worse response was associated to lower GM volumes in two clusters, encompassing the left hippocampus and parahippocampal gyrus, and the right superior and middle temporal gyrus. Investigating ROIs, lower bilateral hippocampi and amygdalae volumes predicted worse treatment outcomes. Functional connectivity in the right temporal and parahippocampal gyrus was also associated to response. Conclusion: Our results expand existing literature on the relationship between the structure and function of several brain regions and treatment response in MDD. While we are still far from routine use of MRI biomarkers in clinical practice, we confirm a possible role of these techniques in guiding treatment choices and predicting their efficacy.
MeSH term(s)	Humans ; Depressive Disorder, Major/diagnostic imaging ; Depressive Disorder, Major/drug therapy ; Depression ; Brain ; Antidepressive Agents/therapeutic use ; Neuroimaging ; Hippocampus/pathology ; Magnetic Resonance Imaging/methods ; Biomarkers
Chemical Substances	Antidepressive Agents ; Biomarkers
Language	English
Publishing date	2023-08-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639313-5
ISSN	1461-7285 ; 0269-8811
ISSN (online)	1461-7285
ISSN	0269-8811
DOI	10.1177/02698811231190859
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